CN1081924C - 包括虫草和巴西榥榥木的药物组合物 - Google Patents
包括虫草和巴西榥榥木的药物组合物 Download PDFInfo
- Publication number
- CN1081924C CN1081924C CN96199360A CN96199360A CN1081924C CN 1081924 C CN1081924 C CN 1081924C CN 96199360 A CN96199360 A CN 96199360A CN 96199360 A CN96199360 A CN 96199360A CN 1081924 C CN1081924 C CN 1081924C
- Authority
- CN
- China
- Prior art keywords
- huang
- crude drug
- whole crude
- cordyceps
- wood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000340987 Ptychopetalum olacoides Species 0.000 title abstract description 5
- 241000196324 Embryophyta Species 0.000 title abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims abstract description 26
- 239000002023 wood Substances 0.000 claims description 28
- 241000190633 Cordyceps Species 0.000 claims description 27
- 210000003205 muscle Anatomy 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- 208000019914 Mental Fatigue Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 53
- 229940079593 drug Drugs 0.000 description 52
- 239000007788 liquid Substances 0.000 description 25
- 238000002360 preparation method Methods 0.000 description 22
- 239000000284 extract Substances 0.000 description 15
- -1 correctives Substances 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 229930006000 Sucrose Natural products 0.000 description 8
- 229930003270 Vitamin B Natural products 0.000 description 8
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 8
- 239000005720 sucrose Substances 0.000 description 8
- 235000019156 vitamin B Nutrition 0.000 description 8
- 239000011720 vitamin B Substances 0.000 description 8
- 241000424773 Epimedium alpinum Species 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 235000018905 epimedium Nutrition 0.000 description 7
- 230000009182 swimming Effects 0.000 description 7
- 241000208340 Araliaceae Species 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 235000008434 ginseng Nutrition 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 229960002920 sorbitol Drugs 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 5
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 5
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 229960001948 caffeine Drugs 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000005711 Benzoic acid Substances 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 4
- 240000001307 Myosotis scorpioides Species 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 210000003056 antler Anatomy 0.000 description 4
- 235000010233 benzoic acid Nutrition 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical class CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 241000416162 Astragalus gummifer Species 0.000 description 3
- 241001480006 Clavicipitaceae Species 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 244000248557 Ophiopogon japonicus Species 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 3
- 229920001615 Tragacanth Polymers 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 3
- 229910000323 aluminium silicate Inorganic materials 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 238000005470 impregnation Methods 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 235000014214 soft drink Nutrition 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 235000010487 tragacanth Nutrition 0.000 description 3
- 239000000196 tragacanth Substances 0.000 description 3
- 229940116362 tragacanth Drugs 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- 241001632409 Aralia elata Species 0.000 description 2
- 235000015888 Aralia elata Nutrition 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 239000001856 Ethyl cellulose Substances 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- 239000000899 Gutta-Percha Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- 241000221014 Olacaceae Species 0.000 description 2
- 240000000342 Palaquium gutta Species 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 240000006079 Schisandra chinensis Species 0.000 description 2
- 235000008422 Schisandra chinensis Nutrition 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 2
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 229950008138 carmellose Drugs 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000019325 ethyl cellulose Nutrition 0.000 description 2
- 229920001249 ethyl cellulose Polymers 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 229920000588 gutta-percha Polymers 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000021058 soft food Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- KWTQSFXGGICVPE-UHFFFAOYSA-N 2-amino-5-(diaminomethylideneamino)pentanoic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCCN=C(N)N KWTQSFXGGICVPE-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000271039 Agkistrodon Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 229920000945 Amylopectin Polymers 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 241000005787 Cistanche Species 0.000 description 1
- 241000113542 Codium tomentosum Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000271042 Gloydius halys Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 240000004670 Glycyrrhiza echinata Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229930195210 Ophiopogon Natural products 0.000 description 1
- 241001474977 Palla Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 241000271897 Viperidae Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 229960000678 carnitine chloride Drugs 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000007765 cera alba Substances 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 229940017545 cinnamon bark Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N methyl undecanoic acid Natural products CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229940046664 taurine 500 mg Drugs 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
包括虫草和巴西榥榥木的组合物,该组合物在解除体力和精神上的疲劳以及使弱化的体质转佳方面很有效,甚至长时间施用也不会产生任何副作用。
Description
本发明涉及用于解除体力和精神上的疲劳以及转佳或恢复弱化的体质等的组合物,该组合物包括巴西榥榥木(muirapuama)和虫草(plantworms)。
巴西榥榥木是一种天然药材,从古时候起亚马孙河流域的人们就应用它增益精力或恢复强壮。虫草也是一种天然药材,古代的中国应用它作镇静药或镇咳药。
口服只含巴西榥榥木提取物或虫草的提取物作为有效组分的组合物已为人所知,但同时含巴西榥榥木和虫草的组合物尚未报道。
Dialog Information Service,File 377,Derwent Drug File,DialogAccession No.00510368,Derwent Accession No.92-51335描述了包括巴西榥榥木的组合物在治疗体力和精神上的疲劳方面的应用。
本发明的一个目的是提供一种组合物,该组合物通过虫草增强巴西榥榥木对因紧张而引起压抑的体力或精力的恢复效果,而且还具有解除紧张和体力疲劳的效果以及改善或恢复弱化的体质的效果,即使长时间施用也没有任何副作用。
由于广泛研究的结果,本发明人发现了巴西榥榥木与虫草的新型组合,它对于解除因紧张而引起的体力和精神上的疲劳,以及使弱化的体质改善有协同效果,此处,巴西榥榥木能有效地使紧张即各种外部因素和内部因素引起的体内障碍正常化,而虫草能有效地促进代谢作用并解除体力和精神上的疲劳如通常的疲乏、瞌睡感觉,伸展的感觉,从而构成本发明。
本发明提供了用于解除体力和精神上的疲劳以及使弱化的体质改善的组合物,它包括作为有效组分的巴西榥榥木和虫草。
用于本发明的巴西榥榥木的来源植物是生长在巴西亚马孙河流域的铁青树科(Olacaceae)灌木,它包括下列种:Ptychopetalum olacoides、Ptychopetlum uncinatum和Liriosma ovata,其中Ptychopetalumolacoides种是优选的。不用说,Ptychopetlum uncinatum种和Lriosmaovata种也可应用。在本发明中,应用这些来源植物的根。
虫草是优选麦角科(Clavicipitaceae)冬虫夏草属(Cordyceps)的子座(stomas)和该冬虫夏草属寄生于其上的昆虫幼虫。麦角科的那些Simizuomyces、Podonectrioides和Torrbiella属也可应用。
本发明的巴西榥榥木可用其提取物,该提取物可按如下方法制备:
将切得细碎的巴西榥榥木树根与稀乙醇混合并浸渍2天,其间不时搅拌,再过滤所得浸渍液。将残渣进一步与稀乙醇混合并浸渍2天,期间不时搅拌,也过滤所得浸渍液。合并所得的两份滤液,减压下浓缩而得巴西榥榥木提取物。
本发明的虫草可用其提取物或流体提取物,这类提取物可按如下方法制备:
将粗略切碎的虫草与稀乙醇混合并在室温下放置约2小时,然后将所得溶液进一步与稀乙醇混合,在室温下静置3天进行浸渍,得浸渍液形式的提取物。将这样得到的提取物在室温下放置2天,再通过滤纸过滤而得流体提取物。
按本发明,巴西榥榥木提取物的有效用量以整体天然药材计对成人来说为10~5,000mg/天,优选为50~1,500mg/天,而虫草的流体提取物的有效用量以整体天然药材计对成人来说为10~5,000mg/天,优选为50~1,000mg/天。也就是说,以整体天然药材计,对每重量份虫草的流体提取物,应用的巴西榥榥木提取物为0.002~500重量份,优选为0.03~30重量份,更优选为0.5~8重量份。
本发明的组合物可含有咖啡碱,水溶性维生素如维生素B1、维生素B2、维生素B6、维生素B12、维生素C,生物素,肉碱,泛酸(pantotenicacid)和烟酸以及它们的衍生物,脂溶性维生素如维生素A、维生素E及其衍生物、牛磺酸,氨基酸如精氨酸,以及其它天然药物,例如下列物质的提取物或酊剂:蝮蛇属(agkistrodon),人参(ginseng),黄芪(astragalus)根,黄精(polygonati)根,甘草(licorice),poria sclerotium,地黄(rehmannia)根,刺老牙根(Japanese angelica root),lycii果,肉桂皮(cinnamon bark),velvet horm,barren-worts,肉苁蓉触角茎(cistanchis caulis),杜仲橡胶(chinese gutta percha),五味子果(schisandra fruit),eleutherococc,沿阶草(ophiopogon)块茎,polygoni multiflori root,牛胆汁。
本发明的组合物可按原状或按下列药物制剂形式施药或直接服用,例如,口服制剂(如颗粒、粉末、胶囊、片、干糖浆、液态制剂),或注射剂,或食物如软饮料或固体食物(如饼干),是与其它已知的添加剂混合而制备的,这类添加剂例如:载体、崩解剂、粘结剂、润滑剂、抗氧剂、涂覆剂、着色剂、矫味剂、表面活性剂、增塑剂、pH调节剂、清新剂、悬浮剂、消泡剂、增稠剂、增溶助剂等,按通常的方法进行制备或者将它们作为功能性组分或添加剂加入软饮料或食物。
按本发明,巴西榥榥木提取物的单一组合物和虫草提取物的单一组合物可被分别密封入安瓿中,施用时可将单一组合物混合后使用或不同时混合而使用。
该载体例如包括:糖醇如D-甘露糖醇、木糖醇和D-山梨糖醇,糖类如葡萄糖、蔗糖、乳糖和果糖,结晶纤维素,sodium carmellose,磷酸氢钙、小麦淀粉,大米淀粉,玉米淀粉,马铃薯淀粉,糊精,β-环糊精,轻质无水硅酸,二氧化钛,硅铝酸镁。
该崩解剂例如包括:低取代的羟丙基纤维素、羧甲基纤维素钙、sodium croscarmellose hvdroxypropyl starch、部分糊化的淀粉。
该粘结剂例如包括:甲基纤维素、羟丙基纤维素、羟丙基甲基纤维素、聚乙烯基吡咯烷酮、明胶、***胶、乙基纤维素、聚乙烯醇、支链淀粉、糊化淀粉、琼脂、黄蓍胶、藻酸钠、丙二醇藻酸酯。
该润滑剂例如包括:硬脂酸、硬脂酸镁、硬脂酸钙、硬脂酸聚烃氧基酯、十六醇、滑石、氢化油、蔗糖脂肪酸酯、二甲基聚硅氧烷、黄蜂蜡、白蜂蜡。
该抗氧剂例如包括:二丁基羟基甲苯(BHT)、棓酸丙酯、丁基羟基茴香醚(BHA)、生育酚、柠檬酸。
该涂覆剂例如包括:羟丙基甲基纤维素、羟丙基纤维素、甲基纤维素、乙基纤维素、羟丙基甲基纤维素邻苯二甲酸酯、羟丙基甲基纤维素乙酸丁二酸酯、羧甲基乙基纤维素、纤维素乙酸邻苯二甲酸酯、聚乙烯醇缩乙醛二乙氨基乙酸酯、氨烷基甲基丙烯酸酯共聚物、羟丙基甲基纤维素乙酸丁二酸酯、甲基丙烯酸共聚物、聚乙酸乙烯酯二乙氨基乙酸酯、紫胶。
该着色剂例如包括:姜黄提取物、核黄素、胡萝卜素溶液、二氧化钛。
该表面活性剂例如包括:聚氧乙烯氢化蓖麻油、甘油一硬脂酸酯、脱水山梨醇一硬脂酸酯、脱水山梨醇一月桂酸酯、聚氧乙烯聚氧丙烯、聚溶剂化物(polysolvates)、月桂基硫酸钠、聚乙二醇(macrogols)、蔗糖脂肪酸酯。
该增塑剂例如包括:柠檬酸三乙酯、聚乙二醇、三醋精、十六醇。
该pH调节剂例如包括:柠檬酸、苹果酸、磷酸氢二钠、磷酸氢二钾。
该清新剂例如包括:1-薄荷醇、薄荷水。
该悬浮剂例如包括:高岭土、sodium carmellose、呫吨胶、黄蓍胶。
该消泡剂例如包括:二甲基聚硅氧烷、硅氧烷消泡剂。
该增稠剂例如包括:呫吨胶、黄蓍胶、甲基纤维素、糊精。
该增溶助剂例如包括:乙醇、蔗糖脂肪酸酯、聚乙二醇。
至于软饮料,除了上述添加剂外,可通过将其它生理活性物质、矿物质、维生素、激素、营养物、调味剂加入本组合物中而得特别需要的味道和气味。
本发明的组合物对体力或精神上的疲劳、紧张和弱化的体质具有预防性或改善效果或能促使它们恢复,即使长时间施用也没有任何副作用。
图1示出大鼠分别服用本液体制剂(虫草和巴西榥榥木)、虫草单一液体制剂和巴西榥榥木单一液体制剂,以及对比物(纯化的水)后被迫游水的持续游水时间。
图2示出训练组和未训练组分别对本液体制剂(虫草和巴西榥榥木)、虫草单一液体制剂和巴西榥榥木单一液体制剂,以及对照物(纯化的水)的总摄取量。
下面将参考实施例和测试实施例,以及附图来详细叙述本发明。
实施例1配方虫草 100mg(按整体天然药材计)巴西榥榥木 300mg(按整体天然药材计)蝮蛇 250mg(按整体天然药材计)牛磺酸 500mg人参 600mg(按整体天然药材计)黄芪 300mg(按整体天然药材计)黄精根 300mg(按整体天然药材计)甘草根 150mg(按整体天然药材计)Poria sclerotium 300mg(按整体天然药材计)地黄根 200mg(按整体天然药材计)刺老牙根 200mg(按整体天然药材计)Lycii果 200mg(按整体天然药材计)肉桂皮 150mg(按整体天然药材计)鹿茸角(Velvet horn) 300mg(按整体天然药材计)Barren-worts 1000mg(按整体天然药材计)维生素B2 5mg维生素B6 5mg无水咖啡碱 50mg
将上述组分进一步与适当量的柠檬酸钠、苹果酸、蔗糖、D-山梨糖醇、苯甲酸、聚氧乙烯氢化蓖麻油和蒸馏水混合得50ml液体制剂。
实施例2配方虫草 150mg(按整体天然药材计)巴西榥榥木 350mg(按整体天然药材计)蝮蛇 300mg(按整体天然药材计)牛磺酸 500mg人参 600mg(按整体天然药材计)黄芪根 300mg(按整体天然药材计)黄精根 300mg(按整体天然药材计)甘草 150mg(按整体天然药材计)Poria sclerotium 300mg(按整体天然药材计)地黄根 200mg(按整体天然药材计)刺老牙根 200mg(按整体天然药材计)Lvcii果 200mg(按整体天然药材计)肉桂皮 150mg(按整体天然药材计)鹿茸角 300mg(按整体天然药材计)Barren-worts 1000mg(按整体天然药材计)维生素B2 5mg维生素B6 5mg无水咖啡碱 50mg
将上述组分进一步与适当量的柠檬酸、柠檬酸钠、蔗糖、D-山梨糖醇溶液、苯甲酸、聚氧乙烯氢化蓖麻油和蒸馏水混合得50ml液体制剂。
实施例3配方虫草 300mg(按整体天然药材计)巴西榥榥木 300mg(按整体天然药材计)蝮蛇 250mg(按整体天然药材计)牛磺酸 500mg人参 600mg(按整体天然药材计)黄芪根 300mg(按整体天然药材计)甘草根 100mg(按整体天然药材计)Poria sclerotium 250mg(按整体天然药材计)地黄根 300mg(按整体天然药材计)刺老牙根 300mg(按整体天然药材计)肉苁蓉触角茎 300mg(按整体天然药材计)杜仲橡胶 300mg(按整体天然药材计)五味子果 200mg(按整体天然药材计)肉桂皮 200mg(按整体天然药材计)鹿茸角 300mg(按整体天然药材计)Barren-worts 1000mg(按整体天然药材计)维生素B2 5mg维生素B6 5mg无水咖啡碱 50mg
将上述组分进一步与适当量的柠檬酸、柠檬酸钠、蔗糖、D-山梨糖醇溶液、苯甲酸、聚氧乙烯氢化油和蒸馏水混合得50ml液体制剂。
实施例4配方虫草 330mg(按整体天然药材计)巴西榥榥木 450mg(按整体天然药材计)蝮蛇 400mg(按整体天然药材计)牛磺酸 500mg人参 600mg(按整体天然药材计)黄芪根 300mg(按整体天然药材计)甘草根 100mg(按整体天然药材计)Poria sclerotium 250mg(按整体天然药材计)地黄根 300mg(按整体天然药材计)刺老牙根 300mg(按整体天然药材计)肉苁蓉触角茎 300mg(按整体天然药材计)杜仲橡胶 300mg(按整体天然药材计)五味子果 200mg(按整体天然药材计)肉桂皮 200mg(按整体天然药材计)鹿茸角 300mg(按整体天然药材计)Barren-worts 1000mg(按整体天然药材计)维生素B2 5mg维生素B6 5mg无水咖啡碱 50mg
将上述组分进一步与适当量的柠檬酸钠、苹果酸、蔗糖、D-山梨糖醇溶液、苯甲酸、聚氧乙烯氢化油和蒸馏水混合得50ml液体制剂。
实施例5配方虫草 100mg(按整体天然药材计)巴西榥榥木 300mg(按整体天然药材计)地黄根 1500mg(按整体天然药材计)Barren-worts 500mg(按整体天然药材计)Eleutherococc 750mg(按整体天然药材计)黄精根 750mg(按整体天然药材计)鹿茸角 250mg(按整体天然药材计)人参 3000mg(按整体天然药材计)沿阶草块茎 1200mg(按整体天然药材计)五叶子果 500mg(按整体天然药材计)Polygoni multiflori root 750mg(按整体天然药材计)肉桂皮 500mg(按整体天然药材计)
将上述组分与适当量的甘露糖醇、羟丙基纤维素、硅铝酸镁、aspartame和调味剂均匀地混合再制成3包粒状物。
实施例6配方虫草 300mg(按整体天然药材计)巴西榥榥木 300mg(按整体天然药材计)地黄根 1000mg(按整体天然药材计)黄精根 500mg(按整体天然药材计)鹿茸角 250mg(按整体天然药材计)人参 2000mg(按整体天然药材计)维生素B2 10mg维生素B6 5mg
将上述组分与适当量的硅铝酸镁、聚溶剂化物60和丙二醇均匀地混合,将所得混合物均匀地填入软胶囊而得9颗胶囊。
实施例7配方虫草 100mg(按整体天然药材计)巴西榥榥木 200mg(按整体天然药材计)Barren-worts 500mg(按整体天然药材计)鹿茸角 200mg(按整体天然药材计)人参 600mg(按整体天然药材计)Polygoni multiflori root 300mg(按整体天然药材计)牛胆汁 650mg(按整体天然药材计)L-精氨酸盐酸化物 100mgdl-肉碱氯化物 50mg维生素A 2000 I.U.维生素B1 20mg维生素B2 15mg生素B6 5mg维生素B12 10μg烟酰胺 20mg泛酸钙 30mg维生素C 50mg维生素E 5mg
将上述组分与适当量的碳酸氢钠、聚乙烯基吡咯烷酮、轻质无水硅酸、硬脂酸镁、聚乙二醇、聚溶剂化物80和调味剂均匀地混合而制成单独的9片。
测试实施例1
下列组各包括7只平均体重为200g的雄性SD大鼠,使它们口服预定等体积的如下液体制剂后迫使它们游水以测定持续游水时间。
A组:服用本液体制剂(虫草:0.2w/v%+巴西榥榥木:0.6w/v%,以整体天然药材计)
B组:服用虫草单一液体制剂(0.8w/v%,以整体天然药材计)
C组:服用巴西榥榥木单一液体制剂(0.8w/v%,以整体天然药材计)
D组:对照组(只服用纯化的水)
A、B、C和D组持续游水时间的结果示于图1。
从图1明显地看出,服用本液体制剂的A组游水时间远远长于服用单一液体制剂的B组和C组。
测试实施例2
将平均体重为200g的雄性SD大鼠分成如下各包括5只大鼠的训练组和各包括7只大鼠的未训练组。对训练组进行被迫游水测试,方法是迫使它们每天游水30分钟总计10天,同时对每只大鼠施加其体重的约5wt%~约10wt%的负荷,从迫使负荷游水的第1天至第10天用下列液体制剂进行两瓶选择性试验以测定它们的总摄取量。对未训练组也用如上方法测试,但未迫使它们负荷游水。
A组:摄取本液体制剂(虫草:0.2w/v%+巴西榥榥木:0.6w/v%,以整体天然药材计)
B组:摄取虫草单一液体制剂(0.8w/v%,以原始的天然药材计)
C组:摄取巴西榥榥木单一液体制剂(0.8w/v%,以整体天然药材计)
D组:对照组(摄取纯化的水)
比较了训练组和未训练组的总摄取量,结果示于图2。
从图2明显看出,与训练组摄取单一液体制剂B和C的总量相比,训练组摄取本液体制剂A的总量急剧增大。
Claims (1)
1.一种用于解除体力和精神上的疲劳以及转佳弱化的体质的组合物,其特征在于,它由下列原料制成:
虫草100-330mg;和
巴西榥榥木200-450mg。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP340680/95 | 1995-12-27 | ||
JP34068095 | 1995-12-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1206349A CN1206349A (zh) | 1999-01-27 |
CN1081924C true CN1081924C (zh) | 2002-04-03 |
Family
ID=18339289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96199360A Expired - Fee Related CN1081924C (zh) | 1995-12-27 | 1996-12-20 | 包括虫草和巴西榥榥木的药物组合物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6024984A (zh) |
EP (1) | EP0869806B1 (zh) |
KR (1) | KR19990076828A (zh) |
CN (1) | CN1081924C (zh) |
AT (1) | ATE207756T1 (zh) |
AU (1) | AU706059B2 (zh) |
CA (1) | CA2240257A1 (zh) |
DE (1) | DE69616591T2 (zh) |
TW (1) | TW504385B (zh) |
WO (1) | WO1997024134A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002308649A1 (en) * | 2001-05-04 | 2002-11-18 | Theralife, Inc. | Compositions and methods for enhancing drug delivery |
DE10214168A1 (de) * | 2002-03-27 | 2003-10-09 | Siegfried Irion | Coffeinhaltiges Getränkeerzeugnis |
US7790176B2 (en) * | 2007-06-01 | 2010-09-07 | Botanica Bioscience Corporation | Formula for improving physical performance and related methods |
US20090263514A1 (en) * | 2008-04-21 | 2009-10-22 | Govindan Gopinathan | Cold and flu tonic |
US20110229553A1 (en) * | 2010-01-22 | 2011-09-22 | Elaine Elisabetsky | Plant Extract with Pharmacological Profile for Treating or Preventing Diseases, Dysfunctions and Disorders of the Central Nervous System, Neurodegenerative Disorders and Sequel from Vascular Dementia |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1098264A (zh) * | 1994-10-17 | 1995-02-08 | 凌青 | 一种养生液 |
CN1099992A (zh) * | 1994-06-24 | 1995-03-15 | 爱新觉罗松石 | 养生茶 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4584293A (en) * | 1992-07-20 | 1994-02-14 | Taisho Pharmaceutical Co., Ltd. | Tonic |
WO1996016956A1 (fr) * | 1994-12-02 | 1996-06-06 | Kao Corporation | Derives de flavanonol et composition contenant ces derives propre a nourrir les cheveux et a stimuler leur croissance |
-
1996
- 1996-12-20 CN CN96199360A patent/CN1081924C/zh not_active Expired - Fee Related
- 1996-12-20 EP EP96942599A patent/EP0869806B1/en not_active Expired - Lifetime
- 1996-12-20 US US09/077,869 patent/US6024984A/en not_active Expired - Fee Related
- 1996-12-20 AT AT96942599T patent/ATE207756T1/de not_active IP Right Cessation
- 1996-12-20 KR KR1019980704954A patent/KR19990076828A/ko not_active Application Discontinuation
- 1996-12-20 TW TW085115773A patent/TW504385B/zh active
- 1996-12-20 AU AU11722/97A patent/AU706059B2/en not_active Ceased
- 1996-12-20 CA CA002240257A patent/CA2240257A1/en not_active Abandoned
- 1996-12-20 WO PCT/JP1996/003733 patent/WO1997024134A1/en not_active Application Discontinuation
- 1996-12-20 DE DE69616591T patent/DE69616591T2/de not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1099992A (zh) * | 1994-06-24 | 1995-03-15 | 爱新觉罗松石 | 养生茶 |
CN1098264A (zh) * | 1994-10-17 | 1995-02-08 | 凌青 | 一种养生液 |
Also Published As
Publication number | Publication date |
---|---|
US6024984A (en) | 2000-02-15 |
TW504385B (en) | 2002-10-01 |
EP0869806B1 (en) | 2001-10-31 |
DE69616591T2 (de) | 2002-09-05 |
AU706059B2 (en) | 1999-06-10 |
DE69616591D1 (de) | 2001-12-06 |
ATE207756T1 (de) | 2001-11-15 |
AU1172297A (en) | 1997-07-28 |
CN1206349A (zh) | 1999-01-27 |
CA2240257A1 (en) | 1997-07-10 |
WO1997024134A1 (en) | 1997-07-10 |
EP0869806A1 (en) | 1998-10-14 |
KR19990076828A (ko) | 1999-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104623201B (zh) | 一种保肝排毒降脂降糖药物及其应用 | |
CN1853682A (zh) | 用于改善睡眠持续时间和质量的基于植物的食品强化剂 | |
CN101062289A (zh) | 治疗痛风的外用药物组合物 | |
CN106362020B (zh) | 一种具有改善通便作用的松花粉组合物及其制备方法 | |
CN1081924C (zh) | 包括虫草和巴西榥榥木的药物组合物 | |
CN1055638C (zh) | 富硒虫草口服液及其制备方法 | |
CN1038585A (zh) | 牛黄清心液及其制作方法 | |
US20050142235A1 (en) | Composition comprising an aqueous extract of red vine leaves and an antithrombotic agent | |
CN1857449A (zh) | 一种治疗产后缺乳的中药制剂 | |
CN1466976A (zh) | 防治佝偻病和骨质疏松症的药物及其制备方法 | |
CN1799582A (zh) | 降血糖、降血压的药物 | |
CN1232279C (zh) | 一种降血脂的中药 | |
CN106539892B (zh) | 一种猫爪草中药组合物及其制备方法和应用 | |
CN1692938A (zh) | 一种用于明目的中药复方制剂及其制备方法 | |
CN100340266C (zh) | 一种降脂益肝的胶囊及其制备方法 | |
CN101249207A (zh) | 一种治疗冠心病的药物配方 | |
CN1199683C (zh) | 一种降血脂和延缓衰老药物组合物及药物 | |
CN1237998C (zh) | 治疗小儿咳喘的泡腾片 | |
CN1195537C (zh) | 一种治疗高血压的外用中药及其制备工艺 | |
CN1559523A (zh) | 脑得生软胶囊及其制备方法 | |
CN112057535B (zh) | 一种预防或/和治疗血脂异常的中药组合物的制备方法 | |
CN1126558C (zh) | 一种***所致肾脏损害的药物 | |
CN1279961C (zh) | 一种止咳祛痰中成药制剂及其制备方法 | |
CN1772172A (zh) | 一种治疗妇科疾病、皮肤病的药制龟苓制剂及其生产方法 | |
CN1429587A (zh) | 一种具有护心益脑作用的银杏叶复方制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1016905 Country of ref document: HK |