CN103550711A - Medicine for treating menses disease and preparation method - Google Patents
Medicine for treating menses disease and preparation method Download PDFInfo
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Abstract
The invention relates to a medicine for treating menses disease. The medicine is prepared from the following raw materials in parts by weight: 25 parts of white atractylodes rhizome, 25 parts of polygonum perfoliatum, 25 parts of astragalus membranaceus, 22 parts of caulis spatholobi, 22 parts of lilium brownie, 20 parts of rhizoma cyperi, 20 parts of curcuma zedoary, 20 parts of radices sileris, 18 parts of poria cocos, 18 parts of japanese tripterospermum herb, 15 parts of safflower carthamus, 15 parts of madder, 15 parts of leonurus, 15 parts of dandelion, 13 parts of trogopterus dung, 13 parts of artemisia anomala, 10 parts of prepared rhizome of rehmannia, 10 parts of pepper, 10 parts of dried tangerine or orange peel, 8 parts of cortex albiziae, 5 parts of malt, 5 parts of ginkgo, 5 parts of hawthorn, 3 parts of radix aucklandiae and 3 parts of ligusticum wallichii. The medicine disclosed by the invention has wide medicinal herb sources, is simple and convenient to prepare and low in cost, and has wide application prospect.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to particularly a kind of medicine for the treatment of menopathy and preparation method of this medicine that Chinese herbal medicine prepared as raw material of take.
Background technology
Menopathy is the change in menstrual cycle characteristics that general reference a variety of causes causes, physiological and pathological feature due to women, menopathy is mainly with the stagnation of QI, blood stasis, the paathogenic factor damage punchings such as phlegm-damp are appointed, QI and blood, cause function not normal, vim and vigour imbalance, rush due to wantonly two arteries and veins damages, mainly with stagnant, the stasis of blood, wet (liver-spleen disharmony), empty (prolonged illness must be empty) is feature, therefore its many and liver, spleen, the dirty relation of kidney three is the tightst, spleen is the main transporting of middle soil, for source of generating QI and blood, liver is organ of general, its property is firm, main free flow of qi, take soft as suitable, if losing bar, liver reaches, dysfunction of the spleen in transportation causes incoordination between the liver and spleen, mechanism of qi retardance can cause lower abdomen pain, distending pain in the chest and hypochondrium, profuse leukorrhea, lumbosacral aching pain, channels is hindered sees fallopian tube adhesion or pelvic adhesion, qi depression to blood stasis, phlegm resistance hair growth promoting note of the ancient Chinese abdominal mass mass in the abdomen as hysteromyoma, ovarian cyst, the kidney being the origin of congenital constitution, main reproduction, " through water, going out all kidneys ", and there is menoxenia in the imbalance between YIN and YANG of kidney, dysmenorrhea is infertile etc.
The fundamental symptoms of menopathy is: 1. advanced menstruation.Menstruation refers to that menstrual cycle is normal at ordinary times in advance, occurs that suddenly menstrual cycle shortens, and be shorter than 21 days, and occur that continuously 2 more than the cycle, but menstrual blood volume is normal.Belong to ovulation type anovulatory dysfunctional uterine hemorrhage basal body temperature two-phase, follicular phase is short, and only 7～8 days, or be shorter than 10 days luteal phase, or 0.5 ℃ of body temperature rise less than; 2. postpone menstruation rule at ordinary times menstrual period, postponed menstruation is more than 7 days, 40～50 days a line even, and occur that continuously two are more than menstrual cycle, but menstrual blood volume is normal.There is ovulation person, basal body temperature two-phase, but follicular phase is long, and high-temperature-phase is on the low side; Anovulation person, basal body temperature is single-phase; 3. menostaxis menstrual cycle is normal, normal through measuring, but menostaxis, menstrual period, even 2 weeks sides were clean over more than 7 days.Have inflammation person's lower abdomen pain at ordinary times, increase the weight of menstrual period, and leucorrhea amount is many at ordinary times, and yellow skin or HUANGBAI(sic), matter is thick, have taste.The infull person of atrophy of corpus iuteum is simultaneously with menorrhagia; Endometrium reparation is prolonged elder at menorrhea after date, still has a small amount of persistence vaginal hemorrhage; Menoxenia menstruation successively irregularly, menstruation in advance or postpone, cycle or be shorter than 21 days, or be longer than 35 days; 5. what Intermenstrual bleeding referred to occur in the middle of the normal menstrual cycle of twice rule is hemorrhage, is due to the of short duration decline of estrogen level, makes endometrium lose the support of hormone and that the endometrium that causes comes off and causes is hemorrhage.
A lot of reasons can cause menopathy, as endocrine disturbance or self some disease all can cause menoxenia, also have some bad habits as irregular in the daily schedule, greedy cool, overwork, excessively go on a diet, have a liking for tobacco and wine, mood disorders, pressure is large etc., takes some drugs and also can cause menoxenia.According to Ministry of Public Health investigation statistics, show, China's gynaecopathia sickness rate is up to 75%, and wherein menoxenia, dysmenorrhea patient account for 50%.Also discovery of China's menstrual physiology constant cooperative groups investigation, in 71746 women, 33.2% has dysmenorrhea, and 13.6% dysmenorrhea patient life is subject to obvious impact with work.Equally, after U.S.'s adolescence, in women, there is menoxenia in various degree 50% left and right, and 10% monthly needs rest 1-3 days because of dysmenorrhea.In recent years, the female irregular menstruation age presents rejuvenation trend, and sickness rate improves year by year.This long-term, general and unavoidable gynaecopathia, has had a strong impact on healthy and quality of life of China women.Huge disease crowd has facilitated huge gynecological's drug market simultaneously.China's gynecological drug sales volume in 2011 is up to more than 100 hundred million yuans, and in recent years, is continuation growing trend.Therefore, the medicine of research and development menopathy, has good social benefit and optimistic market prospect, for meeting medical clinical demand and the market demand, significant.
Summary of the invention
The object of the invention is the weak point of avoiding prior art to exist, understanding based on motherland's medical science to menopathy, regulating menstruation should focus on and regulate the flow of vital energy, and holds up spleen, the kidney invigorating, soothing the liver, the traditional Chinese medical science focuses on regulating menstruation to effect a permanent cure, and depressed liver-energy dispersing and QI regulating, clearing away heat and cooling blood, invigorating the spleen and benefiting QI make irritability Shu Da, menses are smooth, and a kind of Chinese medicine for the treatment of both the principal and secondary aspects of a disease treatment menopathy is provided.
For achieving the above object, the technical solution used in the present invention is as follows:
The medicine of menopathy and a preparation method, its raw material by following weight parts is prepared and is obtained:
25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Herba Polygoni cymosis, 25 parts of the Radixs Astragali, 22 parts of Caulis Spatholobis, 22 parts of Bulbus Liliies,
20 parts of Rhizoma Cyperis, 20 parts of Rhizoma Curcumae, 20 parts of Radix Saposhnikoviaes, 18 parts, Poria, 18 parts of Herba Tripterospermi japonicis,
15 parts, Flos Carthami, 15 parts, Radix Rubiae, 15 parts of Herba Leonuris, 15 parts of Herba Taraxacis, 13 parts of Oletum Trogopteroris,
13 parts of Herba Artemisiae Anomalaes, 10 parts, Radix Rehmanniae Preparata, 10 parts, Pericarpium Zanthoxyli, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Albiziaes,
5 parts, Fructus Hordei Germinatus, 5 parts of Semen Ginkgoes, 5 parts of Fructus Crataegis, 3 parts of the Radix Aucklandiae, 3 parts of Rhizoma Chuanxiongs.
Its preparation of medicine of the present invention and instructions of taking are:
(1) take the crude drug (proportioning unit: gram) of above-mentioned weight portion, standby;
(2) get the Rhizoma Atractylodis Macrocephalae, Herba Polygoni cymosi, the Radix Astragali, Herba Taraxaci, Oletum Trogopterori, Herba Artemisiae Anomalae, Fructus Hordei Germinatus, Semen Ginkgo and add 70% soak with ethanol 1 hour, reflux, extract, twice, each 1 hour, merge extractive liquid,, filters, and is condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtains complex A;
(3) get Caulis Spatholobi, Bulbus Lilii, Rhizoma Cyperi, Rhizoma Curcumae, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Cortex Albiziae levigation, crosses 80 mesh sieves and obtains complex B;
(4) get Poria, Herba Tripterospermi japonici, Flos Carthami, Radix Rubiae, Herba Leonuri, Radix Rehmanniae Preparata, Pericarpium Zanthoxyli, Fructus Crataegi, the Radix Aucklandiae, Rhizoma Chuanxiong water boiling and extraction 2 times, extract for the first time the water that adds 6 times of weight, extraction time is 0.5 hour; Extract for the second time the water that adds 4 times of weight, extraction time is 0.5 hour; Filter, merging filtrate, is concentrated into the thick paste that density is 1.2g/ml, and crushed after being dried obtains complex C;
(5) by complex A, B, C mixing and stirring, sterilization makes capsule product, and three times on the oral one, one after each meal, each 5g, two weeks is a course for the treatment of.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, with low cost, and it follows the prescriptions principle of the traditional Chinese medical science, and through clinical practice inflammation, it is evident in efficacy reliable, and the property of medicine is gentle, does not occur toxic and side effects, has a extensive future.
The specific embodiment
Embodiment 1
The medicine of menopathy and a preparation method, its raw material by following weight proportioning is prepared and is obtained:
25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Herba Polygoni cymosis, 25 parts of the Radixs Astragali, 22 parts of Caulis Spatholobis, 22 parts of Bulbus Liliies,
20 parts of Rhizoma Cyperis, 20 parts of Rhizoma Curcumae, 20 parts of Radix Saposhnikoviaes, 18 parts, Poria, 18 parts of Herba Tripterospermi japonicis,
15 parts, Flos Carthami, 15 parts, Radix Rubiae, 15 parts of Herba Leonuris, 15 parts of Herba Taraxacis, 13 parts of Oletum Trogopteroris,
13 parts of Herba Artemisiae Anomalaes, 10 parts, Radix Rehmanniae Preparata, 10 parts, Pericarpium Zanthoxyli, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Albiziaes,
5 parts, Fructus Hordei Germinatus, 5 parts of Semen Ginkgoes, 5 parts of Fructus Crataegis, 3 parts of the Radix Aucklandiae, 3 parts of Rhizoma Chuanxiongs.
Its preparation of medicine of the present invention and instructions of taking are:
(1) take the crude drug (proportioning unit: gram) of above-mentioned parts by weight, standby;
(2) get the Rhizoma Atractylodis Macrocephalae, Herba Polygoni cymosi, the Radix Astragali, Herba Taraxaci, Oletum Trogopterori, Herba Artemisiae Anomalae, Fructus Hordei Germinatus, Semen Ginkgo and add 70% soak with ethanol 1 hour, reflux, extract, twice, each 1 hour, merge extractive liquid,, filters, and is condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtains complex A;
(3) get Caulis Spatholobi, Bulbus Lilii, Rhizoma Cyperi, Rhizoma Curcumae, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Cortex Albiziae levigation, crosses 80 mesh sieves and obtains complex B;
(4) get Poria, Herba Tripterospermi japonici, Flos Carthami, Radix Rubiae, Herba Leonuri, Radix Rehmanniae Preparata, Pericarpium Zanthoxyli, Fructus Crataegi, the Radix Aucklandiae, Rhizoma Chuanxiong water boiling and extraction 2 times, extract for the first time the water that adds 6 times of weight, extraction time is 0.5 hour; Extract for the second time the water that adds 4 times of weight, extraction time is 0.5 hour; Filter, merging filtrate, is concentrated into the thick paste that density is 1.2g/ml, and crushed after being dried obtains complex C;
(5) by complex A, B, C mixing and stirring, sterilization makes capsule product, and three times on the oral one, one after each meal, each 5g, two weeks is a course for the treatment of.
Embodiment 2
Through clinical front pharmacy, pharmacology, toxicological study, reasonable, the total effective ingredient of pharmaceutical preparation of the present invention is high, steady quality, controlled.
Pharmacodynamics test proves, this medicine has analgesic activity, and there is to spasmolysis in uterus;
Toxicity test: 40 of healthy Kunming Strains of Mouses, male and female half and half, body weight is 18.5 ± 2.0g, and 40 mices are divided into two groups at random, male and female half and half, wherein 20 as matched group, fills with ordinary water; Other 20 mices give embodiment 1 medicine, and mice carries out acute toxicity testing and shows in application: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation two weeks, mice overall health of patients, ingest, drinking-water, body weight gain is all normal.After the administration same day and administration, in two weeks, have no animal dead, point out this medicine acute toxicity very little, clinical drug safety.
Clinical efficacy is summed up:
General data, Chinese medicine of the present invention is applied to clinical observation 99 examples
The selection of study subject: according to Ministry of Public Health < < new Chinese medicine treatment menoxenia clinical trial guideline > >.
Chinese medical discrimination: the stagnation of QI due to depression of the liver syndrome of blood stasis person that holds concurrently
1), main symptom: (1) menoxenia; (2) distention and pain of breast before menstruation; (3) dark tongue quality or have ecchymosis;
2), inferior disease: (1) is depressed or irritated; (2) dysmenorrhea or amenorrhea; (3) lower abdomen or few abdomen pain; (4) dark red through color or held clot under the arm; (5) xerostomia wish drink not; (6) white and thin fur, stringy pulse or puckery.
Dialectical requirement: 1. possess two persons in main symptom (1) and other main symptom; 2. each any 2 persons of main symptom (1) and inferior card all belong to assertive evidence.
The women at 18～50 years old age, menoxenia person, Chinese medical discrimination are stagnation of QI due to depression of the liver blood stasis type card
Exclusion standard
(1) within nearly 3 months, once participated in other clinical trial person
(2) Chinese medical discrimination does not belong to stagnation of QI due to depression of the liver syndrome of blood stasis person
(3) the menoxenia person who causes for genitals's organic disease on inspection.
Clinical data is totally 99 examples, wherein: 18～30 years old age, 33 examples, 31～40 years old 27 example, 41～50 years old 39 example, 35.5 years old mean age.
Indication: the diagnostic criteria of the menopathy in the < < Chinese medicine card Standardization of diagnosis and curative effect > > that all case diagnosis are all issued with reference to national Chinese Medicine Pharmacy in 1994 is carried out.Preceeded menorrhea: menstrual cycle is in advance more than 7 days; Delayed menstrual cycle: menstrual cycle postpones more than 7 days; Irregular menstrual period: menstruation was risen not according to the cycle, or before or after; Menorrhagia: menstrual cycle is normal, and surpass menorrhea person through amount; Hypomenorrhea: menstrual cycle is normal, and through measuring obvious minimizing, or pass through time shorten or drop clean.
Therapeutic Method: three times on the oral one, one after each meal, each 5g, two weeks is a course for the treatment of, treats two courses for the treatment of.
Criterion of therapeutical effect: cure: menstrual blood loss, menstrual cycle recover normal, after drug withdrawal, 5 menstrual cycle are without repeatedly.Effective: menstrual blood loss, menstrual cycle normal, have clear improvement, after drug withdrawal, 5 menstrual cycle are without repeatedly.Invalid: menstrual blood loss, menstrual cycle are not improved.
Therapeutic outcome: take Chinese medicine composition of the present invention, cure 59 examples, effective 35 examples, invalid 5 examples, total effective rate (curing+effective) 94.9%; It is remarkable that the present invention treats the effect of drugs of menopathy, and total effective rate is high.
Embodiment 3
High certain, 41 years old, suffer from menstruation in advance, through the many gynaecopathia of blood volume more than a year, take the curative effects such as Tiaojing tablets, Extractum Herba Leonuri very micro-, spiritlessness and weakness, lumbosacral aching pain, dizziness and tinnitus.Have a medical check-up: yellow complexion, become thin and give the embodiment medicine of 1 preparation, three times on the oral one, one after each meal, each 5g, two weeks is a course for the treatment of; After the course for the treatment of, in the menstrual period of next month, distending pain of the breast obviously alleviates, and menstrual period was than two days in advance last month, through blood volume, also reduce to some extent, after this month is clean, continue to take, inferior menstrual phase, distending pain of the breast symptom disappears substantially, menstrual period is normal, and above-mentioned disease disappears completely, follows up a case by regular visits to without recurrence.
Summer so-and-so, 30 years old, educate rear beginning menoxenia, or 45-50 days tides, or first quarter moon once, less slightly through measuring, color is dark red, distention and pain of breast before menstruation is tired, soreness of waist pain, stomach is received generally, leucorrhea is many.Dull and sallow complexion, has skin dark stain, and light red tongue is slightly dim, and tongue is white, deep-thready pulse CHI-pulse being weak.Menstruation tide 15 the beginning of the year, 28 days before cycle.Last menstrual period was apart from modern 40 days.Give embodiment 1 Chinese medicine after one week, patient's fatigue and weakness is alleviated to some extent, Lve Sina food.Menstrual onset, in 47 days cycles, through row 7 days, less slightly through measuring, color was red.A course for the treatment of of following the service Chinese medicine composition of the present invention, dizzy tired out sense disappears substantially usually, complexion amelioration, and leucorrhea is without extremely.Following the service medicine of the present invention, next menstrual onset, in 30 days cycles, through row 6 days, distention and pain of breast before menstruation was not obvious.Two courses for the treatment of of following the service Chinese medicine composition of the present invention, patient's body constitution takes a turn for the better, and has rosy cheeks.Follow up a case by regular visits to menstrual cycle normal without recurrence.
The present invention treats between the various compositions of medicine of menopathy and makes mutually compatibility, coordinates usefulness, with low cost, through clinical verification, menopathy is had to good therapeutic effect, in the applicant's medical practice for many years, the case number of curing is numerous, obtains good effect, has broad application prospects.
Claims (2)
1. treat medicine and the preparation method of menopathy, it is characterized in that being obtained by the raw material preparation of following weight parts:
25 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts of Herba Polygoni cymosis, 25 parts of the Radixs Astragali, 22 parts of Caulis Spatholobis, 22 parts of Bulbus Liliies,
20 parts of Rhizoma Cyperis, 20 parts of Rhizoma Curcumae, 20 parts of Radix Saposhnikoviaes, 18 parts, Poria, 18 parts of Herba Tripterospermi japonicis,
15 parts, Flos Carthami, 15 parts, Radix Rubiae, 15 parts of Herba Leonuris, 15 parts of Herba Taraxacis, 13 parts of Oletum Trogopteroris,
13 parts of Herba Artemisiae Anomalaes, 10 parts, Radix Rehmanniae Preparata, 10 parts, Pericarpium Zanthoxyli, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Cortex Albiziaes,
5 parts, Fructus Hordei Germinatus, 5 parts of Semen Ginkgoes, 5 parts of Fructus Crataegis, 3 parts of the Radix Aucklandiae, 3 parts of Rhizoma Chuanxiongs.
2. the preparation method of medicine according to claim 1, is characterized in that preparation method comprises the steps:
(1) take the crude drug of above-mentioned weight portion standby;
(2) get the Rhizoma Atractylodis Macrocephalae, Herba Polygoni cymosi, the Radix Astragali, Herba Taraxaci, Oletum Trogopterori, Herba Artemisiae Anomalae, Fructus Hordei Germinatus and Semen Ginkgo and add 70% soak with ethanol 1 hour, reflux, extract, twice, each 1 hour, merge extractive liquid,, filters, and is condensed into the extractum that density is 1.2g/ml, crushed after being dried, obtains complex A;
(3) get Caulis Spatholobi, Bulbus Lilii, Rhizoma Cyperi, Rhizoma Curcumae, Radix Saposhnikoviae, Pericarpium Citri Reticulatae and Cortex Albiziae levigation, cross 80 mesh sieves and obtain complex B;
(4) get water boiling and extraction 2 times of Poria, Herba Tripterospermi japonici, Flos Carthami, Radix Rubiae, Herba Leonuri, Radix Rehmanniae Preparata, Pericarpium Zanthoxyli, Fructus Crataegi, the Radix Aucklandiae and Rhizoma Chuanxiong, extract for the first time the water that adds 6 times of weight, extraction time is 0.5 hour; Extract for the second time the water that adds 4 times of weight, extraction time is 0.5 hour; Filter, merging filtrate, is concentrated into the thick paste that density is 1.2g/ml, and crushed after being dried obtains complex C;
(5) by complex A, complex B and complex C mixing and stirring, sterilization and get final product.
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| CN105582476A (en) * | 2016-02-25 | 2016-05-18 | 林立朋 | Pharmaceutical preparation for treating irregular menstruation and application thereof |
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| CN101485863A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating gynaecologic disease and technique for preparing the same |
| CN102512632A (en) * | 2011-12-23 | 2012-06-27 | 荣成市崖头美全口腔诊所 | Chinese herbal composition for treating abnormal menstruation |
| CN102861202A (en) * | 2011-07-08 | 2013-01-09 | 天津太平洋制药有限公司 | Traditional Chinese medicine for treating irregular menstruation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101485863A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating gynaecologic disease and technique for preparing the same |
| CN102861202A (en) * | 2011-07-08 | 2013-01-09 | 天津太平洋制药有限公司 | Traditional Chinese medicine for treating irregular menstruation |
| CN102512632A (en) * | 2011-12-23 | 2012-06-27 | 荣成市崖头美全口腔诊所 | Chinese herbal composition for treating abnormal menstruation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582476A (en) * | 2016-02-25 | 2016-05-18 | 林立朋 | Pharmaceutical preparation for treating irregular menstruation and application thereof |
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