CN106798862A - A kind of Chinese medicine microecological preparation, preparation method for improving chicken immunity and usage thereof - Google Patents
A kind of Chinese medicine microecological preparation, preparation method for improving chicken immunity and usage thereof Download PDFInfo
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- CN106798862A CN106798862A CN201710028917.6A CN201710028917A CN106798862A CN 106798862 A CN106798862 A CN 106798862A CN 201710028917 A CN201710028917 A CN 201710028917A CN 106798862 A CN106798862 A CN 106798862A
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Abstract
The present invention relates to a kind of Chinese medicine microecological preparation, preparation method for improving chicken immunity and usage thereof, belong to veterinary Chinese medicine probiotics technical field.Chinese medicine microecological preparation of the invention is made up of fermented bacterium and following raw material mixed fermentation：15~20 parts of the Radix Astragali, 5~10 parts of Radix Angelicae Sinensis, 5~10 parts of the fruit of glossy privet, 5~10 parts of Radix Isatidis, 5~10 parts of folium isatidis, 15~20 parts of the bark of eucommia, 5~10 parts of hawthorn, 5~10 parts of malt, 1~2 part of brown sugar, 1~3 part of FOS, 1~3 part of lysine, the fermented bacterium include Bacillus subtilis strain, Lactobacillus plantarum strain, VREF strain and saccharomyces cerevisiae.Chinese medicine microecological preparation of the invention can strengthen chicken immunity, improve chick enteron aisle digestion and absorption function, and the purpose for improving chick resistance against diseases, reducing morbidity and mortality is reached on the whole, increase economic efficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine microecological preparation, preparation method for improving chicken immunity and usage thereof, category
In veterinary Chinese medicine probiotics technical field.
Background technology
Survivability of chicks be influence meat, laying hen entirety production performance a key index, directly affect the rate of animals delivered to the slaughter-house or
The incubation rate of laying hen.The chick gone out after shell, on the one hand the undesirable element resistance to external world in environment is weaker, in transport and preceding
The invasion and attack of stress factor are highly prone in phase feeding process；On the other hand, the Development of Immune Organs imperfection of chick, enteron aisle digestion
Absorption function is poor, is susceptible to pathogenicity and nutritive disease, and mismanagement often results in the brood time death rate higher, makes
Into larger economic loss.
Solved that the chick incidence of disease was higher, method the problems such as digest and assimilate bad is mainly and adds in feed and drinking-water in the past
Added with antibiotic, but the addition of long-term, high-dose result in many problems, such as enteric flora disturbance, the generation of antibody-resistant bacterium, meat
Product drug residue is exceeded, causes serious environmental pollution and directly threatens the health of people.Chinese herbal medicine replaces anti-
Infant animal hypoimmunity, morbidity can be effectively solved during animal feeding for raw element and the death rate is higher and bacterial resistance
The problem of property.Such as Chinese patent (publication number：CN102743495A a kind of Chinese medicinal granule for improving chicken immunity is disclosed in)
Agent and preparation method thereof, described Chinese medicinal granule according to following parts by weight 2~5 parts of Radix Codonopsis, 2~4 parts of the Radix Astragali, the bighead atractylodes rhizome 1~3
Part, 1~3 part of Radix Angelicae Sinensis, 1~2 part of cultivated land adds sucrose to be obtained after cooking.Although the Chinese medicinal granular formulation can improve chick
Immunity, but its action effect is poor, and Chinese medicine utilization rate is low, and without improving the effect that enteron aisle is digested and assimilated.Chinese patent
(publication number：CN105581048A a kind of feed addictive for improving chicken immunity) is disclosed, it is by the as follows of parts by weight
Raw material is constituted：Psoralea corylifolia 20~30, the fleece-flower root 10~20,15~30 parts of the Radix Astragali, 8~15 parts of Radix Angelicae Sinensis, 4~12 parts of hawthorn, dried orange peel
10~15 parts, 12~18 parts of Radix Codonopsis, 15~30 parts of Radix Glycyrrhizae.The feed addictive composition is simple, with chicken immunity is improved, subtracts
The effect of few chick P, but its Chinese medicinal ingredients utilization rate is low, and chick enteron aisle abilities of digestive and absorption can not be improved.
The content of the invention
In order to overcome Chinese medicinal ingredients utilization rate in the prior art low, single technological deficiency is acted on, the present invention provides a kind of
Chinese medicine microecological preparation for improving chicken immunity, the Chinese medicine microecological preparation can strengthen chicken immunity, improve young
Chicken intestinal digestion and absorption function, reaches the purpose for improving chick resistance against diseases, reducing morbidity and mortality on the whole.
To achieve these goals, the technical solution adopted by the present invention is：
A kind of Chinese medicine microecological preparation for improving chicken immunity, by fermented bacterium and the following raw material mixed fermentation system
Into：The Radix Astragali, Radix Angelicae Sinensis, the fruit of glossy privet, Radix Isatidis, folium isatidis, the bark of eucommia, hawthorn, malt, brown sugar, FOS and lysine；The hair
Yeast-like fungi kind includes Bacillus subtilis strain, Lactobacillus plantarum strain, VREF strain and saccharomyces cerevisiae.
Preferred scheme, described Chinese medicine microecological preparation by fermented bacterium and following parts by weight raw material mixed fermentation
It is made：15~20 parts of the Radix Astragali, 5~10 parts of Radix Angelicae Sinensis, 5~10 parts of the fruit of glossy privet, 5~10 parts of Radix Isatidis, 5~10 parts of folium isatidis, the bark of eucommia
15~20 parts, 5~10 parts of hawthorn, 5~10 parts of malt, 1~2 part of brown sugar, 1~3 part of FOS, 1~3 part of lysine；It is described
Fermented bacterium includes Bacillus subtilis strain, Lactobacillus plantarum strain, VREF strain and saccharomyces cerevisiae.
Further preferred scheme, described Chinese medicine microecological preparation is mixed by the raw material of fermented bacterium and following parts by weight
Fermentation is closed to be made：20 parts of the Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of the fruit of glossy privet, 10 parts of Radix Isatidis, 10 parts of folium isatidis, 20 parts of the bark of eucommia, hawthorn 7
Part, 7 parts of malt, 1.5 parts of brown sugar, 3 parts of FOS, 2 parts of lysine；The fermented bacterium comprising Bacillus subtilis strain,
Lactobacillus plantarum strain, VREF strain and saccharomyces cerevisiae.
The consumption of the fermented bacterium is：5~the 15mL of Radix Astragali correspondence addition Bacillus subtilis strain of every 15~20g,
5~15mL of Lactobacillus plantarum strain, 3~10mL of 15~30mL of VREF strain and saccharomyces cerevisiae.
Preferred scheme, the consumption of the fermented bacterium is：Radix Astragali correspondence per 20g adds Bacillus subtilis strain
10mL, Lactobacillus plantarum strain 10mL, VREF strain 30mL, saccharomyces cerevisiae 5mL.
The viable count of the Bacillus subtilis strain is 5.0 × 109~10.0 × 109CFU/mL, Lactobacillus plantarum strain
Viable count be 5.0 × 107~10.0 × 107CFU/mL, the viable count of VREF strain is 5.0 × 107~10.0 ×
107CFU/mL, the viable count of S. cervisiae strain is 1.0 × 109~5.0 × 109CFU/mL。
Preferred scheme, the viable count of the Bacillus subtilis strain is 1.0 × 1010CFU/mL, Lactobacillus plantarum bacterium
The viable count planted is 7.0 × 107CFU/mL, the viable count of VREF strain is 1.0 × 108CFU/mL, S. cervisiae strain
Viable count be 2.0 × 109CFU/mL。
A kind of Chinese medicine microecological preparation for improving chicken immunity of the invention, the characteristic of each raw material is as follows：
The Radix Astragali：It is warm in nature, it is sweet；Returns spleen, lung channel；With tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, the work(of promoting pus discharge and tissue regeneration
Effect.Modern pharmacological research shows that its Main Function composition is polysaccharide, first glycosides, flavones etc., and its Main Function has：Strengthen the normal heart
Dirty contractility, has cardiotonic to the heart of exhaustion, expands whole body peripheral vessel, improves microcirculation；Kidney is protected in liver protection, neutralizes poison
Element；Promote the development of immune organs and tissues, promote the propagation of immunocyte and improve its activity, improve the effect of vaccine immunity
Really, the generation of antibody is promoted；The generation of interferon can be stimulated, antivirus action is played；There is suppression to pathogens such as Escherichia coli
Make and use.
Radix Angelicae Sinensis：It is warm in nature；It is sweet, pungent；The thoughts of returning home, liver, the spleen channel；With tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, relax bowel the effect of.
Modern pharmacological research shows that its Main Function composition is the composition of volatile oil, polysaccharide and a kind of excited uterus of energy, is also contained in addition
Several amino acids and vitamin.Its Main Function has：Adjustment uterine state, prevents miscarriage；With calmness, analgesia, diuresis, anti-
Scorching, antiallergy and bacteriostasis；Can relax bowel, protect liver, prevent hepatic glycogen from reducing；Promote hemoglobin and red blood cell
Growth, anti-anemia action；Strengthen non-specific and specific immunity.
The fruit of glossy privet：It is cool in nature；Sweet, hardship；Return liver and kidney channel；With tonifying the liver and kidney, the effect of heat-clearing improving eyesight.Modern pharmacology grinds
Study carefully and show, its main component is oleanolic acid, the sour fruit of glossy privet, various alcohol, glycoside and sugar etc..Main Function has：Cardiac stimulant diuresis stops
Cough；The content of cholesterol and triglycerides is reduced, it is hypoglycemic；Protection liver, have certain antibacterial, antiviral, anti-inflammatory, anti-aging and
Antitumaous effect；The effect of humoral immunity and cellular immunity can be strengthened.
Radix Isatidis：It is cold in nature；Bitter；The thoughts of returning home, stomach；The effect of with clearing heat and detoxicating, cool blood relieving sore-throat.Modern study shows,
Its main component is the materials such as polysaccharide, uridine, daucosterol.Main Function：There is suppression to various Gram-positives, negative bacteria
Make and use；Enhancing immunologic function, it is antiviral；Can suppress to be had moral integrity platelet aggregation by ADP.
Folium isatidis：Property Great Cold；It is bitter, salty；The thoughts of returning home, lung, stomach；The effect of with clearing heat and detoxicating, blood cooling and ecchymoses removing.Modern medicine
Reason research shows that main component is woaded blue glycosides, indigo, indigo red, tryptophan, couroupitine A etc..Main Function：It is anti-with wide spectrum
Bacterium, antiviral, anti-endotoxin effect；Strengthen immunity；Antipyretic, anti-inflammatory.
The bark of eucommia：It is warm in nature；It is sweet；Return liver kidney channel；With filling liver kidney, strengthen the bone, antiabortive, hypotensive the effect of.Modern pharmacology
Research shows that its main component is gutta-percha, glucosides, chlorogenic acid etc..Main Function：Expansion of blood vessels, reduce serum cholesterol, drop
Blood pressure；Calmness, analgesia, anti-inflammatory, antiviral and hepatoprotective effect；Enhancing immunity of organisms；It is hypoglycemic, anti-aging, antitumor.
Hawthorn：Slightly warm in nature；It is sour, sweet；Returns spleen, stomach, Liver Channel；With promoting digestion and removing indigestion, it is promoting blood circulation and removing blood stasis the effect of.Modern pharmacology
Research shows that main component is flavonoids and organic acid.Main Function：Increase the secretion of digestive ferment in stomach, and strengthen digestion
The activity of enzyme, promotes digestion；Stomach and intestine pH value is reduced, suppresses pathogenic microorganism；Shrink uterus, cardiac stimulant, anti-arrhythmia, step-down,
Reducing blood lipid etc..
Malt：It is mild-natured；It is sweet；Returns spleen, stomach, Liver Channel；With help digestion and in, delaactation the effect of.Modern pharmacological research shows,
Its composition is mainly amylase, maltose, protein decomposition enzyme, vitamin and amino acid etc..Main Function：Aid digestion, drop blood
Sugar, the tensity for reducing muscle.
FOS, lysine, brown sugar：This 3 kinds of materials are added in Chinese-medicinal culture medium mainly as fermentation auxiliary material, oligomeric
Fructose can promote the propagation of fermented bacterium and animal intestinal tract beneficial bacterium, improve gut flora balance and function of intestinal canal；Brown sugar is main
It is utilized as the nutriment of fermented bacterium, with the effect for promoting growing microorganism；Lysine is then as a kind of required amino
Acid, utilizes for animal body and fermented bacterium.
Bacillus subtilis：Belong to aerobic-type bacterium, can be bred rapidly under conditions of aerobic, the oxygen in consumption environment
Gas, for the growth of lactic acid bacteria, Bifidobacterium etc. provides anaerobic environment, and can produce promotion lactic acid bacteria, the benefit of bifidobacterium growth
Bacteria factor；Contain substantial amounts of enzyme in fermented bacterium, the degraded of plant medicine cell membrane can be promoted, improve active ingredient
Dissolution rate；Various enzymes are produced in fermentation process, is conducive to the degraded of fermentation substrate and enteron aisle food, improve efficiency of feed utilization；Generation
Thank to product such as subtilin, bacitracin has inhibitory action to pathogenic microorganism；The generation of ammonia, hydrogen sulfide can be reduced, is improved
Growth of animals or poultry and the environment of plant.
Lactobacillus plantarum, VREF：Belong to anaerobic type bacterium, substantial amounts of organic acid and digestion can be produced in metabolic process
Enzyme, can reduce gastrointestinal pH, can promote the generation of digestive ferment and improve the activity of enzyme；Sour environment can suppress pathogen life
Breeding long；Contain substantial amounts of enzyme in fermented bacterium, the degraded of plant medicine cell membrane can be promoted, improve active ingredient
Dissolution rate；Improve gut flora balance, stimulate the development of intestine immunity tissue, improve intestinal immunity.
Saccharomyces cerevisiae：Belong to facultative anaerobic bacteria, substantial amounts of high-quality thalline, digestive ferment, amino acid can be produced in metabolic process
And vitamin, the nutrition of animal can be supplemented；Abundant enzyme can be produced in fermentation process, plant medicine cell membrane can be promoted
Degraded, improve active ingredient dissolution rate；Improve gut flora balance, stimulate the development of intestine immunity tissue, improve enteron aisle
Immunologic function；Improve the local flavor of tunning.
Chinese medicine microecological preparation for improving chicken immunity of the invention, the Radix Astragali, Radix Angelicae Sinensis, Radix Isatidis of selection etc. have
There are the effects such as tonifying Qi qi-restoratives, liver protection shield kidney, clearing heat and detoxicating, promoting digestion and removing indigestion, Chinese herbal compounds medicinal powder is carried out with four kinds of probiotics
Solid state fermentation, first, the Chinese medicinal plant that can degrade cell membrane, improve medicinal ingredient dissolution rate, improve medicine utilization rate and
Drug effect；Secondly, the Radix Astragali, Radix Angelicae Sinensis, Radix Isatidis etc. are respectively provided with growth and promote to fermenting with probiotics strain and chick enteron aisle autochthonous flora
Enter effect, the quantity of probiotics in this Chinese medicine microecological preparation can be improved, while promoting chick gut flora balance；Finally,
Probiotics produces the materials such as substantial amounts of high-quality thalline, organic acid, vitamin during the fermentation, is not only able to supplement the battalion of animal
Support, but also with extensive BA, there is facilitation to the raising of chicken immunity；Fermentation process is as beneficial
Bacterium is also possible to produce new active component in the process to the biotransformation of Chinese medicine, plays certain pharmacological action.
A kind of Chinese medicine microecological preparation for improving chicken immunity of the invention, using the Chinese medicines such as the Radix Astragali, Radix Angelicae Sinensis with
Brown sugar, lysine, FOS coordinate, and are made through solid state fermentation using fermented bacterium.The Radix Astragali, Radix Angelicae Sinensis tonifying middle-Jiao and Qi in side, support
Blood and tranquilizing mind；Radix Isatidis, folium isatidis are clearing heat and detoxicating, clearing heat and cooling blood；The bark of eucommia, the fruit of glossy privet tonify the liver and kidney；Hawthorn, malt promoting digestion,
It is promoting blood circulation and removing blood stasis.Most Chinese medicines have the effects such as enhancing immunity of organisms, antiviral, antibacterial in side, with brown sugar, lysine, oligomeric
Through Chinese medicine microecological preparation obtained in probiotics fermention after fructose is compound, from from the aspect of pharmacological action, not only improved after fermentation
The effect of former Chinese medicine, and its action function is extended, and solve bacterial drug resistance, medicament residue that antibiotic brings
And the problems such as toxic and side effect；Nutrition aspect, produces mycoprotein, amino acid, vitamin and disappears in growth of probiotics reproductive process
Change enzyme, for chick provides high-quality nutritional ingredient, also improve digestion and absorption function, improve efficiency of feed utilization；From chick in itself
Application effect aspect, the immunity that improves body are, the balance for improving gut flora, hence it is evident that improve its general level of the health and incubation
Rate.
Present invention also offers the preparation method of the Chinese medicine microecological preparation：Formula content of starting materials is ground into particle, then
The crushing raw material for taking formula ratio mixes with brown sugar, FOS and lysine and fermented bacterium, closed under the conditions of 20~40 DEG C
Fermentation 15~60 days, obtains final product.
The preparation method of preferred Chinese medicine microecological preparation is, by the raw material of formula ratio：The Radix Astragali, Radix Angelicae Sinensis, the fruit of glossy privet, plate are blue
Root, folium isatidis, the bark of eucommia, hawthorn and malt are ground into 60~120 mesh particles, then take the crushing raw material of formula ratio and brown sugar, oligomeric
Fructose and lysine and fermented bacterium mixing, sealed fermenting 15~60 days, obtain final product under the conditions of 20~40 DEG C.
The preparation method of further preferred Chinese medicine microecological preparation is：By the raw material of formula ratio：The Radix Astragali, Radix Angelicae Sinensis, glossy privet
Son, Radix Isatidis, folium isatidis, the bark of eucommia, hawthorn and malt are ground into 60~120 mesh particles, then take the crushing raw material of formula ratio with it is red
Sugar, FOS and lysine and fermented bacterium mixing, sealed fermenting 15 days, obtain final product under the conditions of 28 DEG C.
Preparation method for improving the Chinese medicine microecological preparation of chicken immunity of the invention, is by Chinese medicine, brown sugar, relies
Propylhomoserin, FOS are made after mixing with fermented bacterium through solid state fermentation；The method is easy to operate, without three industrial wastes etc. after fermentation
Harmful substance, utilization rate is high, and feasibility is good, it is adaptable to large-scale industrial production, with preferable application value.
Present invention also offers the application method of the Chinese medicine microecological preparation for improving chicken immunity：It is continuous to chick first
The feed of feeding addition Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton；Continuous feeding is not again
Add the feed 7 days of Chinese medicine microecological preparation, then continuous feeding adds the feed 7 days of Chinese medicine microecological preparation, in feed per ton
Add 3kg Chinese medicine microecological preparations.
Present invention also offers the application method of the Chinese medicine microecological preparation of described raising chicken immunity：For 1~7
Japanese instar chickling, adds the feed of Chinese medicine microecological preparation 7 to the continuous feeding of chick first, and 3kg Chinese medicines are added in feed per ton
Probiotics；Continuous feeding is added without the feed 7 days of Chinese medicine microecological preparation again, then continuous feeding adds Traditional Chinese drug microecology system
The feed of agent 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton, be added without Traditional Chinese drug microecology system during feeding afterwards
Agent carries out feeding.
Chinese medicine microecological preparation application method of the invention is simple, and Chinese medicine microecological preparation is proportionally added into feeding during feeding
After material is well mixed, you can allow chick to eat.
Specific embodiment
To make the purpose of the present invention, technical scheme clearer, embodiment of the present invention will be made below further detailed
Thin description.
Embodiment 1
The Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment is made up of following raw material mixed fermentation：The Radix Astragali 15
Part, 10 parts of Radix Angelicae Sinensis, 5 parts of the fruit of glossy privet, 10 parts of Radix Isatidis, 5 parts of folium isatidis, 20 parts of the bark of eucommia, 5 parts of hawthorn, 10 parts of malt, 1 part of brown sugar,
3 parts of FOS, 1 part of lysine；The consumption of the fermented bacterium is：Radix Astragali correspondence per 15g adds bacillus subtilis bacterium
Plant 10mL, Lactobacillus plantarum strain 5mL, VREF strain 20mL, saccharomyces cerevisiae 5mL；The Bacillus subtilis strain
Viable count is 10.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 5.0 × 107CFU/mL, VREF strain
Viable count is 5.0 × 107CFU/mL, the viable count of S. cervisiae strain is 4.0 × 109CFU/mL。
The preparation method of the Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment：Take Radix Astragali 15g, Radix Angelicae Sinensis 10g,
Fruit of glossy privet 5g, Radix Isatidis 10g, folium isatidis 5g, bark of eucommia 20g, hawthorn 5g, malt 10g, be first ground into 80 mesh particles, then with brown sugar
1g, FOS 3g, lysine 1g and Bacillus subtilis strain 10mL, Lactobacillus plantarum strain 5mL, VREF strain
20mL, saccharomyces cerevisiae 5mL mix, and the viable count of the Bacillus subtilis strain is 10.0 × 109CFU/mL, Lactobacillus plantarum
The viable count of strain is 5.0 × 107CFU/mL, the viable count of VREF strain is 5.0 × 107CFU/mL, S. cervisiae bacterium
The viable count planted is 4.0 × 109CFU/mL, sealed fermenting is obtained final product after 60 days under the conditions of 20 DEG C after mixing.
The usage of Chinese medicine microecological preparation that the present embodiment improves chicken immunity is：The continuous feeding of chick is added first
The feed of the Chinese medicine microecological preparation of the present embodiment 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton；Continuous feeding again
It is added without the feed of Chinese medicine microecological preparation 7, then continuous feeding adds the feed 7 of the Chinese medicine microecological preparation of the present embodiment
Day, 3kg Chinese medicine microecological preparations are added in feed per ton, feeding is added without the feed of Chinese medicine microecological preparation afterwards, until going out
Column.
Embodiment 2
The Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment is made up of following raw material mixed fermentation：The Radix Astragali 18
Part, 5 parts of Radix Angelicae Sinensis, 8 parts of the fruit of glossy privet, 5 parts of Radix Isatidis, 8 parts of folium isatidis, 15 parts of the bark of eucommia, 7 parts of hawthorn, 5 parts of malt, 1.5 parts of brown sugar,
1 part of FOS, 2 parts of lysine；The consumption of the fermented bacterium is：Radix Astragali correspondence per 18g adds bacillus subtilis bacterium
Plant 5mL, Lactobacillus plantarum strain 15mL, VREF strain 15mL, saccharomyces cerevisiae 3mL；The Bacillus subtilis strain
Viable count is 5.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 7.0 × 107CFU/mL, the work of VREF strain
Bacterium number is 10.0 × 107CFU/mL, the viable count of S. cervisiae strain is 2.0 × 109CFU/mL。
The preparation method of the Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment, takes Radix Astragali 180g, Radix Angelicae Sinensis
50g, fruit of glossy privet 80g, Radix Isatidis 50g, folium isatidis 80g, bark of eucommia 150g, hawthorn 70g, malt 50g are first ground into 120 mesh particles,
Again with brown sugar 15g, FOS 10g, lysine 20g, Bacillus subtilis strain 50mL, Lactobacillus plantarum strain 150mL, dung
Enterococcal species 150mL, saccharomyces cerevisiae 30mL mix, and the viable count of the Bacillus subtilis strain is 5.0 × 109CFU/
ML, the viable count of Lactobacillus plantarum strain is 7.0 × 107CFU/mL, the viable count of VREF strain is 10.0 × 107CFU/
ML, the viable count of S. cervisiae strain is 2.0 × 109CFU/mL, after mixing under the conditions of 25 DEG C sealed fermenting after 45 days i.e.
.
The usage of Chinese medicine microecological preparation that the present embodiment improves chicken immunity is：To the continuous feeding of chick of 1 age in days
Add the feed of Chinese medicine microecological preparation 7,3kg Chinese medicine microecological preparations are added in feed per ton；Continuous feeding is added without again
The feed of Chinese medicine microecological preparation 7 days, then continuous feeding adds the feed 7 days of Chinese medicine microecological preparation, is added in feed per ton
3kg Chinese medicine microecological preparations, afterwards feeding be added without the feed of Chinese medicine microecological preparation, until delivering for sale.
Embodiment 3
The Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment, is made up of following raw material mixed fermentation：The Radix Astragali
18 parts, 8 parts of Radix Angelicae Sinensis, 10 parts of the fruit of glossy privet, 8 parts of Radix Isatidis, 7 parts of folium isatidis, 18 parts of the bark of eucommia, 10 parts of hawthorn, 6 parts of malt, brown sugar 2
Part, 2 parts of FOS, 1 part of lysine；The consumption of the fermented bacterium is：Radix Astragali correspondence per 18g adds bacillus subtilis
Strain 15mL, Lactobacillus plantarum strain 10mL, VREF strain 15mL, saccharomyces cerevisiae 10mL；The bacillus subtilis bacterium
The viable count planted is 7.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 10.0 × 107CFU/mL, VREF bacterium
The viable count planted is 7.0 × 107CFU/mL, the viable count of S. cervisiae strain is 1.0 × 109CFU/mL。
The preparation method of the Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment, takes Radix Astragali 1800g, Radix Angelicae Sinensis
800g, fruit of glossy privet 1000g, Radix Isatidis 800g, folium isatidis 700g, bark of eucommia 1800g, hawthorn 1000g, malt 600g are first ground into 60
Mesh particle, then with brown sugar 200g, FOS 200g, lysine 100g and Bacillus subtilis strain 1500mL, plant breast bar
Bacterium strain 1000mL, VREF strain 1500mL, saccharomyces cerevisiae 1000mL mixing, the viable bacteria of the Bacillus subtilis strain
Number is 7.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 10.0 × 107CFU/mL, the viable bacteria of VREF strain
Number is 7.0 × 107CFU/mL, the viable count of S. cervisiae strain is 1.0 × 109CFU/mL, it is close under the conditions of 35 DEG C after mixing
Obtained final product after closing fermentation 30 days.
The usage of Chinese medicine microecological preparation that the present embodiment improves chicken immunity is：Chick first to 1 age in days is continuous
The feed of feeding addition Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton；Continuous feeding is not again
Add the feed 7 days of Chinese medicine microecological preparation, then continuous feeding adds the feed 7 days of Chinese medicine microecological preparation, in feed per ton
3kg Chinese medicine microecological preparations are added, feeding is added without the feed of Chinese medicine microecological preparation afterwards, until delivering for sale.
Embodiment 4
The Chinese medicine microecological preparation of the raising chicken immunity of the present embodiment, is made up of following raw material mixed fermentation：The Radix Astragali
19 parts, 10 parts of Radix Angelicae Sinensis, 5 parts of the fruit of glossy privet, 10 parts of Radix Isatidis, 8 parts of folium isatidis, 17 parts of the bark of eucommia, 8 parts of hawthorn, 8 parts of malt, brown sugar 1.5
Part, 1 part of FOS, 3 parts of lysine；The consumption of the fermented bacterium is：Radix Astragali correspondence per 19g adds bacillus subtilis
Strain 15mL, Lactobacillus plantarum strain 5mL, VREF strain 25mL, saccharomyces cerevisiae 8mL；The Bacillus subtilis strain
Viable count be 5.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 5.0 × 107CFU/mL, VREF strain
Viable count is 7.0 × 107CFU/mL, the viable count of S. cervisiae strain is 5.0 × 109CFU/mL。
The present embodiment raising chicken immunity Chinese medicine microecological preparation preparation method, take Radix Astragali 19g, Radix Angelicae Sinensis 10g,
Fruit of glossy privet 5g, Radix Isatidis 10g, folium isatidis 8g, bark of eucommia 17g, hawthorn 8g, malt 8g are ground into 100 mesh particles, then with brown sugar
1.5g, FOS 1g, lysine 3g and Bacillus subtilis strain 15mL, Lactobacillus plantarum strain 5mL, VREF strain
25mL, saccharomyces cerevisiae 8mL mix, and the viable count of the Bacillus subtilis strain is 5.0 × 109CFU/mL, Lactobacillus plantarum
The viable count of strain is 5.0 × 107CFU/mL, the viable count of VREF strain is 7.0 × 107CFU/mL, S. cervisiae bacterium
The viable count planted is 5.0 × 109CFU/mL, sealed fermenting is obtained final product after 15 days under the conditions of 40 DEG C after mixing.
The present embodiment improves the usage of the Chinese medicine microecological preparation of chicken immunity：Add Chinese medicine micro- the continuous feeding of chick
The feed of ecological agent 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton；Continuous feeding is added without Traditional Chinese drug microecology again
The feed of preparation 7 days, then continuous feeding adds the feed 7 days of Chinese medicine microecological preparation, and the micro- life of 3kg Chinese medicines is added in feed per ton
State preparation, afterwards feeding be added without the feed of Chinese medicine microecological preparation.
Embodiment 5
The present embodiment is used to improve the Chinese medicine microecological preparation of chicken immunity, by fermented bacterium and following parts by weight
Raw material mixed fermentation is made：20 parts of the Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of the fruit of glossy privet, 10 parts of Radix Isatidis, 10 parts of folium isatidis, 20 parts of the bark of eucommia,
7 parts of hawthorn, 7 parts of malt, 1.5 parts of brown sugar, 3 parts of FOS, 2 parts of lysine；The consumption of the fermented bacterium is：Per 20g
Radix Astragali correspondence adds Bacillus subtilis strain 10mL, Lactobacillus plantarum strain 10mL, VREF strain 30mL, saccharomyces cerevisiae
5mL；The viable count of the Bacillus subtilis strain is 10.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 7.0
×107CFU/mL, the viable count of VREF strain is 10.0 × 107CFU/mL, the viable count of S. cervisiae strain is 2.0
×109CFU/mL。
The present embodiment raising chicken immunity Chinese medicine microecological preparation preparation method, take Radix Astragali 20g, Radix Angelicae Sinensis 7g,
Fruit of glossy privet 10g, Radix Isatidis 10g, folium isatidis 10g, bark of eucommia 20g, hawthorn 7g, malt 7g are ground into 100 mesh particles, then with brown sugar
1.5g, FOS 3g, lysine 2g and Bacillus subtilis strain 10mL, Lactobacillus plantarum strain 10mL, VREF bacterium
30mL, saccharomyces cerevisiae 5mL mixing are planted, the viable count of the Bacillus subtilis strain is 10.0 × 109CFU/mL, plant breast bar
The viable count of bacterium strain is 7.0 × 107CFU/mL, the viable count of VREF strain is 10.0 × 107CFU/mL, saccharomyces cerevisiae
The viable count of bacterium strain is 2.0 × 109CFU/mL, sealed fermenting is obtained final product after 15 days under the conditions of 40 DEG C after mixing.
The usage of Chinese medicine microecological preparation that the present embodiment improves chicken immunity is：Chick first to 1 age in days is continuous
The feed of feeding addition Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton；Continuous feeding is not again
Add the feed 7 days of Chinese medicine microecological preparation, then continuous feeding adds the feed 7 days of Chinese medicine microecological preparation, in feed per ton
3kg Chinese medicine microecological preparations, feeding afterwards is added Chinese medicine microecological preparation to be added without in feed, until delivering for sale.
Comparative example
This comparative example is used to improving the Chinese medicine microecological preparation of chicken immunity and is obtained by following methods, will take Radix Astragali 20g,
Radix Angelicae Sinensis 7g, fruit of glossy privet 10g, Radix Isatidis 10g, folium isatidis 10g, bark of eucommia 20g, hawthorn 7g, malt 7g are ground into 100 mesh particles, then
With the particle that brown sugar 1.5g, FOS 3g, lysine 2g are ground into 100 mesh, then with brown sugar 1.5g, FOS 3g, rely ammonia
Sour 2g, without everfermentation, is well mixed and is obtained.
In order to further verify beneficial effects of the present invention, following reality is also carried out to Chinese medicine microecological preparation of the invention
Test：
Test example 1
This test example investigates the production performance and immune organ hair of the Chinese medicine microecological preparation to AA broiler chicken of different embodiments
The influence educated.
(1) experiment material
Trial drug：Chinese medicine microecological preparation prepared by Chinese medicine microecological preparation and comparative example prepared by embodiment 1~5.
Experimental animal：1 close age in days healthy AA Broiler chicks 2100 of body weight, are provided by Henan Province Hebi broiler chicken.
(2) test method
By the close 1 age in days Broiler chicks 2100 of body weight, 7 groups are randomly divided into, wherein group 1~5 is test group, test group 1
~5 difference feedings add the feed of the Chinese medicine microecological preparation of the embodiment of the present invention 1~5；Group 6 is control group, and it is right that feeding is added
Ratio improves the feed of the Chinese medicine microecological preparation of chicken immunity；Group 7 is blank group, and feeding is added without Chinese medicine microecological preparation
Feed, test group, control group be identical with the feeding method of blank group, and whether it differs only in add Traditional Chinese drug microecology system
Agent.
Test group feeding method：The feed of Chinese medicine microecological preparation is added to the continuous feeding of the Broiler chicks of 1 age in days 7, often
3kg Chinese medicine microecological preparations are added in ton feed；Continuous feeding is added without the feed 7 days of Chinese medicine microecological preparation again, then continuously
The feed of feeding addition Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton, feeding is not added with afterwards
Enter the feed of Chinese medicine microecological preparation, until delivering for sale.
Each group feeding environment is consistent during experiment, and feeding and management and disinfection are carried out according to a conventional method, and chicken group periodically enter
Row routine immunization.
(3) index determining
The measure of Immune Organs Index：Put to death per 10 Broiler chicks of group selection in the 21d of experiment, gathered under gnotobasis
Thymus gland, the bursa of farbricius and spleen, peel off its adipose tissue, claim immune organ weight, Computation immunity shoot formation.Bursal index=method
Family name's capsule weight (g)/body weight (kg)；Index and spleen index=spleen weight (g)/body weight (kg)；Thymus index=thymic weight (g)/body
Weight (kg).
Production performance is detected：The age in days rate of animals delivered to the slaughter-house of each group 42, weightening, death rate etc. are recorded respectively.
Experimental result is shown in Table 1, table 2：
The age in days each group Immune Organs Index measurement result of table 1 21
From table 1, compared with blank group, the broiler chicken Immune Organs Index of test group 1~5 and control group increases obvious,
Illustrate that feeding adds development of the feed of Chinese medicine microecological preparation to the thymus gland of Broiler chicks, the bursa of farbricius, spleen to have facilitation,
Test group 1~5 increases notable than control group broiler chicken Immune Organs Index, test group thymus index, bursal index, index and spleen index
Do not increase by 7.4%~16%, 21%~25%, 10%~26% than control component.Data above shows that Chinese medicine of the invention is micro-
Ecological agent is compared with comparative example, and the facilitation to Broiler chicks thymus gland, the bursa of farbricius, the development of spleen and immunity is brighter
It is aobvious, so that illustrating the Chinese medicine microecological preparation addition feed of technique by fermentation can improve chick enteron aisle digestion and absorption function,
Effect is significant.Wherein most obvious with the effect of test group 5, compared with blank group, thymus index, bursal index, index and spleen index are carried
Height is respectively 26%, 57% and 38%, and compared with comparative example, thymus index, bursal index, index and spleen index are improved and be respectively
16%, 25%, 26%.
The age in days each group production performance index determining result of table 2 42
As can be seen from Table 2, compared with blank group, be fed with the test group 1 of Chinese medicine microecological preparation feed of the invention~
5th, control group average weight gain has been respectively increased 18.54%, 17.21%, 17.97%, 18.12%, 20.21% and 10.46%, extremely
Rate of dying reduces 3.66%, 4.33%, 4%, 4.66%, 5% and 2.33% respectively, the rate of animals delivered to the slaughter-house improves and be respectively 5%,
5.67%th, 5.67%, 6%, 6.33% and 3.33%；Result above shows the not fermented Traditional Chinese drug microecology of feeding comparative example
There is preparation raising broiler chicken son to grow, the reduction death rate, the effect increased the number of heads of livestock for sale, and Chinese medicine microecological preparation of the invention ratio
The average weight gain of comparative example is further improved, and the death rate is further reduced, and the rate of animals delivered to the slaughter-house is further improved, and can be obtained from data above
Go out Chinese medicine microecological preparation of the invention to promote chick growth, reduce the dead and effect of increasing the number of heads of livestock for sale substantially, be conducive to economy
The raising of interests.
Test example 2
The Chinese medicine microecological preparation that this test example investigates different embodiments refers to the production performance and immune organ of 817 chicks
Several influences.
(1) experiment material
Trial drug：Chinese medicine microecological preparation prepared by Chinese medicine microecological preparation and comparative example prepared by embodiment 1~5.
Experimental animal：Close 1 age in days health 817 chick 1260 of body weight, is provided by Anyang in Henan province chicken house.
(2) test method
By close 1 age in days, 817 chick 1260 of body weight, 7 groups are randomly divided into, wherein group 1~5 is test group, test group 1
~5 difference feedings add the feed of the Chinese medicine microecological preparation of the embodiment of the present invention 1~5；Group 6 is control group, and it is right that feeding is added
Ratio improves the feed of the Chinese medicine microecological preparation of chicken immunity；Group 7 is blank group, and feeding is added without Chinese medicine microecological preparation
Feed, test group, control group be identical with the feeding method of blank group, and whether it differs only in add Traditional Chinese drug microecology system
Agent.
Test group feeding method：The feed of Chinese medicine microecological preparation is added to the continuous feeding of the chick of 1 age in days 7, it is per ton
3kg Chinese medicine microecological preparations are added in feed；Continuous feeding is added without the feed 7 days of Chinese medicine microecological preparation again, then continuous feeds
The feed of food addition Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton, feeding is added without afterwards
The feed of Chinese medicine microecological preparation, until delivering for sale.
Each group feeding environment is consistent during experiment, and feeding and management and disinfection are carried out according to a conventional method, and chicken group periodically enter
Row routine immunization.
(3) index determining
The measure of Immune Organs Index：Put to death per 10 chick of group selection in the 21d of experiment, chest is gathered under gnotobasis
Gland, the bursa of farbricius and spleen, peel off its adipose tissue, claim immune organ weight, Computation immunity shoot formation.Bursal index=Fa Shi
Capsule weight (g)/body weight (kg)；Index and spleen index=spleen weight (g)/body weight (kg)；Thymus index=thymic weight (g)/body weight
(kg)。
Production performance is detected：The age in days weightening of each group 49, the death rate, rate of animals delivered to the slaughter-house etc. are recorded respectively.
Experimental result is shown in Table 3, table 4：
The age in days each group Immune Organs Index measurement result of table 3 21
From table 3, compared with blank group, test group and the chick immune organ of control group 817 have all increased weight, and show this
A little developments of the Chinese medicine preparation to 817 chick thymus gland, the bursa of farbricius, spleen have facilitation, it is noted that test group 1~5 compares
The 817 chick immune organs weightening of control group is more obvious, wherein it is most obvious with the effect of test group 5, compared with blank group, thymus gland
Index, bursal index, index and spleen index are improved and are respectively 23.70%, 46.45% and 45.10%, and data above shows the present invention
Probiotics can significantly improve the Immune Organs Index of chick, and the immunity of chick and index of immunity into positive correlation
Property, can significantly improve the immunity of chick so as to demonstrate probiotics of the invention.
The age in days each group production performance index determining result of table 4 49
As shown in Table 4, compared with blank group, test group 1~5, control group average weight gain be respectively increased 14.31%,
11.23%th, 9.87%, 8.87%, 13.23% and 5.87%, the death rate reduces 4.56% respectively, 4%, 4%, 3.45%,
5.67% and 1.78%, the rate of animals delivered to the slaughter-house is improved and is respectively 6.67%, 6.11%, 5.55%, 5.55%, 7.77% and 3.33%.Say
Bright Chinese medicine microecological preparation of the invention is conducive to improving 817 chick growths, reducing the dead and effect of increasing the number of heads of livestock for sale substantially
The raising of economic interests.
Test example 3
This test example investigates the production performance and Development of Immune Organs of the Chinese medicine microecological preparation to laying hen of different embodiments
Influence.
(1) experiment material
Trial drug：Chinese medicine microecological preparation prepared by Chinese medicine microecological preparation and comparative example prepared by embodiment 1~5.
Experimental animal：The close 1 age in days health Egg chickens 350 of body weight, are provided by Henan Province Luohe chicken house.
(2) test method
By the close 1 age in days Egg chickens 1750 of body weight, 7 groups are randomly divided into, wherein group 1~5 is test group, test group 1
~5 difference feedings add the feed of the Chinese medicine microecological preparation of the embodiment of the present invention 1~5；Group 6 is control group, and it is right that feeding is added
Ratio improves the feed of the Chinese medicine microecological preparation of chicken immunity；Group 7 is blank group, and feeding is added without Chinese medicine microecological preparation
Feed, test group, control group be identical with the feeding method of blank group, and whether it differs only in add Traditional Chinese drug microecology system
Agent.
Test group feeding method：The feed of Chinese medicine microecological preparation is added to the continuous feeding of the chick of 1 age in days 7, it is per ton
3kg Chinese medicine microecological preparations are added in feed；Continuous feeding is added without the feed 7 days of Chinese medicine microecological preparation again, then continuous feeds
The feed of food addition Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton, feeding is added without afterwards
The feed of Chinese medicine microecological preparation, until delivering for sale.
Each group feeding environment is consistent during testing, and feeding and management and disinfection are carried out according to a conventional method, and chicken group is periodically
Carry out routine immunization.
(3) index determining
Production performance is detected：Record each group 42 age in days increases weight and the death rate respectively.
The measure of antibody level：When testing 42 days, each test group randomly selects 10 chickens and is taken a blood sample.Using Hemagglutination Method
Antibody titres to newcastle disease virus is determined with Hemagglutination Inhibition.
Experimental result is shown in Table 5：
The age in days each group production performance index of table 5 42 and antibody titer of ND measurement result
Test result indicate that, compared with blank group, test group 1~5, control group average weight gain be respectively increased 16.9%,
15.5%th, 18.8%, 17.8%, 23.9% and 8.5%, the death rate reduces 4.4% respectively, 4%, 4.4%, 4.8%,
5.2% and 2%, illustrate to add the Chinese medicine microecological preparation of test example or comparative example to be conducive to improving Laying chicks growth in feed
Performance, the reduction death rate.Test example 1~5 has been respectively increased 8.4%, 7.0%, 10.3%, 8.9% than control group average weight gain,
15.4%, the death rate reduces 2.2%, 2.0%, 2.2%, 2.8%, 3.2% respectively, and data above shows, by Chinese medicine material
After crushing mixes with brown sugar, oligomeric fruit, lysine, adding four kinds of probiotics carries out the Chinese medicine microecological preparation of fermentation preparation,
Its effect more preferably, is possible to produce economic benefit higher during actual breeding production.
Antibody titer of ND reflects the defence capability of animal body, and antibody level is in positive with immunity of organism level
Close.Test group Laying-hen Serum antibody titres to newcastle disease virus is above control group and blank group, and to be fed with the test group of embodiment 5
5 best results.Indicating probiotics of the present invention can strengthen the immune response and resistance of body.
Claims (9)
1. a kind of Chinese medicine microecological preparation for improving chicken immunity, it is characterized in that：By fermented bacterium and following weight portion
Several raw material mixed fermentations are made：It is 15~20 parts of the Radix Astragali, 5~10 parts of Radix Angelicae Sinensis, 5~10 parts of the fruit of glossy privet, 5~10 parts of Radix Isatidis, big
5~10 parts of leafiness, 15~20 parts of the bark of eucommia, 5~10 parts of hawthorn, 5~10 parts of malt, 1~2 part of brown sugar, 1~3 part of FOS, rely
1~3 part of propylhomoserin；The fermented bacterium includes Bacillus subtilis strain, Lactobacillus plantarum strain, VREF strain and wine brewing
Yeast.
2. Chinese medicine microecological preparation according to claim 1, it is characterized in that：The consumption of the fermented bacterium is：Every 15~
The Radix Astragali correspondence of 20g adds 5~15mL of Bacillus subtilis strain, 5~15mL of Lactobacillus plantarum strain, VREF strain 15
3~10mL of~30mL and saccharomyces cerevisiae.
3. Chinese medicine microecological preparation according to claim 2, it is characterized in that：By fermented bacterium and the original of following parts by weight
Material mixed fermentation is made：20 parts of the Radix Astragali, 7 parts of Radix Angelicae Sinensis, 10 parts of the fruit of glossy privet, 10 parts of Radix Isatidis, 10 parts of folium isatidis, 20 parts of the bark of eucommia, mountain
7 parts of short, bristly hair or beard, 7 parts of malt, 1.5 parts of brown sugar, 3 parts of FOS, 2 parts of lysine；The consumption of the fermented bacterium is：Huang per 20g
Stilbene correspondence adds Bacillus subtilis strain 10mL, Lactobacillus plantarum strain 10mL, VREF strain 30mL, saccharomyces cerevisiae
5mL。
4. the Chinese medicine microecological preparation according to claims 1 to 3 any one, it is characterized in that：The bacillus subtilis
The viable count of strain is 5.0 × 109~10.0 × 109CFU/mL, the viable count of Lactobacillus plantarum strain is 5.0 × 107~10.0
×107CFU/mL, the viable count of VREF strain is 5.0 × 107~10.0 × 107CFU/mL, the work of S. cervisiae strain
Bacterium number is 1.0 × 109~5.0 × 109CFU/mL。
5. Chinese medicine microecological preparation according to claim 4, it is characterized in that：The viable count of the Bacillus subtilis strain
It is 1.0 × 1010CFU/mL, the viable count of Lactobacillus plantarum strain is 7.0 × 107CFU/mL, the viable count of VREF strain
It is 1.0 × 108CFU/mL, the viable count of S. cervisiae strain is 2.0 × 109CFU/mL。
6. the preparation method of Chinese medicine microecological preparation according to claim 1, it is characterized in that：Formula content of starting materials is ground into
60~120 mesh particles, the crushing raw material for then taking formula ratio mixes with brown sugar, FOS and lysine and fermented bacterium,
Sealed fermenting 15~60 days, obtain final product under the conditions of 20~40 DEG C.
7. the preparation method of Chinese medicine microecological preparation according to claim 6, it is characterized in that：Formula content of starting materials is ground into
100 mesh particles, the crushing raw material for then taking formula ratio mixes with brown sugar, FOS and lysine and fermented bacterium, 20~
Sealed fermenting 15~60 days, obtain final product under the conditions of 40 DEG C.
8. the preparation method of Chinese medicine microecological preparation according to claim 6, it is characterized in that：The sealed fermenting is 28
Fermented 15 days under the conditions of DEG C.
9. the usage of Chinese medicine microecological preparation according to claim 1, it is characterized in that：The continuous feeding of chick is added first
The feed of Chinese medicine microecological preparation 7 days, adds 3kg Chinese medicine microecological preparations in feed per ton；Continuous feeding is added without Chinese medicine again
The feed of probiotics 7 days；Continuous feeding adds the feed 7 days of Chinese medicine microecological preparation again, in adding 3kg in feed per ton
Medicine probiotics.
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| CN108651759A (en) * | 2018-07-26 | 2018-10-16 | 石阡县毅峰农牧开发有限公司 | A kind of chicken feed additive and preparation method thereof |
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