CN104689006A - Medicine for treating diabetes and preparation method of medicine - Google Patents
Medicine for treating diabetes and preparation method of medicine Download PDFInfo
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- CN104689006A CN104689006A CN201510082105.0A CN201510082105A CN104689006A CN 104689006 A CN104689006 A CN 104689006A CN 201510082105 A CN201510082105 A CN 201510082105A CN 104689006 A CN104689006 A CN 104689006A
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Abstract
The invention discloses a medicine for treating diabetes and a preparation method of the medicine. The medicine is prepared from the following raw materials in parts by weight: Chinese yam, puerarin, wild lycium barbaruml, bitter gourd, poria cocos, salviae miltiorrhizae, dried rehmannia root, red peony root, coptis chinensis, angelica sinensis, semen cuscutae, atractylodes, rhizoma atractylodis macrocephalae, cortex lycii radicis, dark plum, tomatoes, lemon, starch, microcrystalline cellulose, a flavoring agent, hydrolase, alcohol and an additive. The preparation method comprises the following steps: (1) preparing a mixed extract liquid A; (2) preparing a mixed extract liquid B; (3) preparing clear paste; (4) preparing mixed clear paste; (5) preparing primary instant granules; and (6) filtering, filling and sterilizing to obtain the instant granules. The medicine is characterized in that the product is the instant granules, and is free of a side effect; through addition of the dark plum, tomatoes and lemon, the medicine is relatively good in taste, sweet in taste, is infused by only water, and is relatively convenient to take. In the preparation process, CO2 supercritical fluid extraction is adopted, so that the medicinal value loss of the raw material can be relatively well reduced.
Description
Technical field
The invention belongs to a kind of medicine manufacture field, be specifically related to one and treat diabetes medicament and preparation method thereof.
Background technology
Diabetes are a kind of multifactorial metabolic diseases, its clinical characters chronic hyperglycemia, the sugar, fat, the protein metabolism disorder that cause with insulin secretion or effect defect, and can cause multiple serious secondary disease.Wherein general diabetics involves renal function in morbidity after 6 ~ 8 years.
Along with our people's growth in the living standard, the increase of living-pattern preservation and the aged, onset diabetes rate just increases year by year with the speed of 0.1%.Current oral antidiabetic thing, what mainly containing the effect of stimulating insulin secretion and strengthening periphery sugar utilizes hypoglycemic drug, also has euglycemic agent, glycosidase inhibitor, AR inhibitor and glycated protein inhibitor etc. in addition.But from current clinical used or be about to application hypoglycemic medicine, various Western medicine has certain limitation and untoward reaction, and as insulin resistant, hypoglycemia, lactic acidosis, life-time service leads to complications.Therefore, this provides a space for TCM Treatment of Diabetes.Diabetes and complication thereof focus on prevention, and most of Chinese medicine blood sugar lowering have the feature of comprehensive function, and therefore blood sugar lowering can prevent and treat again the medicine of complication is simultaneously optimal selection.
Treatment diabetes medicament has also has Patents to put into effect, such as CN01130678 discloses a kind of medicine for the treatment of diabetes and preparation method thereof, with the Radix Astragali, the Radix Rehmanniae, Flos Lonicerae, fruit base of Fructus Momordicae charantiae, Fructus Corni, Radix Panacis Quinquefolii for raw material, make powder, honeyed pill, the watered pill, capsule preparations by steps such as pulverizing, sterilization, oven dry.CN201210014768 discloses a kind of pharmaceutical composition being used for the treatment of diabetes and preparation method thereof, the pharmaceutical composition being preparation of raw material with Fructus Momordicae charantiae, Rhizoma Dioscoreae, Semen Coicis, Fructus Mume, Poria etc.
Summary of the invention
The object of the present invention is to provide one to treat diabetes electuary and preparation method thereof, diabetic symptom can be improved significantly, and side effect is little, adopt the Chinese medicine material of pure natural to make.
For realizing above-mentioned technical problem, the technical solution used in the present invention is as follows:
One treats diabetes medicament, its component is: Rhizoma Dioscoreae 1 ~ 5 part, Radix Puerariae 5 ~ 10 parts, wild barbarum 1 ~ 5 part, 1 ~ 10 part, Fructus Momordicae charantiae, 3 ~ 7 parts, Poria, Radix Salviae Miltiorrhizae 1 ~ 5 part, Radix Rehmanniae 1 ~ 10 part, Radix Paeoniae Rubra 2 ~ 8 parts, Rhizoma Coptidis 1 ~ 4 part, Radix Angelicae Sinensis 2 ~ 8 parts, Semen Cuscutae 1 ~ 10 part, Rhizoma Atractylodis 3 ~ 7 parts, the Rhizoma Atractylodis Macrocephalae 3 ~ 7 parts, Cortex Lycii 1 ~ 7 part, Fructus Mume 2 ~ 10 parts, Fructus Lycopersici esculenti 2 ~ 10 parts, 2 ~ 10 parts, Fructus Citri Limoniae, starch 0.1 ~ 1 part, microcrystalline Cellulose 0.1 ~ 0.5 part, flavoring agent 1 ~ 10 part, hydrolytic enzyme 0.1 ~ 0.5 part, ethanol 0.01 ~ 0.1 part, additives 0.01 ~ 0.1 part.
In such scheme, further, described treatment diabetes electuary, its component is: Rhizoma Dioscoreae 2 ~ 4 parts, Radix Puerariae 7 ~ 9 parts, wild barbarum 2 ~ 4 parts, 3 ~ 7 parts, Fructus Momordicae charantiae, 4 ~ 6 parts, Poria, Radix Salviae Miltiorrhizae 2 ~ 4 parts, Radix Rehmanniae 3 ~ 7 parts, Radix Paeoniae Rubra 4 ~ 7 parts, Rhizoma Coptidis 2 ~ 4 parts, Radix Angelicae Sinensis 3 ~ 7 parts, Semen Cuscutae 3 ~ 7 parts, Rhizoma Atractylodis 4 ~ 6 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Cortex Lycii 2 ~ 6 parts, Fructus Mume 4 ~ 8 parts, Fructus Lycopersici esculenti 4 ~ 8 parts, 4 ~ 8 parts, Fructus Citri Limoniae, starch 0.3 ~ 0.8 part, microcrystalline Cellulose 0.2 ~ 0.4 part, flavoring agent 3 ~ 8 parts, hydrolytic enzyme 0.2 ~ 0.4 part, ethanol 0.03 ~ 0.08 part, additives 0.03 ~ 0.08 part.
In such scheme, preferably, described treatment diabetes electuary, its component is: Rhizoma Dioscoreae 3 parts, Radix Puerariae 6 parts, wild barbarum 3 parts, 5 parts, Fructus Momordicae charantiae, 5 parts, Poria, Radix Salviae Miltiorrhizae 3 parts, Radix Rehmanniae 5 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Coptidis 3 parts, Radix Angelicae Sinensis 4 parts, Semen Cuscutae 4 parts, Rhizoma Atractylodis 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Cortex Lycii 4 parts, Fructus Mume 6 parts, Fructus Lycopersici esculenti 6 parts, 6 parts, Fructus Citri Limoniae, starch 0.5 part, microcrystalline Cellulose 0.3 part, flavoring agent 5 parts, hydrolytic enzyme 0.3 part, ethanol 0.03 part, additives 0.03 part.
In such scheme, described flavoring agent is one or more in oligofructose, citric acid, xylitol, Sorbitol, maltose alcohol, mannitol, Rhizoma Marantae arundinaceae glucin.
In such scheme, the adjuvant that described raw material accepts in bromatology can be mixed and made into liquid state or solid product.
Treat a preparation method for diabetes medicament, comprise the following steps:
(1) Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii, Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae raw material are cut into bulk after cleaning up, Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer are shattered into 30 ~ 65 object granules, adopt CO2 supercritical extraction, at extracting pressure 20 ~ 25Mpa, temperature is 50 ~ 60 DEG C, time is 0.5 ~ 2h, separated and collected volatile oil, then obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae slurry by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating; Starched centrifugalize again, collecting by filtration obtains juice; By juice recentrifuge, collect after supernatant and regulate pH to be 5.5 ~ 6.0, heat while stirring and then add hydrolytic enzyme, temperature rises to 90 ~ 100 DEG C and stops stirring, then regulates pH 4.0 ~ 5.0 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A;
(2) wild barbarum, Radix Paeoniae Rubra, Semen Cuscutae, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae are cleaned up post-drying, then decoct with water 20 ~ 30min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 40 ~ 50min at 90 ~ 100 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 95 ~ 100 DEG C in temperature, and being concentrated into relative density is 1.1 ~ 1.2 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol, fully stirs, and leaves standstill 20 ~ 24h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 45 ~ 50 DEG C, obtains clear paste 1.1 ~ 1.2;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add starch, microcrystalline Cellulose, flavoring agent, additives, and with water adjustment, stir;
(6) cold preservation 45 ~ 55h, filter, fill, sterilizing, to obtain final product.
In above-mentioned preparation method, the additives described in described step (5) are antiseptic, antioxidant, and its ratio is 1: 1.
In above-mentioned preparation method, the sterilizing described in described step (6) is high temperature sterilize, and temperature is 250 ~ 300 DEG C.
Compared with prior art, the present invention has the following advantages: this product is electuary, has no side effect, and add Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae make mouthfeel better, taste is sweet, only with water punching, takes more convenient.In preparation process of the present invention, adopt CO2 supercritical extraction, the property of medicine that better can reduce raw material is worth and runs off.
Detailed description of the invention
Embodiment 1
One treats diabetes medicament, and its component is: Rhizoma Dioscoreae 1 part, Radix Puerariae 5 parts, wild barbarum 1 part, 1 part, Fructus Momordicae charantiae, 3 parts, Poria, Radix Salviae Miltiorrhizae 1 part, Radix Rehmanniae 1 part, Radix Paeoniae Rubra 2 parts, Rhizoma Coptidis 1 part, Radix Angelicae Sinensis 2 parts, Semen Cuscutae 1 part, Rhizoma Atractylodis 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Cortex Lycii 1 part, Fructus Mume 2 parts, Fructus Lycopersici esculenti 2 parts, 2 parts, Fructus Citri Limoniae, starch 0.1 part, microcrystalline Cellulose 0.1 part, flavoring agent 1 part, hydrolytic enzyme 0.1 part, ethanol 0.01 part, additives 0.01 part.
Above-mentioned treatment diabetes granule is realized by following steps:
(1) by Rhizoma Dioscoreae 1 part, Radix Puerariae 5 parts, 1 part, Fructus Momordicae charantiae, 3 parts, Poria, Radix Salviae Miltiorrhizae 1 part, Radix Rehmanniae 1 part, connect 1 part, Radix Angelicae Sinensis 2 parts, Cortex Lycii 1 part, Fructus Mume 2 parts, Fructus Lycopersici esculenti 2 parts, bulk is cut into after Fructus Citri Limoniae 2 parts of raw materials clean up, by Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer shatters into 30 object granules, adopt CO2 supercritical extraction, at extracting pressure 20Mpa, temperature is 50 DEG C, time is 0.5h, separated and collected volatile oil, then by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae is starched, starched centrifugalize again, collecting by filtration obtains juice, by juice recentrifuge, collect after supernatant and regulate pH to be 5.5, heat while stirring and then add hydrolytic enzyme, temperature rises to 90 DEG C and stops stirring, then regulates pH 4.0 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A,
(2) wild barbarum 1 part, Radix Paeoniae Rubra 2 parts, Semen Cuscutae 1 part, Rhizoma Atractylodis 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts are cleaned up post-drying, then decoct with water 20min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 40min at 90 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 95 DEG C in temperature, and being concentrated into relative density is 1.1 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol 0.01 part, fully stirs, and leaves standstill 20h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 45 DEG C, obtains clear paste 1.1;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add starch 0.1 part, microcrystalline Cellulose 0.1 part, oligofructose 1 part, hydrolytic enzyme 0.1 part, antiseptic 0.05 part, 0.05 part, antioxidant, and with water adjustment, stir;
(6) cold preservation 45h, filter, fill, sterilizing, to obtain final product.
Embodiment 2
One treats diabetes medicament, and its component is: Rhizoma Dioscoreae 2 parts, Radix Puerariae 7 parts, wild barbarum 2 parts, 3 parts, Fructus Momordicae charantiae, 4 parts, Poria, Radix Salviae Miltiorrhizae 2 parts, Radix Rehmanniae 3 parts, Radix Paeoniae Rubra 4 parts, Rhizoma Coptidis 2 parts, Radix Angelicae Sinensis 3 parts, Semen Cuscutae 3 parts, Rhizoma Atractylodis 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, Cortex Lycii 2 parts, Fructus Mume 4 parts, Fructus Lycopersici esculenti 4 parts, 4 parts, Fructus Citri Limoniae, starch 0.3 part, microcrystalline Cellulose 0.2 part, flavoring agent 3 parts, hydrolytic enzyme 0.2 part, ethanol 0.03 part, additives 0.03 part.
Above-mentioned treatment diabetes granule is realized by following steps:
(1) by Rhizoma Dioscoreae 2 parts, Radix Puerariae 7 parts, 3 parts, Fructus Momordicae charantiae, 4 parts, Poria, Radix Salviae Miltiorrhizae 2 parts, Radix Rehmanniae 3 parts, Rhizoma Coptidis 2 parts, Radix Angelicae Sinensis 3 parts, Cortex Lycii 2 parts, Fructus Mume 4 parts, Fructus Lycopersici esculenti 4 parts, bulk is cut into after Fructus Citri Limoniae 4 parts of raw materials clean up, by Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer shatters into 40 granules, adopt CO2 supercritical extraction, at extracting pressure 21pa, temperature is 52, time is 1h, separated and collected volatile oil, then by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae is starched, starched centrifugalize again, collecting by filtration obtains juice, by juice recentrifuge, collect after supernatant and regulate pH to be 5.6, heat while stirring and then add hydrolytic enzyme, temperature rises to 92 DEG C and stops stirring, then regulates pH 4.2 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A,
(2) wild barbarum 2 parts, Radix Paeoniae Rubra 4 parts, Semen Cuscutae 3 parts, Rhizoma Atractylodis 4 parts, the Rhizoma Atractylodis Macrocephalae 4 parts are cleaned up post-drying, then decoct with water 22min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 42min at 92 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 96 DEG C in temperature, and being concentrated into relative density is 1.12 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol, fully stirs, and leaves standstill 21h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 46 DEG C, obtains clear paste 1.12;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add starch 0.3 part, microcrystalline Cellulose 0.2 part, citric acid 3 parts, hydrolytic enzyme 0.2 part, antiseptic 0.015 part, 0.015 part, antioxidant, and with water adjustment, stir;
(6) cold preservation 47h, filter, fill, sterilizing, to obtain final product.
Embodiment 3
One treats diabetes medicament, and its component is: Rhizoma Dioscoreae 3 parts, Radix Puerariae 6 parts, wild barbarum 3 parts, 5 parts, Fructus Momordicae charantiae, 5 parts, Poria, Radix Salviae Miltiorrhizae 3 parts, Radix Rehmanniae 5 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Coptidis 3 parts, Radix Angelicae Sinensis 4 parts, Semen Cuscutae 4 parts, Rhizoma Atractylodis 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Cortex Lycii 4 parts, Fructus Mume 6 parts, Fructus Lycopersici esculenti 6 parts, 6 parts, Fructus Citri Limoniae, starch 0.5 part, microcrystalline Cellulose 0.3 part, flavoring agent 5 parts, hydrolytic enzyme 0.3 part, ethanol 0.03 part, additives 0.03 part.
Above-mentioned treatment diabetes granule is realized by following steps:
(1) by Rhizoma Dioscoreae 3 parts, Radix Puerariae 6 parts, 5 parts, Fructus Momordicae charantiae, 5 parts, Poria, Radix Salviae Miltiorrhizae 3 parts, Radix Rehmanniae 5 parts, Rhizoma Coptidis 3 parts, Radix Angelicae Sinensis 4 parts, Cortex Lycii 4 parts, Fructus Mume 6 parts, Fructus Lycopersici esculenti 6 parts, 6 parts, Fructus Citri Limoniae, bulk is cut into after raw material cleans up, by Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer shatters into 55 object granules, adopt CO2 supercritical extraction, at extracting pressure 23Mpa, temperature is 55 DEG C, time is 1.2h, separated and collected volatile oil, then by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae is starched, starched centrifugalize again, collecting by filtration obtains juice, by juice recentrifuge, collect after supernatant and regulate pH to be 5.7, heat while stirring and then add hydrolytic enzyme, temperature rises to 95 DEG C and stops stirring, then regulates pH 4.5 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A,
(2) wild barbarum 3 parts, Radix Paeoniae Rubra 6 parts, Semen Cuscutae 4 parts, Rhizoma Atractylodis 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts are cleaned up post-drying, then decoct with water 25min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 45min at 95 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 97 DEG C in temperature, and being concentrated into relative density is 1.15 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol 0.03 part, fully stirs, and leaves standstill 22h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 47 DEG C, obtains clear paste 1.15;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add starch 0.5 part, microcrystalline Cellulose 0.3 part, xylitol 5 parts, hydrolytic enzyme 0.3 part, antiseptic 0.015 part, 0.015 part, antioxidant, and with water adjustment, stir;
(6) cold preservation 47h, filter, fill, sterilizing, to obtain final product.
Embodiment 4
One treats diabetes medicament, and its component is: Rhizoma Dioscoreae 4 parts, Radix Puerariae 9 parts, wild barbarum 4 parts, 7 parts, Fructus Momordicae charantiae, 6 parts, Poria, Radix Salviae Miltiorrhizae 4 parts, Radix Rehmanniae 7 parts, Radix Paeoniae Rubra 7 parts, Rhizoma Coptidis 4 parts, Radix Angelicae Sinensis 7 parts, Semen Cuscutae 7 parts, Rhizoma Atractylodis 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Cortex Lycii 6 parts, Fructus Mume 8 parts, Fructus Lycopersici esculenti 8 parts, 8 parts, Fructus Citri Limoniae, starch 0.8 part, microcrystalline Cellulose 0.4 part, flavoring agent 8 parts, hydrolytic enzyme 0.4 part, ethanol 0.08 part, additives 0.08 part.
Above-mentioned treatment diabetes granule is realized by following steps:
(1) by Rhizoma Dioscoreae 4 parts, Radix Puerariae 9 parts, 7 parts, Fructus Momordicae charantiae, 6 parts, Poria, Radix Salviae Miltiorrhizae 4 parts, Radix Rehmanniae 7 parts, Rhizoma Coptidis 4 parts, Radix Angelicae Sinensis 7 parts, Cortex Lycii 6 parts, Fructus Mume 8 parts, Fructus Lycopersici esculenti 8 parts, 8 parts, Fructus Citri Limoniae, bulk is cut into after raw material cleans up, by Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer shatters into 60 object granules, adopt CO2 supercritical extraction, at extracting pressure 24Mpa, temperature is 58 DEG C, time is 1.8h, separated and collected volatile oil, then by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae is starched, starched centrifugalize again, collecting by filtration obtains juice, by juice recentrifuge, collect after supernatant and regulate pH to be 5.9, heat while stirring and then add hydrolytic enzyme, temperature rises to 98 DEG C and stops stirring, then regulates pH 4.8 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A,
(2) wild barbarum 4 parts, Radix Paeoniae Rubra 7 parts, Semen Cuscutae 7 parts, Rhizoma Atractylodis 6 parts, the Rhizoma Atractylodis Macrocephalae 6 parts are cleaned up post-drying, then decoct with water 28min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 48min at 98 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 99 DEG C in temperature, and being concentrated into relative density is 1.18 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol 0.08 part, fully stirs, and leaves standstill 23h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 49 DEG C, obtains clear paste 1.18;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add 8 parts, Fructus Citri Limoniae, starch 0.8 part, microcrystalline Cellulose 0.4 part, maltose 8 parts, hydrolytic enzyme 0.4 part, antiseptic 0.04 part, 0.04 part, antioxidant, and with water adjustment, stir;
(6) cold preservation 53h, filter, fill, sterilizing, to obtain final product.
Embodiment 5
One treats diabetes medicament, and its component is: Rhizoma Dioscoreae 5 parts, Radix Puerariae 10 parts, wild barbarum 5 parts, 10 parts, Fructus Momordicae charantiae, 7 parts, Poria, Radix Salviae Miltiorrhizae 5 parts, Radix Rehmanniae 10 parts, Radix Paeoniae Rubra 8 parts, Rhizoma Coptidis 4 parts, Radix Angelicae Sinensis 8 parts, Semen Cuscutae 10 parts, Rhizoma Atractylodis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Cortex Lycii 7 parts, Fructus Mume 10 parts, Fructus Lycopersici esculenti 10 parts, 10 parts, Fructus Citri Limoniae, starch 1 part, microcrystalline Cellulose 0.5 part, flavoring agent 10 parts, hydrolytic enzyme 0.5 part, ethanol 0.1 part, additives 0.1 part.
Above-mentioned treatment diabetes granule is realized by following steps:
(1) by Rhizoma Dioscoreae 5 parts, Radix Puerariae 10 parts, 10 parts, Fructus Momordicae charantiae, 7 parts, Poria, Radix Salviae Miltiorrhizae 5 parts, Radix Rehmanniae 10 parts, Rhizoma Coptidis 4 parts, Radix Angelicae Sinensis 8 parts, Cortex Lycii 7 parts, Fructus Mume 10 parts, Fructus Lycopersici esculenti 10 parts, 10 parts, Fructus Citri Limoniae, bulk is cut into after raw material cleans up, by Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer shatters into 65 object granules, adopt CO2 supercritical extraction, at extracting pressure 25Mpa, temperature is 60 DEG C, time is 2h, separated and collected volatile oil, then by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae is starched, starched centrifugalize again, collecting by filtration obtains juice, by juice recentrifuge, collect after supernatant and regulate pH to be 6.0, heat while stirring and then add hydrolytic enzyme, temperature rises to 100 DEG C and stops stirring, then regulates pH 5.0 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A,
(2) wild barbarum 5 parts, Radix Paeoniae Rubra 8 parts, Semen Cuscutae 10 parts, Rhizoma Atractylodis 7 parts, the Rhizoma Atractylodis Macrocephalae 7 parts are cleaned up post-drying, then decoct with water 30min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 50min at 100 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 100 DEG C in temperature, and being concentrated into relative density is 1.2 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol 0.1 part, fully stirs, and leaves standstill 24h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 50 DEG C, obtains clear paste 1.2;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add starch 1 part, microcrystalline Cellulose 0.5 part, mannitol 10 parts, hydrolytic enzyme 0.5 part, ethanol 0.1 part, antiseptic 0.05 part, 0.05 part, antioxidant, and with water adjustment, stir;
(6) cold preservation 55h, filter, fill, sterilizing, to obtain final product.
Claims (8)
1. a treatment diabetes medicament, its characteristic is, its component is: Rhizoma Dioscoreae 1 ~ 5 part, Radix Puerariae 5 ~ 10 parts, wild barbarum 1 ~ 5 part, 1 ~ 10 part, Fructus Momordicae charantiae, 3 ~ 7 parts, Poria, Radix Salviae Miltiorrhizae 1 ~ 5 part, Radix Rehmanniae 1 ~ 10 part, Radix Paeoniae Rubra 2 ~ 8 parts, Rhizoma Coptidis 1 ~ 4 part, Radix Angelicae Sinensis 2 ~ 8 parts, Semen Cuscutae 1 ~ 10 part, Rhizoma Atractylodis 3 ~ 7 parts, the Rhizoma Atractylodis Macrocephalae 3 ~ 7 parts, Cortex Lycii 1 ~ 7 part, Fructus Mume 2 ~ 10 parts, Fructus Lycopersici esculenti 2 ~ 10 parts, 2 ~ 10 parts, Fructus Citri Limoniae, starch 0.1 ~ 1 part, microcrystalline Cellulose 0.1 ~ 0.5 part, flavoring agent 1 ~ 10 part, hydrolytic enzyme 0.1 ~ 0.5 part, ethanol 0.01 ~ 0.1 part, additives 0.01 ~ 0.1 part.
2. treat diabetes medicament as claimed in claim 1, it is characterized in that, its component is: Rhizoma Dioscoreae 2 ~ 4 parts, Radix Puerariae 7 ~ 9 parts, wild barbarum 2 ~ 4 parts, 3 ~ 7 parts, Fructus Momordicae charantiae, 4 ~ 6 parts, Poria, Radix Salviae Miltiorrhizae 2 ~ 4 parts, Radix Rehmanniae 3 ~ 7 parts, Radix Paeoniae Rubra 4 ~ 7 parts, Rhizoma Coptidis 2 ~ 4 parts, Radix Angelicae Sinensis 3 ~ 7 parts, Semen Cuscutae 3 ~ 7 parts, Rhizoma Atractylodis 4 ~ 6 parts, the Rhizoma Atractylodis Macrocephalae 4 ~ 6 parts, Cortex Lycii 2 ~ 6 parts, Fructus Mume 4 ~ 8 parts, Fructus Lycopersici esculenti 4 ~ 8 parts, 4 ~ 8 parts, Fructus Citri Limoniae, starch 0.3 ~ 0.8 part, microcrystalline Cellulose 0.2 ~ 0.4 part, flavoring agent 3 ~ 8 parts, hydrolytic enzyme 0.2 ~ 0.4 part, ethanol 0.03 ~ 0.08 part, additives 0.03 ~ 0.08 part.
3. treat diabetes medicament as claimed in claim 2, it is characterized in that, its component is: Rhizoma Dioscoreae 3 parts, Radix Puerariae 6 parts, wild barbarum 3 parts, 5 parts, Fructus Momordicae charantiae, 5 parts, Poria, Radix Salviae Miltiorrhizae 3 parts, Radix Rehmanniae 5 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Coptidis 3 parts, Radix Angelicae Sinensis 4 parts, Semen Cuscutae 4 parts, Rhizoma Atractylodis 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Cortex Lycii 4 parts, Fructus Mume 6 parts, Fructus Lycopersici esculenti 6 parts, 6 parts, Fructus Citri Limoniae, starch 0.5 part, microcrystalline Cellulose 0.3 part, flavoring agent 5 parts, hydrolytic enzyme 0.3 part, ethanol 0.03 part, additives 0.03 part.
4. the treatment diabetes medicament as described in claims 1 to 3 any one, is characterized in that: described flavoring agent is one or more in oligofructose, citric acid, xylitol, Sorbitol, maltose alcohol, mannitol, Rhizoma Marantae arundinaceae glucin.
5. the treatment diabetes medicament as described in claims 1 to 3 any one, is characterized in that: the adjuvant that described raw material accepts in bromatology can be mixed and made into liquid state or solid product.
6. as Claims 1 to 5 arbitrarily as described in the preparation method for the treatment of diabetes medicament, it is characterized in that, comprise the following steps:
(1) Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii, Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae raw material are cut into bulk after cleaning up, Rhizoma Dioscoreae, Radix Puerariae, Fructus Momordicae charantiae, Poria, Radix Salviae Miltiorrhizae, Radix Rehmanniae, Rhizoma Coptidis, Radix Angelicae Sinensis, Cortex Lycii pulverizer are shattered into 30 ~ 65 object granules, adopt CO2 supercritical extraction, at extracting pressure 20 ~ 25Mpa, temperature is 50 ~ 60 DEG C, time is 0.5 ~ 2h, separated and collected volatile oil, then obtains Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae slurry by Fructus Mume, Fructus Lycopersici esculenti, Fructus Citri Limoniae crushing and beating; Starched centrifugalize again, collecting by filtration obtains juice; By juice recentrifuge, collect after supernatant and regulate pH to be 5.5 ~ 6.0, heat while stirring and then add hydrolytic enzyme, temperature rises to 90 ~ 100 DEG C and stops stirring, then regulates pH 4.0 ~ 5.0 to add hydrolytic enzyme, enzyme denaturing, filters, obtains mixed extract A;
(2) wild barbarum, Radix Paeoniae Rubra, Semen Cuscutae, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae are cleaned up post-drying, then decoct with water 20 ~ 30min, filter, collect filtrate; In filtering residue, add water again, temperature controls to soak 40 ~ 50min at 90 ~ 100 DEG C, filters, collects filtrate; Merging filtrate obtains mixed extract B;
(3) volatile oil preserved in step (1), (2), mixed extract A, mixed extract B merge, and are 95 ~ 100 DEG C in temperature, and being concentrated into relative density is 1.1 ~ 1.2 one-tenth clear paste;
(4) clear paste in cooling step (3), adds ethanol, fully stirs, and leaves standstill 20 ~ 24h, filters, outwells filtering residue, and reclaiming ethanol and being concentrated into relative density is that temperature is 45 ~ 50 DEG C, obtains clear paste 1.1 ~ 1.2;
(5) volatile oil that the clear paste of step (4) and (1) are preserved is merged, add starch, microcrystalline Cellulose, flavoring agent, additives, and with water adjustment, stir;
(6) cold preservation 45 ~ 55h, filter, fill, sterilizing, to obtain final product.
7. treatment diabetes medicament preparation method as claimed in claim 6, it is characterized in that, the additives described in step (5) are antiseptic, antioxidant, and its ratio is 1: 1.
8. the preparation method for the treatment of diabetes medicament as claimed in claim 6, it is characterized in that, the sterilizing described in step (6) is high temperature sterilize, and temperature is 250 ~ 300 DEG C.
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| CN105833019A (en) * | 2016-03-21 | 2016-08-10 | 东莞市东卓中天生物科技有限公司 | Health care product for treatment of diabetes and preparation method thereof |
| CN105920556A (en) * | 2016-05-27 | 2016-09-07 | 惠州同富康生物科技有限公司 | Application of plum extract containing composition to preparation of blood sugar reducing health product |
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| CN106262918A (en) * | 2016-10-14 | 2017-01-04 | 胡松茂 | A kind of diabetes vegetable food product formula |
| CN109393260A (en) * | 2018-11-09 | 2019-03-01 | 洪雅县瓦屋山药业有限公司 | Improve hyperglycemia and the plant beverage of diabetes patient's constitution and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105535275A (en) * | 2015-12-30 | 2016-05-04 | 韩志强 | Huanglian Shangqing tablet and preparation method thereof |
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| CN105920556A (en) * | 2016-05-27 | 2016-09-07 | 惠州同富康生物科技有限公司 | Application of plum extract containing composition to preparation of blood sugar reducing health product |
| CN106038926A (en) * | 2016-08-16 | 2016-10-26 | 汪培杰 | Traditional Chinese medicine for treating diabetes and preparation method thereof |
| CN106262918A (en) * | 2016-10-14 | 2017-01-04 | 胡松茂 | A kind of diabetes vegetable food product formula |
| CN109393260A (en) * | 2018-11-09 | 2019-03-01 | 洪雅县瓦屋山药业有限公司 | Improve hyperglycemia and the plant beverage of diabetes patient's constitution and preparation method thereof |
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