CN107802385A - A kind of titanium alloy intravascular stent - Google Patents
A kind of titanium alloy intravascular stent Download PDFInfo
- Publication number
- CN107802385A CN107802385A CN201711222454.3A CN201711222454A CN107802385A CN 107802385 A CN107802385 A CN 107802385A CN 201711222454 A CN201711222454 A CN 201711222454A CN 107802385 A CN107802385 A CN 107802385A
- Authority
- CN
- China
- Prior art keywords
- tube wall
- titanium alloy
- intravascular stent
- rack body
- hollow tubular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910001069 Ti alloy Inorganic materials 0.000 title claims abstract description 48
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 10
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 10
- 239000010936 titanium Substances 0.000 claims description 10
- 229910052719 titanium Inorganic materials 0.000 claims description 10
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- 229910052750 molybdenum Inorganic materials 0.000 claims description 6
- 239000011733 molybdenum Substances 0.000 claims description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 5
- 229910052758 niobium Inorganic materials 0.000 claims description 5
- 239000010955 niobium Substances 0.000 claims description 5
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 5
- 229910052763 palladium Inorganic materials 0.000 claims description 5
- 229910052726 zirconium Inorganic materials 0.000 claims description 5
- 229910052786 argon Inorganic materials 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000005245 sintering Methods 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 238000005275 alloying Methods 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 238000000498 ball milling Methods 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000004663 powder metallurgy Methods 0.000 claims description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 17
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract description 16
- 229910052759 nickel Inorganic materials 0.000 abstract description 8
- 238000006073 displacement reaction Methods 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 5
- 206010067484 Adverse reaction Diseases 0.000 abstract description 4
- 230000006838 adverse reaction Effects 0.000 abstract description 4
- 229910001220 stainless steel Inorganic materials 0.000 abstract description 3
- 239000010935 stainless steel Substances 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 11
- 239000000956 alloy Substances 0.000 description 7
- 229910045601 alloy Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000030961 allergic reaction Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000009172 bursting Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- IUYOGGFTLHZHEG-UHFFFAOYSA-N copper titanium Chemical compound [Ti].[Cu] IUYOGGFTLHZHEG-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/10—Sintering only
- B22F3/105—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/04—Making non-ferrous alloys by powder metallurgy
- C22C1/045—Alloys based on refractory metals
- C22C1/0458—Alloys based on titanium, zirconium or hafnium
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C14/00—Alloys based on titanium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/10—Sintering only
- B22F3/105—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding
- B22F2003/1054—Sintering only by using electric current other than for infrared radiant energy, laser radiation or plasma ; by ultrasonic bonding by microwave
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy
- B22F2998/10—Processes characterised by the sequence of their steps
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Metallurgy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Manufacturing & Machinery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of titanium alloy intravascular stent, it is related to medical instruments field.The titanium alloy intravascular stent of the present invention, it includes rack body, and the rack body is made up of titanium alloy;The rack body is in hollow tubular structure, tube wall reticulates structure, tube wall is divided into symmetrical upper tube wall and lower tube wall by the plane where the axis of hollow tubular structure, projection is respectively arranged with the upper tube wall and the lower tube wall, the line of the raised geometric center of the raised and lower tube wall of adjacent upper tube wall is not orthogonal to the axis of hollow tubular structure.The titanium alloy intravascular stent of the present invention prevents the relative displacement between support and blood vessel on the one hand by setting anti-skid bulge;On the other hand, the material of rack body is improved, replaces containing nickel and stainless steel using titanium alloy, avoids nickel to adverse reaction caused by human body, it is common to improve clinical practice security.
Description
Technical field
The present invention relates to medical instruments field, especially a kind of titanium alloy intravascular stent.
Background technology
Puncture shaping surgery, abbreviation PTA arts, it is under the guiding of medical imaging device, utilizes puncture needle, seal wire
The foley's tube for the support for being cased with tightening is injected human vas with guide sheath, and is transported at hemadostewnosis, with the expansion of sacculus
, support is also softened, and after sacculus contraction is withdrawn, the metallic support for producing plastic deformation then stays in original place, and embedded in blood vessel,
Play a part of expanding blood vessel.This method is widely used in treating angiocardiopathy at present.
The intravascular stent form of prior art have it is a variety of, most commonly rest body using shape-memory alloy wire weave
Form or be welded after being cut using marmem thin plate, through axial tension, make its axial elongation, radially shorten.
Its purpose is all the functions such as the radial support intensity of support to be improved and axially soft property.Its major defect is, on the one hand, branch
Frame is integrally in the flat segments of cylinder, and after implantable intravascular, with angiogenesis relative displacement, potential prestige is easily caused to patient for support
The side of body.On the other hand, the main material of intravascular stent is the medical embedded stainless steels of 316L at present, although its function admirable, contains
The mass percent of nickel element be 13-15%, allergic reaction is produced to human body, contact dermatitis occurs, teratogenesis, carcinogenic be present
Harmfulness.German scholar thinks:" it is probably to trigger in-stent restenosis mechanism to discharging nickel and molybdenum allergic reaction on support
One of ".Therefore further improving the structure and material of intravascular stent turns into the main development and application trend of intravascular stent.
The content of the invention
The goal of the invention of the present invention is:For above-mentioned problem, there is provided a kind of titanium alloy intravascular stent, the blood vessel
Support prevents the relative displacement between support and blood vessel on the one hand by setting anti-skid bulge;On the other hand, rack body is improved
Material, replace contain nickel and stainless steel using titanium alloy, avoid nickel to adverse reaction caused by human body, it is common to improve clinical practice and pacify
Quan Xing.
The technical solution adopted by the present invention is as follows:
A kind of titanium alloy intravascular stent, it includes rack body, and the rack body is made up of titanium alloy;The rack body is in
Hollow tubular structure, tube wall reticulate structure, and tube wall is divided on symmetrical by the plane where the axis of hollow tubular structure
Projection, the raised and lower tube wall of adjacent upper tube wall are respectively arranged with tube wall and lower tube wall, the upper tube wall and the lower tube wall
The line of raised geometric center is not orthogonal to the axis of hollow tubular structure.
By adopting the above-described technical solution, by adopting the above-described technical solution, the upper tube wall and down tube of rack body
Wall is provided with projection, projection extruding blood vessel, increases the frictional force between blood vessel and rack body, prevents support sheet
Relative displacement occurs between body and blood vessel.Because the line for the geometric center that adjacent upper tube wall is raised and lower tube wall is raised does not hang down
Directly in the axis of hollow tubular structure, same section of blood vessel is solely subjected to that upper tube wall is raised or lower tube wall projection one of which is squeezed
Pressure, i.e. one-sided compression, can effectively reduce the probability that blood vessel is bursting at the collision, improve the security of Clinical practice.In addition, rack body
It is made of titanium alloy material, avoids causing adverse reaction to human body using nickel-containing material, further improves clinical practice safety
Property.
The company of the geometric center of a kind of titanium alloy intravascular stent of the present invention, adjacent upper tube wall projection and lower tube wall projection
Angle between line and the axis of hollow tubular structure is in 30 ° -75 ° or 105 ° -150 °.
By adopting the above-described technical solution, by adopting the above-described technical solution, upper tube wall is raised raised with lower tube wall
Asymmetry is set, and distance is suitable between the raised and lower tube wall projection of adjacent upper tube wall, ensures its skidproof effect.
A kind of titanium alloy intravascular stent of the present invention, the projection are in arc-shaped, and the central angle of circular arc is 135 ° -180 °.
By adopting the above-described technical solution, arc-shaped projection avoids contacting the wind that blood vessel is broken up in increase with vascularization point
Danger.Central angle is too small, and raised squeezing action is too small, and skidproof effect is weak;Central angle is excessive, and it is difficult to paste completely with blood vessel
Close, it is also difficult to reach satisfied skidproof effect, or even play reverse effect.
A kind of titanium alloy intravascular stent of the present invention, the diameter at the rack body both ends are less than the diameter of middle part.
By adopting the above-described technical solution, middle part diameter is slightly larger, have using therapeutic purposes are reached, both ends diameter is slightly
It is small, there is the injury for using transition bonding is formed between support and blood vessel, preventing edge to blood vessel.
A kind of titanium alloy intravascular stent of the present invention, the titanium alloy include niobium 14.3% by weight percentage, zirconium
5.2%, molybdenum 4.7%, copper 2.4%, palladium 0.18%, surplus is titanium and inevitable impurity, wherein oxygen≤0.1%, carbon≤0.04%, nitrogen
≤ 0.03, hydrogen≤0.002%.
A kind of titanium alloy intravascular stent of the present invention, the titanium alloy are prepared with the following method:By titanium valve and
Alloying element powder dispensing in proportion, ball milling mixing is carried out by powder metallurgy blank-making technology, is mechanically pressed into base, then puts blank
Microwave agglomerating furnace is put into heat-preserving container, vacuum keeps vacuum to be less than 0.1Pa in furnace chamber, and it is 99.999% to be filled with purity
Argon gas forms recycling-guard, is heated to 900 DEG C of sintering temperature with 22 DEG C/min heating rate, is incubated 15min, closes microwave
Source, furnace cooling produce.
It is anticorrosive, intensity is high, extensibility is strong, its alloy material by adopting the above-described technical solution, titanium nature is excellent
Expect that niobium, zirconium, molybdenum, palladium, the biocompatibility of copper are excellent.Wherein, niobium, zirconium, molybdenum are beneficial to alloy strengthening, drop low-alloyed springform
Amount, improves its plasticity;Palladium is cathode active metallic element, has excellent corrosion resistance, improves alloy in physiological saline
Stability;Copper forms titanium copper under heat treatment condition with titanium, and mutually even dispersion separates out from titanium alloy.Titanium copper is mainly mutually
CuTi2, when in the environment or liquid that titanium alloy is in moist, Cu2+From titanium alloy surface dissolution so as to playing antibacterium sense
Function is contaminated, if copper content is relatively too high, can cause to separate out titanium copper phase too much in titanium alloy, titanium can be seriously affected
The mechanical property and process industrial art performance of alloy.
A kind of titanium alloy intravascular stent of the present invention, the length of the rack body is 0.5-20cm.
A kind of titanium alloy intravascular stent of the present invention, a diameter of 1.0-8.0mm of the rack body.
By adopting the above-described technical solution, by adopting the above-described technical solution, in Clinical practice, can be according to trouble
The difference of person or the different sizes to intravascular stent of disease location select.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows:
Titanium alloy intravascular stent provided by the invention, on the one hand set on the relative upper tube wall with contacts blood and lower tube wall
Have projection, this project through extruding vascular wall to increase the frictional force between intravascular stent and vascular wall, so as to prevent support with
Relative displacement between blood vessel;It is asymmetric between the raised and lower tube wall projection of adjacent upper tube wall to set, ensure same section of blood vessel
It is solely subjected to that upper tube wall is raised or the extruding of lower tube wall projection one of which, i.e. one-sided compression, can effectively reduces blood vessel and be bursting at the collision
Probability, improve the security of Clinical practice.On the other hand, rack body is made up of titanium alloy material, and the titanium alloy not only has
There is good biocompatibility, be avoided that nickel adverse reaction to caused by human body, and property is stable in body fluid, has anti-thin
The function of bacterium infection, improves Clinical practicability.
Brief description of the drawings
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein:
The planar structure schematic diagram of Fig. 1 titanium alloy intravascular stents provided by the invention;
The dimensional structure diagram of Fig. 2 titanium alloy intravascular stents provided by the invention.
In figure, 1 is rack body, and 12 be upper tube wall, and 13 be lower tube wall, and 21 be raised, and 22 be raised.
Embodiment
All features disclosed in this specification, or disclosed all methods or during the step of, except mutually exclusive
Feature and/or step beyond, can combine in any way.
This specification(Including any accessory claim, summary)Disclosed in any feature, unless specifically stated otherwise,
Replaced by other equivalent or with similar purpose alternative features.I.e., unless specifically stated otherwise, each feature is a series of
An example in equivalent or similar characteristics.
Embodiment 1
The present embodiment provides a kind of titanium alloy film-coated vascular support, and it includes rack body 1, and rack body 1 is in hollow tubular knot
Structure, tube wall is into hollow mesh structure.Rack body 1 in the present embodiment is made of titanium alloy.The diameter of rack body 1 is in
Between be gradually reduced to both ends, the 75%-80% of a diameter of middle part diameter in both ends.Anti-skidding intravascular stent provided by the invention, branch
The length of frame body 1 is 0.5-20cm, a diameter of 1.0-8.0cm of rack body 1.
Rack body 1 is divided into symmetrical upper tube wall 12 and lower tube wall by the plane where the axis of hollow tubular structure
13, projection 21 is provided with upper tube wall 12, projection 22, adjacent projection 21 of any two and raised 22 are provided with lower tube wall 13
The line of geometric center be not orthogonal to the axis of hollow tubular structure, the i.e. adjacent projection 21 of any two and projection 22 not
It is symmetrical arranged.Preferably, the line of geometric center and the axis of hollow tubular structure of two adjacent projections 21 and projection 22
Angle between line is in 30 ° -75 ° or 105 ° -150 °.Projection 21 and projection 22 are in arc-shaped, it is preferable that the central angle of circular arc
For 135 ° -180 °.
Embodiment 2
The present embodiment provides a kind of titanium alloy material, and the titanium alloy stability is high, and biocompatibility is good, can also be sent out in body
Wave anti-infective function.The titanium alloy includes the niobium 14.3% being calculated in mass percent, zirconium 5.2%, molybdenum 4.7%, copper 2.4%, palladium
0.18%, surplus is titanium and inevitable impurity, wherein oxygen≤0.1%, carbon≤0.04%, nitrogen≤0.03, hydrogen≤0.002%.
The titanium alloy is prepared via a method which to form:
Titanium valve and each alloying element powder are weighed by above-mentioned raw materials and mass ratio, according to powder metallurgy base of the prior art
Technique carries out ball milling mixing, is mechanically pressed into base.Blank is placed in heat-preserving container, and heat-preserving container then is put into microwave agglomerating furnace.It is micro-
The furnace chamber of ripple sintering furnace is evacuated to vacuum and is less than 0.1Pa, is filled with the argon gas that purity is 99.999% and forms recycling-guard.
Under conditions of argon gas protection, 900 DEG C of sintering temperature is heated to 22 DEG C/min heating rate, is then incubated at 900 DEG C
15min, closes microwave source, and furnace cooling produces.
The invention is not limited in foregoing embodiment.The present invention, which expands to, any in this manual to be disclosed
New feature or any new combination, and disclose any new method or process the step of or any new combination.
Claims (8)
1. a kind of titanium alloy intravascular stent, it is characterised in that it includes rack body, and the rack body is made up of titanium alloy;
The rack body is in hollow tubular structure, and tube wall reticulates structure, and tube wall is by flat where the axis of hollow tubular structure
Face is divided into symmetrical upper tube wall and lower tube wall, and projection, adjacent upper tube are respectively arranged with the upper tube wall and the lower tube wall
The line of the raised geometric center of the raised and lower tube wall of wall is not orthogonal to the axis of hollow tubular structure.
2. titanium alloy intravascular stent according to claim 1, it is characterised in that adjacent upper tube wall projection and lower tube wall are dashed forward
Angle between the line of geometric center risen and the axis of hollow tubular structure is in 30 ° -75 ° or 105 ° -150 °.
3. titanium alloy intravascular stent according to claim 2, it is characterised in that the projection is in arc-shaped, the circle of circular arc
Heart angle is 135 ° -180 °.
4. titanium alloy intravascular stent according to claim 3, it is characterised in that the diameter at the rack body both ends is less than
The diameter of middle part.
5. titanium alloy intravascular stent according to claim 4, it is characterised in that the titanium alloy is included with percentage by weight
The niobium 14.3% of meter, zirconium 5.2%, molybdenum 4.7%, copper 2.4%, palladium 0.18%, surplus are titanium and inevitable impurity, wherein oxygen≤
0.1%, carbon≤0.04%, nitrogen≤0.03, hydrogen≤0.002%.
6. titanium alloy intravascular stent according to claim 5, it is characterised in that the titanium alloy is prepared with the following method
Form:By titanium valve and alloying element powder dispensing in proportion, ball milling mixing is carried out by powder metallurgy blank-making technology, is mechanically pressed into
Base, then blank is placed in heat-preserving container and is put into microwave agglomerating furnace, vacuum keeps vacuum to be less than 0.1Pa in furnace chamber, is filled with
The argon gas that purity is 99.999% forms recycling-guard, and 900 DEG C of sintering temperature is heated to 22 DEG C/min heating rate, is incubated
15min, closes microwave source, and furnace cooling produces.
7. the titanium alloy intravascular stent according to any one of claim 1-6, it is characterised in that the length of the rack body
Spend for 0.5-20cm.
8. titanium alloy intravascular stent according to claim 7, it is characterised in that a diameter of 1.0- of the rack body
8.0mm。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711222454.3A CN107802385A (en) | 2017-11-29 | 2017-11-29 | A kind of titanium alloy intravascular stent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711222454.3A CN107802385A (en) | 2017-11-29 | 2017-11-29 | A kind of titanium alloy intravascular stent |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107802385A true CN107802385A (en) | 2018-03-16 |
Family
ID=61582077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711222454.3A Withdrawn CN107802385A (en) | 2017-11-29 | 2017-11-29 | A kind of titanium alloy intravascular stent |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107802385A (en) |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5626602A (en) * | 1992-10-12 | 1997-05-06 | Schneider (Europe) A.G. | Catheter with a vascular support |
US20040167605A1 (en) * | 2003-02-26 | 2004-08-26 | Elliott Christopher J. | Endoluminal device having enhanced affixation characteristics |
CN1741772A (en) * | 2002-11-25 | 2006-03-01 | 先进生物假体表面有限公司 | Implantable expandable medical devices having regions of differential mechanical properties and methods of making same |
CN101014300A (en) * | 2004-07-29 | 2007-08-08 | 先进生物假体表面有限公司 | Metallic drug-releasing medical devices and method of making same |
CN101141935A (en) * | 2004-09-09 | 2008-03-12 | 先进生物假体表面有限公司 | Support with metallic covers |
US20090118811A1 (en) * | 2007-11-05 | 2009-05-07 | Medtronic Vascular, Inc. | Globe Stent |
CN101496754A (en) * | 2008-01-29 | 2009-08-05 | 太雄医疗器株式会社 | Biodegradable double stent |
CN201977965U (en) * | 2011-03-10 | 2011-09-21 | 南京医科大学第二附属医院 | Lacrimal canaliculi stent |
CN102534284A (en) * | 2011-12-12 | 2012-07-04 | 南昌航空大学 | Method for preparing medical porous NiTi shape memory alloy by microwave sintering |
CN102747245A (en) * | 2012-07-06 | 2012-10-24 | 淮阴工学院 | Preparation method of medical porous titanium and titanium alloy |
CN102936670A (en) * | 2011-08-15 | 2013-02-20 | 中国科学院金属研究所 | Anti-infective medical titanium alloy |
CN103547222A (en) * | 2011-05-11 | 2014-01-29 | 柯惠有限合伙公司 | Vascular remodeling device |
CN103582466A (en) * | 2011-05-03 | 2014-02-12 | 帕尔玛兹科学公司 | Endoluminal implantable surfaces and method of making the same |
CN204318981U (en) * | 2014-12-12 | 2015-05-13 | 刘新锋 | A kind of intravascular stent |
CN105640679A (en) * | 2014-11-27 | 2016-06-08 | 首都医科大学附属北京友谊医院 | Customized alimentary canal support and moulding method and application method thereof |
-
2017
- 2017-11-29 CN CN201711222454.3A patent/CN107802385A/en not_active Withdrawn
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5626602A (en) * | 1992-10-12 | 1997-05-06 | Schneider (Europe) A.G. | Catheter with a vascular support |
CN1741772A (en) * | 2002-11-25 | 2006-03-01 | 先进生物假体表面有限公司 | Implantable expandable medical devices having regions of differential mechanical properties and methods of making same |
US20040167605A1 (en) * | 2003-02-26 | 2004-08-26 | Elliott Christopher J. | Endoluminal device having enhanced affixation characteristics |
CN101014300A (en) * | 2004-07-29 | 2007-08-08 | 先进生物假体表面有限公司 | Metallic drug-releasing medical devices and method of making same |
CN101141935A (en) * | 2004-09-09 | 2008-03-12 | 先进生物假体表面有限公司 | Support with metallic covers |
US20090118811A1 (en) * | 2007-11-05 | 2009-05-07 | Medtronic Vascular, Inc. | Globe Stent |
CN101496754A (en) * | 2008-01-29 | 2009-08-05 | 太雄医疗器株式会社 | Biodegradable double stent |
CN201977965U (en) * | 2011-03-10 | 2011-09-21 | 南京医科大学第二附属医院 | Lacrimal canaliculi stent |
CN103582466A (en) * | 2011-05-03 | 2014-02-12 | 帕尔玛兹科学公司 | Endoluminal implantable surfaces and method of making the same |
CN103547222A (en) * | 2011-05-11 | 2014-01-29 | 柯惠有限合伙公司 | Vascular remodeling device |
CN102936670A (en) * | 2011-08-15 | 2013-02-20 | 中国科学院金属研究所 | Anti-infective medical titanium alloy |
CN102534284A (en) * | 2011-12-12 | 2012-07-04 | 南昌航空大学 | Method for preparing medical porous NiTi shape memory alloy by microwave sintering |
CN102747245A (en) * | 2012-07-06 | 2012-10-24 | 淮阴工学院 | Preparation method of medical porous titanium and titanium alloy |
CN105640679A (en) * | 2014-11-27 | 2016-06-08 | 首都医科大学附属北京友谊医院 | Customized alimentary canal support and moulding method and application method thereof |
CN204318981U (en) * | 2014-12-12 | 2015-05-13 | 刘新锋 | A kind of intravascular stent |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2375961T3 (en) | ENDOLUMINAL NULL WITH EXPANDABLE BALL AND METHODS TO DO THE SAME. | |
JP5990823B2 (en) | Degradable medical device | |
CN101385669B (en) | Anti-coagulation stainless steel coronary arterial bracket and uses thereof | |
JP5959854B2 (en) | Drug-bearing grooved coronary stent | |
CN104739478B (en) | Spring coil and production method thereof | |
CN204951247U (en) | Biodegradable metal blood vessel support | |
CN104587532A (en) | Corrosion-resistant high-toughness zinc-magnesium alloy implanting material capable of being absorbed by human body | |
WO2017012386A1 (en) | Biodegradable metal vascular scaffold and use thereof | |
US9427500B2 (en) | Stent made of a cobalt alloy | |
CN110123502A (en) | Blood vessel distensible devices | |
CN114159197B (en) | Degradable biomedical magnesium alloy drug-eluting intravascular stent and preparation method thereof | |
CN105147424A (en) | Novel vascular stent | |
JP2010532222A (en) | Molybdenum prosthesis | |
US20130338756A1 (en) | Stent composed of an iron alloy | |
CN105411643B (en) | Degradable medical spring ring | |
CN107802377A (en) | A kind of titanium alloy film-coated vascular support | |
CN215083995U (en) | Delivery guidewire | |
CN107802385A (en) | A kind of titanium alloy intravascular stent | |
CN107744415A (en) | A kind of titanium alloy carries medicine intravascular stent | |
CN106880428B (en) | A kind of bioabsorbable stent system and method | |
CN107184296B (en) | Sacculus, bracket conveyer and stent delivery system | |
CN108113784A (en) | A kind of multi-layer backhand intravascular stent | |
CN107753149A (en) | A kind of intravascular stent with developing function | |
CN105407935A (en) | Hypotube with enhanced strength and ductility | |
TWI407942B (en) | Preventing vascular stenosis of cardiovascular stent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180316 |