CN110226661A - 一种提高睡眠质量的刺梨保健糖果及其制备方法 - Google Patents
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Abstract
本发明涉及保健糖果技术领域,具体涉及一种提高睡眠质量的刺梨保健糖果及其制备方法。一种提高睡眠质量的刺梨保健糖果,按重量份计由以下成分组成:刺梨15‑50份、樱桃5‑10份、南酸枣10‑15份、牛***10‑15份、天冬10‑20份、麦冬10‑20份、乌梅5‑15份、龙眼肉10‑15份、甘草3‑10份、桑葚5‑20份和低聚果糖3‑5份。本发明保健糖果是在药理论指导下,结合发明人多年临床实践经验,精选多种原材料制备而成,调和脾胃,改善脾胃功能,进而改善失眠状况,提高睡眠质量,且不会使人产生依赖性,无毒副作用。
Description
技术领域
本发明涉及保品领域,具体涉及一种提高睡眠质量的刺梨保健糖果及其制备方法。
背景技术
睡眠占据人们生命活动的三分之一的时间,对人体的生理机能和心理健康都有非常重要的影响。睡眠能增强免疫力、消除疲劳、保护大脑、促进发育、提高记忆力和美容养颜,但随着现在生活节奏的加快,睡眠问题渐渐突出,人们的睡眠质量随着年龄的增长而降低。失眠是影响睡眠质量的常见问题,失眠是指无法入睡或无法保持睡眠状态,导致睡眠不足,表现为入睡困难、睡后易醒、早醒或睡眠时间不足等,常会引起疲劳感、全身不适、无精打采、反应迟钝、头痛和记忆力差等症状,但最大的影响是精神方面,长期严重的失眠有导致精神***的可能。
中医讲“胃不和则卧不安”,意思是说如果脾胃有疾病,就会导致睡眠质量下降。这是因为脾胃功能失调会引起宿食积滞或肠胃积热,进而内扰心神,最终导致失眠。因此,治疗失眠,提高睡眠治疗还需从调和脾胃入手。
目前存在的含刺梨的糖果保健功能单一,其在改善睡眠方面,仅刺梨一种进行保健的功效有限。
目前改善睡眠的大多采用药物,副作用大,提供一种采用各种水果结合生产的能够帮助睡眠的糖果将受欢迎。
结合中药理论,简单的将各类药材、水果混合,生产的糖果将夺取刺梨的味道,造成“喧宾夺主”,且简单混合口感确实差。但单元采用刺梨效果也很难实现最佳。
生产过程中,不考虑刺梨维生素等容易破坏的情况,混乱一锅处理,会让刺梨失去其营养价值和功效。
公开于该背景技术部分的信息仅仅旨在增加对本发明的总体背景的理解,而不应当被视为承认或以任何形式暗示该信息构成已为本领域一般技术人员所公知的现有技术。
发明内容
为克服上述现有问题,本发明提供一种提高睡眠质量的刺梨保健糖果及其制备方法,本发明的保健糖果可以调和脾胃,改善脾胃功能,进而改善失眠状况,提高睡眠质量。
本发明的技术方案如下:
一种提高睡眠质量的刺梨保健糖果,其特征在于,按重量份计由以下成分组成:刺梨15-50份、樱桃5-10份、南酸枣10-15份、牛***10-15份、天冬10-20份、麦冬10-20份、乌梅5-15份、龙眼10-15份、甘草3-10份、桑葚5-20份和低聚果糖3-5份。
本发明还提供了上述提高睡眠质量的保健糖果的制备方法,包括以下步骤:
1)按重量份计称取组成成分;
(2)将南酸枣、牛***、乌梅、粉碎成粗粉,加水煎煮,煎液滤过,收集滤液;
(3)将步骤(2)所得滤液加乙醇醇沉,静置,滤过,回收乙醇,得到液体a;
(4)将天冬、麦冬和甘草混合,加水煎煮,煎液滤过,收集滤液,得到液体b;
(5)将刺梨、樱桃、龙眼、桑葚粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,得刺梨果汁液体c;
(6)将液体a、液体b、液体c混合,浓缩至清膏,加入低聚果糖,混匀,干燥,粉碎,制粒,整粒,包装,即得所述保健糖果。
上述步骤中采用将南酸枣、牛***、乌梅成粗粉,加水煎煮,煎液滤过,收集滤液,并将所得滤液加乙醇醇沉,后再加入天冬、麦冬、甘草,最后才加入刺梨液,最少的减少南酸枣、牛***、乌梅对口感的影响,最大限度的保留的刺梨的味道,且最大限度保留刺梨维生素B、C,胡萝卜素、苹果酸、柠檬酸等成分;而将樱桃、龙眼、桑葚其“夺味”效果不明显,富含多种果糖和氨基酸,特别是桑葚富含花青素,将它们与刺梨粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,期间樱桃、龙眼、桑葚的有效成分与刺梨一起经过胶酶和5%的纤维素酶的处理,既保证了有效成分不被破坏,而且让口感更好。
上述步骤中,将天冬、麦冬和甘草混合,加水煎煮,煎液滤过,收集滤液,既实现了功效,又让天冬、麦冬的苦味让甘草“中和”。
上述步骤中,其采用少量果糖,含糖量较少适合老年人适用。
作为优选,所述步骤(6)中加入牛奶20-30份、蜂蜜20-30份、蔗糖10-20份。
作为优选,所述樱桃、南酸枣、牛***、乌梅和龙眼在粉碎前去核,制成新的刺梨保健糖果,该糖果保证了疗效的同时,进一步增加了口感,适合年轻人食用。
作为优选,所述步骤(2)中煎煮次数为3次,第1、2次2h,第3次1.5h。
作为优选,所述步骤(3)中乙醇的质量分数为85%。
作为优选,所述步骤(3)中乙与滤液的体积比为2-3:1。
作为优选,所述步骤(4)中煎煮次数为2次,每次2h。
作为优选,所述步骤(6)中清膏在90℃下的相对密度为1.12-1.17。
作为优选,所述步骤(6)干燥时采用真空干燥、喷雾干燥或减压干燥。
药理基础
具体如下:
刺梨:蔷薇科植物茨梨Rosa rozburghii T.的果实,别名刺菠萝、刺莓果、佛朗果、送春归、茨梨、木梨子、刺酸梨子、九头鸟、文先果,性味凉,甘、酸微涩; 清热生津,健胃消食,解暑;含丰富的维生素B、C,胡萝卜素、苹果酸、柠檬酸等成分,被称为维C之王。用于胃阴不足,食欲减退,消化不良,或饮食积滞,饱胀满闷,腹泻便溏;热病或暑热伤津,口干口渴,心烦发热,小便短赤。
配制时,使用刺梨尽量保证其原汁原味,能够充分利用其维生素B、C,胡萝卜素、苹果酸、柠檬酸等成分,解决使用者胃阴不足,食欲减退,消化不良,或饮食积滞,饱胀满闷,腹泻便溏,病或暑热伤津,口干口渴,心烦发热等症状,从多个方面发挥其功效。
樱桃:在水果家族中,一般铁的含量较低,樱桃却卓然不群,一枝独秀,每百克樱桃中含铁量多达59毫克,居于水果首位;维生素A含量比葡萄、苹果、橘子多4~5倍,同时其含糖、枸椽酸、酒石酸、胡萝卜素、维生素C、铁、钙、磷等成分。其性温,味甘、微酸,归脾、肝经;具有补中益气,祛风除湿,主水谷痢,止泄精。常用于病后体虚气弱,气短心悸,倦怠食少,咽干口渴;风湿腰腿疼痛,四肢不仁,关节屈伸不利,冻疮。因其含铁量较高、同时其含维生素C、糖、枸椽酸、酒石酸、胡萝卜素、维生素C、铁、钙、磷等成分,其在归脾、肝经、补中益气,祛风除湿方面具有较好的效果,将其加入能解决气血不足等造成的失眠。
因其果酸较少,配制时,将樱桃与刺梨一起采用原汁原味利用3%果胶酶和5%的纤维素酶与刺梨一起经过酶的处理,其营养得以保存,且利用其独特口味改善糖果的口感,尤其是其丰富的果糖和果胶在与刺梨混合时能让相关酶充分发挥作用。其疗效重点是增加维生素和微量元素的同时,通过微量补铁改善血液提升睡眠的同时从脾、肝入手解决睡眠问题。
桑葚:成熟的桑椹果(紫、红)营养丰富,每100克含:水分81.8克,能量48千卡,蛋白质1.6~1.8克,脂肪0.3~0.4克。膳食纤维(纤维素)3.3~4.9克,碳水化合物10~12.9克,灰分1.2克,维生素A:3微克,胡萝卜素20~30微克,硫胺素0.02毫克、核黄素0.05~0.06毫克,维生素E:6.95~12.78毫克,钾33毫克,钙30毫克,磷33毫克,钾32毫克,钠1.9毫克,铁0.3毫克,锌0.25~0.27毫克,铜0.06~0.08毫克,硒4.8~6.5微克,锰0.29毫克。
此外,桑葚还含有鞣酸,苹果酸,维生素C和脂肪酸等。其脂肪主要为亚油酸、油酸、软脂酸、硬脂酸和少量辛酸、壬酸、癸酸、肉豆蔻酸、亚麻酸等。早在两千多年前,桑葚已是中国皇帝御用的补品。因桑树特殊的生长环境使桑果具有天然生长,无任何污染的特点,所以桑葚又被称为“民间圣果”。现代研究证实,桑葚果实中含有丰富的活性蛋白、维生素、氨基酸、胡萝卜素、矿物质、白藜芦醇、花青素等成份,营养是苹果的5~6倍,是葡萄的4倍,具有多种功效,被医学界誉为“21世纪的最佳保健果品”。
其性寒,味甘,归肝、肾经;具有滋阴补血,生津润燥,润肠排毒之功效,常用于头晕目眩,腰酸耳鸣,须发早白,失眠多梦,津伤口渴,肠燥便秘。
因其和樱桃一样果酸较少,配制时,将其与刺梨一起采用原汁原味利用3%果胶酶和5%的纤维素酶与刺梨一起经过酶的处理,其营养得以保存,且利用其独特口味改善糖果的口感,尤其是其丰富的花青素等能让糖果了功效增倍。其疗效重点是增加维生素和微量元素的同时,从肝、肾入手解决睡眠问题。
龙眼:龙眼肉,性温,味甘,归心、脾经;具有补益心脾,养血安神的功效,常用于气血不足。龙眼果肉中含碳水化合物、蛋白质、脂肪、粗纤维、维生素C、烟酸和维生素K等多种营养成分,同时还含有灰分、钙、磷等微量元素。其中,烟酸和维生素K的含量很高,是其他水果少有的,可以营养神经和脑组织,从而调整大脑皮层功能,对神经性、贫血性或思虑过度所引起的心跳心慌、头晕失眠等具有显著疗效。同时,龙眼中含有丰富的铁元素,并且易于被人体消化吸收,而铁元素能够促进合成人体内的血红蛋白,其和樱桃一样能够解决贫血等造成的睡眠问题。
因其和樱桃一样果酸较少,配制时,将其与刺梨一起采用原汁原味利用3%果胶酶和5%的纤维素酶与刺梨一起经过酶的处理,其营养得以保存,且利用其独特口味改善糖果的口感,尤其是其丰富的铁元素能让糖果了功效增倍。其疗效重点是益气补血,从心、脾入手解决睡眠问题。同时,其性温,克服了部分水果性含的缺陷。
南酸枣:性平,味甘、酸;具有行气活血,养心安神的功效,常用于气滞血瘀,胸痹作痛,心悸气短,心神不安。
其富含广枣总黄酮(TFC),对动物缺氧、心肌缺血、心律失常具有改善作用;同时且可使血流加快速度,改善血液循环和微循环;具有明显扩张冠状血管作用。同时有实验表明,TFC具有非常显着增加小鼠体液免疫和细胞免疫功能、TFC增加免疫功能的特点为较大剂量TFC促进细胞免疫功能强于小剂量,而小剂量TFC增强体液免疫功能则优于大剂量。TFC可通过激活T淋巴细胞***而增强细胞免疫功能,具有增强IgM和IgG介导的体液免疫作用。
本糖果配制中,采用南酸枣,其获取南酸枣其它有效成分外,主要是为了获取广枣总黄酮(TFC),通过广枣总黄酮(TFC)改善食者气滞血瘀,胸痹作痛,心悸气短,心神不安的问题,以此解决睡眠问题,因此采取乙醇提取的方式,实现提取效果最佳的,并避免南酸枣“夺味”。
牛***,性凉,味甘、酸;具有活血行气,止咳止血,清热利湿的功效,常用于泄泻,痢疾,热咳,哮喘,跌打损伤,血崩。牛***具有很高的营养价值,其富含糖类、有机酸、矿质营养、粗蛋白、粗脂肪、多种维生素、多种氨基酸、番茄红素及核黄素等营养物质。
从牛***中能分离得到β-谷甾醇、槲皮素和芦丁这3个化合物,β-谷甾醇具有抗癌和降低胆固醇的作用;槲皮素和芦丁能抑制血小板凝集,抑制胆碱酯酶等,这为牛***的活血行气作用提供了证据。
本糖果配制中,采用牛***,其获取牛***其它有效成分外,主要是为了获取β-谷甾醇、槲皮素和芦丁等帮助食用者行气活血,养心安神,进改善睡眠。因此采取乙醇提取的方式,实现提取效果最佳的,并避免牛***“夺味”。
乌梅,性平,味酸、涩,归肝、脾、肺、大肠经;具有敛肺,涩肠,生津,安蛔的功效,常用于肺虚久咳,久泻久痢,虚热消渴,蛔厥呕吐腹痛。
本糖果配制中,采用牛***,其目的是从肝、脾、肺、大肠经着手,解决食欲不振、肠胃不适等症状,进而改善睡眠,因乌梅具有较强的“夺味”效应,且采用乙醇提取能够有效提取消灭蛔虫等成分,为此本糖配制中采用乙醇提取。
天冬,性寒,味甘、苦,归肺、肾经;具有养阴润燥,清肺生津的功效,常用于肺燥干咳,顿咳痰粘,腰膝酸痛,骨蒸潮热,内热消渴,热病津伤,咽干口渴,肠燥便秘。
麦冬,性微寒,味甘、味苦,归心、肺、胃经;具有养阴生精,润肺清心的功效,常用于肺燥干咳,阴虚劳嗽,喉痹咽痛,津伤口渴,内热消渴,心烦失眠,肠燥便秘。
甘草,味甘,性平,归心、肺、脾、胃经,具有补脾益气,清热解毒,祛痰止咳,调和诸药之功效,常用于脾胃虚弱,倦怠乏力,心悸气短,缓解药物毒性、烈性。
本糖果配制中,充分利用天冬、麦冬、甘草的功效的同事,利用甘草的甜味中和种天冬、麦冬的苦味,增加了口感。
本糖果配制中,采用相关的果品都是经过试验和研究的,是结合中西医理论,让各个果品药性相互“中和”保证药理温和,适合各类人群,并从改善五脏功能,促进血液循环和免疫力入手,充分考虑各个果品的“药性”和果味,既保证了效果最佳,又保证了味道最正。
与现有技术相比,本发明具有如下有益效果:
(1)本发明保健糖果是在中药理论指导下,结合发明人多年临床实践经验,精选多种原材料制备而成,调和脾胃,改善脾胃功能,养心安神,进而改善失眠状况,提高睡眠质量,治标兼治本。
(2)本发明的保健糖果安全性较好,不会使人产生依赖性,无毒副作用。
(3)本发明的保健糖果还具有清肺生津、清热利湿、润肠排毒等功效,可以进一步提高睡眠质量。
(4)本发明的保健糖果制剂无苦涩辛辣味,使患者比较容易接受。
(5)本发明中采用将南酸枣、牛***、乌梅成粗粉,加水煎煮,煎液滤过,收集滤液,并将所得滤液加乙醇醇沉,后再加入天冬、麦冬、甘草,最后才加入刺梨液,最少的减少南酸枣、牛***、乌梅对口感的影响,最大限度的保留的刺梨的味道,且最大限度保留刺梨维生素B、C,胡萝卜素、苹果酸、柠檬酸等成分;而将樱桃、龙眼、桑葚其“夺味”效果不明显,富含多种果糖和氨基酸,特别是桑葚富含花青素,将它们与刺梨粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,期间樱桃、龙眼、桑葚的有效成分与刺梨一起经过胶酶和5%的纤维素酶的处理,既保证了有效成分不被破坏,而且让口感更好。
(6)本发明中,将天冬、麦冬和甘草混合,加水煎煮,煎液滤过,收集滤液,既实现了功效,又让天冬、麦冬的苦味让甘草“中和”。
(7)本发明中提供两种保健糖果,其中保健糖果A其采用少量果糖,含糖量较少适合老年人适用;保健糖果B加入牛奶、蜂蜜、蔗糖进一步改善口感,适合各类人群食用,广受青年朋友欢迎。
具体的:
图1为本发明保健糖果A对睡眠质量的影响(表1);
图2 本发明保健糖果B对睡眠质量的影响(表2);
图3为本发明不同实施例中的保健糖果对睡眠质量的影响(表3)。
具体实施方式
下面对本发明的具体实施方式进行详细描述,但应当理解本发明的保护范围并不受具体实施方式的限制。
实施例1
一种提高睡眠质量的刺梨保健糖果的制备方法,包括以下步骤:
(1)按重量份计称取组成成分:刺梨15g、樱桃5g、南酸枣10g、牛***10g、天冬10g、麦冬10g、乌梅5g、龙眼10g、甘草3g、桑葚5g和低聚果糖3g;
(2)将南酸枣、牛***、乌梅粉碎成粗粉,加水煎煮3次,第1、2次2h,第3次1.5h,煎液滤过,合并滤液;
(3)将步骤(2)所得滤液加85%乙醇醇沉,静置,滤过,回收乙醇,得到液体a;
(4)将天冬、麦冬和甘草混合,加水煎煮2次,每次2h,煎液滤过,合并滤液,得到液体b;
(5)将刺梨、樱桃、龙眼、桑葚粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,得刺梨果汁液体c;
(6)将液体a、液体b、液体c混合,浓缩至清膏,加入低聚果糖,混匀,干燥,粉碎,制粒,整粒,包装,即得所述保健糖果A;
所述步骤(6)中加入牛奶20g、蜂蜜20g、蔗糖10g即得所述保健糖果B。
其中,所述樱桃、南酸枣、牛***、乌梅和龙眼在粉碎前去核;所述步骤(3)中乙与滤液的体积比为2:1;所述步骤(6)中清膏在90℃下的相对密度为1.12;干燥时采用真空干燥。
实施例2
一种提高睡眠质量的刺梨保健糖果的制备方法,包括以下步骤:
(1)按重量份计称取组成成分:刺梨30g、樱桃7.5g、南酸枣12g、牛***13g、天冬15g、麦冬15g、乌梅10g、龙眼13g、甘草8g、桑葚13g和低聚果糖4g;
(2)将南酸枣、牛***、乌梅粉碎成粗粉,加水煎煮3次,第1、2次2h,第3次1.5h,煎液滤过,合并滤液;
(3)将步骤(2)所得滤液加85%乙醇醇沉,静置,滤过,回收乙醇,得到液体a;
(4)将天冬、麦冬和甘草混合,加水煎煮2次,每次2h,煎液滤过,合并滤液,得到液体b;
(5)将刺梨、樱桃、龙眼、桑葚粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,得刺梨果汁液体c;
(6)将液体a、液体b、液体c混合,浓缩至清膏,加入低聚果糖,混匀,干燥,粉碎,制粒,整粒,包装,即得所述保健糖果A;
所述步骤(6)中加入牛奶15g、蜂蜜25g、蔗糖15g即得所述保健糖果B。
其中,所述樱桃、南酸枣、牛***、乌梅和龙眼在粉碎前去核;所述步骤(3)中乙与滤液的体积比为2.5:1;所述步骤(6)中清膏在90℃下的相对密度为1.14;干燥时采用喷雾干燥。
实施例3
一种提高睡眠质量的刺梨保健糖果的制备方法,包括以下步骤:
(1)按重量份计称取组成成分:刺梨50g、樱桃10g、南酸枣15g、牛***15g、天冬20g、麦冬20g、乌梅15g、龙眼15g、甘草10g、桑葚20g和低聚果糖5g;
(2)将南酸枣、牛***、乌梅粉碎成粗粉,加水煎煮3次,第1、2次2h,第3次1.5h,煎液滤过,合并滤液;
(3)将步骤(2)所得滤液加85%乙醇醇沉,静置,滤过,回收乙醇,得到液体a;
(4)将天冬、麦冬和甘草混合,加水煎煮2次,每次2h,煎液滤过,合并滤液,得到液体b;
(5)将刺梨、樱桃、龙眼、桑葚粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,得刺梨果汁液体c;
(6)将液体a、液体b、液体c混合,浓缩至清膏,加入低聚果糖,混匀,干燥,粉碎,制粒,整粒,包装,即得所述保健糖果A;
所述步骤(6)中加入牛奶30g、蜂蜜30g、蔗糖20g即得所述保健糖果B。
其中,所述樱桃、南酸枣、牛***、乌梅和龙眼在粉碎前去核;所述步骤(3)中乙与滤液的体积比为3:1;所述步骤(6)中清膏在90℃下的相对密度为1.17;干燥时采用减压干燥。
临床实施例1
1. 选取120名睡眠障碍志愿者,年龄25-65岁,性别男女比例1:1,(其中,25-35岁20人,35-45岁20人,45-55岁20人,55-65岁20人)的志愿者对研究知情并签署知情同意书。
2. 将志愿者随机分为A、B、C三个组,每组40人,且每组中25-35岁10人,35-45岁10人,45-55岁10人,55-65岁10人,以确保各个年龄段均覆盖,随机选定其中A组为对照组,B、C组为治疗组。
3.选取按照实施例1、2、3中生产的糖果A且从每个实施例中生产的糖果和糖果A,量均相同,将它们混合搅拌均匀作为实验用;选取按照实施例1、2、3中生产的糖果B且从每个实施例中生产的糖果和糖果B,量均相同,将它们混合搅拌均匀作为实验用。
4. A对照组服用常用安神剂(服用方式依据该药剂的说明书),治疗组B组服用本发明中上述步骤3中混合获得的保健糖果A(早、晚各一次,每次15g,咀嚼或冲服均可),治疗组C组服用本发明中上述步骤3中混合获得的保健糖果B(早、晚各一次,每次15g,咀嚼或冲服均可);
5.三组均4周为一个疗程,1个疗程后采用多导睡眠监测***检测并记录每一组志愿者治疗前后的总睡眠时间、睡眠潜伏期和睡眠效率,计算其平均值将平均值作为该组的总睡眠时间、睡眠潜伏期和睡眠效率。试验结果见下表1、表2。
其中总睡眠时间=睡眠开始到结束的时间-中途觉醒时间;
睡眠潜伏期=关灯上床到出现任何睡眠分期的时间间隔;
睡眠效率=总睡眠时间占总卧床时间的百分比。
表1 本发明保健糖果A对睡眠质量的影响(参见说明书附图1)。
表2 本发明保健糖果B对睡眠质量的影响(参见说明书附图2。
由表1可以看出,1个疗程后治疗组B的总睡眠时间和睡眠效率均相对对照组A均有明显提升,睡眠潜伏期也有明显缩短,且3种睡眠参数均明显优于对照组A,说明本发明的保健糖果A可以有效改善失眠状况,提高睡眠质量。
由表2可以看出,1个疗程后治疗组C的总睡眠时间和睡眠效率均相对对照组A也均有明显提升,睡眠潜伏期也有明显缩短,但3种睡眠参数均明显优于对照组A,说明本发明的保健糖果B可以有效改善失眠状况,提高睡眠质量。
由表2可以看出,保健糖果B中由于增加了牛奶、蜂蜜、蔗糖,其改善睡眠的效果没有服用常用安神剂和服用保健糖果A。其原因是虽然牛奶、蜂蜜、蔗糖具有改善睡眠的作用,但是其效果明显小于其它组份的综合效果,其添加不影响其它组分的作用,但是因为其增加降低了其它组份的含量,其产生的综合效果略小于保健糖果A。但是因为其增加让糖果更具有优越的口感,为此保健糖果B相对于保健糖果A仍然具有独特优势。
由表1、表2综合可以看出,保健糖果A、还是保健糖果B其对实验对象总体样本产生改善睡眠质量的有益效果显著的。
临床实施例2
1. 选取120名睡眠障碍志愿者,年龄25-65岁,性别男女比例1:1,(其中,25-35岁20人,35-45岁20人,45-55岁20人,55-65岁20人)的志愿者对研究知情并签署知情同意书。
2. 将志愿者随机分为A、B、C、D、E、F共六个组,每组20人,且每组中25-35岁5人,35-45岁5人,45-55岁5人,55-65岁5人,以确保各个年龄段均覆盖。
2. A组服用实施例1中生产的糖果A(早、晚各一次,每次15g,咀嚼或冲服均可);B组服用实施例2中生产的糖果A(早、晚各一次,每次15g,咀嚼或冲服均可);C组服用实施例3中生产的糖果A(早、晚各一次,每次15g,咀嚼或冲服均可);D组服用实施例1中生产的糖果B(早、晚各一次,每次15g,咀嚼或冲服均可);E组服用实施例2中生产的糖果B(早、晚各一次,每次15g,咀嚼或冲服均可);F组服用实施例3中生产的糖果B(早、晚各一次,每次15g,咀嚼或冲服均可)。
5.六组均4周为一个疗程,1个疗程后采用多导睡眠监测***检测并记录每一组志愿者治疗前后的总睡眠时间、睡眠潜伏期和睡眠效率,计算其平均值将平均值作为该组的总睡眠时间、睡眠潜伏期和睡眠效率。试验结果见下表3。
其中总睡眠时间=睡眠开始到结束的时间-中途觉醒时间;
睡眠潜伏期=关灯上床到出现任何睡眠分期的时间间隔;
睡眠效率=总睡眠时间占总卧床时间的百分比。
表3为本发明不同实施例中的保健糖果对睡眠质量的影响(参见说明书附图3)。
由表3可以看出,无论是食用任何实施例1、2、3中的何种保健糖果,其对实验者改善睡眠方面均产生了有益效果。本实验中,由于每一组样本数据较少,个体差异对效果的不同体现对数据影响较大,故不能从实验数据中分析出何种实施例中的何种糖果对改善睡眠效果最好,但无论各组实验样品数据还是总体样本数据均能够体现本发明中的糖果对改善睡眠的显著效果。
前述对本发明的具体示例性实施方案的描述是为了说明和例证的目的。这些描述并非想将本发明限定为所公开的精确形式,并且很显然,根据上述教导,可以进行很多改变和变化。对示例性实施例进行选择和描述的目的在于解释本发明的特定原理及其实际应用,从而使得本领域的技术人员能够实现并利用本发明的各种不同的示例性实施方案以及各种不同的选择和改变。本发明的范围意在由权利要求书及其等同形式所限定。
Claims (10)
1.一种提高睡眠质量的刺梨保健糖果,其特征在于,按重量份计由以下成分组成:刺梨15-50份、樱桃5-10份、南酸枣10-15份、牛***10-15份、天冬10-20份、麦冬10-20份、乌梅5-15份、龙眼10-15份、甘草3-10份、桑葚5-20份和低聚果糖3-5份。
2.根据权利要求1所述提高睡眠质量的保健糖果的制备方法,其特征在于, 包含有牛奶20-30份、蜂蜜20-30份、蔗糖10-20份。
3.根据权利要求1所述提高睡眠质量的保健糖果的制备方法,其特征在于,包括以下步骤:
(1)按重量份计称取组成成分;
(2)将南酸枣、牛***、乌梅、粉碎成粗粉,加水煎煮,煎液滤过,收集滤液;
(3)将步骤(2)所得滤液加乙醇醇沉,静置,滤过,回收乙醇,得到液体a;
(4)将天冬、麦冬和甘草混合,加水煎煮,煎液滤过,收集滤液,得到液体b;
(5)将刺梨、樱桃、龙眼、桑葚粉碎后成为混合物,按混合物与纯净水按1:2比例混合加热至65℃后,分别投入混合物重量的3%果胶酶和5%的纤维素酶,边冷却边搅拌,时间为4小时,得刺梨果汁液体c;
(6)将液体a、液体b、液体c混合,浓缩至清膏,加入低聚果糖,混匀,干燥,粉碎,制粒,整粒,包装,即得所述保健糖果。
4.根据权利要求2所述提高睡眠质量的保健糖果的制备方法,其特征在于,采用权利要求3的方制备时,在所述步骤(6)中加入牛奶20-30份、蜂蜜20-30份、蔗糖10-20份。
5.根据权利要求3或4所述提高睡眠质量的保健糖果的制备方法,其特征在于,所述樱桃、南酸枣、牛***、乌梅和龙眼在粉碎前去核。
6.根据权利要求3或4所述提高睡眠质量的保健糖果的制备方法,其特征在于,所述步骤(2)中煎煮次数为3次,第1、2次2h,第3次1.5h。
7.根据权利要求3或4所述的提高睡眠质量的保健糖果的制备方法,其特征在于,所述步骤(3)中乙醇的质量分数为85%。
8.根据权利要求3或4所述的提高睡眠质量的保健糖果的制备方法,其特征在于,所述步骤(3)中乙与滤液的体积比为2-3:1。
9.根据权利要求3或4所述的提高睡眠质量的保健糖果的制备方法,其特征在于,所述步骤(4)中煎煮次数为2次,每次2h。
10.根据权利要求3或4所述的提高睡眠质量的保健糖果的制备方法,其特征在于,所述步骤(6)中清膏在90℃下的相对密度为1.12-1.17。
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