CN105622412B - The method of one kind 2 [2 (2,4 difluorophenyl) pi-allyl] 1,3 diethyl malonates of synthesis - Google Patents
The method of one kind 2 [2 (2,4 difluorophenyl) pi-allyl] 1,3 diethyl malonates of synthesis Download PDFInfo
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- CN105622412B CN105622412B CN201610022153.5A CN201610022153A CN105622412B CN 105622412 B CN105622412 B CN 105622412B CN 201610022153 A CN201610022153 A CN 201610022153A CN 105622412 B CN105622412 B CN 105622412B
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- Prior art keywords
- difluorophenyls
- allyl
- synthesis
- hydrochloric acid
- dichloromethane
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/25—Preparation of halogenated hydrocarbons by splitting-off hydrogen halides from halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610022153.5A CN105622412B (en) | 2016-01-14 | 2016-01-14 | The method of one kind 2 [2 (2,4 difluorophenyl) pi-allyl] 1,3 diethyl malonates of synthesis |
Applications Claiming Priority (1)
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CN201610022153.5A CN105622412B (en) | 2016-01-14 | 2016-01-14 | The method of one kind 2 [2 (2,4 difluorophenyl) pi-allyl] 1,3 diethyl malonates of synthesis |
Publications (2)
Publication Number | Publication Date |
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CN105622412A CN105622412A (en) | 2016-06-01 |
CN105622412B true CN105622412B (en) | 2017-11-24 |
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CN201610022153.5A Active CN105622412B (en) | 2016-01-14 | 2016-01-14 | The method of one kind 2 [2 (2,4 difluorophenyl) pi-allyl] 1,3 diethyl malonates of synthesis |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5349099A (en) * | 1993-12-13 | 1994-09-20 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
CN102906087A (en) * | 2010-05-19 | 2013-01-30 | 桑多斯股份公司 | Process for the preparation of chiral triazolones |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH09188637A (en) * | 1996-01-09 | 1997-07-22 | Mitsubishi Chem Corp | Production of 3-bromo-2-(substituted)-1-propene |
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2016
- 2016-01-14 CN CN201610022153.5A patent/CN105622412B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5349099A (en) * | 1993-12-13 | 1994-09-20 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
CN102906087A (en) * | 2010-05-19 | 2013-01-30 | 桑多斯股份公司 | Process for the preparation of chiral triazolones |
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CN105622412A (en) | 2016-06-01 |
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Effective date of registration: 20160809 Address after: 315100 Zhejiang city of Ningbo province Yinzhou District River Street Tianyuan Lane No. 127 building A Applicant after: Luo Chengcai Address before: 315000 Zhejiang city of Ningbo province high tech Zone Jinghua Road No. 188 Building 2 room 1048 Applicant before: NINGBO XINKAI BIOTECHNOLOGY CO., LTD. |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20161202 Address after: Camphor Street Jiangdong District 315040 in Zhejiang province Ningbo City No. 515 building 053 (10-1) (central office) Applicant after: NINGBO XINKAI BIOTECHNOLOGY CO., LTD. Address before: 315100 Zhejiang city of Ningbo province Yinzhou District River Street Tianyuan Lane No. 127 building A Applicant before: Luo Chengcai |
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Effective date of registration: 20191209 Address after: Chaoyang Industrial Park, 408300 Chongqing County of Dianjiang city (Dianjiang Guixi) Patentee after: Tiansheng Pharmaceutical Group Co., Ltd. Address before: Camphor Street Jiangdong District 315040 in Zhejiang province Ningbo City No. 515 building 053 (10-1) (central office) Patentee before: NINGBO XINKAI BIOTECHNOLOGY CO., LTD. |