CN105961845A - New antibiotic substitute and application thereof in livestock and poultry breeding - Google Patents
New antibiotic substitute and application thereof in livestock and poultry breeding Download PDFInfo
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- CN105961845A CN105961845A CN201610300090.5A CN201610300090A CN105961845A CN 105961845 A CN105961845 A CN 105961845A CN 201610300090 A CN201610300090 A CN 201610300090A CN 105961845 A CN105961845 A CN 105961845A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The present invention discloses a new antibiotic substitute and an application thereof in livestock and poultry breeding. The new antibiotic substitute is prepared from the following raw materials in parts by weight: 20-30 parts of pure water, 2-4 parts of brown sugar, 60-80 parts of wheat brans, 30-50 parts of soybean meal, 1-3 parts of compound microorganism liquid, and 0.4-0.6 part of compound Moracin T. The compound microorganism liquid contains bread yeasts and streptococcus thermophiles. The number of the active bread yeast is 90x10^8-110x10^8 cfu/ml and the number of the active thermophilic streptococcus is 190x10^8-210x10^8 cfu/ml. The results show that a thymus index and a spleen index in test group 1 are both higher than those in control group and antibiotic group. The thymus index and spleen index in test group 2-5 are similar to those in the antibiotic group, which indicates that the product can improve the non-specific immune functions of laying hens.
Description
Technical field
The present invention relates to antibiotic substitute, be specifically related to a kind of novel antibiotic substitute and the application in livestock and poultry cultivation thereof.
Background technology
Along with aquaculture intensive degree and the raising of breeding performonce fo animals, the stress level of animal is continuously increased, to various cause of diseases
The resistivity of microorganism declines, and often in clinical or subclinical pathological state, thus has influence on the performance of animal productiong potential
With the economic benefit of aquaculture, in order to prevent disease and increasing economic efficiency, widespread practice be add in feedstuff antibiotic and
Chemosynthesis class medicine.But the use of antibiotic causes Resistant strain or even can resist the generation of superbug of Multiple Classes of Antibiotics,
The quality of animal product also constantly reduces because of drug residue problem.Drug residue in the generation of Resistant strain and animal product is tight
Heavily threaten human health, the production of green safety animal product become worldwide animal foodstuff produce in theme, reduce or
Forbid that the use of antibiotic is imperative.
Owing to most livestock and poultry species all cultivates under conditions of feeding containing antibiotic feed, disable merely antibiotic,
The efficiency of feed utilization that can cause animal declines, and M & M rises, and causes aquaculture cost to increase, causes tremendous economic to damage
Lose.For the highest China of population density and poultry density and Asia, breeding environment is severe, the dependence journey to antibiotic
Du Genggao, the loss that disabling antibiotic causes can be bigger than other area any.
Feed safety is the basis of animal food safety, and along with growth in the living standard, people increasingly pay close attention to meat product peace
Complete and human body health, the requirement to feed safety is more and more higher, therefore develops and uses " green " feed additive to be
China's feedstuff industry and safe animal product produce the severe problem faced.Research and development antibiotic substitute becomes disabling
Antibiotic premise, is to maintain the key of Animal husbandry production sustainable development.
In recent years, domestic and international research worker finds organic acid, enzyme preparation, functional oligosaccharide, microbial ecological agent, Chinese herbal medicine and carries
Take thing etc., all can play the effect of antibiotic substitute under given conditions, but owing to there is various problem, above product
The application of product is very limited, and there is the shortcomings such as strong, the easy caking of hygroscopicity such as acidulant and functional oligosaccharide, enzyme preparation and micro-
Ecological agent has poor heat stability, easily the weakness of inactivation；There is cost height, resource-constrained, formula not in Chinese herbal medicine additive
The shortcomings such as science, quality are unstable.It is badly in need of exploitation novel antibiotic substitute.
Summary of the invention
It is an object of the invention to a kind of novel antibiotic substitute and the application in livestock and poultry cultivation thereof.
The above-mentioned purpose of the present invention is achieved by techniques below scheme:
A kind of novel antibiotic substitute, is prepared from by the raw material of following weight portion: pure water, 20～30 parts；Brown sugar,
2～4 parts；Testa Tritici, 60～80 parts；Bean cake, 30～50 parts；Composite bacteria liquid, 1～3 part；Compound Moracin T, 0.4～0.6
Part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria number of described bread microzyme is 90
× 108～110 × 108cfu/ml, the active bacteria number of described streptococcus thermophilus is 190 × 108～210 × 108cfu/ml.
Further, described novel antibiotic substitute is prepared from by the raw material of following weight portion: pure water, 25 parts；
Brown sugar, 3 parts；Testa Tritici, 70 parts；Bean cake, 40 parts；Composite bacteria liquid, 2 parts；Compound Moracin T, 0.5 part；Wherein,
Containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria number of described bread microzyme is 100 ×
108cfu/ml, the active bacteria number of described streptococcus thermophilus is 200 × 108cfu/ml.
Further, described novel antibiotic substitute is prepared from by the raw material of following weight portion: brown sugar, 2 parts；Wheat
Bran, 60 parts；Bean cake, 30 parts；Composite bacteria liquid, 1 part；Compound Moracin T, 0.4 part；Wherein, described composite bacteria liquid
In containing bread microzyme and streptococcus thermophilus, the active bacteria number of described bread microzyme is 90 × 108cfu/ml, described thermophilic chain
The active bacteria number of coccus is 190 × 108cfu/ml.
Further, described novel antibiotic substitute is prepared from by the raw material of following weight portion: brown sugar, 4 parts；Wheat
Bran, 80 parts；Bean cake, 50 parts；Composite bacteria liquid, 3 parts；Compound Moracin T, 0.6 part；Wherein, described composite bacteria liquid
In containing bread microzyme and streptococcus thermophilus, the active bacteria number of described bread microzyme is 110 × 108cfu/ml, described thermophilic
Streptococcic active bacteria number is 210 × 108cfu/ml.
The preparation method of above-mentioned novel antibiotic substitute, comprises the steps:
Step S1, is heated to 35～45 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs extremely
It is completely dissolved, is subsequently adding composite bacteria liquid, stand 20～30 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 3～5 points with step S1
Spray into the pure water of residue 2/3 weight portion after clock, seal and place 6～10 days and get final product.
Further, described preparation method comprises the steps:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Advantages of the present invention:
The present invention provide novel antibiotic substitute have with antibiotics as effect, the immunologic function of laying hen can be significantly improved.
Detailed description of the invention
Further illustrate the essentiality content of the present invention below in conjunction with embodiment, but do not limit scope with this.To the greatest extent
The present invention is explained in detail by pipe with reference to preferred embodiment, it will be understood by those within the art that, can be to the present invention
Technical scheme modify or equivalent, without deviating from the spirit and scope of technical solution of the present invention.
The preparation method of compound Moracin T sees document: Prenylated arylbenzofuran derivatives fromMorus
mesozygiawith antioxidant activity,Phytochemistry,70(2009),216–221。
Embodiment 1: the preparation of novel antibiotic substitute
Parts by weight of raw materials compares:
Pure water, 25 parts；Brown sugar, 3 parts；Testa Tritici, 70 parts；Bean cake, 40 parts；Composite bacteria liquid, 2 parts；Compound Moracin
T, 0.5 part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria of described bread microzyme
Number is 100 × 108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 200 × 108cfu/ml。
Preparation method:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Embodiment 2: the preparation of novel antibiotic substitute
Parts by weight of raw materials compares:
Brown sugar, 2 parts；Testa Tritici, 60 parts；Bean cake, 30 parts；Composite bacteria liquid, 1 part；Compound Moracin T, 0.4 part；
Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria number of described bread microzyme is
90×108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 190 × 108cfu/ml。
Preparation method:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Embodiment 3: the preparation of novel antibiotic substitute
Parts by weight of raw materials compares:
Brown sugar, 4 parts；Testa Tritici, 80 parts；Bean cake, 50 parts；Composite bacteria liquid, 3 parts；Compound Moracin T, 0.6 part；
Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria number of described bread microzyme is
110×108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 210 × 108cfu/ml。
Preparation method:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Embodiment 4: the preparation of novel antibiotic substitute
Parts by weight of raw materials compares:
Pure water, 25 parts；Brown sugar, 3 parts；Testa Tritici, 70 parts；Bean cake, 40 parts；Composite bacteria liquid, 2 parts；Compound Moracin
T, 0.4 part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria of described bread microzyme
Number is 100 × 108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 200 × 108cfu/ml。
Preparation method:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Embodiment 5: the preparation of novel antibiotic substitute
Parts by weight of raw materials compares:
Pure water, 25 parts；Brown sugar, 3 parts；Testa Tritici, 70 parts；Bean cake, 40 parts；Composite bacteria liquid, 2 parts；Compound Moracin
T, 0.6 part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria of described bread microzyme
Number is 100 × 108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 200 × 108cfu/ml。
Preparation method:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Embodiment 6: the contrast of embodiment 1, without compound Moracin T
Parts by weight of raw materials compares:
Pure water, 25 parts；Brown sugar, 3 parts；Testa Tritici, 70 parts；Bean cake, 40 parts；Composite bacteria liquid, 2 parts；Compound Moracin
T, 0.5 part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria of described bread microzyme
Number is 100 × 108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 200 × 108cfu/ml。
Preparation method:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Embodiment 7: effect example
Add the antibiotic substitute 1～6 of example 1～6 to layer diets by 4 ‰ and carry out feeding experiment (the most corresponding test group
1～7), test chicken meter 720, divide equally eight groups, respectively blank group, antibiotic group and test group 1～6, often organize 90
Chicken.1 age in days starts, and 8 week old terminate.All test chickens in 3 age in days immunity newcastle II system Attenuate vaccine eye dripping, 1 plumage part/
Only；In 10 age in days cervical region subcutaneous injection H9 subtype avian influenza inactivated vaccines, 0.3ml/ is only；The 20 age in days Newcastle disease attenuated Seedling (Lasota of immunity
System), drinking-water, 2 plumage parts/only.Often organize in 35 ages in days and select 10 execution at random, measure Immune Organs Index.Result shows,
The Thymus and Spleen index of test group 1 is above matched group and antibiotic group, and thymus index and the spleen of test group 2～5 refer to
Number is close with antibiotic group, illustrates that product of the present invention can improve the non-specific immunity of laying hen.
The effect of above-described embodiment indicates that the essentiality content of the present invention, but does not limit protection scope of the present invention with this.
It will be understood by those within the art that, technical scheme can be modified or equivalent, and not take off
Essence and protection domain from technical solution of the present invention.
Claims (6)
1. a novel antibiotic substitute, it is characterised in that be prepared from by the raw material of following weight portion: pure water, 20～30
Part；Brown sugar, 2～4 parts；Testa Tritici, 60～80 parts；Bean cake, 30～50 parts；Composite bacteria liquid, 1～3 part；Compound Moracin T,
0.4～0.6 part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria of described bread microzyme
Number is 90 × 108～110 × 108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 190 × 108～210 × 108cfu/ml。
Novel antibiotic substitute the most according to claim 1, it is characterised in that prepared by the raw material of following weight portion
Form: pure water, 25 parts；Brown sugar, 3 parts；Testa Tritici, 70 parts；Bean cake, 40 parts；Composite bacteria liquid, 2 parts；Compound
Moracin T, 0.5 part；Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, described bread microzyme
Active bacteria number be 100 × 108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 200 × 108cfu/ml。
Novel antibiotic substitute the most according to claim 1, it is characterised in that prepared by the raw material of following weight portion
Form: brown sugar, 2 parts；Testa Tritici, 60 parts；Bean cake, 30 parts；Composite bacteria liquid, 1 part；Compound Moracin T, 0.4 part；
Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria number of described bread microzyme is
90×108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 190 × 108cfu/ml。
Novel antibiotic substitute the most according to claim 1, it is characterised in that prepared by the raw material of following weight portion
Form: brown sugar, 4 parts；Testa Tritici, 80 parts；Bean cake, 50 parts；Composite bacteria liquid, 3 parts；Compound Moracin T, 0.6 part；
Wherein, containing bread microzyme and streptococcus thermophilus in described composite bacteria liquid, the active bacteria number of described bread microzyme is
110×108Cfu/ml, the active bacteria number of described streptococcus thermophilus is 210 × 108cfu/ml。
5. the preparation method of the arbitrary described novel antibiotic substitute of Claims 1 to 4, it is characterised in that comprise the steps:
Step S1, is heated to 35～45 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs extremely
It is completely dissolved, is subsequently adding composite bacteria liquid, stand 20～30 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 3～5 points with step S1
Spray into the pure water of residue 2/3 weight portion after clock, seal and place 6～10 days and get final product.
Preparation method the most according to claim 5, it is characterised in that comprise the steps:
Step S1, is heated to 40 DEG C by the pure water of 1/3 weight portion, adds brown sugar and compound Moracin T and stirs to complete
CL, is subsequently adding composite bacteria liquid, stands 25 minutes；；
Step S2, weighs the Testa Tritici after pulverizing and bean cake, mix homogeneously, and obtains solution mix and blend 4 minutes with step S1
After spray into the pure water of residue 2/3 weight portion, seal and place 8 days and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610300090.5A CN105961845A (en) | 2016-05-06 | 2016-05-06 | New antibiotic substitute and application thereof in livestock and poultry breeding |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610300090.5A CN105961845A (en) | 2016-05-06 | 2016-05-06 | New antibiotic substitute and application thereof in livestock and poultry breeding |
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| Publication Number | Publication Date |
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| CN105961845A true CN105961845A (en) | 2016-09-28 |
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| CN201610300090.5A Pending CN105961845A (en) | 2016-05-06 | 2016-05-06 | New antibiotic substitute and application thereof in livestock and poultry breeding |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836688A (en) * | 2009-04-30 | 2010-09-22 | 李海泉 | Preparation method of antibiotic-free microbial fermentation feed |
| CN102187956A (en) * | 2011-06-22 | 2011-09-21 | 毕景阳 | Non-antibiotic biological compound premix |
| CN102860407A (en) * | 2012-09-07 | 2013-01-09 | 云南轩瑜生物科技有限公司 | Livestock and poultry fermented feed as well as preparation method and use method thereof |
-
2016
- 2016-05-06 CN CN201610300090.5A patent/CN105961845A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101836688A (en) * | 2009-04-30 | 2010-09-22 | 李海泉 | Preparation method of antibiotic-free microbial fermentation feed |
| CN102187956A (en) * | 2011-06-22 | 2011-09-21 | 毕景阳 | Non-antibiotic biological compound premix |
| CN102860407A (en) * | 2012-09-07 | 2013-01-09 | 云南轩瑜生物科技有限公司 | Livestock and poultry fermented feed as well as preparation method and use method thereof |
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Application publication date: 20160928 |
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