CN108578454A - Treat the Chinese medicine composition of wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, the preparation method of Chinese medicine preparation and decoction - Google Patents
Treat the Chinese medicine composition of wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, the preparation method of Chinese medicine preparation and decoction Download PDFInfo
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Abstract
The invention discloses the preparation method of a kind of Chinese medicine composition for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, Chinese medicine preparation and decoction, which includes the raw material of following number：3~50 parts of 5~50 parts of Radix Angelicae Pubescentis, 5~50 parts of rhizome of chuanxiong, 3~50 parts of stiff silkworm, 3~50 parts of earthworm and ground bettle.The Chinese medicine composition of the present invention selects natural Chinese traditional medicines raw material, using Radix Angelicae Pubescentis as monarch drug in a prescription, using rhizome of chuanxiong as ministerial drug, using stiff silkworm, earthworm and ground bettle as adjutant, it comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually acts synergistically, it is notable for wind chill blockage and qi stagnation and blood stasis type Lumbar Intervertebral Disc with expelling wind and eliminating dampness, eliminating cold to stop pain, clearing damp eliminating impediment and promoting blood circulation and removing blood stasis and other effects.
Description
Technical field
The present invention relates to Chinese medicine compound prescription technical fields, and wind chill blockage and qi stagnation and blood stasis type are treated in particular to a kind of
The Chinese medicine composition of the protrasion of the lumbar intervertebral disci, the preparation method of Chinese medicine preparation and decoction.
Background technology
The protrasion of the lumbar intervertebral disci be it is a kind of with degeneration pathology change into basis illness, lumber ertebral disc each section (nucleus pulposus,
Fibrous ring and cartilage plate), especially nucleus pulposus, after having different degrees of degenerative change, under the action of external force factor, interverbebral disc
Anular disruption, nucleus pulposus in rear or intraspinal tube, causes adjacent spinal nerve root to meet with from rupture place prominent (or abjection)
Stimulated or compressing, to generate flank pain, a series of clinical symptoms such as side lower limb or double lower limb numbness, pain.Chinese medicine
Think protrasion of the lumbar intervertebral disci disease located in liver kidney, it is closely related with qi and blood, it is easily invaded by cold-dampness, characteristic of disease category asthenia in origin and asthenia in superficiality；With liver
Kidney, deficiency of qi and blood are this, are mark with wet, qi depression to blood stasis of catching cold, and wherein caused by liver and kidney deficiency is morbidity root, and chill is wet, blood stasis
It is important pathogenic factor.
Drug therapy and physiotherapy are relied primarily on to the treatment of the protrasion of the lumbar intervertebral disci at present, drug therapy generallys include
Nonsteroidal anti-inflammatory drug (such as aspirin, paracetamol, Indomethacin, naproxen, Nabumetone, Diclofenac, brufen,
Aulin, rofecoxib, celecoxib etc.), Chinese patent drug (such as red deer logical superintends and directs piece, " Yaobitong Capsule", XIANLING GUBAO JIAONANG).
These drugs are mostly expensive, and have obvious side effect.And according to recent external in relation to aspirin can inhibit ring
The activity of oxygenase and the formation for reducing thromboxane A2, prevent platelet aggregation, make it be not easy to release coagulation factor, easily cause out
Blood, haemolysis, hematopoietic disorder；And Diclofenac class easily causes gastrointestinal reaction or even gastroenteritic ulcer, perforation bleeding etc..Object
Reason treatment includes traction therapeutic, infrared radiation, ultrasonic therapy, Selecting Acupoints of ZIWULIUZHU ruling by law treatment etc..And physiotherapy can only
As auxiliary treatment, and can only be in hospitalize, traffic and time cost are high back and forth.
Invention content
In view of this, a kind of Chinese medicine for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci provided by the invention
The preparation method of composition, Chinese medicine preparation and decoction, preferably overcomes the above-mentioned problems of the prior art and defect, this is controlled
The Chinese medicine composition for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci selects natural Chinese traditional medicines raw material, is with Radix Angelicae Pubescentis
Monarch drug in a prescription, using rhizome of chuanxiong as ministerial drug, using stiff silkworm, earthworm and ground bettle as adjutant, the effect for comprehensively utilizing above-mentioned each Chinese herb is excellent
Gesture and mutually synergistic effect have expelling wind and eliminating dampness, eliminating cold to stop pain, clearing damp eliminating impediment and promoting blood circulation and removing blood stasis and other effects, for wind chill blockage
It is notable with qi stagnation and blood stasis type Lumbar Intervertebral Disc, it is easy to use, and low in raw material price, it is without any side effects.
A kind of Chinese medicine composition for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, including following number
Raw material：3~50 parts of 5~50 parts of Radix Angelicae Pubescentis, 5~50 parts of rhizome of chuanxiong, 3~50 parts of stiff silkworm, 3~50 parts of earthworm and ground bettle.
Further, the Chinese medicine composition includes the raw material of following number：5~30 parts of Radix Angelicae Pubescentis, 5~30 parts of rhizome of chuanxiong, deadlock
3~20 parts of 3~20 parts of silkworm, 3~20 parts of earthworm and ground bettle.
Further, the Chinese medicine composition includes the raw material of following number：15 parts of Radix Angelicae Pubescentis, 15 parts of rhizome of chuanxiong, stiff silkworm 10
10 parts of part, 10 parts of earthworm and ground bettle.
The present invention also provides a kind of Chinese medicine preparation for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, institutes
State the Chinese medicine composition that Chinese medicine preparation includes above-mentioned treatment wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci.
Further, the dosage form of the Chinese medicine preparation is decoction, pill or granule.
Further, the dosage form of the Chinese medicine preparation is decoction.
The present invention also provides a kind of preparations of pill that treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Method, the decoction include the Chinese medicine composition of above-mentioned treatment wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, institute
Stating preparation method includes：
Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle are mixed, added water to cook, is filtered.
Further, the number added water to cook is 2 times, and described plus water the amount is the Chinese medicine material gross weight for the first time
3~6 times of amount, second of described plus water amount are 1~3 times of the Chinese medicine material total weight；It is described to add water to cook process packet
It includes：It is first boiled by intense fire after adding water, then with continuing boiling by slow fire 10~35min.
Further, it is described add water to cook before first impregnate Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle with clear water.
Further, the dregs of a decoction obtained after the filtering continue to pressurize strand acquirement to liquid, by the liquid and the mistake
The filtrate obtained after filter is uniformly mixed.
Compared with prior art, of the invention a kind of to treat in wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
The advantageous effect of the preparation method of drug composition, Chinese medicine preparation and pill is：
(1) treatment wind chill blockage of the invention and the Chinese medicine composition of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci select pure day
Right Chinese herb, using Radix Angelicae Pubescentis as monarch drug in a prescription, with expelling wind and eliminating dampness, eliminating cold to stop pain and the work(for dispelling the sluggish numbness pain of waist mansion cold-dampness
Effect；Using rhizome of chuanxiong as ministerial drug, have effects that wind-expelling pain-stopping, promoting blood circulation, can principal drug assistance dispel lumbar rheumatism, have scattered waist mansion gas concurrently
It is stagnant, dispel waist mansion hemostasis the effect of；Assistant with nourishing qi and blood, holds back the moon, the work(that flourish muscle relieves pain with animal drugs stiff silkworm, earthworm, ground bettle
Effect；Assistant has effects that promoting blood circulation and removing blood stasis and wind-expelling pain-stopping with Rhizoma Chuanxiong；Assistant has blood-breaking by silt, increases with animal drugs earthworm and stiff silkworm
The effect of adding promoting blood circulation and removing blood stasis for promoting tissue regeneration.It comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually acts synergistically, have
Very strong clearing damp eliminating impediment and promoting blood circulation and removing blood stasis and other effects, it is notable to wind chill blockage and qi stagnation and blood stasis type Lumbar Intervertebral Disc,
It is easy to use, and low in raw material price, it is without any side effects.
(2) present invention is prepared using the treatment wind chill blockage and the Chinese medicine composition of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Chinese medicine preparation, safe to use, no pain has no toxic side effect.
(3) present invention is prepared using the treatment wind chill blockage and the Chinese medicine composition of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Decoction by by Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle mix, add water to cook, the decoction being obtained by filtration is to wind chill blockage
It is more preferable with the therapeutic effect of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, and preparation method is simple.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment cited below particularly is made detailed
It is described as follows.
Specific implementation mode
To facilitate the understanding of the present invention, it elaborates to technical scheme of the present invention with reference to the mode of embodiment,
Many details are elaborated in the following description in order to fully understand the present invention.
But the invention can be embodied in many other ways as described herein, those skilled in the art can be with
Similar improvement is done without violating the connotation of the present invention, therefore the present invention is not limited to the specific embodiments disclosed below.
A kind of Chinese medicine composition for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, including following number
Raw material：
5~50 parts of Radix Angelicae Pubescentis is such as 5 parts, 8 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts；
5~50 parts of rhizome of chuanxiong is such as 5 parts, 8 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts；
3~50 parts of stiff silkworm is such as 3 parts, 5 parts, 8 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50
Part；
3~50 parts of earthworm is such as 3 parts, 5 parts, 8 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50
Part；
Such as 3 parts, 5 parts, 8 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts of 3~50 parts of ground bettle or
50 parts.
Above-mentioned, theory of traditional Chinese medical science thinks：
Radix Angelicae Pubescentis also known as Hu king envoy, solely to shake careless, only cunning, houseleek, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, meat Radix Angelicae Pubescentis, qualifications and record of service Qiu Radix Angelicae Pubescentis, the east of Sichuan only
Living, fragrant Radix Angelicae Pubescentis, achievement Radix Angelicae Pubescentis, big work, the big work in mountain, jade are living；It is pungent, bitter, tepor.The effect of it is with expelling wind and eliminating dampness, eliminating cold to stop pain.
Rhizome of chuanxiong, also known as big rhizome of chuanxiong, comfort vault, wine rhizome of chuanxiong；It is with promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dispelling wind and removing obstruction in the meridians, sensible qi and blood
And other effects.
Stiff silkworm also known as flying worm have effects that expel endogenous wind to relieve convulsion, reducing phlegm and resolving masses.
Earthworm, also known as earthworm, the protein content of earthworm account for about the 53.5%~65.1% of dry weight, and fat content is about
4.4%~17.38%, carbohydrate is about 11%~17.4%, ash content 7.8%~23%.Also contain in earthworm body abundant
Vitamin D (account for about fresh weight 0.04%~0.073%) and calcium and phosphorus (account for about fresh weight 0.124%~
0.188%) mineral matter elements such as.Contain earthworm element, earthworm toxolysin, xanthine, antihistaminicum and vitamin B etc. in earthworm body
A variety of medicinal ingredients.Earthworm has heat-clearing, soothing the liver, Zhichuan, dredging collateral and other effects.
Ground bettle also known as ground beetle, Eupolyphoge sinensis, tortoise, female ground beetles, taste it is salty, cold；It is total containing volatile oil and amino acid volatile oil
Amount about 22.19%, main is naphthalene, separately contains various fatty aldehydes and aromatic aldehyde, accounts for 24.95%. and also contains dichloro-benzenes and dimethyl disulfide
The rare ingredient total amino acid contents of other Chinese medicines such as ether account for about 40%.Ground bettle has broken stasis of blood blood and continuous muscles and bones and other effects.
The treatment wind chill blockage of the present invention and the Chinese medicine composition of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci are selected pure natural
Chinese herb has effects that expelling wind and eliminating dampness, eliminating cold to stop pain and dispels the sluggish numbness pain of waist mansion cold-dampness using Radix Angelicae Pubescentis as monarch drug in a prescription；
Using rhizome of chuanxiong as ministerial drug, have effects that wind-expelling pain-stopping, promoting blood circulation, can principal drug assistance dispel lumbar rheumatism, have concurrently the scattered waist mansion stagnation of the circulation of vital energy,
Dispel waist mansion hemostasis the effect of；Assistant has effects that nourishing qi and blood, holds back cloudy, flourish muscle analgesic with animal drugs stiff silkworm, earthworm, ground bettle；
Assistant has effects that promoting blood circulation and removing blood stasis and wind-expelling pain-stopping with Rhizoma Chuanxiong；Assistant has blood-breaking by silt, increases with animal drugs earthworm and stiff silkworm
The effect of promoting blood circulation and removing blood stasis for promoting tissue regeneration.It comprehensively utilizes the Action advantage of above-mentioned each Chinese herb and mutually acts synergistically, have very
Strong clearing damp eliminating impediment and promoting blood circulation and removing blood stasis and other effects, it is notable for wind chill blockage and qi stagnation and blood stasis type Lumbar Intervertebral Disc,
It is easy to use, and low in raw material price, it is without any side effects.
Preferably, the Chinese medicine composition includes the raw material of following number：5~30 parts of Radix Angelicae Pubescentis, 5~30 parts of rhizome of chuanxiong, stiff silkworm
3~20 parts of 3~20 parts, 3~20 parts of earthworm and ground bettle.
More preferably, the Chinese medicine composition includes the raw material of following number：15 parts of Radix Angelicae Pubescentis, 15 parts of rhizome of chuanxiong, 10 parts of stiff silkworm,
10 parts of 10 parts of earthworm and ground bettle.
The present invention also provides a kind of Chinese medicine preparation for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, institutes
State the Chinese medicine composition that Chinese medicine preparation includes above-mentioned treatment wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci.
Preferably, the dosage form of the Chinese medicine preparation is decoction, pill or granule.Certainly, the embodiment of the present invention and unlimited
The dosage form of the treatment wind chill blockage and the Chinese medicine preparation of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci is made, dosage form can also be powder
Agent, capsule etc..
More preferably, the dosage form of the Chinese medicine preparation is decoction.
The present invention also provides a kind of preparations of decoction that treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Method, the decoction include the Chinese medicine composition of above-mentioned the treatment wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci of power,
The preparation method includes：
Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle are mixed, added water to cook, is filtered.
Further, the number added water to cook is 2 times, and described plus water the amount is the Chinese medicine material gross weight for the first time
3~6 times such as 3 times, 4 times, 5 times or 6 times of amount；Second of described plus water amount is 1~3 times of the Chinese medicine material total weight
Such as 1 times, 2 times or 3 times.
The process of adding water to cook includes：It is first boiled by intense fire after adding water, then with continuing boiling by slow fire 10~35min such as
10min, 15min, 20min, 25min, 30min or 35min etc., so as not to concoction overflow or it is too fast boil dry so as not to concoction overflow or mistake
It boils dry soon.
Preferably, it is described add water to cook before first impregnate Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle with clear water.
Preferably, the dregs of a decoction obtained after the filtering continue to pressurize strand acquirement to liquid, specially：After above-mentioned decoction
Admixing medical solutions are filtered, and obtained filtrate is spare, and the obtained dregs of a decoction, which are put into double gauze, to be wrapped, and after slightly cool, pressurization twists
The liquid adsorbed in the dregs of a decoction is taken, finally the dregs of a decoction are thrown away；The filtrate obtained after obtained liquid and above-mentioned filtering is mixed
It is even.
The present invention is prepared using the treatment wind chill blockage and the Chinese medicine composition of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Decoction is added water to cook by mixing Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle, the decoction being obtained by filtration to wind chill blockage and
The therapeutic effect of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci is more preferable, and preparation method is simple.
To facilitate the understanding of the present invention, the technical side further illustrated the present invention with reference to embodiment and specific case
Case.
Embodiment 1
(1) Chinese medicine material is weighed：5 parts of 5 parts of Radix Angelicae Pubescentis, 5 parts of rhizome of chuanxiong, 3 parts of stiff silkworm, 3 parts of earthworm and ground bettle.
(2) five kinds of above-mentioned Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle Chinese medicine materials are first impregnated into 1h with clear water respectively, so
Five kinds of Chinese medicine materials after immersion are mixed afterwards and are put into marmite, five kinds of Chinese medicine material total weights are added into marmite for the first time
3 times of amounts water, first boil with high heat, it is rear with continuing boiling by slow fire 10min；It is then added for the second time into marmite in this five kinds
The water of 3 times of medicine raw material gross weight amounts first boils with high heat, rear with continuing boiling by slow fire 15min.It again will be after decocting twice
Admixing medical solutions are filtered, obtained filter residue and filtrate, and filtrate is spare.
(3) the above-mentioned dregs of a decoction are put into double gauze and are wrapped, after slightly cool, pressurization twists and takes the liquid adsorbed in the dregs of a decoction,
Finally the dregs of a decoction are thrown away.
(4) filtrate obtained after obtained liquid and above-mentioned filtering is uniformly mixed, obtains decoction.
Embodiment 2
(1) Chinese medicine material is weighed：50 parts of 50 parts of Radix Angelicae Pubescentis, 50 parts of rhizome of chuanxiong, 50 parts of stiff silkworm, 50 parts of earthworm and ground bettle.
(2) five kinds of above-mentioned Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle Chinese medicine materials are first impregnated into 1h with clear water respectively, so
Five kinds of Chinese medicine materials after immersion are mixed afterwards and are put into marmite, five kinds of Chinese medicine material total weights are added into marmite for the first time
6 times of amounts water, first boil with high heat, it is rear with continuing boiling by slow fire 30min；It is then added for the second time into marmite in this five kinds
The water of 2 times of medicine raw material gross weight amounts first boils with high heat, rear with continuing boiling by slow fire 35min.It again will be after decocting twice
Admixing medical solutions are filtered, obtained filter residue and filtrate, and filtrate is spare.
(3) the above-mentioned dregs of a decoction are put into double gauze and are wrapped, after slightly cool, pressurization twists and takes the liquid adsorbed in the dregs of a decoction,
Finally the dregs of a decoction are thrown away.
(4) filtrate obtained after obtained liquid and above-mentioned filtering is uniformly mixed, obtains decoction.
Embodiment 3
(1) Chinese medicine material is weighed：25 parts of 40 parts of Radix Angelicae Pubescentis, 35 parts of rhizome of chuanxiong, 30 parts of stiff silkworm, 30 parts of earthworm and ground bettle.
(2) five kinds of above-mentioned Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle Chinese medicine materials are first impregnated into 2h with clear water respectively, so
Five kinds of Chinese medicine materials after immersion are mixed afterwards and are put into marmite, five kinds of Chinese medicine material total weights are added into marmite for the first time
4 times of amounts water, first boil with high heat, it is rear with continuing boiling by slow fire 20min；It is then added for the second time into marmite in this five kinds
The water of 1 times of medicine raw material gross weight amount first boils with high heat, rear with continuing boiling by slow fire 25min.It again will be after decocting twice
Admixing medical solutions are filtered, obtained filter residue and filtrate, and filtrate is spare.
(3) the above-mentioned dregs of a decoction are put into double gauze and are wrapped, after slightly cool, pressurization twists and takes the liquid adsorbed in the dregs of a decoction,
Finally the dregs of a decoction are thrown away.
(4) filtrate obtained after obtained liquid and above-mentioned filtering is uniformly mixed, obtains decoction.
Embodiment 4
(1) Chinese medicine material is weighed：5 parts of 10 parts of Radix Angelicae Pubescentis, 10 parts of rhizome of chuanxiong, 8 parts of stiff silkworm, 5 parts of earthworm and ground bettle.
(2) five kinds of above-mentioned Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle Chinese medicine materials are first impregnated into 1h with clear water respectively, so
Five kinds of Chinese medicine materials after immersion are mixed afterwards and are put into marmite, five kinds of Chinese medicine material total weights are added into marmite for the first time
4 times of amounts water, first boil with high heat, it is rear with continuing boiling by slow fire 15min；It is then added for the second time into marmite in this five kinds
The water of 1 times of medicine raw material gross weight amount first boils with high heat, rear with continuing boiling by slow fire 20min.It again will be after decocting twice
Admixing medical solutions are filtered, obtained filter residue and filtrate, and filtrate is spare.
(3) the above-mentioned dregs of a decoction are put into double gauze and are wrapped, after slightly cool, pressurization twists and takes the liquid adsorbed in the dregs of a decoction,
Finally the dregs of a decoction are thrown away.
(4) filtrate obtained after obtained liquid and above-mentioned filtering is uniformly mixed, obtains decoction.
Embodiment 5
(1) Chinese medicine material is weighed：10 parts of 15 parts of Radix Angelicae Pubescentis, 15 parts of rhizome of chuanxiong, 10 parts of stiff silkworm, 10 parts of earthworm and ground bettle.
(2) five kinds of above-mentioned Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle Chinese medicine materials are first impregnated into 2h with clear water respectively, so
Five kinds of Chinese medicine materials after immersion are mixed afterwards and are put into marmite, five kinds of Chinese medicine material total weights are added into marmite for the first time
4 times of amounts water, first boil with high heat, it is rear with continuing boiling by slow fire 25min；It is then added for the second time into marmite in this five kinds
The water of 2 times of medicine raw material gross weight amounts first boils with high heat, rear with continuing boiling by slow fire 30min.It again will be after decocting twice
Admixing medical solutions are filtered, obtained filter residue and filtrate, and filtrate is spare.
(3) the above-mentioned dregs of a decoction are put into double gauze and are wrapped, after slightly cool, pressurization twists and takes the liquid adsorbed in the dregs of a decoction,
Finally the dregs of a decoction are thrown away.
(4) filtrate obtained after obtained liquid and above-mentioned filtering is uniformly mixed, obtains decoction.
Embodiment 6
(1) Chinese medicine material is weighed：20 parts of 30 parts of Radix Angelicae Pubescentis, 25 parts of rhizome of chuanxiong, 20 parts of stiff silkworm, 15 parts of earthworm and ground bettle.
(2) five kinds of above-mentioned Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle Chinese medicine materials are first impregnated into 2h with clear water respectively, so
Five kinds of Chinese medicine materials after immersion are mixed afterwards and are put into marmite, five kinds of Chinese medicine material total weights are added into marmite for the first time
5 times of amounts water, first boil with high heat, it is rear with continuing boiling by slow fire 30min；It is then added for the second time into marmite in this five kinds
The water of 3 times of medicine raw material gross weight amounts first boils with high heat, rear with continuing boiling by slow fire 35min.It again will be after decocting twice
Admixing medical solutions are filtered, obtained filter residue and filtrate, and filtrate is spare.
(3) the above-mentioned dregs of a decoction are put into double gauze and are wrapped, after slightly cool, pressurization twists and takes the liquid adsorbed in the dregs of a decoction,
Finally the dregs of a decoction are thrown away.
(4) filtrate obtained after obtained liquid and above-mentioned filtering is uniformly mixed, obtains decoction.
Comparative example 1
With embodiment 5 difference lies in：Remove the Radix Angelicae Pubescentis in Chinese medicine material, the other the same as in Example 5.
Comparative example 2
With embodiment 5 difference lies in：Remove the rhizome of chuanxiong in Chinese medicine material, the other the same as in Example 5.
Comparative example 3
With embodiment 5 difference lies in：Remove the stiff silkworm in Chinese medicine material, the other the same as in Example 5.
Comparative example 4
With embodiment 5 difference lies in：Remove the earthworm in Chinese medicine material, the other the same as in Example 5.
Comparative example 5
With embodiment 5 difference lies in：Remove the ground bettle in Chinese medicine material, the other the same as in Example 5.
Comparative example 6
5 identical Chinese medicine material of logical embodiment is weighed, is then prepared into using the preparation method of conventional Chinese herbal granules
To granule.
Comparative example 7
5 identical Chinese medicine material of logical embodiment is weighed, is then prepared using the preparation method of conventional medicine pill
Pill.
Comparative example 8
With embodiment 5 difference lies in：Increase by 10 parts of 10 parts of Chinese medicine material safflower and peach kernel, the other the same as in Example 5.
Comparative example 9
(1) 35 parts of ramulus mori, 35 parts of lopseed, 35 parts of safflower, 35 parts of Radix Angelicae Sinensis, 30 parts of the root of Dahurain angelica, 30 parts of Chinese ephedra, monkshood 50 are taken
Part, 30 parts of frankincense, 30 parts of myrrh, 30 parts of bark of ash, 35 parts of caulis piperis futokadsurae, 35 parts of Sabia japonica, 35 parts of the root of bidentate achyranthes, 30 parts of Radix Paeoniae Alba, pawpaw 42
Part, 42 parts of Rhizoma Chuanxiong, 42 parts of Radix Salviae Miltiorrhizae, 30 parts of Herba Lycopi, 30 parts of trigone, 30 parts of zedoary, 10 parts of leech, 10 parts of ground bettle, scorpio 5
Part, 25 parts of bush, 25 parts of giant knotweed, 25 parts of dragon's blood, 25 parts of Radix Notoginseng, 25 parts of the root of Chinese clematis, 35 parts of berba aristolochiae mollissimae, 35 parts of Rhizoma Et Radix Notopterygii, windproof 35
Part, 35 parts of monkshood, 35 parts of semen brassicae, 25 parts of rhizoma atractylodis, 25 parts of the root of fangji, 25 parts of Radix Angelicae Pubescentis, 25 parts of peach kernel, 15 parts of grass-leaved sweetflag, Fructus Liquidambaris
15 parts, 25 parts of pyrola, 35 parts of cassia twig, 35 parts of lycopodium calvatum, 15 parts of baked ginger, 12 parts of Chinese prickly ash, 35 parts of caulis trachelospermi, 35 parts of Caulis Spatholobi,
5 parts of stiff silkworm, 10 parts of centipede, 5 parts of pangolin.
(2) by ramulus mori, cassia twig, lycopodium calvatum, lopseed, safflower, Radix Angelicae Sinensis, the root of Dahurain angelica, Chinese ephedra, monkshood, baked ginger, Chinese prickly ash, frankincense,
Myrrh, bark of ash, caulis piperis futokadsurae, Sabia japonica, caulis trachelospermi, Caulis Spatholobi, the root of bidentate achyranthes, Radix Paeoniae Alba, pawpaw, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Herba Lycopi, trigone, fluffy cowherb
Art is separately dried, after pulverization process, obtains the fine powder that granularity is the above-mentioned each raw material of 120 purposes, by the fine powder of each raw material
It is sufficiently mixed, obtains the first mixture, for use.
(3) ethyl alcohol of volumetric concentration 60%, the quality of first mixture are added to step (2) first mixture
It is 1 with the ratio between the volume of the ethyl alcohol:First mixture is first carried out immersion 10min by 15g/ml in ethanol, then 60
DEG C refluxing extraction 1.5h obtains the first extracting solution after recycling ethyl alcohol；First extracting solution is filtered successively, concentrate, is done
Dry, pulverization process obtains the first premix, for use；
(4) leech, ground bettle, scorpio, stiff silkworm, centipede and pangolin are weighed respectively, through being separately dried, after pulverization process,
The fine powder that granularity is the above-mentioned each raw material of 120 purposes is obtained, the fine powder of each raw material is sufficiently mixed, it is mixed to obtain second
Material is closed, for use；
(5) 8 times of quality water are added to step (4) second mixture, first carry out second mixture in water
4.5h is impregnated, then carries out boiling distillation, distillate is collected, the distillate is filtered successively, is concentrated, is dried, at crushing
Reason, obtains the second premix, for use；
(6) bush, giant knotweed, dragon's blood, Radix Notoginseng, the root of Chinese clematis, berba aristolochiae mollissimae, Rhizoma Et Radix Notopterygii, windproof, monkshood, semen brassicae, grey is weighed respectively
Art, the root of fangji, Radix Angelicae Pubescentis, peach kernel, grass-leaved sweetflag, Fructus Liquidambaris, pyrola, through being separately dried, after pulverization process, it is 120 to obtain granularity
The fine powder of the above-mentioned each raw material of purpose, the fine powder of each raw material is sufficiently mixed, obtains third mixture, for use；
(7) ethyl alcohol of volumetric concentration 80%, the quality of the third mixture are added to step (2) the third mixture
It is 1 with the ratio between the volume of ethyl alcohol:The third mixture is first carried out immersion 20min, then is returned at 75 DEG C by 10g/ml in ethanol
Stream extraction 1.5h, the second extracting solution is obtained after recycling ethyl alcohol；Second extracting solution is filtered successively, concentrate, is dried, powder
Broken processing obtains third premix, for use；
(8) step (3) first premix, (5) second premix of step, step (6) third premix are filled
Divide mixing to get the pharmaceutical composition of the treatment rheumatism bone disease.
Clinical test
It now collects 480 famous physicians and is diagnosed as qi depression to blood stasis and the sluggish type protrasion of the lumbar intervertebral disci of cold-dampness, doctor trained in Western medicine is diagnosed as god
Through root myelopathy patient, 16 groups are randomly divided by random digits table, every group 30, the age is 25~65 years old, uses this respectively
The Chinese medicine preparation and conventional western medicine of decoction, the preparation of comparative example 1~9 prepared by inventive embodiments 1~6 are treated.
Application method：Pill, granule and decoction are directly for oral administration, pill and each 5g of granule；Decoction is each
200ml；Medication is each 1 time sooner or later.
Observation index：Neck and shoulder ache visual analogue scales (VAS)：
0 point, without apparent pain in waist and lower extremities；
1~3 point, there is slight pain in waist and lower extremities, can endure；
4~6 points, pain in waist and lower extremities influences sleep, can endure；
7~10 points, there is the pain in waist and lower extremities that progressive aggravates, and can not endure, influence appetite and sleep.
The JOA scorings of Japanese Orthopaedic Society low back pain：JOA score values are up to 29 points, minimum 0 point, the lower expression of score
Dysfunction is more apparent.
Disability index (ODI indexes)：ODI indexes are divided by score value domain section：Excellent (0~25%)；Good (25~
50%)；It can (50~75%)；Poor (75~100%).
MacNab curative effects judge：
It cures：Symptom and sign disappears substantially.
Effectively：Symptom and sign is alleviated.
In vain：Symptom and sign is preceding without improvement with treatment.
10 days as a treatment course, after 3 courses for the treatment of are used continuously, statistical result is as follows：
1. pretherapy and post-treatment VAS of table scorings, JOA scorings, NDI indexes compare (x+s, n=450)
Note：VAS scores：Before VS treatments▲P=0.00, embodiment 5VS comparative example 7#P=0.00, VS comparative example 8★P=
0.13, VS conventional western medicine●FP=0.00；JOA scores：Before VS treatments▲P=0.00, embodiment 5VS comparative example 7#P=0.00, VS
Comparative example 8★P=0.38, VS conventional western medicine●P=0.00；NDI indexes：Before VS treatments▲P=0.00, embodiment 5VS comparative examples
7#P=0.00, VS comparative example 8★P=0.06, VS conventional western medicine●P=0.00.
By 1 result of upper table it is found that the pill of the preparation of the embodiment of the present invention 1~6 is to qi depression to blood stasis and the sluggish type lumbar vertebrae of cold-dampness
The therapeutic effect of disc herniation is more preferable.
Table 2.MacNab curative effects compare
| Group | Total number of persons | It cures | Effectively | In vain | Total effective rate |
| Embodiment 1 | 30 | 22 | 3 | 5 | 83% |
| Embodiment 2 | 30 | 21 | 4 | 5 | 83% |
| Embodiment 3 | 30 | 22 | 4 | 4 | 87% |
| Embodiment 4 | 30 | 24 | 4 | 2 | 93% |
| Embodiment 5 | 30 | 27 | 2 | 0 | 100% |
| Embodiment 6 | 30 | 25 | 4 | 1 | 93% |
| Comparative example 1 | 30 | 1 | 8 | 21 | 30% |
| Comparative example 2 | 30 | 1 | 6 | 23 | 23% |
| Comparative example 3 | 30 | 0 | 6 | 24 | 20% |
| Comparative example 4 | 30 | 2 | 9 | 19 | 37% |
| Comparative example 5 | 30 | 3 | 10 | 17 | 57% |
| Comparative example 6 | 30 | 15 | 7 | 8 | 73% |
| Comparative example 7 | 30 | 13 | 8 | 9 | 70% |
| Comparative example 8 | 30 | 12 | 8 | 10 | 67% |
| Comparative example 9 | 30 | 19 | 8 | 3 | 90% |
| Conventional western medicine | 30 | 13 | 8 | 9 | 70% |
By upper table 2 it is found that the decoction through the embodiment of the present invention 1~6 dashes forward to qi depression to blood stasis and the sluggish type lumber ertebral disc of cold-dampness
Go out the treated effect of disease 83% or more, cure rate is above the effective of comparative example 1~9 and conventional western medicine up to 73% or more
Rate and cure rate, and it is suitable with the therapeutic effect of comparative example 9, it can be seen that, decoction of the invention is solidifying to qi depression to blood stasis and cold-dampness
The therapeutic effect of the stagnant type protrasion of the lumbar intervertebral disci is notable.In addition, in general from cure rate and effective percentage, in embodiment 4~6
Therapeutic effect is more preferable, and the therapeutic effect of wherein embodiment 5 is best.
Clinical case
Case 1：Flood certain, man, 50 years old, waist pain of buttock 8 years, aggravate 1 month, have no apparent through Dressed plaster, acupuncture etc.
Curative effect.Waist pain of buttock, the small leg outer side of right lower extremity feel that decline, physical examination are shown in that lumbar physiological-curvature exists, and mobility is good,
60 ° of right straight-leg raising test (+), right femoral nerve stretching test (+), right tibialis anterior muscular strength weaken, and right patellar reflex weakens, pathology
Reflection is not drawn, and CT, which makes film, is diagnosed as prominent on the right side of 4/5 interverbebral disc of waist, Minor articulus hypertrophy cohesion, tongue purple is dark, tongue is greasy in vain,
Arteries and veins is tight, the past superficial atrophic gastritis, 2 grades of high blood pressure.The decoction for taking the preparation of the embodiment of the present invention 5, according to sooner or later each one
Secondary, each taking each 200ml, after 15 days, waist pain of buttock is substantially reduced, is further continued for preparing using the embodiment of the present invention 5
Decoction 1 month, waist buttocks and right lower extremity symptom are relieved, and it is good to visit curative effect for many years for life of taking care of oneself, extensive recovery operation.
Case 2：Cao, female, 43 years old, flank pain 5 years aggravated 3 months, apparent treatment is had no through Dressed plaster, acupuncture etc.
Effect.Waist pain of buttock, the small leg outer side of left lower extremity feel that decline, physical examination are shown in that lumbar physiological-curvature exists, and mobility is good, left
60 ° of straight-leg raising test (+), left femoral nerve stretching test (+), left tibialis anterior muscular strength weaken, and left patellar reflex weakens, and pathology is anti-
It penetrates and does not draw, CT film makings are diagnosed as prominent on the left of 4/5 interverbebral disc of waist, Minor articulus hypertrophy cohesion, purple dark, the white greasy, arteries and veins of tongue of tongue
Tightly, no past medical history.The decoction for taking the preparation of the embodiment of the present invention 5, according to once in the morning and once at night, each taking each 200ml, 15 days
Afterwards, waist pain of buttock is substantially reduced, is further continued for the decoction prepared using the embodiment of the present invention 53 months, waist buttocks and left lower extremity disease
Shape is relieved, and it is good to visit curative effect for many years for life of taking care of oneself, extensive recovery operation.
Case 3：Side certain, female, 49 years old, waist pain of buttock 7 days, aggravate 1 day, have no apparent treatment through Dressed plaster, acupuncture etc.
Effect.Waist pain of buttock, the small leg outer side of double lower limb feel that decline, physical examination are shown in that lumbar physiological-curvature exists, and patient cannot stand,
Lumbar vertebrae mobility inspection can not be coordinated.20 ° of double lower limb straight-leg raising test (+), bilateral femoral nerve stretching test (+), physiology are anti-
Presence is penetrated, pathologic reflex is not drawn, and CT film makings are diagnosed as 5/ sacrum of waist, 1 disc herniation, Minor articulus hypertrophy cohesion, tongue purple
Secretly, tongue is greasy in vain, arteries and veins is tight, takes orally Euthyrox treatment in more than 20 years of the past hypothyroidism.Take the preparation of the embodiment of the present invention 5
Decoction, according to once in the morning and once at night, each taking each 200ml, after 7 days, waist pain of buttock is substantially reduced, is further continued for using this
Decoction two weeks prepared by inventive embodiments 5, waist buttocks and symptoms of lower extremity are relieved, and life of taking care of oneself, extensive recovery operation is visited
Half a year curative effect is good.
Animal experiment
The pill for the sluggish myelopathy for the treatment of qi depression to blood stasis and cold-dampness prepared using the embodiment of the present invention 1 is directed to below
BBB scorings, hemorheology detection and the inflammation and immune factor test experience that animal carries out.
This animal experiment is quasi- to pierce rotary-cut preparation rabbit intervertebral disc degeneration model by minimally invasive needle, is examined by modern Histopathology
It looks into, the methods of biochemistry, molecular biology and means, system observes the traditional Chinese herbal decoction and stagnates type waist to qi depression to blood stasis and cold-dampness
The action pathway and the mechanism of action of the protrusion of the intervertebral disc, desk study medicine prevention qi depression to blood stasis and the sluggish type lumber ertebral disc of cold-dampness
The mechanism of herniation.
1, minimally invasive needle thorn rotary-cut prepares the foundation of rabbit intervertebral disc degeneration model
6 monthly age new zealand white rabbit 50 is taken, male and female are unlimited, weight (2.9 ± 0.3) kg.
Rotary-cut nucleus pulposus establishes IDD models, specific steps after experimental group uses microtrauma puncture：Animal foot is bowed after fixing
It crouches on desktop, the padded abdomen of cushion, side lower limb muscles inject Benzylpenicillin sodium salt (400,000 U/ are only) and prevent infection.Most in crista iliaca
The flat L7 spinous process of high point positions L4, L5, L6 spinous process and articular process, takes 18G puncture needles with right outside about 45° angle degree inserting needle after local anaesthesia,
Outside is pierced into L4,5, L5,6 intervertenral spaces after interverbebral disc under C arm X-ray machines perspective, and needle point is located in nucleus pulposus；Using needle body rotary process
Needle point rotary-cut nucleus pulposus is driven, it is suitable, be rotated by 360 ° counterclockwise each 1 time, to promote its regression.Puncture needle, disinfection are finally exited,
Animal conventinal breeding.
Control group does not make any processing.
2, grouping and medication
The successful protrasion of the lumbar intervertebral disci rabbit of modeling is randomly divided into 5 groups using random digits table, every group 10, i.e. sky
White group (physiological saline), positive controls (" Yaobitong Capsule"), decoction low, middle and high dose groups of the invention.Separately 10 are taken to set up
Pseudo- operation group (physiological saline).Positive controls give " Yaobitong Capsule" 6g/Kg/d, low middle high dose group 4g/kg/d, 6g/kg/
D, 8g/kg/d, blank group and pseudo- operation group give normal saline, successive administration 3 months.
3, Testing index
Before experiment, month after operation, 3 months after operation to White Rabbit carry out BBB scoring measure；3 months after operation is with chloramines
White Rabbit is put to death in the excessive anesthesia of ketone (0.1g/kg weights) intraperitoneal injection.Venous blood is acquired, is placed in anticoagulant tube and measures blood stream
Become and learns index (packed cell volume, whole blood undercut/high shear viscosity, erythrocyte aggregation index)；White Rabbit lumbar is taken carefully to pick
Go out spinal cord, myeloid tissue carries out homogenate and takes supernatant, and inflammatory factor prostaglandin E2 is detected using ELISA kit
(prostaglandin E2, PGE2) and phospholipase A2 (phospholipase A2, PLA2).
3.1, BBB scores
Animal is put into opening basin, tapping tub wall makes it creep, and observes the stern of animal, SCID Mice is walked, torso exercise
And its coordinate situation.Under the complete waking state of animal, its myodynamia is carried out by observing lower limb exercise and load-bearing capacity
Assessment, two trained experimenters are independent separately to carry out blind assessment.
3.2, hemorheology detects
Sample collection method：Above-mentioned new zealand white rabbit, after anaesthetizing successfully, jugular vein blood collection is placed in be measured in anticoagulant tube.
Packed cell volume (PCV)：Using wynn's method.The anticoagulation being mixed is drawn with elongated capillary burette, is inserted into Wen Shi pipes
Then anticoagulation is slowly injected into scale " 10 " by bottom, place pays attention to preventing bubble from generating.With horizontal centrifuge with it is opposite from
3000r/min centrifuges 30min when mental and physical efforts (RCF) 2246g, i.e. effective radius 22.5cm.Read the pillar height millimeter of red blood cell layer
Number, is multiplied by 1%, the amount of as every liter blood rbc volume reports result as unit of percentage.
Whole blood undercut/high shear viscosity：Extracting vein blood 5ml constant temperature 5min under measuring temperature, are loaded after mixing well, with
The full-automatic blood viscosity analyzer row whole blood viscosity of ZL-6000 measures, and record height cuts (200s-1), undercut (1s-1) whole blood respectively
Viscosity number.
Erythrocyte aggregation index (red blood cell aggregation index, AI)：Erythrocyte aggregation index=
Low shear viscosity/high shear viscosity.
3.3 inflammation and immune factor detection
Prostaglandin E2 (prostaglandin E2, PGE2), phospholipase A2 (phospholipase A2, PLA2) are surveyed
It is fixed：It is detected using ELISA kit.Appropriate physiological saline is added in tissue to smash to pieces.3000r/min is centrifuged 10 minutes, takes supernatant
Liquid.1, it is coated with：It is 1-10 μ g/ml that antibody, which is diluted to protein content, with 0.05MPH9. You carbonate coating buffer solution.Every
Add 0.1ml in the reacting hole of a polystyrene board, 4 DEG C overnight.Next day discards solution in hole, washes 3 times with washing buffer, often
3 minutes secondary (referred to as washing, similarly hereinafter).2, it is loaded：In addition clear liquid 0.1ml, which in the above-mentioned reacting hole being coated with, sets 37 DEG C, is incubated 1
Hour.It is washed out.(while doing blank well, negative control hole and Positive control wells).3, enzyme labeling antibody：In each reacting hole
In, enzyme labelled antibody (dilution after titration) 0.1ml of diluted fresh is added.37 DEG C are incubated 0.5~1 hour, washing.4、
Substrate solution is added to develop the color：Be added the tmb substrate solution 0.1ml of Extemporaneous in each reacting hole, 37 DEG C 10~30 minutes.5, it terminates
Reaction：2M sulfuric acid 0.05ml is added in each reacting hole.6, result judgement：It can be in the knot that in white background, directly detects by an unaided eye
Fruit:Color is deeper in reacting hole, and positive degree is stronger, and negative reaction is colourless or extremely shallow, the depth of the be in color of foundation, with
"+", "-" number indicate.Also OD values can be surveyed:On ELISA detectors, at 450nm (if being developed the color with ABTS, 410nm), with
Each hole OD values are surveyed after blank control wells zeroing, it is as positive if more than 2.1 times of defined negative control OD value.
Test result：As the time pushes away length after blank group modeling, BBS scorings increase, " Yaobitong Capsule" group and it is low in
3 months BBS scorings apparent increase (P after high dose group modeling<0.05), wherein high dose group increases most apparent (P<0.05)
(being shown in Table 3)；Compared to other group blank group packed cell volume, erythrocyte aggregation index, whole blood low shear viscosity highest, and whole blood is high
Cut the then minimum (P of viscosity<0.05)；Packed cell volume, erythrocyte aggregation index, whole blood low shear viscosity each group compare, and waist numbness is logical
Capsules group<Low dose group<Middle dose group<High dose group, whole blood high shear viscosity each group compare, " Yaobitong Capsule" group>Low dosage
Group>Middle dose group>High dose group (P<0.05) (4 are shown in Table)；PGE2 and PLA2 contents blank group is apparently higher than it in myeloid tissue
He is group (P<0.05), other each groups compare, " Yaobitong Capsule" group>Low dose group>Middle dose group>High dose group (P<0.05)
(being shown in Table 5).
3 preoperative and postoperative White Rabbit BBB scorings of table are compared
Note：Compared with blank group●P<0.05；Compared with " Yaobitong Capsule" group◆P>0.05；Compared with " Yaobitong Capsule" group▲P
<0.05；Compared with " Yaobitong Capsule" group★P<0.05。
43 months after operation hemorheology of table compares
Note：Compared with blank group●P<0.05；Compared with " Yaobitong Capsule" group◆P>0.05；Compared with " Yaobitong Capsule" group▲P
<0.05；Compared with " Yaobitong Capsule" group★P<0.05。
53 months after operation PGE of table2And PLA2Comparision contents
Note：Compared with blank group●P<0.05；Compared with " Yaobitong Capsule" group◆P>0.05；Compared with " Yaobitong Capsule" group▲P
<0.05；Compared with " Yaobitong Capsule" group★P<0.05。
To sum up, the decoction high dose group of the embodiment of the present invention 1 can improve qi depression to blood stasis to the greatest extent and cold-dampness stagnates
The BBS of the White Rabbit model of the type protrasion of the lumbar intervertebral disci scores, and improves hemorheology, accelerates blood flow, reduces lumbar vertebrae office
The aggregation of portion's inflammatory factor.
It should be noted that treatment wind chill blockage and stagnation of the circulation of vital energy blood prepared by the embodiment of the present invention 1 in above-mentioned animal experiment
The decoction of the stasis of blood type protrasion of the lumbar intervertebral disci replaces with the treatment wind chill blockage and qi stagnation and blood stasis type of the preparation of the embodiment of the present invention 2~6
The decoction of the protrasion of the lumbar intervertebral disci can reach above-mentioned same experiment effect.
The preferred embodiment of the present invention is above are only, is not intended to restrict the invention, for those skilled in the art
For member, inventive formulation and preparation process can have various modifications and variations.All within the spirits and principles of the present invention, institute
Any modification, equivalent substitution, improvement and etc. of work, should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, it is characterised in that：Including
The raw material of following number：5~50 parts of Radix Angelicae Pubescentis, 5~50 parts of rhizome of chuanxiong, 3~50 parts of stiff silkworm, 3~50 parts of earthworm and ground bettle 3~50
Part.
2. the Chinese medicine composition for the treatment of wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci according to claim 1,
It is characterized in that：Include the raw material of following number：5~30 parts of Radix Angelicae Pubescentis, 5~30 parts of rhizome of chuanxiong, 3~20 parts of stiff silkworm, 3~20 parts of earthworm
With 3~20 parts of ground bettle.
3. the Chinese medicine composition for the treatment of wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci according to claim 2,
It is characterized in that：Include the raw material of following number：15 parts of Radix Angelicae Pubescentis, 15 parts of rhizome of chuanxiong, 10 parts of stiff silkworm, 10 parts of earthworm and ground bettle 10
Part.
4. a kind of Chinese medicine preparation for treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, it is characterised in that：In described
Medicine preparation includes treatment wind chill blockage according to any one of claims 1 to 3 and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Chinese medicine composition.
5. the Chinese medicine preparation for the treatment of wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci according to claim 4,
It is characterized in that：The dosage form of the Chinese medicine preparation is decoction, pill or granule.
6. the Chinese medicine preparation for the treatment of wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci according to claim 5,
It is characterized in that：The dosage form of the Chinese medicine preparation is decoction.
7. a kind of preparation method of decoction that treating wind chill blockage and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci, it is characterised in that：
The decoction includes treatment wind chill blockage according to any one of claims 1 to 3 and the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Chinese medicine composition, the preparation method includes：
Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle are mixed, added water to cook, is filtered.
8. the preparation side for the treatment of wind chill blockage according to claim 7 and the decoction of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Method, it is characterised in that：The number added water to cook is 2 times, and described plus water the amount is the Chinese medicine material total weight for the first time
3~6 times, second described plus water amount is 1~3 times of the Chinese medicine material total weight；The process of adding water to cook includes：
It is first boiled by intense fire after adding water, then with continuing boiling by slow fire 10~35min.
9. the preparation side for the treatment of wind chill blockage according to claim 7 and the decoction of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Method, it is characterised in that：It is described add water to cook before first impregnate Radix Angelicae Pubescentis, rhizome of chuanxiong, stiff silkworm, earthworm and ground bettle with clear water.
10. the preparation for the treatment of wind chill blockage according to claim 7 and the decoction of the qi stagnation and blood stasis type protrasion of the lumbar intervertebral disci
Method, it is characterised in that：The dregs of a decoction obtained after the filtering continue to pressurize strand acquirement to liquid, by the liquid and the filtering
The filtrate obtained afterwards is uniformly mixed.
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| CN108465059A (en) * | 2018-06-25 | 2018-08-31 | 深圳市中医院 | Treat the Chinese medicine composition of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, the preparation method of Chinese medicine preparation and pill |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156619A (en) * | 1996-02-09 | 1997-08-13 | 李毅 | Capsule for treating pain or numbness and preparing process thereof |
| CN107281440A (en) * | 2017-05-22 | 2017-10-24 | 刘冉 | It is a kind of to can be used for Chinese medicine for the treatment of neck lumbar disc herniation and/or rheumatism bone disease and preparation method thereof |
-
2018
- 2018-08-09 CN CN201810901300.5A patent/CN108578454A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1156619A (en) * | 1996-02-09 | 1997-08-13 | 李毅 | Capsule for treating pain or numbness and preparing process thereof |
| CN107281440A (en) * | 2017-05-22 | 2017-10-24 | 刘冉 | It is a kind of to can be used for Chinese medicine for the treatment of neck lumbar disc herniation and/or rheumatism bone disease and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 吕周焕: "温经止痛汤治疗腰椎间盘突出症160例", 《内蒙古中医药》 * |
| ***等: "中西医综合疗法治疗腰椎间盘突出症的疗效观察", 《中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108465059A (en) * | 2018-06-25 | 2018-08-31 | 深圳市中医院 | Treat the Chinese medicine composition of wind chill blockage and qi stagnation and blood stasis type cervical spondylosis, the preparation method of Chinese medicine preparation and pill |
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