CN105343652A - 一种检验科用洗手液及制备方法 - Google Patents
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Abstract
本发明涉及一种检验科用洗手液及制备方法,制成所述洗手液有效成分的原料组成为:竹叶蕉、水松、明党参、芦荟、荩草、蜂胶、地梢瓜、美穗草、黄三七、金银花、桉叶、儿茶、余甘子、青木香、独活和百两金;本发明洗手液所选药材配伍相宜,诸药相和具有杀菌能力强、作用速度快、易溶于水、无毒副作用、稳定性高、价格低廉等优点,且对人体皮肤无刺激,且具有消炎止痛、促使伤口愈合的功效,可广泛应用于检验科人员皮肤的消毒,是一种理想的洗手液,值得广泛推广使用。
Description
技术领域
本发明涉及中药领域,特别涉及一种检验科用洗手液及制备方法。
背景技术
检验科作为一门医学学科,在临床疾病诊断检查中发挥着重要作用,应用现代检验技术及时准确地为临床提供可靠的诊断依据,在医院各科室中有着重大的作用。
检验科需要对病患提取标本进行检测,才能准确诊断出对应所患的疾病,检验科是临床医学和基础医学之间的桥梁,包括临床化学、临床微生物学、临床免疫学、血液学、体液学以及输血学等分支学科,检验科每天承担包括病房、门急诊病人、各类体检以及科研的各种人体和动物标本的检测化验的任务,必须要保证检验的准确性,所以检验工作应保证在无菌条件下进行,以消除掉细菌、真菌、病原微生物的影响。所以检验科工作人员以及接受检验的病患需要对双手进行清洗和消毒。
目前,现有的洗手液不具备良好的杀菌消毒作用,一般采用的方法是将双手浸泡在消毒液中,现有的消毒液主要为酒精,双氧水,碘酒,高锰酸钾,还有戊二醛、碘伏等。这些消毒液大多为化学制剂,具有强烈的刺激性,长期使用会严重刺激医护人员皮肤,一些皮肤敏感的人,双手表面会变得干燥和皱裂,甚至会发生皮炎和湿疹。而消毒液的重复使用使得细菌等产生抗药性,严重影响消毒效果,不仅增加了检验人员的工作难度,也影响了检验的结果。
因此,需要寻找一种杀菌广谱、杀菌能力强、作用速度快、稳定性好、刺激性小、易溶于水、对人和动物安全且价廉易得的既能消毒又能护肤的洗手液,而中药学作为我国的传统医学,具有作用强、见效快、药效持久等优点,且没有依赖性及毒副作用,因此选择一种中药制剂作为检验科用洗手液,对于检验科的工
作人员及病患具有十分重要的意义。
发明内容
本发明提供了一种检验科用洗手液及制备方法;本发明洗手液所选药材配伍相宜,诸药相和具有杀菌能力强、作用速度快、易溶于水、无毒副作用、稳定性高、价格低廉等优点,且对人体皮肤无刺激,且具有消炎止痛、促使伤口愈合的功效,可广泛应用于检验科人员皮肤的消毒,是一种理想的洗手液,值得广泛推广使用。
为实现上述目的,本发明的技术方案实施如下:
一种检验科用洗手液,制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉57-87份水松55-85份明党参53-83份芦荟52-80份
荩草50-78份蜂胶50-78份地梢瓜47-75份美穗草45-75份
黄三七40-68份金银花40-68份桉叶38-66份儿茶35-62份
余甘子35-62份青木香33-60份独活30-55份百两金20-40份。
制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉78份水松76份明党参74份芦荟72份
荩草70份蜂胶70份地梢瓜65份美穗草65份
黄三七58份金银花58份桉叶56份儿茶53份
余甘子53份青木香51份独活45份百两金33份。
制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉71份水松69份明党参67份芦荟64份
荩草62份蜂胶62份地梢瓜59份美穗草59份
黄三七52份金银花52份桉叶50份儿茶47份
余甘子47份青木香45份独活40份百两金29份。
制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉64份水松62份明党参60份芦荟58份
荩草56份蜂胶56份地梢瓜53份美穗草53份
黄三七46份金银花46份桉叶44份儿茶41份
余甘子41份青木香39份独活35份百两金24份。
一种检验科用洗手液的制备方法,包括以下工艺步骤:
(1)将竹叶蕉、黄三七、儿茶和余甘子放入容器中,加入10倍量蒸馏水浸泡4小时后,加热煮沸4小时,提取;第二次加入8倍量蒸馏水加热煮沸3小时,提取;第三次加入6倍量蒸馏水加热煮沸2小时,提取;合并三次所得提取液,加入蜂胶,拌匀,滤过,得滤液,备用;
(2)将水松、地梢瓜、美穗草和百两金去除杂质,洗净,晒干,研末,得到过100目的细粉,后浸入体积浓度90%酒精溶液内,静置6小时,取出上层清液,得到沉淀下来的浸膏,备用;
(3)将明党参、青木香和独活洗净,将醋液加入其中,拌匀,置锅内用文火炒至醋吸尽并微干,取出干燥,研末,得到过120目的细粉,备用;
(4)将芦荟、荩草、金银花和桉叶去除杂质,洗净,置于容器内绞汁,过滤,得虑液,备用;
(5)将步骤(1)、步骤(4)所得的滤液和步骤(2)所得的浸膏以及步骤(3)所得的细粉混合后,加入10-12倍量的蒸馏水,搅拌溶解均匀后,加热煮沸1小时,置60℃以下,静置3小时,过滤,得滤液,将滤液灌装封存,121℃热压灭菌30分钟,包装,即为所述的检验科用洗手液。
本发明所用中药的药性如下:
竹叶蕉:味淡,性凉;归肺经。清热解毒,止咳定喘,消炎杀菌。用于肺结核,气管炎,支气管炎,哮喘,高热,小儿麻疹,合并肺炎,感冒,发热,各种皮肤病。现代医学研究证实,竹叶蕉对痢疾杆菌、伤寒杆菌、绿脓杆菌、葡萄球菌等具有抑制作用,抗菌谱亦较广。
水松:味甘、咸,性寒;归膀胱、大肠经。利水消肿,杀虫解毒。主水肿,蛔虫病,中暑,小便不利。《本草经集注》载:“疗溪毒。”现代医学研究证实,水松浸出液驱虫效果较海人草强三倍。水松所含成分丙烯酸有强大的抑菌作用。
芳樟醇和牻牛儿醇有抗菌、抗真菌作用。
明党参:味甘、微苦,性寒;归肺、脾、肝经。润肺化痰,养阴和胃,平肝解毒。用于肺热咳嗽,呕吐反胃,食少口干,目赤眩晕,疔毒疮疡。《中药志》载:“润肺化痰止咳,和胃止呕。治咳嗽,呕吐;又能解毒治疔疮。”
芦荟:味苦,性寒;归肝、胃、大肠经。清热,通便,杀虫。用于热结便秘,妇女经闭,小儿惊痫,疳热虫积,癣疮痔瘘,萎缩性鼻炎,瘰疬。《本草再新》载:“治肝火,镇肝风,清心热,解心烦,止渴生津,聪耳明目,消牙肿,解火毒。”
荩草:味苦,性平。清热降逆,止咳平喘,解毒。用于肝炎,久咳气喘,咽喉炎,口腔炎,鼻炎,淋巴腺炎,乳腺炎。《本经》载:“主久咳上气喘逆,久寒,惊悸,痂疥,白秃疡气,杀皮肤小虫。”现代医学研究证实,竹叶蕉对痢疾杆菌、伤寒杆菌、绿脓杆菌、葡萄球菌等具有抑制作用。
蜂胶:味微甘,性平;归肝、脾经。润肤生肌,消炎止痛。用于胃溃疡,口腔溃疡,***,带状疱疹,牛皮屑,银屑病,皮肤裂痛,鸡眼,烧烫伤。《中草药学》载:“保护肉芽组织,利于伤口愈合,对皲裂亦有疗效。”
地梢瓜:味甘,性平;归肺经。补肺气,清热降火,生津止渴,消炎止痛。用于虚火上炎,咽喉疼痛,气阴不足,神疲健忘,虚烦口渴,头昏失眠,产后体虚,乳汁不足。
美穗草:味苦,性寒。消炎解毒,止咳化痰,降气平喘,消肿止痛。用于治扁桃体炎,胃热痛,膀胱炎,乳腺炎,痈肿疮毒,赤白痢疾,慢性气管炎等。
黄三七:味苦,性凉;归心、肺、胃、大肠经。清热除烦,解毒消肿。用于热病烦躁,心悸怔忡,骨蒸潮热,咽炎,口腔炎,结膜炎,疮痈肿毒,湿热泄泻,痢疾。《陕西中草药》载:“泻火燥湿,清心除烦,抗菌消炎,健胃。治咽炎,结膜炎,口腔炎,骨蒸潮热,心慌心悸,烦躁不安,菌痢,肠炎,痈疮肿毒。”现代医学研究证实,黄三七具有杀菌消炎的作用。
金银花:味甘,性寒;归肺、心、胃经。清热,解毒。用于温病发热,热毒
血痢,痈疡肿毒,瘰疬痔漏。《常用中草药手册》载:“清热解毒。治外感发热咳嗽,肠炎,菌痢,麻疹,腮腺炎,败血症,疮疖肿毒,阑尾炎,外伤感染,小儿痱毒。制成凉茶,可预防中暑、感冒及肠道传染病。现代医学研究证实,金银花在体外对伤寒杆菌、副伤寒杆菌、大肠杆菌、变形杆菌、绿脓杆菌、百日咳杆菌,霍乱弧菌以及葡萄球菌、链球菌、肺炎双球菌、脑膜炎球菌等均有抑制作用。
桉叶:味辛、苦,性凉;归肺、胃、脾、肝经。疏风解表,清热解毒,化痰理气,杀虫止痒。用于感冒,高热喘咳,百日咳,脘腹胀痛,腹泻痢疾,丝虫病,风湿痛。现代医学研究证实,桉叶对绿脓杆菌感染等具有一定的治疗作用。
儿茶:味苦、涩,性寒;归肺经。收湿,生肌,敛疮。用于溃疡不敛,湿疹口疮,跌扑伤痛,外伤出血。现代医学研究证实,儿茶煎剂对金黄色葡萄球菌、白喉杆菌、变形杆菌、福氏痢疾杆菌及伤寒杆菌均有抑制作用,对于常见治病性皮肤真菌亦有抑制作用,其叶的提取物对金黄色葡萄球菌、大肠杆菌均有抑制作用。
余甘子:味甘、酸、涩,性凉;归肺、胃经。清热凉血,消食健胃,生津止咳。用于血热血瘀,肝胆病,消化不良,腹痛咳嗽,喉痛口干。
青木香:味苦、辛,性寒;归肺、胃经。平肝止痛,解毒消肿。用于眩晕头痛,胸腹胀痛,痈肿疔疮,蛇虫咬伤。《医林纂要》载:“治击伤,解毒。”
独活:味辛、苦,性微温;归肾、膀胱经。祛风胜湿,散寒止痛。用于风寒湿痹,腰膝酸痛,手脚挛痛,慢性气管炎,头痛齿痛。《药性论》载:“治中诸风湿冷,奔喘逆气,皮肌苦痒,手足挛痛,劳损,主风毒齿痛。”现代医学研究证实,独活具有抗菌作用。
百两金:味苦、辛,性凉。清热利咽,祛痰利湿,活血解毒。主咽喉肿痛,咳嗽咯痰不畅,湿热黄疸,小便淋痛,风湿痹痛,跌打损伤,疔疮,无名肿毒,蛇咬伤。《福建中草药》载:“清热利湿。治湿热黄疸,痢疾,白浊,睾丸肿大坠痛,秃疮,疥癣。”现代医学研究证实,百两金对肺炎双球菌,痢疾杆菌有抑制
作用。
本发明与现有技术相比,具有以下有益效果:
本发明洗手液所选药材配伍相宜,诸药相和具有杀菌能力强、作用速度快、易溶于水、无毒副作用、稳定性高、价格低廉等优点,且对人体皮肤无刺激,且具有消炎止痛、促使伤口愈合的功效,可广泛应用于检验科人员皮肤的消毒,是一种理想的洗手液,值得广泛推广使用。
具体实施方式
下面结合具体实施例对本发明做进一步阐述。
实施例1
本发明洗手液有效成分的原料组成及重量为:
竹叶蕉86g水松84g明党参82g芦荟79g
荩草77g蜂胶77g地梢瓜74g美穗草74g
黄三七67g金银花67g桉叶65g儿茶61g
余甘子61g青木香59g独活54g百两金39g。
本发明的制备方法,包括以下工艺步骤:
(1)将竹叶蕉、黄三七、儿茶和余甘子放入容器中,加入10倍量蒸馏水浸泡4小时后,加热煮沸4小时,提取;第二次加入8倍量蒸馏水加热煮沸3小时,提取;第三次加入6倍量蒸馏水加热煮沸2小时,提取;合并三次所得提取液,加入蜂胶,拌匀,滤过,得滤液,备用;
(2)将水松、地梢瓜、美穗草和百两金去除杂质,洗净,晒干,研末,得到过100目的细粉,后浸入体积浓度90%酒精溶液内,静置6小时,取出上层清液,得到沉淀下来的浸膏,备用;
(3)将明党参、青木香和独活洗净,将醋液加入其中,拌匀,置锅内用文火炒至醋吸尽并微干,取出干燥,研末,得到过120目的细粉,备用;
(4)将芦荟、荩草、金银花和桉叶去除杂质,洗净,置于容器内绞汁,过滤,得虑液,备用;
(5)将步骤(1)、步骤(4)所得的滤液和步骤(2)所得的浸膏以及步骤(3)所得的细粉混合后,加入10-12倍量的蒸馏水,搅拌溶解均匀后,加热煮沸1小时,置60℃以下,静置3小时,过滤,得滤液,将滤液灌装封存,121℃热压灭菌30分钟,包装,即为所述的检验科用洗手液。
实施例2
本发明洗手液有效成分的原料组成及重量为:
竹叶蕉78g水松76g明党参74g芦荟72g
荩草70g蜂胶70g地梢瓜65g美穗草65g
黄三七58g金银花58g桉叶56g儿茶53g
余甘子53g青木香51g独活45g百两金33g。
本实施例洗手液制备方法工艺步骤与实施例1相同。
实施例3
本发明洗手液有效成分的原料组成及重量为:
竹叶蕉71g水松69g明党参67g芦荟64g
荩草62g蜂胶62g地梢瓜59g美穗草59g
黄三七52g金银花52g桉叶50g儿茶47g
余甘子47g青木香45g独活40g百两金29g。
本实施例洗手液制备方法工艺步骤与实施例1相同。
实施例4
本发明洗手液有效成分的原料组成及重量为:
竹叶蕉64g水松62g明党参60g芦荟58g
荩草56g蜂胶56g地梢瓜53g美穗草53g
黄三七46g金银花46g桉叶44g儿茶41g
余甘子41g青木香39g独活35g百两金24g。
本实施例洗手液制备方法工艺步骤与实施例1相同。
验证性实验:
下面将选用本发明进行相应的试验,进一步证明本发明的功效。
一、水溶性试验
1、取本发明检验科用洗手液20ml放入容器中,然后加入蒸馏水,搅拌均匀后,过滤。
2、过滤完成后,观察滤纸,滤纸上无明显残留物残留。
3、结论:本发明检验科用洗手液极易溶于水,使用后无残留杂质出现,水溶性强。
二、毒性试验
1、急性经口性试验:选取质量20-22g的健康昆明种一级小鼠20只,雌性10只,雄性10只,将本发明检验科用洗手液经口灌胃给药,给药观察15天,每天记录小鼠各种表现和死亡情况,计算LD.值。
2、蓄积毒性试验:选取质量180-200g的健康昆明种一级大鼠20只,雌性10只,雄性10只,将本发明检验科用洗手液经口灌胃给药,给药量根据急性经口性试验得出的DL.值,第1-4天,每次给药0.1LD.,以后每四小时递增1.5倍剂量,给药30天,且每四小时称重一次,计算蓄积系数。
3、结果:急性经口性试验小鼠灌药后未见异常反应,未出现死亡,对其进行相应解剖后,组织或内脏未见明显有明显异常改变。
蓄积毒性试验小鼠给药30天后,雌雄小鼠均无死亡情况发生,小鼠蓄积系数5,位弱蓄积毒性。
三、皮肤刺激性与伤口愈合性试验
1、选用健康白色家兔4只,体质量2.5-3.0kg,将家兔背部脊柱两侧脱毛分别为3.0cm×3.0cm,期中2只白色家兔一侧均未损伤表皮,另两只白色家兔一侧均损伤表皮,12小时后,将0.2ml本发明检验科用洗手液均匀涂抹在裸露皮肤的左侧,右侧作为对照不涂抹,36小时后,将皮肤擦拭干净,观察皮肤反应,进行皮肤刺激与伤口愈合评分。
2、结果:未损伤表皮的2只家兔裸露皮肤未见有红斑和水肿反应,皮肤刺
激反应积分值为0,对照侧皮肤未见异常,按皮肤刺激反应评分标准,反应积分均值为0;有损伤表皮的2只白色家兔裸露皮肤处伤口慢慢愈合,本发明检验科用洗手液对皮肤无刺激性,且能促使伤口愈合。
四、稳定性试验
取本发明检验科用洗手液50ml,在37℃条件下放置90天后,用于对金黄色葡萄球菌进行杀菌,其杀灭效果和储存前比较无明显差异。
五、抑菌试验
下面对本发明检验科用洗手液进行抑菌实验:
1、实验菌种:
挑选实验室具有代表性的菌种,金黄色葡萄球菌和绿脓杆菌。
2、菌种培养基:
营养琼脂培养基和营养肉汤培养基。
3、实验分类:
抑菌实验分实验组和对照组,实验组选用本发明检验科用洗手液,对照组选用医用消毒水。
4、具体实验步骤:
(1)菌液的制备:将上述两种菌种分别接种于两个琼脂培养基上,在37℃下培养24小时,分别从上述琼脂培养基中挑取典型菌落分别接种于两个新鲜的营养肉汤培养基中,同温度下,培养20小时,备用;
(2)取本发明检验科用洗手液和医用消毒水各55ml,分别置于稀释容器中,对其分别稀释25倍,将上述两种稀释液溶液分别分置两个容器内,置于无菌条件下,备用;
(3)将上述步骤(1)经营养肉汤培养24小时的实验菌种用无菌的营养肉汤分别稀释50倍,每种菌种分装于两个培养皿中,分别标记对照组和实验组;
(4)将上述步骤(2)所得的两份本发明检验科用洗手液的稀释溶液分别滴入实验组培养皿,两份医用消毒水稀释溶液分别滴入对照组培养皿。
5、试验观察测量:
对上述实验进行观察,观察两组菌种并测量菌种残留面积具体结果。
6、观测测量完毕后,将上述培养皿均置于无菌条件下静置两天,待液体完全挥发后,跟踪观察发现,对照组菌落继续繁殖,而实验组菌落无变化。
7、实验结果:
实验组本发明检验科用洗手液的杀菌能力远大于对照组医用消毒水的杀菌能力,并且能够抑制各类菌种继续繁殖。
Claims (5)
1.一种检验科用洗手液,其特征在于:制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉57-87份水松55-85份明党参53-83份芦荟52-80份
荩草50-78份蜂胶50-78份地梢瓜47-75份美穗草45-75份
黄三七40-68份金银花40-68份桉叶38-66份儿茶35-62份
余甘子35-62份青木香33-60份独活30-55份百两金20-40份。
2.根据权利要求1所述的一种检验科用洗手液,其特征在于:制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉78份水松76份明党参74份芦荟72份
荩草70份蜂胶70份地梢瓜65份美穗草65份
黄三七58份金银花58份桉叶56份儿茶53份
余甘子53份青木香51份独活45份百两金33份。
3.根据权利要求1所述的一种检验科用洗手液,其特征在于:制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉71份水松69份明党参67份芦荟64份
荩草62份蜂胶62份地梢瓜59份美穗草59份
黄三七52份金银花52份桉叶50份儿茶47份
余甘子47份青木香45份独活40份百两金29份。
4.根据权利要求1所述的一种检验科用洗手液,其特征在于:制成所述洗手液有效成分的原料组成及重量份数为:
竹叶蕉64份水松62份明党参60份芦荟58份
荩草56份蜂胶56份地梢瓜53份美穗草53份
黄三七46份金银花46份桉叶44份儿茶41份
余甘子41份青木香39份独活35份百两金24份。
5.一种如权利要求1-4任一项所述的检验科用洗手液的制备方法,其特征在于:包括以下工艺步骤:
(1)将竹叶蕉、黄三七、儿茶和余甘子放入容器中,加入10倍量蒸馏水浸泡4小时后,加热煮沸4小时,提取;第二次加入8倍量蒸馏水加热煮沸3小时,提取;第三次加入6倍量蒸馏水加热煮沸2小时,提取;合并三次所得提取液,加入蜂胶,拌匀,滤过,得滤液,备用;
(2)将水松、地梢瓜、美穗草和百两金去除杂质,洗净,晒干,研末,得到过100目的细粉,后浸入体积浓度90%酒精溶液内,静置6小时,取出上层清液,得到沉淀下来的浸膏,备用;
(3)将明党参、青木香和独活洗净,将醋液加入其中,拌匀,置锅内用文火炒至醋吸尽并微干,取出干燥,研末,得到过120目的细粉,备用;
(4)将芦荟、荩草、金银花和桉叶去除杂质,洗净,置于容器内绞汁,过滤,得虑液,备用;
(5)将步骤(1)、步骤(4)所得的滤液和步骤(2)所得的浸膏以及步骤(3)所得的细粉混合后,加入10-12倍量的蒸馏水,搅拌溶解均匀后,加热煮沸1小时,置60℃以下,静置3小时,过滤,得滤液,将滤液灌装封存,121℃热压灭菌30分钟,包装,即为所述的检验科用洗手液。
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