CN1059594C - Chinese medicine Gutongning and its preparation - Google Patents

Abstract

The present invention relates to Chinese medicine (Gutongning). The present invention comprises psoralea fruit, eucommia barks, radix cyathulae, peach kernel, angelica, spatholobus stems, hemlock parsley, phrymatolin, asarum herb, notoginseng, corydalis tuber, myrrh and curare. The ingredients are manufactured into various traditional Chinese medicine preparations through process steps such as cleaning, baking, pulverizing, leaching, concentrating, mixing, baking, fine crushing, secondary fine crushing, sieving, mixing, etc. The present invention has preeminent causal treatment effect on orthopedic diseases such as hyperosteogeny, etc. The present invention has no side effect, and can be used for both oral administration and external application. The present invention has the advantages of simultaneous internal and external treatment, major direction of causal treatment, dual effect of manifestation treatment and causal treatment, rapid medical effect taking, short course of treatment, outstanding curative effect, stable curative effect, simple production method and easy batch commercial process.

Description

A kind of Chinese medicine and production method thereof for the treatment of orthopaedic diseases such as hyperosteogeny

The invention belongs to motherland's Chinese medicine and production method thereof, especially relate to a kind of Chinese medicine and production method thereof for the treatment of orthopaedic diseases such as hyperosteogeny.

Hyperosteogeny is the middle-aged and elderly people degeneration, people's sickness rate more than 40 years old is up to 83.6-92%, it also is one of commonly encountered diseases, still there is not specific medicament at present, though the sick medicine of multiple orthopaedics is arranged in known product or document record, in orthopaedics diseases such as treatment hyperosteogeny, play better action and effect, treatment time is long, slow deficiency takes effect but exist, these medicines are taken only by the mouth can not external, perhaps can only external application and can not take orally, the medicine that has is that lumbago is controlled waist, skelalgia is controlled lower limb, takes stopgap measures and does not effect a permanent cure, and can not reach radical cure.

The purpose of this invention is to provide a kind of Chinese medicine for the treatment of orthopaedic diseases such as hyperosteogeny, should be able to short, the instant effect of treatment time in orthopaedic disease such as treatment hyperosteogeny etc., can take orally and can external application, effecting a permanent cure is main, treating both the principal and secondary aspects of a disease, should be able to reach radical cure to orthopaedic diseases such as hyperosteogenys.

Another object of the present invention provides a kind of production method for the treatment of the Chinese medicine of orthopaedic diseases such as hyperosteogeny, should be able to be easy to the Chinese medicine of the orthopaedic diseases such as treatment hyperosteogeny of the multiple dosage form of industrialized Development and Production.

The objective of the invention is to adopt following technical proposals to realize:

1, a kind of Chinese medicine for the treatment of orthopaedic diseases such as hyperosteogeny is characterized in that it mainly is to be made by the activated feedstock of following percentage by weight:

Fructus Psoraleae 2-30% Cortex Eucommiae 2-30% river cattle sunset 2-30% Semen Persicae 2-20% Radix Angelicae Sinensis 2-30%

Caulis Spatholobi 2-30% Rhizoma Chuanxiong 2-20% Herba speranskiae tuberculatae 2-30% Herba Asari 2-20% Radix Notoginseng 1-20%

Rhizoma Corydalis 2-30% Myrrha 2-20% Semen Strychni 1-20%

Above-mentioned each raw material of Chinese medicine gross weight is absolutely.

2, a kind of production method for the treatment of the Chinese medicine of orthopaedic diseases such as hyperosteogeny is characterized in that it comprises the following steps:

(1), cleans: earlier with the Cortex Eucommiae, river Niu Xi, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Herba speranskiae tuberculatae, Herba Asari, Myrrha

This eight herbal medicine is cleaned, is dried;

(2), the oven dry: air dried eight herbal medicines are put into drying room, temperature control 40-60 ℃ oven drying at low temperature 3-6 hour;

(3), pulverize: will dry the eight herbal medicines weighing by weight respectively of postcooling, and send pulverizer to room temperature

It is stand-by to mix the pulverizing back;

(4), leach: Fructus Psoraleae, Caulis Spatholobi, Rhizoma Corydalis three herbal medicines respectively by weight weighing, are put into

Decoction pot decocting in water twice, add the water of water 5-8 times weight the first time, decocted 2-3 hour,

Leach medicinal liquid, add the water of water 4-6 times weight for the second time, decocted 1.5-2.5 hour, again

The inferior medicinal liquid that leaches;

(5), concentrate: the medicinal liquid of twice decoction is mixed, decocted again 0.5-1.5 hour, become to concentrate

The medicinal liquid of state;

(6), mix: pour spissated medicinal liquid and the eight flavor medicated powder that crush into the blender mixing and stirring:

(7), oven dry: put into oven for drying again, temperature control 50-70 ℃, water content is in 10%;

(8), in small, broken bits: pulverizing again, the 60-200 mesh sieve is stand-by excessively;

(9), mix: with Semen Strychni make the moxibustion Semen Strychni Pulveratum, Radix Notoginseng is made Radix Notoginseng powder, is the 60-200 order,

Mix with the meticulous powder of above-mentioned ten Herba indigoferae Pseudotinctoriae again, make the loose powder agent;

(10), dress capsule: the loose powder agent is incapsulated, make capsule;

(11), other dosage forms: the loose powder agent is added shape-fixing agent film-making granule type, add filler system cream pill

Type adds baste and makes oral liquid.

The beneficial effect that the present invention is compared with prior art had;

1, from technical scheme traditional Chinese medical science pathological analysis of the present invention:

Motherland's medical science think hyperosteogeny be old suffer from a deficiency of the kidney relevant with bone degeneration, kidney is behaved the beginning originally, kidney storing essence, the main again bone of kidney is given birth to marrow, kidney governing storage, kidney essense benefit is hidden not beneficial letting out, so " interior through the big opinion of YIN YANG classification of natural phenomena ", " interior through nephropathy visceral relationship by " are said " kidney producing bone marrow ", " people crosses 40 kidney qis and declines ".Because old suffering from a deficiency of the kidney gradually lost the function that its main bone is given birth to marrow, causes a little less than the atrophic debility of bones muscle bone degeneration.Modern medicine study proves that the autacoid of kidney has regulating action to calcium, phosphorus metabolism process, when the human body deficiency of kidney-QI, healthy energy must be empty, and battalion defends imbalance, interspaces of skin and muscles being loose, exopathogen invading the interior, so the heresy that susceptible wind and cold is wet, hinder the gas of Yuanyang again, wound can cause coagulation of QI-blood in channels, impatency is not smooth, the bone mistake is moistened foster, and labor of a specified duration etc. also can cause kidney to be hindered, and kidney is hindered also can cause bone degeneration.According to motherland's theory of medicine, the present invention lays particular emphasis on invigorating the liver and kidney, strengthening bone and muscle, warm smart blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, wind-damp dispelling cold expelling, the numbness that disappears pain relieving, the aseptic inflammation that makes outgrowth bony spur thing stimulate surrounding soft tissue to cause disappears rapidly, repair the articular cartilage face of wearing and tearing, the bony spur that has formed is dwindled or stop development.Like this to effect a permanent cure treating both the principal and secondary aspects of a disease, the purpose that reaches radical cure and be difficult for recurring.

2, from technical solution of the present invention traditional Chinese medical science pharmacology analysis-by-synthesis:

According to traditional Chinese medical science pathological analysis, through to plurality of Chinese component screening, analysis, trial-production and clinical and experimental study, proposed to select for use 13 flavor natural Chinese medicine plants such as Fructus Psoraleae, process.The pharmacology analysis-by-synthesis; Be with Fructus Psoraleae, the Cortex Eucommiae, river Niu Xiwei " monarch ", invigorating the liver and kidney, bone and muscle strengthening, strong waist knee joint, the same usefulness of three flavor Chinese medicines, the efficiency of drugs of can mutually promoting." minister " with Caulis Spatholobi, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Corydalis, blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood, collateral dredging stopping numbness pain." assistant " with Herba speranskiae tuberculatae, Herba Asari, wind-damp dispelling cold expelling, relaxing muscles and tendons and activating QI and blood in the collateral." make " with Myrrha, Radix Notoginseng powder, moxibustion Semen Strychni three flavors and share, can go into the twelve regular channels, the logical internal organs meridians of a surname, removing blood stasis and activating blood flow, subduing swelling and relieving pain.

More than all medicines " monarch " synergism, supplement and complement each other, play invigorating the liver and kidney, bone and muscle strengthening jointly, the collateral dredging blood circulation promoting and blood stasis dispelling, arthralgia pain disappears.To orthopaedic diseases such as hyperosteogenys tangible permanent curing action can be arranged, no matter which kind of dosage form this medicine is, all have no side effect, but i.e. oral administration external application again simultaneously, Chinese medicine, it is main effecting a permanent cure, treating both the principal and secondary aspects of a disease, drug effect is fast, short treating period, determined curative effect and stablize.

3, the selected raw material of Chinese medicine of technical solution of the present invention is common Chinese herbal medicine, and cost is low, the finished product price is low, and the patient easily bears.Product forms can have capsule, loose powder agent, sheet granule type, cream pill, oral liquid, external application different dosage form such as to smear, the doctor is clinical select for use or the patient to abide by doctor's Orally taken and externally all very convenient.

4, according to clinical trial analysis:

800 many cases patients' treatment is observed in clinical trial, and 20 days is a course of treatment, and diseases such as human body osteoarthritis, hyperosteogeny, prolapse of intervertebral disc, soft tissue injury, tenosynovitis are had tangible curative effect, and total obvious effective rate reaches 98%, and no longer recurrence, obtains radical cure.Use the patient of other similar Chinese and western drugs DeGrain clinically, still can obtain tangible curative effect after using this medicine instead.

5, the Chinese medicine production method of the orthopaedic diseases such as treatment hyperosteogeny that provide of the present invention, suitability for industrialized production is easy in batch.

Technical scheme of the present invention in sum can obtain beneficial effect preferably.

Further describe technical solution of the present invention: embodiment 1 in conjunction with the embodiments:

A kind of Chinese medicine for the treatment of orthopaedic diseases such as hyperosteogeny, the percentage by weight of each activated feedstock is:

Fructus Psoraleae 13% Cortex Eucommiae 11% river cattle sunset, 11% Semen Persicae, 7% Radix Angelicae Sinensis 8%

Caulis Spatholobi 11% Rhizoma Chuanxiong 5% Herba speranskiae tuberculatae 8% Herba Asari 4% Radix Notoginseng 4%

Rhizoma Corydalis 11% Myrrha 5% Semen Strychni 3% also can add excipient, filler,

Adjuvants such as flavoring agent.

Make dosage forms such as capsule, loose powder agent, sheet granule, cream pill, liquid oral liquid or external application liniment.Embodiment 2:

A kind of production method for the treatment of the Chinese medicine of orthopaedic diseases such as hyperosteogeny comprises the following steps;

(1), cleans: earlier with the Cortex Eucommiae, river Niu Xi, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Herba speranskiae tuberculatae, Herba Asari, Myrrha

This eight herbal medicine is cleaned, is dried;

(2), the oven dry: air dried eight herbal medicines are put into drying room, temperature control 40-60 ℃ oven drying at low temperature 3-6 hour;

(3), pulverize: will dry the eight herbal medicines weighing by weight respectively of postcooling, and send pulverizer to room temperature

It is stand-by to mix the pulverizing back;

(4), leach: Fructus Psoraleae, Caulis Spatholobi, Rhizoma Corydalis three herbal medicines respectively by weight weighing, are put into

Decoction pot decocting in water twice, add the water of water 5-8 times weight the first time, decocted 2-3 hour,

Leach medicinal liquid, add the water of water 4-6 times weight for the second time, decocted 1.5-2.5 hour, again

The inferior medicinal liquid that leaches;

(5), concentrate: the medicinal liquid of twice decoction is mixed, decocted again 0.5-1.5 hour, become to concentrate

The medicinal liquid of state;

(6), mix: pour spissated medicinal liquid and the eight flavor medicated powder that crush into the blender mixing and stirring:

(7), oven dry: put into oven for drying again, temperature control 50-70 ℃, water content is in 10%;

(8), in small, broken bits: pulverizing again, the 60-200 mesh sieve is stand-by excessively;

(9), mix: with Semen Strychni make the moxibustion Semen Strychni Pulveratum, Radix Notoginseng is made Radix Notoginseng powder, is the 60-200 order,

Mix with the meticulous powder of above-mentioned ten Herba indigoferae Pseudotinctoriae again, make loose powder agent or fine grained agent;

(10), dress capsule: loose powder agent or granule are incapsulated, make capsule;

(11), other dosage forms: the loose powder agent is added shape-fixing agent, send pelleter film-making, granule type, adding is filled out

The agent system of filling cream pill-type adds baste and makes oral liquid.Can produce various dosage forms

Chinese patent medicine.

Claims (4)

1, a kind of Chinese medicine for the treatment of orthopaedic diseases such as hyperosteogeny is characterized in that it mainly is to be made by the activated feedstock of following percentage by weight:

Fructus Psoraleae 2-30% Cortex Eucommiae 2-30% river cattle sunset 2-30% Semen Persicae 2-20% Radix Angelicae Sinensis 2-30%

Caulis Spatholobi 2-30% Rhizoma Chuanxiong 2-20% Herba speranskiae tuberculatae 2-30% Herba Asari 2-20% Radix Notoginseng 1-20%

Rhizoma Corydalis 2-30% Myrrha 2-20% Semen Strychni 1-20%

Above-mentioned each raw material of Chinese medicine gross weight is absolutely.

2, the Chinese medicine of orthopaedic disease such as treatment hyperosteogeny according to claim 1 is characterized in that the percentage by weight of each activated feedstock is:

Fructus Psoraleae 13% Cortex Eucommiae 11% river cattle sunset, 11% Semen Persicae, 7% Radix Angelicae Sinensis 8%

Caulis Spatholobi 11% Rhizoma Chuanxiong 5% Herba speranskiae tuberculatae 8% Herba Asari 4% Radix Notoginseng 4%

Rhizoma Corydalis 11% Myrrha 5% Semen Strychni 3%

3, the Chinese medicine of orthopaedic disease such as treatment hyperosteogeny according to claim 1 is characterized in that adding adjuvants such as excipient, filler, flavoring agent, makes dosage forms such as capsule, loose powder agent, sheet granule, cream pill, liquid oral liquid or external application liniment.

4, the production method of the Chinese medicine of orthopaedic disease such as a kind of treatment hyperosteogeny as claimed in claim 1 is characterized in that it comprises the following steps:

(1), cleans: earlier with the Cortex Eucommiae, river Niu Xi, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Herba speranskiae tuberculatae, Herba Asari, Myrrha

This eight herbal medicine is cleaned, is dried;

(2), the oven dry: air dried eight herbal medicines are put into drying room, temperature control 40-60 ℃ oven drying at low temperature 3-6 hour;

(3), pulverize: will dry the eight herbal medicines weighing by weight respectively of postcooling, and send pulverizer to room temperature

It is stand-by to mix the pulverizing back;

(4), leach: Fructus Psoraleae, Caulis Spatholobi, Rhizoma Corydalis three herbal medicines respectively by weight weighing, are put into

Decoction pot decocting in water twice, add the water of water 5-8 times weight the first time, decocted 2-3 hour,

Leach medicinal liquid, add the water of water 4-6 times weight for the second time, decocted 1.5-2.5 hour, again

The inferior medicinal liquid that leaches;

(5), concentrate: the medicinal liquid of twice decoction is mixed, decocted again 0.5-1.5 hour, become to concentrate

The medicinal liquid of state;

(6), mix: pour spissated medicinal liquid and the eight flavor medicated powder that crush into the blender mixing and stirring:

(7), oven dry: put into oven for drying again, temperature control 50-70 ℃, water content is in 10%;

(8), in small, broken bits: pulverizing again, the 60-200 mesh sieve is stand-by excessively;

(9), mix: with Semen Strychni make the moxibustion Semen Strychni Pulveratum, Radix Notoginseng is made Radix Notoginseng powder, is the 60-200 order,

Mix with the meticulous powder of above-mentioned ten Herba indigoferae Pseudotinctoriae again, make the agent of Chinese medicine loose powder;

(10), dress capsule: the loose powder agent is incapsulated, make capsule;

(11), other dosage forms: the loose powder agent is added shape-fixing agent film-making granule type, add filler system cream pill

Type adds baste and makes oral liquid.