CN105853522A - Composition for treating chicken infectious gonads gastritis and preparation method of composition - Google Patents
Composition for treating chicken infectious gonads gastritis and preparation method of composition Download PDFInfo
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- CN105853522A CN105853522A CN201610304978.6A CN201610304978A CN105853522A CN 105853522 A CN105853522 A CN 105853522A CN 201610304978 A CN201610304978 A CN 201610304978A CN 105853522 A CN105853522 A CN 105853522A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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Abstract
The invention provides composition for treating chicken infectious gonads gastritis. The composition comprises, by weight, 35-45 parts of coptis chinensis, 55-65 parts of astragalus membranaceus, 15-25 parts of aspergillus niger, and 25-35 parts of lactic acid bacteria. The preparation having Chinese herbal medicine combined with microbial flora has great treatment effect on chicken infectious gonads gastritis. With coordinative action among Chinese herbal medicine, aspergillus niger and lactic acid bacteria, immunity of human body is strengthened during treatment of chicken infectious gonads gastritis, and cure rate and efficacy are increased accordingly. Meanwhile, the composition has no tolerance and drug resistance to chickens and low drug residues. The composition is made of materials easily obtainable, and is convenient to prepare, highly stable in storage, and suitable for industrialized production.
Description
Technical field
The invention belongs to technical field of veterinary, be specifically related to a kind of compositions for treating chicken proventriculitis
And preparation method thereof.
Background technology
Chicken proventriculitis be a kind of with poultry undergrowth, become thin, regularity poor, the outward appearance symptom such as feces punishment in advance
And glandular stomach enlargement, or glandular stomach applanation nipple even disappears, and glandular stomach mucosa ulcer, comes off, muscular stomach Endothelium corneum and flesh
Gastric mucosa face crateriform ulcer, gizzard erosion are the epidemic diseases of principal character.This disease is a kind of " switch " formula
Disease, the cause of disease complicated (cause of disease+inducement), be mostly perpendicular propagation or pollute Marek's vaccine or fowlpox epidemic disease
Seedling and propagate, the most all have a generation, but high with sickness rate during seasonal law, when especially turning the winter with the autumn
Loss is serious, fairly obvious in northern China performance.Morbidity age in days is indefinite, typically at 30-60 age in days, but
Just can show in 3 Japanese instar chicklings, 16 week old kind chickens also time have been reported that.Sickness rate is 15%～60%,
Average 23%, mortality rate 10%～50%, average 20%.Proventriculitis can betide different cultivars laying hen and
Broiler, wherein falls ill with egg-laying chicken and Growing Chicken more, more serious, and broiler morbidity is less, after morbidity
Glandular stomach swelling degree is also serious not as good as laying hen and Growing Chicken.Course of disease l0～15d, peak mortality is after morbidity 5～8
D, some chicken houses possible persistent period is longer, up to about 35d.When there being serious secondary infection, the most naughty
Rate is higher, and chicken group undergrowth after recovery, Egg Production of Laying Hens is without peak.
Patent CN105381456A provides a kind of pharmaceutical preparation treating chicken proventriculitis, by following weight proportioning
Raw material make: Radix et Caulis Opuntiae Dillenii 32～28 parts, Fructus Hippophae dry fruit 32～28 parts, sea Piao sheath 27～23 parts, Cortex Moutan
22～18 parts, pepsin 18～12 parts, vitamin B1 12～8 parts, zymosan 400～200 parts, micro-
Ecological agent 7～3 parts；Above-mentioned microbial ecological agent is made up of 4 kinds of floras: bacillus subtilis, lichens bud
Born of the same parents bacillus, pediococcus acidilactici, bacillus bifidus, its composition is 6:2:1:1, total viable count is 2 ×
1010CFU/g.Living environment is required extremely harsh by the bacillus bifidus in this pharmaceutical preparation, easily by oxygen, moisture,
The impact of the conditions such as light, protection substrate, the most acidproof the most alkaline-resisting, therefore its microbial ecological agent is difficult to configure.
And the composition of this technology is complicated, during configuration, the requirement to environment is higher, therefore to chicken gland
The therapeutic effect of gastritis is inconspicuous.
Summary of the invention
In order to solve existing treatment treatment chicken proventriculitis pharmaceutical preparation present in problem, the invention provides
A kind of compositions for treating chicken proventriculitis, cheaper starting materials is easy to get, preparation simplicity, cure rate and effective percentage
Height, and do not produce drug resistance and Drug resistance, drug residue is low.
The present invention solves the technical scheme that technical problem used:
A kind of compositions for treating chicken proventriculitis, is made up of following parts by weight component: 35～45 weight
Part Rhizoma Coptidis, 55～65 weight portion Radixs Astragali, 15～25 weight portion Aspergillus niger and 25～35 weight portion lactic acid bacterias.
Chinese Drug Rhizomes of Coptis and the Radix Astragali add and easily obtains and aspergillus niger that survival rate is high, lactic acid bacteria, medicine can be effectively improved
Effect, solving bacillus bifidus in prior art on environmental requirement height thus affects the problem of drug effect, wherein lactic acid
Bacterium weight fraction should be greater than Aspergillus niger weight fraction, it is to avoid affects lactic bacteria activity.
Wherein,
Rhizoma Coptidis: taste company, Rhizoma Coptidis, Rhizoma Coptidis, belongs to Ranunculaceae, Coptis herbaceos perennial, and phyllopodium is hesitated,
Hard papery, ovum shape triangle, three totally cleave, central authorities' sliver ovum shape rhombus, pinniform drastic crack, and there is sharp sawtooth at edge,
The raw sliver in side does not wait 2 drastic cracks；The long 5-12cm of petiole.Wild or cultivate in the mountain valley of height above sea level 1000-1900m
In cool wet concealment thick forest.There is heat clearing and damp drying, effect of eliminating fire and detoxication, there is specially good effect to processing anaerobe.
The Radix Astragali: herbaceos perennial, main root is sturdy, slightly conical, stem four prismatic, base portion multi-branched,
Single leaf is to life；Tool short handle；Blade lanceolar, raceme Xiang Sheng, flower is wilfully in inflorescence, pyrene
Subsphaeroidal, leaf tool short handle, the obvious knee joint of the nearly base portion of cylinder is bent, sliver triangular shape oval in lower lip.Wild Yushan Hill
The place that top, hillside, border etc. are the most relatively dried, likes warm, cold-resistant, drought-enduring fearness flood.Relieve inflammation or internal heat foster
Cloudy, effect of removing toxic substances of purging heat, gives full play to the internal organs of body, makes body more healthy, improve self and exempt from
Epidemic disease power.
Aspergillus niger: Aspergillus niger is a common strain in aspergillus fungi, can produce enzyme preparation (egg
White enzyme, amylase, pectase).Aspergillus niger secretion produce amylase, saccharifying enzyme, citric acid, gluconic acid,
Gallic acid, there is cracking larger molecular organics and indissoluble inorganic matter, it is simple to chicken intestinal is digested and assimilated, thus
Improve the effect of gastroenteritis symptom.
Lactic acid bacteria: lactic acid bacteria refers to that the class that fermenting carbohydrate primary product is lactic acid is positive without spore, Gram’s staining
The general name of property antibacterial, for prokaryote.It is that a class can utilize fermentable carbohydrate to produce a large amount of lactic acid
The common name of antibacterial.This bacterioid is extremely wide in distributed in nature, has abundant species diversity.In must
Indispensable and have the flora of important physiological function, it is widely present in the intestinal of chicken.At present by state
Inside and outside biologist is confirmed, enteral lactic acid bacteria and good health and a long life have very close relationship, can effectively arrange
Scold pathogen determine grow, thus play occupancy protection effect.
Chinese Drug Rhizomes of Coptis and the Radix Astragali add and easily obtains and aspergillus niger that survival rate is high, lactic acid bacteria, can effectively carry
High-drug-effect, solves that bacillus bifidus in prior art is high on environmental requirement thus the problem that affects drug effect.
As preferably, described compositions is made up of following parts by weight component: 40 weight portion Rhizoma Coptidis, 60 weight
Part Radix Astragali, 20 weight portion Aspergillus niger and 30 weight portion lactic acid bacterias.
Invention also provides the preparation method of described compositions: it is yellow that (1) weighs 35～45 weight portions respectively
Even with the 55～65 weight portion Radixs Astragali, it is ground into powder after mix homogeneously, then crosses 150 mesh sieves and obtain mixture
A；(2) weigh 15～25 weight portion Aspergillus niger and 25～35 weight portion lactic acid bacterias, be sufficiently mixed to obtain mixing
Thing B；(3) by after mixture A and mixture B mix homogeneously.
The invention have the benefit that
The compositions of the treatment chicken proventriculitis that 1, the present invention provides uses Chinese medicinal components to combine higher black of survival rate
Aspergillosis and lactic acid bacteria, notable to the therapeutic effect of chicken proventriculitis, by Chinese medicine and aspergillus niger, the association of lactic acid bacteria
Same-action, while preventing and treating chicken proventriculitis, improves the immunity of body, thus improves cure rate.
2, compositions of the present invention does not produce drug resistance and Drug resistance, and drug residue is low.
3, composite formula of the present invention is simple, and cheaper starting materials is easy to get, easy and simple to handle, is suitable for industry metaplasia
Produce.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment pair
The present invention is further elaborated.Should be appreciated that specific embodiment described herein is only in order to explain
The present invention, is not intended to limit the present invention.
Embodiment 1
(1) weigh 400g Rhizoma Coptidis and the 600g Radix Astragali is mixed into and pulverizes last, cross 150 mesh sieves, in obtaining
Medicine mixture；(2) 200g Aspergillus niger and 300g lactic acid bacteria are weighed, after being sufficiently mixed, by itself and step (1)
Gained Traditional Chinese drug mixture uses three-dimensional mixer mix homogeneously.
Embodiment 2
(1) weigh 350g Rhizoma Coptidis and the 550g Radix Astragali is mixed into and pulverizes last, cross 150 mesh sieves, in obtaining
Medicine mixture；(2) 150g Aspergillus niger and 250g lactic acid bacteria are weighed, after being sufficiently mixed, by itself and step (1)
Gained Traditional Chinese drug mixture uses three-dimensional mixer mix homogeneously.
Embodiment 3
(1) weigh 450g Rhizoma Coptidis and the 650g Radix Astragali is mixed into and pulverizes last, cross 150 mesh sieves, in obtaining
Medicine mixture；(2) 250g Aspergillus niger and 350g lactic acid bacteria are weighed, after being sufficiently mixed, by itself and step (1)
Gained Traditional Chinese drug mixture uses three-dimensional mixer mix homogeneously.
Clinical trial:
(1) certain chicken farm, sick chicken 1000,30 ages in days, sick chicken initial stage performance spirit is depressed, drop-head vertical fin,
Wing is sagging, and feather is fluffy and disorderly the most whole, searches for food and drink water minimizing, growth retardation or stagnation, weight gain stop or
Being gradually reduced, chicken body is pale, extremely becomes thin, and feed conversion rate reduces, and has indigested feedstuff in feces,
Some chickens shed tears, swell eye and respiratory symptom, arranges white or green loose stool；
(2) by 1000 sick chickens according to the amount distribution of experimental group with each 500 of matched group, respectively they are put
Putting in the environment of identical, environment is the suitable environment of poultry；
(3) experimental group medicine is drug component described in the embodiment of the present invention 1, and matched group medicine is:
CN102309606A discloses a kind of Chinese medicine oral liquid treating avian infectious proventriculitis, and its crude drug is:
Radix Isatidis 45-55g, Herba Schizonepetae 45-55g, Herb Gynostemmae Pentaphylli 25-35g, Radix Astragali 45-55g, Rhizoma Coptidis 25-35g,
Flos Lonicerae 45-55g, Flos Chrysanthemi Indici 45-55g, Radix Sophorae Tonkinensis 25-35g, Radix Platycodonis 15-25g, Radix Rehmanniae 25-35g,
Semen Armeniacae Amarum 15-25g, Fructus Carthami tinctorii 25-35g, Fructus Forsythiae 15-25g, Gypsum Fibrosum 25-35g, Radix Glycyrrhizae 15-25g；
(4) by experimental group medicine and matched group medicine according to the addition of 1.5 kgs/tonne of feedstuffs, add respectively
During feedstuff adds, often meal is fed to disease chicken and takes, and measurement in two hours after taking for the last time every day
The body temperature of chicken, observes the mental status of chicken, the body weight measuring chicken in every two days, observes body part extensive of chicken
Multiple situation and chicken are by the food-intake in sky；
(5) continued treatment is after one week, and result of the test is shown in Table 1:
Table 1:
Note: cure rate=(total chicken number-do not cure number of elements-death number of elements)/total chicken number × 100%；
Effective percentage=(total chicken number-death number of elements)/total chicken number × 100%.
By the result of the test of experimental group and matched group it follows that the compositions of patent of the present invention can be more preferable
Treatment chicken proventriculitis, under equal conditions cure rate and effective percentage are higher, and chicken resume speed faster, has
Preferably therapeutic effect.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all at this
Any amendment, equivalent and the improvement etc. made within bright spirit and principle, should be included in the present invention
Protection domain within.
Claims (3)
1. the compositions being used for treating chicken proventriculitis, it is characterised in that described compositions is by following weight
Number component forms: 35～45 weight portion Rhizoma Coptidis, 55～65 weight portion Radixs Astragali, 15～25 weight portion Aspergillus niger
With 25～35 weight portion lactic acid bacterias.
2. the compositions for treating chicken proventriculitis as claimed in claim 1, it is characterised in that described group
Compound is made up of following parts by weight component: 40 weight portion Rhizoma Coptidis, the 60 weight portion Radixs Astragali, 20 weight portions are black
Aspergillosis and 30 weight portion lactic acid bacterias.
3. the method being used for treating chicken proventriculitis compositions described in preparation claim 1 or 2, its feature exists
In, described preparation method comprises the steps:
(1) weigh 35～45 weight portion Rhizoma Coptidis and the 55～65 weight portion Radixs Astragali respectively, grind after mix homogeneously
Powdered, then cross 150 mesh sieves and obtain mixture A；(2) weigh 15～25 weight portion Aspergillus niger and
25～35 weight portion lactic acid bacterias, are sufficiently mixed to obtain mixture B；(3) mixture A and mixture B is mixed
After closing uniformly.
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| CN201610304978.6A CN105853522A (en) | 2016-05-09 | 2016-05-09 | Composition for treating chicken infectious gonads gastritis and preparation method of composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106306548A (en) * | 2016-09-21 | 2017-01-11 | 王丽娟 | Feed additive for preventing and treating chicken proventriculitis and ventriculitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106306548A (en) * | 2016-09-21 | 2017-01-11 | 王丽娟 | Feed additive for preventing and treating chicken proventriculitis and ventriculitis |
| CN106306548B (en) * | 2016-09-21 | 2019-12-06 | 王丽娟 | Feed additive for preventing and treating proventriculitis and myogastritis of chicken |
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Application publication date: 20160817 |