CN106028617B - Neutron-capture therapy device - Google Patents

Neutron-capture therapy device Download PDF

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Publication number
CN106028617B
CN106028617B CN201610192434.5A CN201610192434A CN106028617B CN 106028617 B CN106028617 B CN 106028617B CN 201610192434 A CN201610192434 A CN 201610192434A CN 106028617 B CN106028617 B CN 106028617B
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charged particle
particle beam
current value
neutron
accelerator
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CN106028617A (en
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福本康志
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Sumitomo Heavy Industries Ltd
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    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05HPLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/06Generating neutron beams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048Monitoring, verifying, controlling systems and methods
    • A61N5/1075Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05HPLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H6/00Targets for producing nuclear reactions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/109Neutrons

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Veterinary Medicine (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Radiation-Therapy Devices (AREA)
  • Particle Accelerators (AREA)
  • Measurement Of Radiation (AREA)

Abstract

The present invention provides a kind of neutron-capture therapy device.The neutron-capture therapy device can occur to carry out treatment appropriate in the case that current value reduces in the transmission of charged particle beam.The neutron-capture therapy device 1 has:1st amperometric determination portion (11) measures the electric current of charged particle beam (P);2nd amperometric determination portion (32) measures the electric current of charged particle beam (P) in side farther downstream than the 1st amperometric determination portion (11).According to this structure, in the case that the current value of charged particle beam (P) occurs between the 2nd amperometric determination portion (32) and the 1st amperometric determination portion (11) to be reduced, difference is generated between the 1st current value and the 2nd current value.Therefore, in the case where the difference is more than threshold value, the injection for coming from the charged particle beam (P) of accelerator (10) is controlled by control unit (100), control appropriate corresponding with the reduction of current value of charged particle beam (P) can be carried out.According to the above, can occur to carry out treatment appropriate in the case that current value reduces in the transmission of charged particle beam (P).

Description

Neutron-capture therapy device
Technical field
This application claims the Japanese patent applications the 2015-071667th based on March 31st, 2015 in Japanese publication Priority.The entire content of this Japanese application is incorporated by reference in this manual.
The present invention relates to a kind of neutron-capture therapy devices.
Background technology
In the past, as projecting neutron beam, come the device of neutron-capture therapy of killing cancer cell, it has been known that there is patent documents Recorded neutron-capture therapy device in 1.Recorded neutron-capture therapy device has injection band electrochondria in patent document 1 The accelerator 2 of beamlet and the target 5 that neutron beam is generated by irradiating charged particle beam.The neutron-capture therapy device is by setting The electron stripper 7 (stripper) in accelerator is set to measure the intensity (electric current of the charged particle beam projected from accelerator Value).
Patent document 1:International Publication WO2007/093965 specifications
In above patent document 1 in recorded neutron-capture therapy device, by using being arranged in the inside of accelerator 2 Electron stripper 7, measure the current value of charged particle beam projected from accelerator 2.However, being opened from the outlet of accelerator 2 The current value of charged particle beam reduces sometimes between beginning and target 5, and can not be caught with neutron recorded in above patent document 1 Therapy device is caught to detect the reduction phenomenon.At this point, the charged particle beam of preset dosage is not irradiated in target 5, having can The charged particle beam of preset dosage can not be generated.It is thereby possible to neutron beam can not be irradiated according to therapeutic scheme Irradiated body.
Invention content
Therefore, the purpose of the present invention is to provide a kind of neutron-capture therapy devices.The neutron-capture therapy device exists In the case of being lost in the transmission of charged particle beam, treatment appropriate can be carried out.
In order to solve the above problems, neutron-capture therapy device according to the present invention has:Accelerator projects band electrochondria Beamlet;Neutron beam generating unit is generated neutron beam by the irradiation of charged particle beam;Beam transport line will be penetrated from accelerator The Transport of Charged Particle Beams gone out is to neutron beam generating unit;1st amperometric determination portion measures the electric current of charged particle beam;2nd electric current is surveyed Determine portion, the electric current of charged particle beam is measured in side farther downstream than the 1st amperometric determination portion;And control unit, according to by the 1st electric current The 1st current value and accelerator is controlled by the 2nd current value that the 2nd amperometric determination portion measures that determination part measures;In the 1st current value In the case that difference between the 2nd current value is more than preset threshold value, control unit is to the charged particle from accelerator The injection of beam is controlled.
Neutron-capture therapy device according to the present invention has the 1st amperometric determination of the electric current for measuring charged particle beam Portion, and side farther downstream than the 1st amperometric determination portion measure charged particle beam electric current the 2nd amperometric determination portion.According to this Structure, in the case that the current value of charged particle beam occurs between the 2nd amperometric determination portion and the 1st amperometric determination portion to be reduced, Difference is generated between 1st current value and the 2nd current value.As a result, in the case where the difference is more than threshold value, by control unit to coming The injection of the charged particle beam of autoacceleration device is controlled, and can be performed in accordance with the reduction of the current value of charged particle beam Control appropriate.According to the above, can occur to carry out in the case that current value reduces in the transmission of charged particle beam appropriate Treatment.
Also, in neutron-capture therapy device according to the present invention, between the 1st current value and the 2nd current value In the case that difference is more than preset threshold value, control unit stops the injection of the charged particle beam from accelerator.By This can interrupt treatment itself in the case where the current value that charged particle beam occurs reduces.Thereby, it is possible to reduce composition to penetrate The component of beam transmission line it is activation, and can inhibit constitute beam transport line component deterioration.
Also, in neutron-capture therapy device according to the present invention, the 1st amperometric determination portion is set to be penetrated than setting The electromagnet upstream side of most upstream side in beam transmission line.It is possible to generate because of defective mode of electromagnet etc. The current value of charged particle beam reduces.As a result, by being set in the 1st amperometric determination portion than being arranged in beam transport line The electromagnet upstream side of most upstream side, can monitor the influence of all electromagnet in beam transport line, therefore can Improve the reliability of the reduction of the current value of detection charged particle beam.
Also, in neutron-capture therapy device according to the present invention, accelerator is the accelerator for accelerating anion, Has the stripping portion that cation is converted into from accelerated anion stripping electronics, the 1st amperometric determination portion can be by stripping portion It constitutes.Thereby, it is possible to measure the current value of the charged particle beam inside the accelerator than beam transport line upstream side.By This, can improve the reliability that the current value of detection charged particle beam reduces.
Invention effect
In accordance with the invention it is possible to provide a kind of neutron-capture therapy device.The neutron-capture therapy device is in band electrochondria In the case of current value reduction occurs in the transmission of beamlet, treatment appropriate can be carried out.
Description of the drawings
Fig. 1 is the sketch structure figure for the block structure for showing the neutron-capture therapy device involved by present embodiment.
Fig. 2 is the Sketch for the major part for showing schematically the neutron-capture therapy device involved by present embodiment Figure.
In figure:1- neutron-capture therapy devices, 10- accelerators, the 1st amperometric determination portions 11-, the 2nd amperometric determination portions 32-, 48- beam transport lines, 100- control units, T- targets.
Specific implementation mode
Hereinafter, refer to the attached drawing illustrates the embodiment of neutron-capture therapy device according to the present invention.In addition, In the following description, the same symbol is marked to identical or corresponding important document, and the repetitive description thereof will be omitted.
First, using Fig. 1, the summary of neutron-capture therapy device according to the present invention is illustrated.Fig. 1 is to show The sketch structure figure of the block structure of neutron-capture therapy device involved by present embodiment.Neutron involved by present embodiment Therapy device is captured, for example, boron neutron-capture therapy is used to carry out the neutron-capture therapy device that cancer controls Treatment.As shown in Figure 1, Neutron-capture therapy device 1 to injection have boron (10B the irradiated body 40 of patient) etc. irradiates neutron beam N.Neutron-capture therapy fills It sets 1 and has accelerator 10, neutron beam generating unit 36, beam transport line 48, the 1st amperometric determination portion 11, the 2nd amperometric determination portion 32 And control unit 100.
Accelerator 10 is the accelerator for accelerating charged particle and being projected as charged particle beam P.In the present embodiment, make Cyclotron is used for accelerator 10.Accelerator 10, for example, with generate beam radius be 40mm, 60kW (=30MeV × The ability of charged particle beam P 2mA).In addition, as accelerator 10, can use synchrotron, synchrocyclotron or Other accelerators of person's linear accelerator etc. replace cyclotron.
In present embodiment, accelerator 10 is the accelerator for accelerating anion, is had from accelerated anion stripping Electronics and be converted into cation aluminium foil stripper (stripping portion) 9, by aluminium foil stripper 9 remove electronics and be converted into from anion Cation, as charged particle beam P to the outside of accelerator 10 project.1st amperometric determination portion 11 is by 9 structure of aluminium foil stripper At.Due to aluminium foil stripper 9 can from the electronic, horological constant current value of stripping, exported the current value as the 1st current value To control unit 100.
The charged particle beam P projected from accelerator 10 passes through beam transport line 48.Beam transport line 48 becomes vacuum State.Beam transport line 48 is disposed with horizontal type steering gear 12,4 to cutter 14, water from the upstream side toward the downstream side Flat vertical-type steering gear 16, quadrupole electromagnet 18,19,20,90 degree of deflection electromagnet 22, quadrupole electromagnet 24, horizontal vertical types Steering gear 26, quadrupole electromagnet 28,4 are to cutter 30, the 2nd amperometric determination portion 32 and charged particle beam scanner section 34.As a result, Charged particle beam P passes sequentially through horizontal type steering gear 12,4 to cutter 14, horizontal vertical type steering gear 16, quadrupole electromagnet 18,19,20,90 degree of deflection electromagnet 22, quadrupole electromagnet 24, horizontal vertical type steering gear 26, quadrupole electromagnet 28,4 are to cutting Cutter 30, the 2nd amperometric determination portion 32, charged particle beam scanner section 34 and guide to neutron beam generating unit 36.Charged particle beam P It is irradiated in target T in neutron beam generating unit 36, therefore, generates neutron beam N.Neutron beam N is irradiated in illuminated on instrument table 38 Body 40.
In addition, the 1st amperometric determination portion 11 being made of the aluminium foil stripper 9 in accelerator 10 is set to than being arranged in beam The electromagnet (here, being horizontal type steering gear 12) of most upstream side in transmission line 48 is in the beam transmission of charged particle beam P Direction upstream side.
Horizontal type steering gear 12, horizontal vertical type steering gear 16,26 are, for example, to inhibit charged particle beam P using electromagnet Beam diverging steering gear.Similarly, quadrupole electromagnet 18,19,20,24,28 is, for example, and is charged using electromagnet The electromagnet of the adjustment of the beam axis of particle beams P.4 to cutter 14,30 be by cutting away the beam at end to carry out charged particle The cutter of the shaping of the beam of beam P.
90 degree of deflection electromagnet 22 are the electromagnet that the direction of travel of charged particle beam P is deflected into 90 degree.In addition, 90 degree Deflection electromagnet 22 is provided with switching part 42, charged particle beam P can be made to be detached from and draw from normal track by switching part 42 It is directed at beam trap 44.Beam trap 44 is equal before the treatment to confirm the output of charged particle beam P.In addition, beam Transmission line 48 is not limited to the above structure.Such as, it is convenient to omit each electromagnet (part) can also omit beam receipts Storage 44.And it is possible to beam transport line is set as linear or Y-shaped, rather than L-shaped.
2nd amperometric determination portion 32 is the current value (that is, charge, exposure dose rate) to the charged particle beam P for being irradiated in target T Carry out the amperometric determination portion of the real time measure.2nd amperometric determination portion 32 is not necessarily to contact with charged particle beam P and use can measure electricity The DCCT (DC Current Transformer) of the non-damage type (non-contact type) of stream.It 2nd amperometric determination portion 32 will The current value measured is exported as the 2nd current value to control unit 100.
Control unit 100 has the function of the 1 whole action of control neutron-capture therapy device, such as by CPU, ROM and RAM Deng composition.Also, control unit 100 is according to the 1st current value measured by the 1st amperometric determination portion 11 and by the 2nd amperometric determination portion 32 the 2nd current values measured control accelerator 10.
Charged particle beam scanner section 34 is scanning charged particle beam P, and to the irradiation of the charged particle beam P relative to target T The scanner section controlled.Here charged particle beam scanner section 34, for example, photograph of the control relative to the charged particle beam P of target T Penetrate position and the beam diameter etc. of charged particle beam P.Charged particle beam P is set to carry out swing by charged particle beam scanner section 34 dynamic Make or by making the beam diameter of charged particle beam P become larger, to which the irradiation area of the charged particle beam P on target T is extended. In addition, wobbling action is that the beam axis of the charged particle beam P of constant beam diameter is instigated to be periodically moved, and pass through this week Action of the movable expanded relative to the irradiated area of the charged particle beam P of target T of phase property ground.
Neutron beam generating unit 36 generates neutron beam N by charged particle beam P is irradiated in target T, and (not via collimator Diagram) project neutron beam N.Neutron beam generating unit 36 has the beam transport line 48 for being disposed in transmission charged particle beam P The target T of downstream end.In addition, neutron beam generating unit 36 is configured to subtract comprising what the neutron beam N for making to be generated by target T slowed down Fast material and the shield being arranged to cover them.
Then, the action of control unit 100 is described in detail with reference to figure 2.Fig. 2 is shows schematically present embodiment institute The sketch structure figure of the major part for the neutron-capture therapy device 1 being related to.In Fig. 2, show that horizontal type turns to as electromagnet 4 Device 12, horizontal vertical type steering gear 16, quadrupole electromagnet 18,19,20,90 degree of deflection electromagnet 22, quadrupole electromagnet 24, levels Vertical-type steering gear 26 and quadrupole electromagnet 28 etc..
In present embodiment, control unit 100 has the 1st current value and the 2nd electricity that operation is measured by the 1st amperometric determination portion 11 The operational part 51 of the difference between determination part 32 is flowed, and the operation that the difference is compared with preset defined threshold value Portion 52.For control unit 100 by the operation of operational part 51 and operational part 52, the difference between the 1st current value and the 2nd current value is big In the case of preset threshold value, the injection of the charged particle beam P from accelerator 10 is controlled.
Specifically, operational part 51 is electrically connected to the 1st amperometric determination portion 11, and obtain defeated from the 1st amperometric determination portion 11 The 1st current value gone out.Also, operational part 51 is electrically connected to the 2nd amperometric determination portion 32, and obtains from the 2nd amperometric determination portion 32 2nd current value of output.The difference of 51 operation of operational part the 1st current value and the 2nd current value, and export to operational part 52.Here, In the case of current value reduction occurs in the way that charged particle beam P is transmitted by beam transport line 48, the 2nd current value It is lower than the 1st current value.Also, the reduction amount of current value is bigger, and the difference of the 1st current value and the 2nd current value becomes bigger. In addition, as the reason of current value reduces occurs, the diverging and scanning due to charged particle beam P, charged particle beam P can be enumerated Part collision constitute beam transport line 48 vacuum tube wall portion and the case where disappear etc..
Operational part 52 is electrically connected to operational part 51, and obtains the difference of the current value exported from operational part 51.Also, operation Portion 52 is electrically connected to memory etc., and obtains the threshold value for being stored in the memory etc..Operational part 52 is by the difference and threshold of current value Value is compared.In the case where current value difference is more than preset threshold value, operational part 51 will be to from accelerator 10 The control signal that the injection of charged particle beam P is controlled is exported to the accelerator 10.It is more than in the difference of current value and sets in advance In the case of fixed threshold value, operational part 52 can export the control signal for stopping that charged particle beam is projected from accelerator 10.
In the case that the current value of charged particle beam P occurs in beam transport line 48 to be reduced, it is irradiated in irradiated body The dosage of 40 neutron beam N reduces.As a result, in order to compensate for the reduction of the current value of charged particle beam P, operational part 52 can be to prolong The mode of the irradiation time of long neutron beam, output extend the control signal of the injection time of accelerator 10, can also export increase The control signal of the ionic weight sent out from the ion source of accelerator 10.Furthermore it is possible to suitably set threshold value.For example, can set The value being set between the 2~5% of the setting value of the current value from the charged particle beam P that accelerator 10 projects.
Then, effect/effect of the neutron-capture therapy device 1 involved by present embodiment is illustrated.
Neutron-capture therapy device 1 involved by present embodiment has the 1st electric current of the electric current for measuring charged particle beam P Determination part 11, and measure in side farther downstream than the 1st amperometric determination portion 11 the 2nd amperometric determination portion of the electric current of charged particle beam P 32.According to this structure, the current value of charged particle beam P occurs between the 2nd amperometric determination portion 32 and the 1st amperometric determination portion 11 In the case of reduction, difference is generated between the 1st current value and the 2nd current value.As a result, the case where the difference is more than threshold value Under, the injection of the charged particle beam P from accelerator 10 is controlled by control unit 100, and can be with charged particle beam P The reduction of current value be performed in accordance with control appropriate.According to the above, electric current can occur in the transmission of charged particle beam P Value carries out treatment appropriate in the case of reducing.
In addition, in the reduction for thinking the current value only with the 2nd amperometric determination portion 32 detection charged particle beam P, can not grasp It is to produce current value in accelerator 10 (position of side farther downstream than aluminium foil stripper 9) to reduce (whether accelerator 10 occurs Exception), or producing current value in side farther downstream than aluminium foil stripper 9 reduces (whether beam transport line 48 occurs Exception).As a result, in the reduction of the current value of detection charged particle beam P, and treatment is interrupted when being safeguarded, be not only inspection It looks into beam transport line 48 to also need to check 10 ontology of accelerator, to increase cost and labour.On the other hand, according to this reality The neutron-capture therapy device 1 for applying mode, by least detect the 1st amperometric determination portion 11 (here, being aluminium foil stripper 9) with The current value of charged particle beam P has occurred between 2nd amperometric determination portion 32 to be reduced, and will appreciate that in accelerator 10 and beam transmission Exception has occurred in which side of circuit 48, therefore required operation when safeguarding can be greatly reduced.
Also, in the neutron-capture therapy device 1 involved by present embodiment, between the 1st current value and the 2nd current value Difference be more than preset threshold value in the case of, control unit 100 stops the injection of the charged particle beam P of autoacceleration device 10. Charged particle beam P can interrupt treatment itself in the case where current value reduction occurs as a result,.Thereby, it is possible to reduce composition to penetrate The component of beam transmission line it is activation, and inhibit constitute beam transport line component deterioration.
Also, in the neutron-capture therapy device 1 involved by present embodiment, the 1st amperometric determination portion 11 is set to ratio The 4 upstream side of electromagnet of most upstream side in beam transport line 48 is set.Due to the defective mode of electromagnet 4 It is reduced etc. the current value for being likely to occur charged particle beam P.Existed as a result, than setting by being set in the 1st amperometric determination portion 11 The 4 upstream side of electromagnet of most upstream side in beam transport line 48 can monitor all in beam transport line 48 The influence of electromagnet 4, therefore the reliability of the reduction of the current value of detection charged particle beam P can be improved.
Also, in the neutron-capture therapy device 1 involved by present embodiment, accelerator 10 is to accelerate adding for anion Fast device has the stripping portion 9 that cation is converted into from accelerated anion stripping electronics.Also, the 1st amperometric determination portion 11 are made of stripping portion 9.Thereby, it is possible to measure the band electrochondria inside the accelerator 10 than 48 upstream side of beam transport line The current value of beamlet P.Also, it is not required to increase newly the component of the current value for detecting the charged particle beam P projected from accelerator 10, And existing aluminium foil stripper 9 can be continued to use, therefore being capable of restraining device structure the phenomenon that complicating.
The present invention is not limited to the above embodiments.
For example, the 1st amperometric determination portion can not be made of aluminium foil stripper, current monitor etc. can be separately set.Also, it can To be arranged in the 1st amperometric determination portion than the 2nd amperometric determination portion upstream side equipped with multiple.Thereby, it is possible to rest in beam Which position of transmission line has occurred larger current value and reduces.

Claims (3)

1. a kind of neutron-capture therapy device, has:
Accelerator projects charged particle beam;
Neutron beam generating unit is generated neutron beam by the irradiation of the charged particle beam;
Beam transport line, will be from the Transport of Charged Particle Beams that the accelerator projects to the neutron beam generating unit;
1st amperometric determination portion measures the electric current of the charged particle beam;
2nd amperometric determination portion measures the electric current of the charged particle beam in side farther downstream than the 1st amperometric determination portion;With And
Control unit is measured according to the 1st current value measured by the 1st amperometric determination portion and by the 2nd amperometric determination portion The 2nd current value control the accelerator;
The 1st amperometric determination portion is set to more top than the electromagnet that the most upstream side in the beam transport line is arranged Swim side;
In the case that difference between the 1st current value and the 2nd current value is more than preset threshold value, the control Portion processed controls the injection of the charged particle beam from the accelerator.
2. neutron-capture therapy device according to claim 1, wherein
In the case that difference between the 1st current value and the 2nd current value is more than the preset threshold value, institute Control unit is stated to stop projecting the charged particle beam from the accelerator.
3. neutron-capture therapy device according to claim 1 or 2, wherein
The accelerator is the accelerator for accelerating anion, has from accelerated anion stripping electronics and is converted into The stripping portion of cation,
The 1st amperometric determination portion is made of the stripping portion.
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