CN108635470A - One kind is for treating rabic drug and preparation method thereof - Google Patents

One kind is for treating rabic drug and preparation method thereof Download PDF

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CN108635470A
CN108635470A CN201810484870.9A CN201810484870A CN108635470A CN 108635470 A CN108635470 A CN 108635470A CN 201810484870 A CN201810484870 A CN 201810484870A CN 108635470 A CN108635470 A CN 108635470A
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vitaceae
tank body
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drug
rhizome
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卢尽国
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/22Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
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    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses one kind for treating rabic drug, uses the raw material of following parts by weight:Staminiferous plant vitaceae rhizome and female plant vitaceae rhizome;A kind of preparation method for treating rabic drug is additionally provided, is included the following steps:Step 1: taking fresh 5 10 parts of staminiferous plant vitaceae rhizomes and 14 parts of female plant vitaceae rhizomes, shred, mixing obtains rhizome mixture;Step 2: plus water infusion be used to treat rabic drug until boil out brown color colloidal liquid.Preparation method of the present invention is simple, and the colloidal liquid drug being prepared has good effect to treatment rabies.

Description

One kind is for treating rabic drug and preparation method thereof
Technical field
The present invention relates to rabies therapy fields, and in particular to one kind is for treating rabic drug and its preparation side Method.
Background technology
Rabies (rabies) are the acute infectious diseases caused by rabies viruses, and Zoonosis is more common in the meat such as dog, wolf, cat Animal is eaten, people Duo Yin is infected by sick beast bite.Clinical manifestation is distinctive hydrophobia, fear of wind, pharyngismus, progressive paralysis Deng.Because hydrophobia symptom is relatively more prominent, therefore this disease also known as hydrophobia (hydrophobia).Hydrophobin belongs to Rhabdoviridae Lyssavirus, single-stranded RNA virus, animal pass through baiting by transmitted virus with each other.The rabies in China are mainly passed by dog It broadcasts, domesticated dog can become Asymptomatic Carriers, so the dog of surface " health " is very big to the health hazard of people.The rabies state of an illness is fierce Danger, still lacks effective treatment means, and people suffers from the case fatality rate almost 100% after rabies, also useless effective on the market Treat rabic drug.
Invention content
In order to treat rabies, the present invention provides one kind for treating rabic drug, uses following parts by weight Raw material:
Staminiferous plant vitaceae rhizome and female plant vitaceae rhizome, both rhizomes can be described as seeing that poison disappears again.
Preferably, described for treating rabic drug, use the raw material of following parts by weight:5-10 portions of staminiferous plants Vitaceae rhizome, 1-4 parts of female plant vitaceae rhizomes.
Preferably, described for treating rabic drug, use the raw material of following parts by weight:7 parts of staminiferous plant Portugals Grape section plant roots and stems and 3 parts of female plant vitaceae rhizomes.
A kind of preparation method for treating rabic drug includes the following steps:
Step 1: taking fresh 5-10 parts of staminiferous plant vitaceae rhizome and 1-4 parts of female plant vitaceae rhizomes, cut Broken, mixing obtains rhizome mixture;
Step 2: water is added thereto, infusion is used to treat rabic until boiling out brown color colloidal liquid Drug.
Preferably, the described preparation method for treating rabic drug, the infusion in the step 2 are specific For:It is placed in pressure cooker and is heated to 160-200 DEG C of infusion or 100-130 DEG C of normal pressure infusion,
Preferably, the preparation method for treating rabic drug, between the step 1 and step 2 It further include following procedure:
1) 2 portions of cherries, 1 portion of mango and 1.5 portions of peaches are taken, take its pulp, mixing squeezing is the first puree, is laid in face It on plate, and in surface puncture, is placed in acetic acid atmosphere and stands 30min, wherein is primary every being stirred in 10min during standing; Standing finishes, and first puree is mixed into the rhizome mixture that step 1 obtains, and mixing is ground into mud, is placed in mixing nitrogen In atmosphere, 35 DEG C are heated to, 2h is kept the temperature, obtains purees;
2) 1 portion of longan and 2 portions of lichee are taken, it is the second puree to take its pulp, mixing squeezing;
3) second puree is mixed into the purees that the step 1) obtains, is stirred, and added thereto successively Enter 3 parts of deionized waters and 1 portion of konjaku flour, be stirred, 1 part of konjaku particle is added into the mixing purees stirred to get, Obtain third mixed soil;Wherein, the konjaku flour is added in the form of being added while stirring;
The konjaku particle is made by following steps:Deionized water is slowly added into konjaku flour, kneading is agglomerating, until table Face obtains the spherical particle of multiple grain size 0.5mm without apparent talent for swimming, kneading, which, which is placed in -10 DEG C, is frozen up to surely Fixed molding;One layer of sponge is coated on spherical particle surface, obtains the konjaku particle;
4) the third mixed soil is placed in sealed environment and is fermented, be heated to 35 DEG C, kept the temperature 6h, be again heated to 45 DEG C, 18h is kept the temperature, naturally cools to 30 DEG C, keeps the temperature 6h;It is cooled to room temperature, removes mixture sponge therein, obtain tunning; And entire heating and thermal insulation process is all kept stirring;
Preferably, the described preparation method for treating rabic drug, the infusion in the step 2 be It is completed in boiling device, the device of decocting medicinal herbs includes:
Tank body, it is cylindrical, it by tank body top and tank body lower part card and forms, and the outer wall on tank body top extends downwardly Cricoid outer shroud is formed, the inner wall of tank body lower part upwardly extends to form cricoid inner ring, tight between the outer shroud and the inner ring Closely connected attached card and, and the outer shroud attaches multiple sealing rings close to the side circumferential direction of the inner ring;The top on the tank body top Open up multiple gas vents;
Spacing ring, circumferential direction are fixed on the inner wall on the tank body top;
Piston, circumferential direction are tightly attached to the inner wall setting on the tank body top, can be slided up and down along the tank body top;And Below the spacing ring;Connecting rod one end, the pull rod other end are vertically fixedly connected with an agitation to the piston vertically downward Plate is in up big and down small beveled structure, and the agitation plate surface opens up multiple through-holes;
Multiple springs, annular distribution, between the spacing ring and the piston;Each lower spring end is fixed on described The piston lower surface is fixed in spacing ring upper surface, upper end;
Wherein, the side wall circumferential direction on the tank body top opens up multiple relief holes, and the relief hole is located at the spacing ring Top.
Preferably, the preparation method for treating rabic drug, the device of decocting medicinal herbs further includes open fire Stove is located at below the tank body.
The present invention includes at least following advantageous effect:
1, preparation method of the present invention is simple, and with obvious effects, which has treatment rabies good Effect;And there is good therapeutic effect to senile dementia;
2, in preparation process of the present invention, by the cherry, longan and lichee of property heat and V. amurensis cool in nature or porcelain ampelopsis Rhizome is mixed fermentation, and the two is complementary, solves the problems, such as that cold habitus patient can not use the drug, avoid clothes Injury with the drug to cold habitus patient;
3, in preparation process of the present invention, the tartaric acid in acetic acid and cherry, peach will be esterified with the ethyl alcohol in lichee Reaction, obtains the ester of fragrant taste, to effectively remove the sour and astringent mouthfeel in V. amurensis or porcelain ampelopsis rhizome, effectively improves Mouthfeel;
Part is illustrated to embody by further advantage, target and the feature of the present invention by following, and part will also be by this The research and practice of invention and be understood by the person skilled in the art.
Description of the drawings
Fig. 1 is the structural schematic diagram of the device of decocting medicinal herbs in the present invention.
Specific implementation mode
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art with reference to specification text Word can be implemented according to this.
Embodiment 1
Step 1: taking fresh 5-10 parts of staminiferous plant vitaceae rhizome and 1-4 parts of female plant vitaceae rhizomes, cut Broken, mixing obtains rhizome mixture;
Step 2: water is added thereto, it is placed in pressure cooker and is heated to 160-200 DEG C of infusion or 100-130 DEG C of normal pressure is endured It boils, until boiling out brown color colloidal liquid, that is, is used to treat rabic drug.Amount of water does not limit herein, until enduring Chopsticks are inserted on the brown color colloidal liquid made, until not falling.
Embodiment 2
Step 1: taking fresh 5-10 parts of staminiferous plant vitaceae rhizome and 1-4 parts of female plant vitaceae rhizomes, cut Broken, mixing obtains rhizome mixture;
Step 2: water is added thereto, it is placed in pressure cooker and is heated to 160-200 DEG C of infusion or 100-130 DEG C of normal pressure is endured It boils, until boiling out brown color colloidal liquid, that is, is used to treat rabic drug.
Embodiment 3
Step 1: taking fresh 5-10 parts of staminiferous plant vitaceae rhizome and 1-4 parts of female plant vitaceae rhizomes, cut Broken, mixing obtains rhizome mixture;
Step 2: water is added thereto, it is placed in pressure cooker and is heated to 160-200 DEG C of infusion or 100-130 DEG C of normal pressure is endured It boils, until boiling out brown color colloidal liquid, that is, is used to treat rabic drug.
Embodiment 4
Step 1: taking fresh 5 parts of staminiferous plant vitaceae rhizomes and 1 part of female plant vitaceae rhizome, shred, mixes It closes, obtains rhizome mixture;
1) 2 portions of cherries, 1 portion of mango and 1.5 portions of peaches are taken, take its pulp, mixing squeezing is the first puree, is laid in face It on plate, and in surface puncture, is placed in acetic acid atmosphere and stands 30min, wherein is primary every being stirred in 10min during standing; Standing finishes, and first puree is mixed into the rhizome mixture that step 1 obtains, and mixing is ground into mud, is placed in mixing nitrogen In atmosphere, 35 DEG C are heated to, 2h is kept the temperature, obtains purees;
2) 1 portion of longan and 2 portions of lichee are taken, it is the second puree to take its pulp, mixing squeezing;
3) second puree is mixed into the purees that the step 1) obtains, is stirred, and added thereto successively Enter 3 parts of deionized waters and 1 portion of konjaku flour, be stirred, 1 part of konjaku particle is added into the mixing purees stirred to get, Obtain third mixed soil;Wherein, the konjaku flour is added in the form of being added while stirring;
The konjaku particle is made by following steps:Deionized water is slowly added into konjaku flour, kneading is agglomerating, until table Face obtains the spherical particle of multiple grain size 0.5mm without apparent talent for swimming, kneading, which, which is placed in -10 DEG C, is frozen up to surely Fixed molding;One layer of sponge is coated on spherical particle surface, obtains the konjaku particle;
4) the third mixed soil is placed in sealed environment and is fermented, be heated to 35 DEG C, kept the temperature 6h, be again heated to 45 DEG C, 18h is kept the temperature, naturally cools to 30 DEG C, keeps the temperature 6h;It is cooled to room temperature, removes mixture sponge therein, obtain tunning; And entire heating and thermal insulation process is all kept stirring;
Step 2: in the tunning that step 4) obtains is placed in decocting medicinal herbs device, water, infusion are added thereto, until enduring Brown color colloidal liquid is made, that is, is used to treat rabic drug.
Embodiment 5
Step 1: taking fresh 7 parts of staminiferous plant vitaceae rhizomes and 3 parts of female plant vitaceae rhizomes, shred, mixes It closes, obtains rhizome mixture;
1) 2 portions of cherries, 1 portion of mango and 1.5 portions of peaches are taken, take its pulp, mixing squeezing is the first puree, is laid in face It on plate, and in surface puncture, is placed in acetic acid atmosphere and stands 30min, wherein is primary every being stirred in 10min during standing; Standing finishes, and first puree is mixed into the rhizome mixture that step 1 obtains, and mixing is ground into mud, is placed in mixing nitrogen In atmosphere, 35 DEG C are heated to, 2h is kept the temperature, obtains purees;
2) 1 portion of longan and 2 portions of lichee are taken, it is the second puree to take its pulp, mixing squeezing;
3) second puree is mixed into the purees that the step 1) obtains, is stirred, and added thereto successively Enter 3 parts of deionized waters and 1 portion of konjaku flour, be stirred, 1 part of konjaku particle is added into the mixing purees stirred to get, Obtain third mixed soil;Wherein, the konjaku flour is added in the form of being added while stirring;
The konjaku particle is made by following steps:Deionized water is slowly added into konjaku flour, kneading is agglomerating, until table Face obtains the spherical particle of multiple grain size 0.5mm without apparent talent for swimming, kneading, which, which is placed in -10 DEG C, is frozen up to surely Fixed molding;One layer of sponge is coated on spherical particle surface, obtains the konjaku particle;
4) the third mixed soil is placed in sealed environment and is fermented, be heated to 35 DEG C, kept the temperature 6h, be again heated to 45 DEG C, 18h is kept the temperature, naturally cools to 30 DEG C, keeps the temperature 6h;It is cooled to room temperature, removes mixture sponge therein, obtain tunning; And entire heating and thermal insulation process is all kept stirring;
Step 2: in the tunning that step 4) obtains is placed in decocting medicinal herbs device, water, infusion are added thereto, until enduring Brown color colloidal liquid is made, that is, is used to treat rabic drug.
Embodiment 6
Step 1: taking fresh 5 parts of staminiferous plant vitaceae rhizomes and 1 part of female plant vitaceae rhizome, shred, mixes It closes, obtains rhizome mixture;
1) 2 portions of cherries, 1 portion of mango and 1.5 portions of peaches are taken, take its pulp, mixing squeezing is the first puree, is laid in face It on plate, and in surface puncture, is placed in acetic acid atmosphere and stands 30min, wherein is primary every being stirred in 10min during standing; Standing finishes, and first puree is mixed into the rhizome mixture that step 1 obtains, and mixing is ground into mud, is placed in mixing nitrogen In atmosphere, 35 DEG C are heated to, 2h is kept the temperature, obtains purees;
2) 1 portion of longan and 2 portions of lichee are taken, it is the second puree to take its pulp, mixing squeezing;
3) second puree is mixed into the purees that the step 1) obtains, is stirred, and added thereto successively Enter 3 parts of deionized waters and 1 portion of konjaku flour, be stirred, 1 part of konjaku particle is added into the mixing purees stirred to get, Obtain third mixed soil;Wherein, the konjaku flour is added in the form of being added while stirring;
The konjaku particle is made by following steps:Deionized water is slowly added into konjaku flour, kneading is agglomerating, until table Face obtains the spherical particle of multiple grain size 0.5mm without apparent talent for swimming, kneading, which, which is placed in -10 DEG C, is frozen up to surely Fixed molding;One layer of sponge is coated on spherical particle surface, obtains the konjaku particle;
4) the third mixed soil is placed in sealed environment and is fermented, be heated to 35 DEG C, kept the temperature 6h, be again heated to 45 DEG C, 18h is kept the temperature, naturally cools to 30 DEG C, keeps the temperature 6h;It is cooled to room temperature, removes mixture sponge therein, obtain tunning; And entire heating and thermal insulation process is all kept stirring;
Step 2: in the tunning that step 4) obtains is placed in decocting medicinal herbs device, water, infusion are added thereto, until enduring Brown color colloidal liquid is made, that is, is used to treat rabic drug.
Wherein, the device of decocting medicinal herbs includes:
Tank body, it is cylindrical, blocked and formed by tank body top 1 and tank body lower part 2, and the outer wall on tank body top 1 is downward Extend to form cricoid outer shroud 3, the inner wall of tank body lower part 2 upwardly extends to form cricoid inner ring 4, the outer shroud 3 with it is described interior Closely attached between ring 4 card and, and the outer shroud 3 attaches multiple sealing rings 310 close to the side circumferential direction of the inner ring 4;It is described The top on tank body top 1 opens up multiple gas vents 10;
Spacing ring 5, circumferential direction are fixed on the inner wall on the tank body top 1;
Piston 6, circumferential direction are tightly attached to the inner wall setting on the tank body top 1, can glide on the tank body top 1 It is dynamic;And positioned at 5 lower section of the spacing ring;7 one end of connecting rod vertically downward of the piston 6,7 other end of pull rod is vertically fixed to be connected A stir plate 8 is connect, is in up big and down small beveled structure, and 8 surface of the stir plate opens up multiple through-holes;
Multiple springs 9, annular distribution, between the spacing ring 5 and the piston 6;Each 9 lower end of spring is fixed on The piston lower surface is fixed in 5 upper surface of the spacing ring, upper end;
Wherein, the side wall circumferential direction on the tank body top 1 opens up multiple relief holes 11.The relief hole 11 is located at the limit The top of ring 5.And when spring 9 is in nature extended configuration, the piston 6 is located at the lower section of the relief hole 11;
Open fire stove is located at below the tank body.
In actual use, tank body top 1 and the dismounting of tank body lower part 2 are opened, material to be boiled is positioned under tank body In portion 2, then by tank body top 1 and the card of tank body lower part 2 and, and be sealed using sealing ring, as open fire stove open fire burns It handles, steam is more and more in the sealed environment of tank body, and the pressure of 6 underlying space of piston is increasing, and piston 6 will be pushed upward Movement, to drive 8 to move upwards, spring 9 elongates at this time, deforms upon, when piston 6, which continues up, crosses 11, under Steam in square confined space will go out from 11 disposings, and then piston 6 is understood and moved downward under the retraction elastic force of spring 9 again, and It drives 8 to move downward, to reciprocation cycle, realizes the stabilization of reciprocal pressure automatically;Stirring up and down reciprocatingly is carried out to material, So that tanning is uniform, and the waste of a large amount of medicinal material steam can be caused to avoid long-term open tanning in this way.
Below in conjunction with specific embodiment, invention is further described in detail.
One, typical case (treatment rabies)
Rabies are treated using the liquid preparation of the present invention, treat 223:Wherein,
After the onset of rabies, 132 patients, which take, continuously takes the liquid preparation that embodiment 2 is prepared, and takes 15 days left sides It is right, you can to cure, cure rate 100%;
91 patients take the liquid preparation that embodiment 5 is prepared, and take 13 days or so, you can cure, cure rate 100%.
Case 1
Lee's ××, man, 56 years old, lives Hubei Province Xishui County.On December 8th, 2015 by dog bite, does not vaccinate, in On December 23rd, 2015 dog disease of going mad, patient's dry throat, injury very itches unbearably, and mood is very exciting, fidgety fear;
Therapy:3 times a day, the colloidal liquid 50g prepared each taking the present embodiment 2, even served 18 days.
Curative effect:Cured after 16 days, more after do not recur so far.
Case 2
Yellow ××, it is difficult, 34 years old, live Wuhan City, Hubei Province Huangpo District, on March 4th, 2013, by the left leg of wandering dog bite, It does not vaccinate, in dog disease of going mad on April 25, vexed irritability is frightened, fear of wind, afraid of water, fever;
Therapy:3 times a day, the colloidal liquid 50g prepared each taking the present embodiment 2, even served 14 days.
Curative effect:Cured after 14 days, symptom disappear, more after do not recur so far.
Case 3
White ××, female 38 years old, live Hubei Province Tongshan County, on October 2nd, 2017, are bitten left leg by wild dog, do not inject epidemic disease Seedling, in dog disease of going mad on October 29, dry throat, laryngalgia headache, is generated heat, nausea, and constriction walks and walks haltingly;
Therapy:3 times a day, the colloidal liquid 50g prepared each taking the present embodiment 2, even served 15 days.
Curative effect:Cured after 15 days, more after do not recur so far.
Case 4
Cai's ××, female 29 years old, live Hubei Province Chibi City, are not vaccinated by the left leg of dog bite on July 4th, 2015, It is frightened in August dog disease of going mad on the 5th, fear of wind, afraid of water, fever;
Therapy:3 times a day, the colloidal liquid 50g prepared each taking the present embodiment 5, even served 14 days.
Curative effect:Cured after 13 days, symptom disappear, more after do not recur so far.
Case 5
Mr. Wang, female 34 years old, live Hubei Province Tongcheng County, on 2 3rd, 2014, by dog bite, do not vaccinate, in 3 Month dog disease of going mad on the 12nd, vexed irritability is frightened, fear of wind, afraid of water;
Therapy:3 times a day, the colloidal liquid 50g prepared each taking the present embodiment 5, even served 14 days.
Curative effect:Cured after 13 days, symptom disappear, more after do not recur so far.
Two, it is tested for the pharmaceutical activity of senile dementia
1, active animal is tested
1.1 experiment material
The male mice that age is 2-3 months, mouse weight control is in 18g-20g, and control mouse is in normal occupancy condition Lower life 72 hours;Liquid preparation made from embodiment 2;Hyoscine can cause the decline of cognitive function in mice, i.e., silly It is slow-witted.
1.2 experimental method
1) above-mentioned mouse is randomly divided into three groups, respectively control group, blank group and experimental group, every group of quantity is 20;
2) there are three size and environment identical room A, B, C for setting, are intermediate use for any one room Automatically-controlled door is divided into two independent spaces, and one of space is no light conditions, another space is bright environment;
3) it while by experimental mice is placed in the bright environment of room A, control group mice is placed in the bright ring of room B In border, naive mice is placed in the bright environment of room C;
After adapting to 3min, while hyoscine is applied to the mouse of control group and experimental group, blank group is not applied, is being administered 90min afterwards takes 6 days to liquid preparation made from experimental group and blank group gavage medicine feed embodiment 2, every 3 days 1 time, often It is secondary to be fed by 200mg/kg;
It is in the progress first time experiment afterwards for 24 hours of last time administration (liquid preparation made from embodiment 2), experimental group is small Mouse is placed in the bright environment of room A, and control group mice is placed in the bright environment of room B, and naive mice is placed in room Between C bright environment in, the mouse of room A, room B and room C is when entering corresponding no light conditions, with regard to being layed in ground On power grid shocked by electricity (0.5mA, 2 seconds), entered by bright environment by the mouse of second record blank group, control group and experimental group The transfer incubation period (TLT) of no light conditions.Record the TLT of the mouse experiment for the first time of control group and experimental group, repetition training 2 days Afterwards, second of TLT tested of the mouse of blank group, control group and experimental group when recording the 48th hour.The TLT phases of second of experiment For index of the growth as successful learning and memory (cognitive ability) of the TLT of first time experiment.
1.3 experimental result
Second of increased percentage % of the opposite experiment TLT for the first time of experiment TLT is that memory retains, and is shown in Table 3.
Comparison of the 3 each group mouse of table in passive avoidance experiment
As shown in Table 3, second of TLT experiment of experimental group is obviously increased relative to first time experiment, shows excellent It practises and memory function, and with the TLT of hyoscine treated control group mice experiment at second relative to not having for the first time It obviously increases, shows the damage of learning and memory function;The naive mice of liquid preparation made from embodiment 2 is taken For the TLT of second of the experiment shown compared to obviously increasing for the first time, this shows that drug made from the embodiment of the present invention 2 has Effectively anti-dull-witted activity.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited In specific details and legend shown and described herein.

Claims (9)

1. one kind is for treating rabic drug, which is characterized in that it uses the raw material of following parts by weight:
Staminiferous plant vitaceae rhizome and female plant vitaceae rhizome.
2. as described in claim 1 for treating rabic drug, which is characterized in that the vitaceae is mountain Portugal One or both of grape, porcelain ampelopsis.
3. as described in claim 1 for treating rabic drug, which is characterized in that it uses the original of following parts by weight Material:5-10 parts of staminiferous plant vitaceae rhizomes, 1-4 parts of female plant vitaceae rhizomes.
4. as claimed in claim 3 for treating rabic drug, which is characterized in that it uses the original of following parts by weight Material:7 parts of staminiferous plant vitaceae rhizomes and 3 parts of female plant vitaceae rhizomes.
5. a kind of preparation method for treating rabic drug, which is characterized in that include the following steps:
Step 1: taking fresh 5-10 parts of staminiferous plant vitaceae rhizome and 1-4 parts of female plant vitaceae rhizomes, shred, mixes It closes, obtains rhizome mixture;
Step 2: water is added thereto, infusion is used to treat rabic drug until boiling out brown color colloidal liquid.
6. the preparation method as claimed in claim 5 for treating rabic drug, which is characterized in that in the step 2 Infusion be specially:It is placed in pressure cooker and is heated to 160-200 DEG C of infusion or 100-130 DEG C of normal pressure infusion.
7. the preparation method for treating rabic drug as claimed in claim 5, which is characterized in that the step 1 and It further include following procedure between step 2:
1) 2 portions of cherries, 1 portion of mango and 1.5 portions of peaches are taken, take its pulp, mixing squeezing is the first puree, is laid in panel On, and in surface puncture, be placed in acetic acid atmosphere and stand 30min, wherein it is primary every being stirred in 10min during standing;It is quiet It sets and finishes, first puree is mixed into the rhizome mixture that step 1 obtains, mix, be ground into mud, be placed in mixing nitrogen atmosphere In enclosing, 35 DEG C are heated to, 2h is kept the temperature, obtains purees;
2) 1 portion of longan and 2 portions of lichee are taken, it is the second puree to take its pulp, mixing squeezing;
3) second puree is mixed into the purees that the step 1) obtains, is stirred, and be added 3 parts thereto successively Deionized water and 1 portion of konjaku flour, are stirred, and 1 part of konjaku particle is added into the mixing purees stirred to get, obtains third Mixed soil;Wherein, the konjaku flour is added in the form of being added while stirring;
The konjaku particle is made by following steps:Deionized water is slowly added into konjaku flour, kneading is agglomerating, until surface without Apparent talent for swimming, kneading obtain the spherical particle of multiple grain size 0.5mm, by the spherical particle be placed in -10 DEG C be frozen up to stablize at Type;One layer of sponge is coated on spherical particle surface, obtains the konjaku particle;
4) the third mixed soil is placed in sealed environment and is fermented, be heated to 35 DEG C, kept the temperature 6h, be again heated to 45 DEG C, 18h is kept the temperature, naturally cools to 30 DEG C, keeps the temperature 6h;It is cooled to room temperature, removes mixture sponge therein, obtain tunning;And it is whole A heating and thermal insulation process is all kept stirring.
8. the preparation method as claimed in claim 5 for treating rabic drug, which is characterized in that in the step 2 Infusion completed in boiling device, the device of decocting medicinal herbs includes:
Tank body, it is cylindrical, it by tank body top and tank body lower part card and forms, and the outer wall on tank body top is downwardly extending Cricoid outer shroud, the inner wall of tank body lower part are upwardly extended to form cricoid inner ring, closely be pasted between the outer shroud and the inner ring Attached card and, and the outer shroud attaches multiple sealing rings close to the side circumferential direction of the inner ring;It is opened up at the top of the tank body top Multiple gas vents;
Spacing ring, circumferential direction are fixed on the inner wall on the tank body top;
Piston, circumferential direction are tightly attached to the inner wall setting on the tank body top, can be slided up and down along the tank body top;And it is located at Below the spacing ring;Connecting rod one end, the pull rod other end are vertically fixedly connected with a stir plate to the piston vertically downward, In up big and down small beveled structure, and the agitation plate surface opens up multiple through-holes;
Multiple springs, annular distribution, between the spacing ring and the piston;Each lower spring end is fixed on the limit The piston lower surface is fixed in ring upper surface, upper end;
Wherein, the side wall circumferential direction on the tank body top opens up multiple relief holes, and the relief hole is located at the top of the spacing ring.
9. the preparation method as claimed in claim 8 for treating rabic drug, which is characterized in that the device of decocting medicinal herbs Further include open fire stove, is located at below the tank body.
CN201810484870.9A 2018-05-20 2018-05-20 One kind is for treating rabic drug and preparation method thereof Pending CN108635470A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN205339575U (en) * 2016-01-27 2016-06-29 赵伟伟 Herbal decocting machine
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CN206777534U (en) * 2017-01-20 2017-12-22 遵义市第一人民医院 A kind of traditional Chinese herbal decoction boils equipment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN205339575U (en) * 2016-01-27 2016-06-29 赵伟伟 Herbal decocting machine
CN206403658U (en) * 2016-08-20 2017-08-15 佛山市顺德区好生活电子科技有限公司 It is pressurized mixer
CN206777534U (en) * 2017-01-20 2017-12-22 遵义市第一人民医院 A kind of traditional Chinese herbal decoction boils equipment

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Application publication date: 20181012