CN105308033A - Jak2和alk2抑制剂及其使用方法 - Google Patents
Jak2和alk2抑制剂及其使用方法 Download PDFInfo
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- CN105308033A CN105308033A CN201480023826.8A CN201480023826A CN105308033A CN 105308033 A CN105308033 A CN 105308033A CN 201480023826 A CN201480023826 A CN 201480023826A CN 105308033 A CN105308033 A CN 105308033A
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- alkyl
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- cancer
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
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Abstract
Description
Claims (49)
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CN201810830351.3A CN108997225A (zh) | 2013-03-14 | 2014-03-13 | Jak2和alk2抑制剂及其使用方法 |
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PCT/US2014/026595 WO2014151871A2 (en) | 2013-03-14 | 2014-03-13 | Jak2 and alk2 inhibitors and methods for their use |
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CN (2) | CN105308033B (zh) |
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CN109641871A (zh) * | 2016-07-20 | 2019-04-16 | 诺华股份有限公司 | 氨基吡啶衍生物及其作为选择性alk-2抑制剂的用途 |
CN109641871B (zh) * | 2016-07-20 | 2021-10-22 | 诺华股份有限公司 | 氨基吡啶衍生物及其作为选择性alk-2抑制剂的用途 |
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WO2020135488A1 (zh) * | 2018-12-26 | 2020-07-02 | 上海喆邺生物科技有限公司 | 2,4-二氨基嘧啶衍生物及其用途 |
CN113227080A (zh) * | 2018-12-26 | 2021-08-06 | 上海喆邺生物科技有限公司 | 2,4-二氨基嘧啶衍生物 |
CN113227072A (zh) * | 2018-12-26 | 2021-08-06 | 上海喆邺生物科技有限公司 | 2,4-二氨基嘧啶衍生物及其用途 |
CN113227072B (zh) * | 2018-12-26 | 2023-07-18 | 上海喆邺生物科技有限公司 | 2,4-二氨基嘧啶衍生物及其用途 |
CN113227080B (zh) * | 2018-12-26 | 2023-08-15 | 上海喆邺生物科技有限公司 | 2,4-二氨基嘧啶衍生物 |
CN113272281A (zh) * | 2019-01-10 | 2021-08-17 | 大日本住友制药肿瘤公司 | 用于治疗骨髓增生异常综合征的alk5抑制剂 |
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