CN107468793A - A kind of feed addictive of natural plant for preventing and treating diarrhea of weaned piglets and application - Google Patents
A kind of feed addictive of natural plant for preventing and treating diarrhea of weaned piglets and application Download PDFInfo
- Publication number
- CN107468793A CN107468793A CN201710593774.3A CN201710593774A CN107468793A CN 107468793 A CN107468793 A CN 107468793A CN 201710593774 A CN201710593774 A CN 201710593774A CN 107468793 A CN107468793 A CN 107468793A
- Authority
- CN
- China
- Prior art keywords
- feed addictive
- weaned piglets
- natural plant
- natural
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
Abstract
The present invention provides feed addictive and the application of a kind of Purely natural vegetality preventing and treating diarrhea of weaned piglets, and the percentage by weight of its raw material components is wrinkled giant hyssop 15 25%, the bark of official magnolia 10 15%, the bighead atractylodes rhizome 10 15%, dried orange peel 10 15%, balloonflower root 10 15%, radix glycyrrhizae 10 15%, purple perilla 5 10%, the root of Dahurain angelica 5 10%.Each composition is conventional plant in the natural plant feed addictive of the present invention, is a kind of green safe feed addictive.The dosage of each natural plants is to determine that compatibility of drugs is reasonable according to the relation between the property theory of natural plants and plant in the present invention.Gastrointestinal Tract of Weanling Piglets digestive function can be improved using additive of the present invention, reduces diarrhea of weaned piglets rate, improves weaned piglets.
Description
Technical field
The invention belongs to a kind of animal feed additive, particularly a kind of Purely natural vegetality preventing and treating diarrhea of weaned piglets
Feed addictive and application.
Background technology
Diarrhoea is most common problem after weaned piglet, have a strong impact on piglet grow and productivity effect.Diarrhoea
Reason is complicated.From the piglet own physiological stage of development, piglet stomach and intestine 26S Proteasome Structure and Function development imperfection is weakness of the spleen and the stomach, exempts from
Epidemic disease power difference is the main reason for causing diarrhoea.In nursing period, breast milk can provide higher lactose and immunoglobulin to piglet.
Lactose is main lactic origin, and lactic acid is the main matter for adjusting pH in suckling pig stomach.Although suckling pig is from status
The lactic acid deficiency secreted, but because of the still eupepsia of the supply by breast milk lactose.Maternal immunity globulin can help piglet to improve
Immunity of organisms.Therefore piglet seldom triggers diarrhoea under the protection of breast milk nutriment and antibody.But the piglet after weaning
This advantage is lost, wean reduces enteron aisle source of parents digestion enzyme level, causes nutriment in feed sufficiently to be utilized,
It is still relatively low plus hydrochloric acid in gastric juice amount, cause pH in stomach to become big, influence the activation of propepsin, pepsin is also just reduced therewith,
Digesting and assimilating for protein is also just affected in feed, exacerbates protein and is denatured in the enteron aisle second half section, and undigested
Feed just turns into good condition of the pathogens such as Escherichia coli in small intestine internal breeding, while hinders the growth of Bacillus acidi lactici, leads
The digestion power of weanling pig is caused to decline.Piglet loses maternal antibody simultaneously, in addition the developing immune system such as piglet spleen itself
Imperfection, therefore piglet is had a low resistance to pathogenic microorganism, immunity degradation.These cause the generation of diarrhea of weaned piglets.
In the case of piglet own digestive system and developing immune system are incomplete, composition transfer (is particularly in daily ration
High vegetable protein or fiber are higher fatty acid) and inoculating microbe invasion and attack (such as Escherichia coli and rotavirus), can lead
Each stage grice diarrhoea is caused to aggravate, the rise of the piglet death rate.Particularly in the winter time or cold time piglet taste as early spring
The cold of insufficiency type, individual is susceptible, and propagates rapid.
In actual production, addition antibiotic is the major way for the treatment of diarrhoea, but this kind of medicine is for cause of disease
Suffered from diarrhoea caused by microorganism more targetedly, and drawback caused by its long-term use has been to be concerned by more and more people, its
In the most serious is causing, bacterium produces drug resistance and the medicine that remains in animal food to jeopardize human health.Meanwhile should
External cause is emphasized often with antibiotic prophylaxis and treatment disease, does not focus on internal cause, thus is unfavorable for improving the disease-resistant energy of body itself
Power, effective medicine and means are also lacked to some chronic infectious diseases.
With the development of healthy aquaculture and green cultivation, the substitute such as functional plants feed of antibiotic is added
The research of agent, acidulant, enzyme preparation etc. is more and more deep.Experiment shows that these preparations have preferable effect.It is wherein natural to plant
The feed addictive that thing is formed with toxic side effect it is small, be not likely to produce drug resistance, aboundresources and get more and more people's extensive concerning.
Natural plant feed addictive is above conceived to entirety in application, emphasizes to adjust body function, so as to improve itself resistance against diseases.
Natural plant feed addictive is improving digestive system and function of immune system, strengthens body eupepsy and immunity, confrontation
Pathogenic microorganism, prevention disease, the tolerance improve breeding performonce fo animals, reduce stress reaction, increasing animal, improvement product product
Matter etc. has effect well.Natural plant feed addictive is production nuisance free feed, produces the weight of pollution-free food
Want one of link.
The content of the invention
The purpose of the present invention is intended to provide a kind of natural plant feed addictive for diarrhea of weaned piglets, significantly
Improve deficiency-cold in spleen and stomach, promote gastrointestinal motility, improve the immunity of body, prevent and treat diarrhea of weaned piglets, improve weanling pig
Production performance.
The feed addictive of Purely natural vegetality preventing and treating diarrhea of weaned piglets provided by the invention, the weight of its raw material components
Percentage is：Wrinkled giant hyssop 15-25%, bark of official magnolia 10-15%, bighead atractylodes rhizome 10-15%, dried orange peel 10-15%, balloonflower root 10-15%, radix glycyrrhizae 10-
15%th, purple perilla 5-10%, root of Dahurain angelica 5-10%.
Preparation method：Raw material is weighed in proportion, crushed, is sieved (100 mesh), mixing, powder is made, is dispensed after quality inspection.
The principle of the present invention：
The feed addictive of the present invention contains plurality of active ingredients, has pleiotropism.Volatile oil in wrinkled giant hyssop, which has, to be promoted
Gastric secretion and small bowel peristalsis, enhancing digestion, while have middle appetizing, dysentery-stopping efficacy；Estragole and anethole in ageratum,
Have the function that to suppress Escherichia coli, the antibacterial of shigella dysenteriae, anti-convulsion.The bark of official magnolia can with eliminating dampness, lower gas except turgor, consumer product dredge stasis,
Anti-gastric-ulcer；The bark of official magnolia and its volatile oil bitter can stimulate the sense of taste simultaneously, reflexive to cause saliva, gastric secretion, gastrointestinal peristalsis
Accelerate, there is stomach invigorating digestion-aid effect；Bark of official magnolia decoction has inhibitory action to staphylococcus, shigella dysenteriae, Escherichia coli etc..The bighead atractylodes rhizome has
There is drying damp and strengthening spleen, inducing diuresis to remove edema effect.The bighead atractylodes rhizome can effective anti-lipid peroxidation effect；The bighead atractylodes rhizome also has enhancing leukocytes phagocytic
The ability of staphylococcus aureus, strengthen the effect of immunity of organisms.Dried orange peel contains limonoid, helps to digest；It contains
Some volatile oil has gentle stimulation to intestines and stomach, can promote the secretion of digestive juice, excludes pneumatosis in intestinal tube, increases appetite；
Dried orange peel also has anti-inflammatory, antiulcer action.The saponin that balloonflower root contains has antiinflammatory action, it may have antiulcer action.Radix glycyrrhizae is beneficial
Gas bowl spares, tonifying spleen and stomach, clearing heat and detoxicating effect；Especially to weakness of the spleen and the stomach, the disease such as taste-blindness rate is effective in cure.Purple perilla
Complete stool has very high nutritive value, and it contains plain, high mineral element of high microsteping, Gao Huluo etc., has stomach-invigorating and summer-heat relieving function.It is purple
Flavonoid substances in Soviet Union can play the role of anti-aging to antioxidant radical and superoxide anion；Purple perilla has promotion intestines simultaneously
Wriggle, accelerate enteral prods motion.The root of Dahurain angelica has antibacterial action, there is certain inhibitory action to Escherichia coli, shigella dysenteriae etc.；Together
Shi Baizhi plays the role of antipyretic, anti-inflammatory, analgesia, spasmolysis, anticancer.
Wrinkled giant hyssop in the present invention is main ingredient, and it has fragrant stomach invigorating, qi-regulating and middle effect, has and whets the appetite and promotion disappears
The function of change.Purple perilla, the root of Dahurain angelica are adjuvant, can deliver solution sweat, and strengthen wrinkled giant hyssop qi-regulating cold dispelling effect.Help bark of official magnolia eliminating dampness；Dried orange peel row
Inverse, anti-vomiting drops in gas；Balloonflower root opens chest diaphragm；Radix glycyrrhizae, bighead atractylodes rhizome invigorating spleen to remove dampness, strengthen transportation capabilities.Each composition cooperates, finally
Adjust deficiency-cold in spleen and stomach, gastrointestinal dysfunction, so as to reach preventing and treating diarrhea of weaned piglets purpose.
Addition of the feed addictive of the present invention in weanling pig feed is 0.5g/kg~1g/kg feeds.Addition period
For in after wean 4 weeks.
Each composition is conventional plant in the natural plant feed addictive of the present invention, is a kind of green safe feed
Additive.The dosage of each natural plants is determined according to the relation between the property theory of natural plants and plant in the present invention
, compatibility of drugs is reasonable.Gastrointestinal Tract of Weanling Piglets digestive function can be improved using additive of the present invention, reduces diarrhea of weaned piglets
Rate, improve weaned piglets.
The present invention is further illustrated in embodiment below.
Embodiment
Embodiment 1：A kind of natural plant feed addictive of pure natural preventing and treating animal diarrhea.Its raw material components weight hundred
Point ratio is：Wrinkled giant hyssop 20%, the bark of official magnolia 15%, the bighead atractylodes rhizome 12%, dried orange peel 13%, balloonflower root 13%, radix glycyrrhizae 15%, purple perilla 6%, the root of Dahurain angelica 6%.
Preparation method：Raw material is weighed by weight proportion, then crushed, sieving (100 mesh), mixing, powder, quality inspection is made
After dispense.
Using：Addition of the feed addictive in weanling pig feed is 0.5g/kg~1g/kg feeds.
Storage practice：The feed addictive powder should be deposited at aeration-drying.
Embodiment 2：A kind of natural plant feed addictive of pure natural preventing and treating animal diarrhea.Its raw material components weight hundred
Point ratio is：Wrinkled giant hyssop 20%, the bark of official magnolia 13%, the bighead atractylodes rhizome 13%, dried orange peel 14%, balloonflower root 12%, radix glycyrrhizae 15%, purple perilla 7%, the root of Dahurain angelica 6%.
Preparation method：Raw material is weighed by weight proportion, then crushed, sieving (100 mesh), mixing, powder, quality inspection is made
After dispense.
Using：Addition of the feed addictive in weanling pig feed is 0.5g/kg~1g/kg feeds.
Storage practice：The feed addictive powder should be deposited at aeration-drying.
Embodiment 3：A kind of natural plant feed addictive of pure natural preventing and treating animal diarrhea.Its raw material components weight hundred
Point ratio is：Wrinkled giant hyssop 21%, the bark of official magnolia 14%, the bighead atractylodes rhizome 13%, dried orange peel 13%, balloonflower root 12%, radix glycyrrhizae 13%, purple perilla 7%, the root of Dahurain angelica 7%.
Preparation method：Raw material is weighed by weight proportion, then crushed, sieving (100 mesh), mixing, powder, quality inspection is made
After dispense.
Using：Addition of the feed addictive in weanling pig feed is 0.5g/kg~1g/kg feeds.
Storage practice：The feed addictive powder should be deposited at aeration-drying.
Embodiment 4：A kind of natural plant feed addictive of pure natural preventing and treating animal diarrhea.Its raw material components weight hundred
Point ratio is：Wrinkled giant hyssop 19%, the bark of official magnolia 14%, the bighead atractylodes rhizome 15%, dried orange peel 13%, balloonflower root 13%, radix glycyrrhizae 13%, purple perilla 6%, the root of Dahurain angelica 7%.
Preparation method：Raw material is weighed by weight proportion, then crushed, sieving (100 mesh), mixing, powder, quality inspection is made
After dispense.
Using：Addition of the feed addictive in weanling pig feed is 0.5g/kg~1g/kg feeds.
Storage practice：The feed addictive powder should be deposited at aeration-drying.
The present invention combines feeding experiment and biochemical indicator detects, and is applied to be further described：With growth of animal
Can, diarrhea rate, the index such as microorganism species, evaluates making for this natural plant feed addictive in Biochemical Indices In Serum and excrement
Use effect.
Test influence of the natural plant feed addictive to Production Performance of Weaning Pigs, Biochemical Indices In Serum
1 materials and methods
1.1 experimental animals and packet
Experiment choose Weaning Age is close, be in a good state of health, first body weight 7kg or so " Duroc × length is white × greatly
Three way cross weanling pig 60 is used as experimental animal in vain ".Weanling pig is randomly divided into 3 groups, every group of 4 repetitions.1st group is
Basal diet group, the 2nd, the 3rd group of plant feed addictive for adding 0.5mg/kg, 1mg/kg in basal diet respectively (are planted
Physical property feed addictive prescription is embodiment 1).Test pig unifies net bed raising, free choice feeding, carries out prevention on request and connects
Kind.
1.2 test index
1.2.1 the measure of production performance index
Weanling pig weight is weighed before experiment, is made a record, the 14th and 28 day experimental period weighed weight, made a record.Examination
Record daily ingestion amount every day of progress is tested, calculates feedstuff-meat ratio.
1.2.2 the measure of weanling pig Serum Indexes
The 14th day experimental period, the 28th day, each repeat 1 examination close to average weight of middle selection from each processing respectively
Pig is tested, vena cava anterior blood sampling, serum is separated, carries out index determining.
Immune indexes：Immunoglobulin A, complement protein 4, interleukin-6, interleukin-10, nitric oxide.Determine kit
Bioengineering Research Institute's production is built up by Nanjing.
Stress index：Creatine kinase, growth hormone release inhibiting hormone, lactic dehydrogenase.Measure kit builds up bioengineering by Nanjing and ground
Study carefully and produced.
Albumen index；Urea nitrogen, total protein, albumin, globulin.Measure kit builds up bio-engineering research by Nanjing
Produced.
1.2.3 the statistics and analysis of data
Test data uses the one-way analysis of variance (One way ANOVA) in SPSS17.0 softwares to be handled, and uses
DUNCAN methods carry out Multiple range test, with P<0.05 is the level of signifiance, and test bit is represented with average value ± standard error.
2 results and analysis
Influence of 2.1 Chinese herb feed additives to Production Performance of Weaning Pigs
It can be drawn by table 1, natural plant feed addictive significantly improves the daily gain (P of weanling pig<0.05)、
Improve daily ingestion amount (P>0.05) feedstuff-meat ratio (P of weanling pig, is significantly reduced<0.05).From whole experimental period (1-28
My god) from the point of view of, the daily gain of 0.5mg/kg and 1mg/kg plant feed addictive group 6.2% (P higher than control group respectively>
And 17.2% (P 0.05)<0.05).The feed-weight ratio of 0.5mg/kg and 1mg/kg plant feed addictive group is respectively than control
Group reduces by 4.17% (P<0.05), 11.98% (P<0.05), the level of signifiance has been reached with control group ratio.
This result of the test illustrates that this Chinese herb feed additive can effectively improve the production performance of weanling pig.The present invention's
Natural plant feed addictive can play the characteristic of Mutiple Targets, and performance of this characteristic to growth of animal potentiality has promotion to make
With simultaneously the essence of additive of the invention is plant, and it is safe, green, pollution-free also just to determine that it has the advantages that, is not easy
Produce drug resistance.
Influence of the plant feed addictive of table 1 to Production Performance of Weaning Pigs
Note:Data shoulder mark of going together represents difference not significantly (P without letter>0.05)；Shoulder mark difference lowercase letter indication difference
Significantly (P<0.05).Following table is same.
Influence of 2.2 plant feed addictives to weanling pig sero-immunity index
Immunoglobulin A plays a part of protecting body from extraneous pathogen or virus infection, while can also prevent intestines
The generation of tract disease.Complement system can be participated in during Organism immunoregulation, and one in antimicrobial defense reaction
Individual link, and the damaging reaction to immunopathogenesis plays an important role.The content of interleukin-6 can be as judging the immune of body
One foundation of function, it is particular enable to reflect the level of humoral immunity.Interleukin-10 damages in tissue-specific autoimmune
Key adjustment effect is played in the startup and development of wound.Nitric oxide can strengthen non-specific immune function, and can kill disease
Pathogenic microorganism and cancer cell.
Table 2 is influence result of the plant feed addictive to weanling pig sero-immunity index.Result of the test shows, tries
Test the 14th day and 28 days, the content of the serum IgA of 0.5mg/kg and 1mg/kg plant feed addictive group shows
Work is higher than control group (P<0.05).With the increase of plant feed addictive dosage, weanling pig serum complement C4 content
Rise therewith, 1mg/kg plant feed addictive group and control group significant difference (P<0.05).Natural plant feed adds
Agent is added to significantly improve interleukin-6 and interleukin-10 content in weanling pig serum.0.5mg/kg and 1mg/kg vegetalitas
The interleukin content of feed addictive group is all remarkably higher than control group (P<0.05).Test the 14th day and 28 days, weanling pig day
Plant feed addictive is added in grain to be significantly increased serum levels of nitric oxide content (P<0.05).
Multiple components have immunological enhancement in the present invention.Such as estragole and anethole that wrinkled giant hyssop contains, have
Antibacterial, the effect of anti-convulsion；Purple perilla can strengthen the immunologic function of splenocyte；Soluble polysaccharide in the bighead atractylodes rhizome can recover the increasing of lymphocyte
Function is grown, extends the life-span of lymphocyte；Balloonflower root promotes the activation of macrophage, improves animal immunizing power；Radix glycyrrhizae also has one
The effect of fixed strengthen immunity.Therefore the natural plant feed addictive of the present invention can strengthen the immunity of weanling pig
Can, improve the ability that weanling pig resists the invasion and attack of environmental stimuli and endogenous microbes.
Influence of the plant feed addictive of table 2 to weanling pig immune indexes
2.3 plant feed addictives to weanling pig serum stress index influence
Table 3 be plant feed addictive to weanling pig stress index influence result.Compared with control group, 0.5mg/
Kg and 1mg/kg plant feed addictive groups significantly reduce experiment the 14th day and 28 days serum in creatine kinase (P<0.05)、
Lactic dehydrogenase (P<0.05) it is active.Natural plant feed addictive significantly reduces growth hormone release inhibiting hormone in the 28th day serum of experiment
Content (P<0.05).
When animal stimulation stressed, feed intake declines, and energy supply deficiency, makes muscle cell ischemic, anoxic, first shape
Gland hypodynamia causes cellular damage or necrosis, permeability of cell membrane increase, and creatine kinase escapes into blood, blood from muscle
Creatine kinase level can raise；Simultaneously stress caused by anerobic glycolysis stimulate myocyte, cause intracellular lactic dehydrogenase to release
Put, Dehydrogenase Content accordingly rises in blood.Therefore the active increasing of animal body creatine kinase content and lactic dehydrogenase
Add is that stress reaction and selection stress resist the important symbol of pig.Growth hormone release inhibiting hormone is a kind of inhibition braingut petide, suppresses a variety of stomaches
The release of intestinal hormones and the motion for suppressing intestines and stomach.Stress when as investigate intestines and stomach spasmolysis index.
Natural plant feed addictive significantly reduces creatine kinase, lactic dehydrogenase and growth hormone release inhibiting hormone in this experiment.
Because the volatile oil that ageratum contains in the natural plant feed addictive of the present invention can promote gastric secretion, strengthen machine
Body digestion power, while also relieving spasm and pain, the effect of bidirectional modulation；Beta carotene in purple perilla has antioxygenic property, subtracts
The oxidative attacks of few cell membrane；The bark of official magnolia and its volatile oil bitter can stimulate the sense of taste, cause saliva, gastric secretion, gastrointestinal peristalsis to add
It hurry up；Volatile oil in dried orange peel, stimulating gastrointestinal road that can be gentle move, and promote secrete digestive juicess.Therefore the feed of the present invention adds
Agent is added to alleviate the ablactation stress of piglet, the metabolism of Auto-regulator promotes the wriggling of stomach and intestine, and then improves growth performance.
The plant feed addictive of table 3 to weanling pig stress index influence
2.4 plant feed addictives synthesize the influence of index of correlation to weanling pig haemocyanin
Total protein includes albumin and globulin, is mainly used in maintaining plasma osmolarity and acid-base balance, also buffers work(
Energy, transportation function, immunologic function and repair tissue etc. act on.Its content is to reflect the synthesis or metabolism of animal body protein
One index of strong and weak and body immunity height.Wherein globulin is the main matter of antibody, its content how many generation
Table the height of immunity of organisms.And urea nitrogen is the balance of the metabolic condition and daily ration amino acid that judge animal vivo protein
A whether good index of situation.
The result of table 4 shows that natural plant feed addictive significantly improves the synthesis capability of weanling pig albumen.Piglet
Natural plant feed addictive is added in daily ration and improves total protein (P in serum<0.05), albumin (P<And ball egg 0.05)
(P in vain<0.05) content, the content (P of urea nitrogen is significantly reduced<0.05).Result of the test illustrates that the vegetalitas of the present invention is raised
Feed additives promote the synthesis of albumen, reduce the decomposition of albumen, improve the absorption and metabolism of protein, and nitrogen is young in wean
The amount retained in pig body increases, and the catabolite (such as amino acid and peptides) of protein is absorbed to internal amount increase, i.e. egg
Deposition increase of the white matter in weanling pig body, promotes the growth of weanling pig.
Influence of the plant feed addictive of table 4 to weanling pig albumen index
Test two natural plant feed addictives to the material of influence 1 of Microflora in diarrhea of weaned piglets rate and excrement with
Method
1.1 experimental animals and packet
Experiment choose Weaning Age is close, be in a good state of health, first body weight 7kg or so " Duroc × length is white × greatly
Three way cross weanling pig 60 is used as experimental animal in vain ".60 weanling pigs are randomly divided into 3 groups, every group of 4 repetitions.1st
Group is control group, feeds basal diet；Second group is that (natural plant feed addictive formula is plant feed addictive group
Embodiment 2), it is 1mg/kg that natural plant feed addictive concentration is added in basal diet, and the 3rd group is antibiotic group (sulfuric acid
Colistin), it is 30mg/kg that colistin sulfate concentration is added in basal diet.Test pig is unified net bed and raised, free choice feeding,
Immunization campaign is carried out on request.
1.2 test index
1.2.1 the measure of diarrhea rate
The diarrhoea situation of the 7th, 14, the 28 day record weanling pig of experimental period.
Diarrhea rate (%)=respectively repeating accumulative diarrhoea pig head number/respectively repeats always to raise head number × 100
1.2.2 in excrement flora measure
The the 7th, 14,28 day experimental period, about 50 grams of excrement of each repeated acquisition, it is immediately placed in hermetic bag and seals, with flat
Plate count method determines the quantity of each flora in weanling pig excrement.As a result with the logarithm of the total plate count contained in every gram of excrement
Value represents.
1.2.3 the statistics and analysis of data
Test data carries out primary Calculation, statistics in EXCEL2010, uses the single factor test variance in SPSS17.0 softwares
Analysis (One way ANOVA) is handled, and Multiple range test is carried out with DUNCAN methods, with P<0.05 is the level of signifiance, tests number
Value is represented with average value ± standard error.
2 results are with discussing
Influence of 2.1 Chinese herb feed additives to diarrhea of weaned piglets rate
In table 5 as can be seen that when testing the 7th day, 14 days and 28 days, plant feed addictive group (P<And antibiosis 0.05)
Plain group of (P<0.05) diarrhea rate is substantially less than control group.And plant feed addictive group reduces diarrhea rate effect better than anti-
It is raw plain group.To when testing the 28th day, plant feed addictive group diarrhea rate is substantially less than antibiotic group (P<0.05).
Most of composition in the feed addictive of the present invention has the function of suppressing harmful bacteria growing, and can improve
The immunity of animal body, reduce stress generation, so as to improve actual production benefit.If wrinkled giant hyssop, purple perilla are to pathogenic microorganism
There is inhibitory action.The root of Dahurain angelica, the bark of official magnolia, dried orange peel etc. play the role of to suppress or kill to the intestines and stomach such as Escherichia coli harmful bacteria, and
The wriggling of intestines and stomach can be promoted, promote digestion.From result of the test, feed addictive application effect of the invention and antibiotic
(colistin sulfate) is compared to more advantageous.
Influence % of the plant feed addictive of table 5 to diarrhea of weaned piglets rate
Influence of 2.2 Chinese herb feed additives to flora in weanling pig excrement
Intestinal microbial balance plays an important roll to the health of animal.The quantity of flora reflects micro- life in enteron aisle in excrement
The composition situation of thing flora.Bacillus acidi lactici can suppress the growth of other microorganisms and promote intestinal microbial balance, strengthen enteron aisle
The function of epithelial cell, improve immunity of organisms etc. and play its probiotic action.Bifidobacterium can suppress and kill gram
Negative bacterium, and the invasion of other pathogenic bacteria can be prevented, while also there is the absorption for promoting nutriment, enteron aisle balance is maintained, is carried
The functions such as high immunity.And Escherichia coli are the major reasons for causing pathogenicity to be suffered from diarrhoea.Escherichia coli utilize indigested nutrition
Composition, breed such as protein and amino acid, reduce the quantity of intestinal beneficial bacterium (such as Bacillus acidi lactici), destroy micro- life in enteron aisle
Thing balances, and causes the generation of grice diarrhoea.
Table 6 can be seen that plant feed addictive group and the Escherichia coli quantity of antibiotic group is less than control group, test
14th day and 28 days, reach significance degree (P with the difference of control group<0.05), and plant feed addictive group reduces large intestine
The effect of bacillus is better than antibiotic group.
Bacillus acidi lactici and Bifidobacterium result show, the 28th day experimental period, plant feed addictive group and antibiotic group
Significantly improve Bacillus acidi lactici and bifidobacteria.In terms of whole experimental period, plant feed addictive carries to beneficial bacterium
Height effect is better than antibiotic.
The natural plant feed addictive of the present invention has antibacterial, sterilization, drives away the effect of internal pathogenic microorganism,
The function of intestines and stomach can also be adjusted simultaneously, improve immunity of organisms, reduction stress.The purple perilla wherein contained has bacteriostasis；
The root of Dahurain angelica also has inhibitory action to harmful bacterias such as Escherichia coli, shigella dysenteriae, proteus；The bark of official magnolia can hinder gram flora
Growth, and its antibacterial action is eager to excel than some other Chinese herbal medicine, and contained by the bark of official magnolia the effect of antimicrobial component not by heating shadow
Ring.In addition the active component in wrinkled giant hyssop, radix glycyrrhizae, dried orange peel also has different degrees of bacteriostasis.
Influence log of the plant feed addictive of table 6 to flora in weanling pig excrement10cfu/g
The natural plant feed addictive of the present invention promotes albumen synthesis, alleviated by strengthening weanling pig immunity
Ablactation stress, the balance of Tiny ecosystem in weanling pig enteron aisle is adjusted, the generation of diarrhea of weaned piglets rate is prevented and treated, so as to promote to resolve
The production performance of milk piglet.
Claims (2)
1. a kind of feed addictive for the natural plant for preventing and treating diarrhea of weaned piglets, it is characterized in that：Its raw material components weight hundred
Point ratio is：Wrinkled giant hyssop 15-25%, bark of official magnolia 10-15%, bighead atractylodes rhizome 10-15%, dried orange peel 10-15%, balloonflower root 10-15%, radix glycyrrhizae 10-15%, purple perilla
5-10%, root of Dahurain angelica 5-10%;
Above-mentioned raw materials are weighed in proportion, crushes, sieve, mixing, powder is made.
2. a kind of application of the feed addictive of the natural plant of preventing and treating diarrhea of weaned piglets as claimed in claim 1, its
It is characterized in：Addition in weanling pig feed is 0.5 ~ 1g/kg feeds, addition period for wean after in 4 weeks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710593774.3A CN107468793A (en) | 2017-07-20 | 2017-07-20 | A kind of feed addictive of natural plant for preventing and treating diarrhea of weaned piglets and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710593774.3A CN107468793A (en) | 2017-07-20 | 2017-07-20 | A kind of feed addictive of natural plant for preventing and treating diarrhea of weaned piglets and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107468793A true CN107468793A (en) | 2017-12-15 |
Family
ID=60596704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710593774.3A Pending CN107468793A (en) | 2017-07-20 | 2017-07-20 | A kind of feed addictive of natural plant for preventing and treating diarrhea of weaned piglets and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107468793A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740434A (en) * | 2018-06-19 | 2018-11-06 | 郭林超 | A kind of Weanling pig compound feed |
| CN110024909A (en) * | 2019-04-24 | 2019-07-19 | 贵州中宝药业有限公司 | Feeding natural vegetable Chinese herbal medicine is for anti-additive and preparation method thereof |
| CN113598276A (en) * | 2021-07-29 | 2021-11-05 | 湖北省农业科学院畜牧兽医研究所 | Application of magnolol in improving reproductive performance of sows |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912042A (en) * | 2010-08-06 | 2010-12-15 | 沈阳农业大学 | Pure natural plant feed additive for preventing and controlling diarrhea and application |
| CN103766656A (en) * | 2014-01-22 | 2014-05-07 | 中国科学院东北地理与农业生态研究所 | Feed additive for relieving stress of piglets and preparation method thereof |
| CN106039248A (en) * | 2016-06-17 | 2016-10-26 | 李业静 | Formula for traditional Chinese medicines for treating different types of porcine diarrhea |
-
2017
- 2017-07-20 CN CN201710593774.3A patent/CN107468793A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912042A (en) * | 2010-08-06 | 2010-12-15 | 沈阳农业大学 | Pure natural plant feed additive for preventing and controlling diarrhea and application |
| CN103766656A (en) * | 2014-01-22 | 2014-05-07 | 中国科学院东北地理与农业生态研究所 | Feed additive for relieving stress of piglets and preparation method thereof |
| CN106039248A (en) * | 2016-06-17 | 2016-10-26 | 李业静 | Formula for traditional Chinese medicines for treating different types of porcine diarrhea |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740434A (en) * | 2018-06-19 | 2018-11-06 | 郭林超 | A kind of Weanling pig compound feed |
| CN110024909A (en) * | 2019-04-24 | 2019-07-19 | 贵州中宝药业有限公司 | Feeding natural vegetable Chinese herbal medicine is for anti-additive and preparation method thereof |
| CN113598276A (en) * | 2021-07-29 | 2021-11-05 | 湖北省农业科学院畜牧兽医研究所 | Application of magnolol in improving reproductive performance of sows |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104758318B (en) | A kind of compound formulation and preparation method thereof reducing diarrhea of weaned piglets rate | |
| KR100694820B1 (en) | A bacterial strain, and probiotic compositions for human and veterinary use | |
| CN101912042B (en) | Pure natural plant feed additive for preventing and controlling diarrhea and application | |
| CN104381681A (en) | Antibiotic-free pig creep conservation general concentrate and complete feed thereof | |
| CN109770078A (en) | A kind of feed addictive preventing nursing period calf diarrhea and its application method | |
| CN105535387B (en) | Animal and bird intestines diarrhea ferment and preparation method thereof can be improved | |
| CN108904546A (en) | A kind of pair of helicobacter pylori has inhibition, the probiotic combinations preparation of killing effect and preparation method thereof | |
| CN106387435A (en) | Feed additive, and application thereof, as well as feed | |
| CN107468793A (en) | A kind of feed addictive of natural plant for preventing and treating diarrhea of weaned piglets and application | |
| CN104208240A (en) | Traditional Chinese herbal microecological preparation for preventing and treating piglet bacterial dysentery and preparation method thereof | |
| CN103099067A (en) | Chinese herbal medicine pig feed additive capable of substituting antibiotic | |
| CN106509415A (en) | Feed additive capable of improving anti-stress and immunity of ruminants and preparation method thereof | |
| CN102919956B (en) | Nutrient solution capable of nursing human digestive system and preparation method thereof | |
| CN107927793A (en) | Prevention mitigates symphysis unit preparation of human body constipation and preparation method thereof | |
| CN104322985A (en) | Piglet feed | |
| CN115517367B (en) | Application of lactobacillus paracasei SMN-LBK in preparation of intestinal health promoting product | |
| CN107095061A (en) | Improve the fermented feed preparation method and applications of growing and fattening pigs gut barrier function | |
| CN110089619A (en) | A kind of Chinese medicine bacteria preparation fermented feed and preparation method thereof | |
| CN105029123A (en) | Piglet conservation feed formula | |
| CN107595988A (en) | It is a kind of to be used to prevent and treat enteric modulators of prevention of sow constipation and preparation method thereof | |
| CN108740335A (en) | A kind of formula of piglet feed | |
| CN105941934A (en) | Starter feed for Bama miniature pigs | |
| CN112674232A (en) | Feed for improving muscular stomach development of yellow-feathered broilers and preparation method and application thereof | |
| CN110506854A (en) | A kind of cattle and sheep health-caring feedstuff addictive and the preparation method and application thereof | |
| CN105265807A (en) | Formula of piglet creep feed |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171215 |
|
| RJ01 | Rejection of invention patent application after publication |