CN105456689A - Traditional Chinese medicine composition for treating diabetes as well as preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating diabetes as well as preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes as well as a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of radix ophiopogonis, 10-16 parts of Chinese mahonia, 18-24 parts of pseudo-ginseng, 16-22 parts of honey-fried licorice root, 8-14 parts of radix cyathulae, and 1-2 parts of saffron crocus. The preparation method comprises the following steps: carrying out ethanol extraction and aqueous extraction on the raw materials, filtering the extracting solution to obtain extract, drying, smashing, and screening by a sieve, thus obtaining the traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition can be used for preparing medicines for treating type I diabetes, type II diabetes and secondary diabetes, and is good in curative effect, rapid in taking effects, and small in toxic and side effects when used for treating diabetes, is convenient to prepare, can improve the immunity of the organism and comprehensively regulate metabolic disorders, has a certain repairing effect for pancreatic tissue damage, and can inhibit the expression of insulinase gene mRNA, a patient can not have dependency on medicine, and thus the traditional Chinese medicine composition is suitable for being widely popularized.
Description
Technical field
The present invention relates to field of medicaments, specifically a kind of Chinese medicine composition for the treatment of diabetes and its production and use.
Background technology
Diabetes in the world many countries have become commonly encountered diseases and the frequently-occurring disease that mortality rate is only second to cancer, acquired immune deficiency syndrome (AIDS) and cardiovascular disease, and about there are 100,000,000 diabeticss in China at present, is the second in the world diabetes big countries; Comparatively commonly type Ⅱdiabetes mellitus clinically, be called non-insulin-dependent diabetes mellitus, type Ⅱdiabetes mellitus is also Adult Onset's patients with type Ⅰ DM in the past, how 35-40 year sequela, onset is slow, concealment, and some patients finds in physical examination or when checking other diseases.The ability producing insulin in type Ⅱdiabetes mellitus ward mate body not completely loses, and in some patient bodies, insulin even produces too much, but the action effect of insulin is had a greatly reduced quality, and the insulin therefore in patient body is a kind of shortage relatively; The secretion of insulin in body can be stimulated by some oral drugs, but still have some patients to need to carry out insulinize as type Ⅰ diabetes mellitus patient to the later stage; The main purpose for the treatment of diabetes comprises: correct metabolism disorder, eliminate symptom, safeguard good live and work ability; Prevent various acute or chronic complicating diseases and the generation with disease, life-saving, reduce disability rate and die of illness; In hypoglycemic medicine clinical used at present, various Western medicine has certain limitation and very serious untoward reaction, as caused hypoglycemia, lactic acidosis etc., and Chinese medicine lacks curative effect affirmative, clinician and all acceptant antihypelipidemic preparation of patient, go back neither one medicine so far and thoroughly can cure diabetes, Western medicine also just can control blood glucose, by contrast, Chinese medicine has himself advantage, and there is good development prospect, therefore, in the urgent need to a kind of Chinese medicinal formulae effectively treating diabetes of developmental research to solve the blank in this field.
Summary of the invention
The object of the present invention is to provide Chinese medicine composition of the treatment diabetes that a kind of cost is low, good effect, instant effect, toxic and side effects are little and its production and use, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine composition for diabetes, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 6-12 part, Mahonia fortunei (Lindl.) Fedde 10-16 part, Radix Notoginseng 18-24 part, Radix Glycyrrhizae Preparata 16-22 part, Radix Cyathulae 8-14 part, Stigma Croci 1-2 part.
As the further scheme of the present invention: the Chinese medicine composition of described treatment diabetes, is prepared from by the raw material of following weight portion: Radix Ophiopogonis 8-10 part, Mahonia fortunei (Lindl.) Fedde 12-14 part, Radix Notoginseng 20-22 part, Radix Glycyrrhizae Preparata 18-20 part, Radix Cyathulae 10-12 part, Stigma Croci 1-2 part.
As the present invention's further scheme: the Chinese medicine composition of described treatment diabetes, is prepared from by the raw material of following weight portion: Radix Ophiopogonis 9 parts, Mahonia fortunei (Lindl.) Fedde 13 parts, Radix Notoginseng 21 parts, Radix Glycyrrhizae Preparata 19 parts, Radix Cyathulae 11 parts, Stigma Croci 1 part.
As the present invention's further scheme: the preparation method of the Chinese medicine composition of described treatment diabetes, comprises the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:5 ~ 1:8 adds the alcoholic solution that volume fraction is 75 ~ 95% in extraction pot, extract 1 ~ 4 time under 70 ~ 95 DEG C of conditions, each 30 ~ 50 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 1 ~ 2 time, with raw material: the weight ratio of water=1:10 ~ 1:15 adds purified water in extraction pot, heat to 80 ~ 100 DEG C, slow fire heating makes it keep micro-to boil, 30 ~ 60 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, merge permeate and leave standstill cooling within more than 6 hours, to get supernatant for subsequent use;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
As the present invention's further scheme: with raw material: the weight ratio of alcoholic solution=1:6 adds the alcoholic solution that volume fraction is 75% in extraction pot, extract 2 times under 85 DEG C of conditions, each 40 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract; Medicinal residues continue water extraction 2 times, with raw material: the weight ratio of water=1:12 adds purified water in extraction pot, heat to 90 DEG C, slow fire heating makes it keep micro-to boil, 45 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, it is for subsequent use that merging permeate standing cooling 7.5h gets supernatant.
As the present invention's further scheme: the Chinese medicine composition that step 3 obtains is prepared into tablet, granule, capsule or honeyed pill.
As the present invention's further scheme: the application of Chinese medicine composition in preparation treatment type Ⅰ diabetes mellitus, II diabetes and secondary diabetes medicine of described treatment diabetes.
In the present invention, the pharmacological action of each raw material comprises:
1. Radix Ophiopogonis: Liliaceae Ophiopogon perennial evergreen herbaceous plant, sweet in the mouth, micro-hardship, cold nature; Return stomach, lung, heart channel; Lung moistening clears away heart-fire, purge heat and promote the production of body fluid, the preventing or arresting vomiting that reduces phlegm, control and cough row water; Cough for dryness of the lung dry cough, deficiency of YIN consumptive disease, sore throat pharyngalgia, Tianjin wound be thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation; Modern pharmacological research shows, Radix Ophiopogonis mainly containing dwarf lilyturf glycosides, steroidal saponin, alkaloid, sitosterol, glucose, aminoacid, vitamin etc., has resisting fatigue, scavenging free radicals, raising cellular immune function and hypoglycemic effect; Have calmness, hypnosis Radix Ophiopogonis, resist myocardial ischemia, the effect of the anti-rhythm of the heart.
2. Mahonia fortunei (Lindl.) Fedde: Berberidaceae Mahonia fortunei (Lindl.) Fedde platymiscium, flower sweet in the mouth, cool in nature, root, stem bitter in the mouth, cold in nature; Enter lung, liver, large intestine channel; Heat clearing away tonify deficiency, relieving cough and resolving phlegm; Control pulmonary tuberculosis hemoptysis, osteopyrexia and fever, dizziness and tinnitus, waist soreness, vexed, conjunctival congestion; Modern pharmacological research shows, containing berberine, jateorhizine, magnoflorine; There is antibacterial action, of short duration or slight blood pressure drops can be caused, can adrenergic boosting be suppressed;
3. Radix Notoginseng: be the dry root welding technology of panax araliaceae plant Panaxnotoginseng (Burk.) F.H.Chen; Sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp; Dissipating blood stasis hemostasis, subduing swelling and relieving pain; Modern pharmacological research show long-term taking can vessel softening, blood circulation promoting, reduction blood fat, skin care of invigorating blood circulation.
4. Radix Glycyrrhizae Preparata: be leguminous plant is the Preparation process product of Radix Glycyrrhizae; Sweet in the mouth, property are flat; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, the mitigation property of medicine, heat-clearing and toxic substances removing; The symptoms such as treatment weakness of the spleen and stomach, deficiency of QI in middle-JIAO, cough and asthma; Modern pharmacological research shows, Radix Glycyrrhizae Preparata also has the chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, has the effect of antiinflammatory and antiallergic action, scalable body's immunity, antitumor and pain relieving; With middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription, nourishing YIN of enriching blood.
5. Radix Cyathulae: be the dry root of amaranthaceous plant Radix Cyathulae CyathulaofficinalisKuan; Sweet in the mouth, micro-hardship; Property is put down; Return liver, kidney channel; Blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, a surname is loose fall let out, easing joint movement, inducing diuresis for treating stranguria syndrome; For amenorrhea lump in the abdomen, retention of placenta, injury from falling down, rheumatic arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood; Promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, ignite descending; Modern pharmacological research shows, Polysaccharide From Cyathula Officinalis Kuan not only has antitumor action, can also alleviate ring phosphorus and dislike peripheral blood leucocyte caused by amine to reduce, can significantly promote mouse peripheral blood leukocyte; Serum IgM and IgG level can be made to raise, all have stronger facilitation to nonspecific immunity, humoral immunization and cellular immune function.
6. Stigma Croci: be the dry stigma of irides Stigma Croci CrocussativusL; Sweet in the mouth, property are flat; GUIXIN, Liver Channel; Blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization; Be used for the treatment of amenorrhea lump in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad; Modern pharmacology will just show, Stigma Croci has the effect of blood circulation promoting and blood stasis dispelling, broad spectrum anticancer, enhancing immunity, treatment cardiovascular and cerebrovascular disease.
Owing to being furnished with Radix Glycyrrhizae Preparata and Stigma Croci in the present invention, therefore not inventing and be not suitable for diabetes in pregnancy patient.
Compared with prior art, the invention has the beneficial effects as follows: the combination of Chinese medicine selected by the present invention based on the traditional Chinese medical science to pathogenetic understanding of diabetes and Therapeutic Principle, with reference to modern pharmacology achievement in research, mutually worked in coordination with by each material medicine, all medicines share, selected medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, carry out preferably to the parts by weight of each material medicine, significantly can reduce the effect of experimental NIDDM rat fasting blood-glucose, glycolated hemoglobin, have the effect regulating diabetic nephropathy rats lipid metabolism simultaneously; Clinical trial shows, for type Ⅱdiabetes mellitus, the treatment total effective rate of the present invention to patients with NIDDM is more than 95%, has significant difference with metformin hydrochloride tablet matched group, and is better than metformin hydrochloride tablet in the clinical symptoms improving type Ⅱdiabetes mellitus and adjustment lipid metabolism; Raw material of the present invention is simple, and preparation method is simple and convenient, and cost is low, and for the preparation for the treatment of type Ⅰ diabetes mellitus, II diabetes and secondary diabetes, good effect, instant effect, is suitable for extensive popularization.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
Treat a Chinese medicine composition for diabetes, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 6 parts, Mahonia fortunei (Lindl.) Fedde 10 parts, Radix Notoginseng 18 parts, Radix Glycyrrhizae Preparata 16 parts, Radix Cyathulae 8 parts, Stigma Croci 1 part; The preparation method of the Chinese medicine composition of described treatment diabetes, comprises the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:5 adds the alcoholic solution that volume fraction is 75% in extraction pot, extract 1 time under 70 DEG C of conditions, each 50 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 1 time, with raw material: the weight ratio of water=1:10 adds purified water in extraction pot, heat to 80 DEG C, slow fire heating makes it keep micro-to boil, 60 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, merge permeate and leave standstill cooling within more than 6 hours, to get supernatant for subsequent use;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
Embodiment 2
Treat a Chinese medicine composition for diabetes, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 12 parts, Mahonia fortunei (Lindl.) Fedde 16 parts, Radix Notoginseng 24 parts, Radix Glycyrrhizae Preparata 22 parts, Radix Cyathulae 14 parts, Stigma Croci 2 parts.
The preparation method of the Chinese medicine composition of described treatment diabetes, comprises the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:8 adds the alcoholic solution that volume fraction is 95% in extraction pot, extract 4 times under 95 DEG C of conditions, each 30 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 2 times, with raw material: the weight ratio of water=1:15 adds purified water in extraction pot, heat to 100 DEG C, slow fire heating makes it keep micro-to boil, 30 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, merge permeate and leave standstill cooling within more than 6 hours, to get supernatant for subsequent use;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
Embodiment 3
Treat a Chinese medicine composition for diabetes, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 9 parts, Mahonia fortunei (Lindl.) Fedde 13 parts, Radix Notoginseng 21 parts, Radix Glycyrrhizae Preparata 19 parts, Radix Cyathulae 11 parts, Stigma Croci 1 part.
The preparation method of the Chinese medicine composition of described treatment diabetes, comprises the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:6 adds the alcoholic solution that volume fraction is 75% in extraction pot, extract 2 times under 85 DEG C of conditions, each 40 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 2 times, with raw material: the weight ratio of water=1:12 adds purified water in extraction pot, heat to 90 DEG C, slow fire heating makes it keep micro-to boil, 45 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, it is for subsequent use that merging permeate standing cooling 7.5h gets supernatant;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
Embodiment 4
Treat a Chinese medicine composition for diabetes, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 8 parts, Mahonia fortunei (Lindl.) Fedde 12 parts, Radix Notoginseng 20 parts, Radix Glycyrrhizae Preparata 18 parts, Radix Cyathulae 10 parts, Stigma Croci 1 part.
The preparation method of the Chinese medicine composition of described treatment diabetes, comprises the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:7 adds the alcoholic solution that volume fraction is 95% in extraction pot, extract 3 times under 80 DEG C of conditions, each 35 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 1 time, with raw material: the weight ratio of water=1:13 adds purified water in extraction pot, heat to 95 DEG C, slow fire heating makes it keep micro-to boil, 60 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, merge permeate and leave standstill cooling within 6.5 hours, to get supernatant for subsequent use;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
Embodiment 5
Treat a Chinese medicine composition for diabetes, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 10 parts, Mahonia fortunei (Lindl.) Fedde 14 parts, Radix Notoginseng 22 parts, Radix Glycyrrhizae Preparata 20 parts, Radix Cyathulae 12 parts, Stigma Croci 2 parts.
The preparation method of the Chinese medicine composition of described treatment diabetes, comprises the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:8 adds the alcoholic solution that volume fraction is 95% in extraction pot, extract 4 times under 90 DEG C of conditions, each 30 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 2 times, with raw material: the weight ratio of water=1:14 adds purified water in extraction pot, heat to 90 DEG C, slow fire heating makes it keep micro-to boil, 40 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, merge permeate and leave standstill cooling within 6 hours, to get supernatant for subsequent use;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
The Chinese medicine composition of the treatment diabetes described in embodiment 1-5 can be prepared into tablet, granule, capsule or honeyed pill; This Chinese medicine composition also can be widely used in preparation treatment type Ⅰ diabetes mellitus, II diabetes and secondary diabetes medicine.
Below further research is done to drug effect of the present invention:
The present invention is on the impact of experimental NIDDM rat fasting blood-glucose and glycolated hemoglobin
This experiment, is investigated pharmacological action of the present invention for animal model with the experimental NIDDM rat caused by streptozotocin.
1, materials and methods
1) material
A. animal: SD rat, healthy male, body weight 160 ~ 210g;
B. medicine and reagent: the Chinese medicine composition prepared in the embodiment of the present invention, during test, use water is mixed with the solution of desired concn;
C. Glucose estimation kit and glycolated hemoglobin measure test kit.
2) method
A. rat model of type 2 diabetes mellitus is divided at random Normal group, model control group, embodiment 1 group, embodiment 2 groups, embodiment 3 groups, embodiment 4 groups, embodiment 5 groups;
B. medication
Normal group: gavage distilled water;
Model control group: gavage metformin hydrochloride;
Embodiment 1 ~ 5 group: every day, dosage was 5g crude drug/kg; Often group gavage every day once, continuous 30 days.
3) statistical method
Experimental data is with mean ± standard deviation
represent, adopt spss13.0 statistical software, compare between one factor analysis of variance group, significance level with 0.05 and 0.01 for standard.
2, result
1) after experimental NIDDM rat copies successfully grouping, through 4 weeks Drug therapys, model group fasting glucose compared with normal matched group obviously raises (P<0.01), and embodiment 1 group, embodiment 2 groups, embodiment 3 groups, embodiment 4 groups, embodiment 5 groups of fasting glucose compared with normal matched groups significantly decline (P<0.01); Model group glycolated hemoglobin and Normal group significantly raise (P<0.01), and embodiment 1 group, embodiment 2 groups, embodiment 3 groups, embodiment 4 groups, embodiment 5 groups of glycated hemoglobin levels comparatively model group obviously reduce (P<0.05 or P<0.01); Result shows the present invention and has the effect significantly reducing experimental NIDDM rat blood sugar and glycolated hemoglobin.
Table 1 the present invention is on the impact of experimental NIDDM rat fasting blood-glucose and glycolated hemoglobin
Note: with Normal group ratio
*p<0.01; With model group ratio
△p<0.05,
△ △p<0.01.
2) fasting blood glucose level can the basic carbohydrate metabolism situation of a time point in antimer, a time period glycometabolic average level in the main antimer of glycolated hemoglobin, usually clinically carrys out Diagnosis and Treat diabetes with this two indices.Result of the test shows, the present invention has the effect significantly reducing experimental NIDDM rat fasting blood-glucose, glycolated hemoglobin.The present invention is the compound Chinese patent medicine summed up in clinical practice for many years, improving type Ⅱdiabetes mellitus clinical symptoms, reduces in blood glucose and has good effect.
The present invention is to the clinical research of II phase diabetics
Treat II phase diabetics 250 example with embodiment of the present invention 1-5, be divided into 5 groups, often organize 50 examples, and treat 50 examples for matched group with metformin hydrochloride.
Specific experiment method is as follows:
1, materials and methods
1) 300 routine patients are divided into each 50 examples for the treatment of 1-5 group and matched group 50 routine, often organize age, sex, the course of disease, body weight, fasting glucose (FBG) 2 hours blood glucoses after the meal early, not obvious through statistical procedures difference, there is comparability.
2) diagnostic criteria fasting glucose >=7.0mmol/L (or random blood sugar >=11.1mmol/L), or oral glucose tolerance test 2h blood glucose >=11.1mmol/L.
3) treatment and observational technique
1. Therapeutic Method all patients is stopped using, and all have the medicine of blood sugar lowering, effect for reducing blood fat.Keeping on a diet, to move and on diabetes education basis, matched group gives metformin hydrochloride tablet 0.5g, every day 2 times is oral; Treatment 1-5 group gives medicine of the present invention, and every day three times is oral, each 2 (tablets), and often group was all 1 course for the treatment of with 4 weeks, altogether 3 courses for the treatment of of treatment.
2. observation index clinical symptoms integration, FBG, glycolated hemoglobin (HbAlc), T-CHOL (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C).
3. statistical method measurement data adopts t inspection, and enumeration data adopts x
2inspection.
4) curative effect determinate standard is with reference to the criterion of therapeutical effect in " new Chinese medicine studies guideline when participating in the cintest ": effective: symptom integral reduces >=70%, FBG is normal or decline more than 40%, the improvement of normal or more than 30%, the TC that declines of HbAlc, TG, LDL-C is more than 30% or recover normal; Effective: symptom integral reduces that >=30%, FBG is normal or more than 20%, the HbAlc that declines is normal or more than 10%, the TC that declines, TG, LDL-C make moderate progress before comparatively treating, but not enough effective standard; Invalid: clinical symptoms thing change or to increase the weight of or less than 30%, lab index is unchanged or raise.
2, result
1) 1 group of effective 42 example is treated, effective 7 examples, invalid 3 examples, total effective rate 96%.
Treat 2 groups of effective 40 examples, effective 8 examples, invalid 2 examples, total effective rate 96%.
Treat 3 groups of effective 42 examples, effective 7 examples, invalid 1 example, total effective rate 98%.
Treat 4 groups of effective 43 examples, effective 5 examples, invalid 1 example, total effective rate 98%.
Treat 5 groups of effective 45 examples, effective 4 examples, invalid 1 example, total effective rate 98%.
Effective 35 examples of matched group, effective 7 examples, invalid 8 examples, total effective rate 84%.
Each group of total effective rate compares, and treatment group is better than matched group, and the present invention just has high cure rate and effective percentage under the mutual compatibility effect of each raw material.
2) clinical symptoms integration is respectively organized clinical symptoms integration before and after treatment and is improved situation and compare in table 4; Compare before and after treatment, treatment 1-5 group has pole significant difference (P<0.01), and matched group has statistical significance (P<0.05); Often compare after group treatment, have significant difference (P<0.01), prompting the present invention is better than Western medicine in the clinical symptoms of improvement II phase diabetes.
Table 4 respectively group treatment front and back clinical symptoms integration improvement situation compares
| Group | Number of cases | Before treatment | After treatment |
| Matched group | 50 | 16.4±3.13 | 12.6±2.22 * |
| Treat 1 group | 50 | 16.3±3.10 | 8.4±2.37 **△ |
| Treat 2 groups | 50 | 16.3±3.09 | 8.2±2.18 **△ |
| Treat 3 groups | 50 | 16.5±3.11 | 8.1±2.34 **△ |
| Treat 4 groups | 50 | 16.6±3.07 | 8.1±2.09 **△ |
| Treat 5 groups | 50 | 16.2±3.15 | 8.0±2.07 **△ |
Note: compare with before treatment, * P<0.05, * * P<0.0,1; △ P<0.01 is compared with after treatment of control group.
3) carbohydrate metabolism respectively organize treatment before and after FBG, HbAlc change compare in table 5; All obviously can reduce FBG and HbAlc after each group for the treatment of, difference has significance (P<0.01), but each group is compared without significant difference, and it is suitable with metformin hydrochloride that prompting the present invention improves glycometabolic effect.
Table 5 respectively group treatment front and back FBG, HbAlc change compares
Note: compare with before treatment, * P<0.01.
4) blood lipid metabolism respectively organize treatment before and after Blood Lipid compare in table 6; Compare before and after treatment group treatment, by significant difference (P<0.01), matched group difference thing significant (P>0.05); After treatment, treatment group, compared with matched group, has significant difference (P<0.01), shows that the present invention has the lipometabolic effect of good adjustment, is better than metformin hydrochloride tablet.
Table 6 each group treatment front and back lipid metabolism change is compared (
mmol/L)
Note: compare with before treatment,
*p<0.01; Compare with after treatment of control group
△p<0.01.
Model case is illustrated:
1) Wang, 55 years old, ill about 20 years, insulin injection every day 58 units, simultaneously oral acarbose and N'-Dimethylguanylguanidine, when coming medical, detect blood glucose 16-18mmol/L, glucose in urine +++, there is insulin resistant, clinical needle-like is: the whole body is weak, soreness of the waist and knees, thirsty, frequent micturition, polyphagia, spontaneous perspiration, and two lower limb muscles is stiff, deep,thready and forceless pulse, tongue falls few tongue also; Take Chinese medicine composition of the present invention (capsule) after five weeks, gradually reduce insulin injection amount; Inactive hypoglycemic medicine and injection of insulin after three months, only take separately Chinese medicine composition of the present invention, after four months, patient is not when using insulin and hypoglycemic medicine, and diabetes clinical symptoms disappears substantially; Clinical detection patient insulin release test euglycemia is 6.5mmol/L, without recurring after following the trail of half a year.
2) Song, man, 41 years old, ill about 3 years, seek medical advice effect of taking medicine of many places was undesirable, when coming medical, detects: glucose in urine ++++, blood glucose 12.46mmol/L; Clinical symptoms for: constipated when dizzy, vexed, irritability, bitter taste, dry pharynx, oral erosion, stool, time and suffer from diarrhoea, dream at night is peaceful, little furuncle and phyma has appearred in skin, symptom more than three is not obvious, body constitution is partially fat, normal sense is weak, can not adhere to normal work; Stringy and thready pulse, body of the tongue are partially red, purple lip is blue or green, dark complexion is not flourish; After patient's oral account, its inducement is diagnosed to be: because of thorny, brain overwork, the feelings will damage of working, psychological unbalance and bringing out; Then examine as depressed emotion, stagnation of liver-QI with deficiency of the spleen, damage of kidney-YIN makes so; Take Chinese medicine composition of the present invention (capsule) after 20 days, orally-taken blood sugar reducing medicine of stopping using, after testing, blood glucose, glucose in urine recover normal, and all disease knowing are moved back; Clinical detection patient insulin release test euglycemia is 6.1mmol/L, without recurring after following the trail of half a year.
3) Korea Spro, man, 46 years old, ill about 16 years, festers one week because of biped redness more and goes to a doctor, and when examining, spiritlessness and weakness, Mian Koushi in vain, fester depending on illiteracy, xerostomia, stomach poor appetite, numb limbs and tense tendons, biped red swelling of the skin, night bedroom poor, be hard and dry, constipation; Fasting glucose is 21.15mmol/L, and glucose in urine is +++, blood pressure is 160/100 millimetres of mercury; Tcm diagnosis is: glycosuria disease, and disease belongs to deficiency of both QI and YIN, stops in turbid damp; Western medicine diagnose is: type Ⅱdiabetes mellitus, and diabetes merge acra ulcer; After taking 6 courses for the treatment of of Chinese medicine composition of the present invention (capsule), patient mental is amelioration day by day, mouth is dry, numb limbs and tense tendons alleviates, glycemic control is stablized, biped portion flushing disappears, interdigit without pus and sepage, interdigit appears, wound healing is good, the newborn light red tissue growth of part, the burned black dead bark in vola portion comes off gradually; Blood glucose 6.7mmol/L, walking of having gone out.
Finally should be noted that: above embodiment only for illustration of technical scheme of the present invention, is not intended to limit; Although the present invention will be described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or it is replaced on an equal basis to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. treat a Chinese medicine composition for diabetes, it is characterized in that, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 6-12 part, Mahonia fortunei (Lindl.) Fedde 10-16 part, Radix Notoginseng 18-24 part, Radix Glycyrrhizae Preparata 16-22 part, Radix Cyathulae 8-14 part, Stigma Croci 1-2 part.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterized in that, be prepared from by the raw material of following weight portion: Radix Ophiopogonis 8-10 part, Mahonia fortunei (Lindl.) Fedde 12-14 part, Radix Notoginseng 20-22 part, Radix Glycyrrhizae Preparata 18-20 part, Radix Cyathulae 10-12 part, Stigma Croci 1-2 part.
3. the Chinese medicine preparation for the treatment of diabetes according to claim 1, is characterized in that, is prepared from by the raw material of following weight portion: Radix Ophiopogonis 9 parts, Mahonia fortunei (Lindl.) Fedde 13 parts, Radix Notoginseng 21 parts, Radix Glycyrrhizae Preparata 19 parts, Radix Cyathulae 11 parts, Stigma Croci 1 part.
4., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment diabetes of claim 1-3, it is characterized in that, comprise the following steps:
1) each raw material is taken by formula ratio, the removal of impurity, cleaning drain and are placed in extraction pot, with raw material: the weight ratio of alcoholic solution=1:5 ~ 1:8 adds the alcoholic solution that volume fraction is 75 ~ 95% in extraction pot, extract 1 ~ 4 time under 70 ~ 95 DEG C of conditions, each 30 ~ 50 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract, under 4 DEG C of temperature conditions, cold preservation is for subsequent use;
2) medicinal residues in step 1 are proceeded water extraction 1 ~ 2 time, with raw material: the weight ratio of water=1:10 ~ 1:15 adds purified water in extraction pot, heat to 80 ~ 100 DEG C, slow fire heating makes it keep micro-to boil, 30 ~ 60 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, merge permeate and leave standstill cooling within more than 6 hours, to get supernatant for subsequent use;
3) mixed with the supernatant in step 2 by the ethanol extract in step 1, concentrating under reduced pressure removes solvent, obtains and gets dry extract, by broken for dried cream powder mistake 120 mesh sieve, and the Chinese medicine composition of the diabetes that obtain medical treatment.
5. the preparation method of the Chinese medicine composition for the treatment of diabetes according to claim 4, it is characterized in that: with raw material: the weight ratio of alcoholic solution=1:6 adds the alcoholic solution that volume fraction is 75% in extraction pot, extract 2 times under 85 DEG C of conditions, each 40 minutes, cross 2 ㎜ and collect filtrate with lower screen cloth, obtain ethanol extract; Medicinal residues continue water extraction 2 times, with raw material: the weight ratio of water=1:12 adds purified water in extraction pot, heat to 90 DEG C, slow fire heating makes it keep micro-to boil, 45 minutes water extraction time, cross 2 below ㎜ sieve water intaking extracts, it is for subsequent use that merging permeate standing cooling 7.5h gets supernatant.
6. the preparation method of the Chinese medicine composition for the treatment of diabetes according to claim 4, is characterized in that: the Chinese medicine composition that step 3 obtains is prepared into tablet, granule, capsule or honeyed pill.
7. according to the application of Chinese medicine composition in preparation treatment type Ⅰ diabetes mellitus, II diabetes and secondary diabetes medicine of the arbitrary described treatment diabetes of claim 1-6.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995971A (en) * | 2016-05-13 | 2016-10-12 | 腾科宝迪（厦门）生物科技有限公司 | Nutritional liquid food for promoting diabetes recovery and preparation method thereof |
| CN107375770A (en) * | 2017-08-17 | 2017-11-24 | 王中田 | A kind of Chinese medicine composition for treating diabetes and preparation method thereof |
| CN113577202A (en) * | 2021-09-13 | 2021-11-02 | 浙江理工大学 | Dendrobium officinale composition for treating diabetes and preparation method and application thereof |
-
2015
- 2015-12-14 CN CN201510934451.7A patent/CN105456689A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 温梦霞: "《传世中医秘方》", 31 July 2015, 福建科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105995971A (en) * | 2016-05-13 | 2016-10-12 | 腾科宝迪（厦门）生物科技有限公司 | Nutritional liquid food for promoting diabetes recovery and preparation method thereof |
| CN107375770A (en) * | 2017-08-17 | 2017-11-24 | 王中田 | A kind of Chinese medicine composition for treating diabetes and preparation method thereof |
| CN113577202A (en) * | 2021-09-13 | 2021-11-02 | 浙江理工大学 | Dendrobium officinale composition for treating diabetes and preparation method and application thereof |
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