CN103214591A - 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 - Google Patents
一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 Download PDFInfo
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- CN103214591A CN103214591A CN2013101274470A CN201310127447A CN103214591A CN 103214591 A CN103214591 A CN 103214591A CN 2013101274470 A CN2013101274470 A CN 2013101274470A CN 201310127447 A CN201310127447 A CN 201310127447A CN 103214591 A CN103214591 A CN 103214591A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (15)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310127447.0A CN103214591B (zh) | 2013-04-12 | 2013-04-12 | 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
US14/779,934 US10494452B2 (en) | 2013-04-12 | 2013-12-20 | Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof |
CA2908959A CA2908959C (en) | 2013-04-12 | 2013-12-20 | Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof |
JP2016506758A JP6248179B2 (ja) | 2013-04-12 | 2013-12-20 | 末端2,5−脱水タロース又はその誘導体を含んでなる低分子量グリコサミノグリカン誘導体 |
PCT/CN2013/090124 WO2014166282A1 (zh) | 2013-04-12 | 2013-12-20 | 一种含末端2,5−脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
EP13881924.8A EP2985298B1 (en) | 2013-04-12 | 2013-12-20 | Low-molecular-weight fucosylated glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivative thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310127447.0A CN103214591B (zh) | 2013-04-12 | 2013-04-12 | 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103214591A true CN103214591A (zh) | 2013-07-24 |
CN103214591B CN103214591B (zh) | 2015-11-04 |
Family
ID=48812790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310127447.0A Active CN103214591B (zh) | 2013-04-12 | 2013-04-12 | 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10494452B2 (zh) |
EP (1) | EP2985298B1 (zh) |
JP (1) | JP6248179B2 (zh) |
CN (1) | CN103214591B (zh) |
CA (1) | CA2908959C (zh) |
WO (1) | WO2014166282A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103788222A (zh) * | 2014-01-08 | 2014-05-14 | 中国科学院昆明植物研究所 | Fuc3S4S取代的低聚糖胺聚糖及其制备方法 |
WO2014166282A1 (zh) * | 2013-04-12 | 2014-10-16 | 中国科学院昆明植物研究所 | 一种含末端2,5−脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
CN108285498A (zh) * | 2017-01-10 | 2018-07-17 | 九芝堂股份有限公司 | 一种抑制内源性凝血因子x酶复合物的寡糖化合物及其制备方法与用途 |
WO2018129647A1 (zh) | 2017-01-10 | 2018-07-19 | 九芝堂股份有限公司 | 一种抑制内源性凝血因子x酶复合物的寡糖化合物及其制备方法与用途 |
WO2020010534A1 (zh) * | 2018-07-11 | 2020-01-16 | 浙江大学 | 一种海参硫酸软骨素寡糖及其快速制备方法 |
CN114252546A (zh) * | 2020-09-23 | 2022-03-29 | 牡丹江友搏药业有限责任公司 | 一种低分子量岩藻糖化糖胺聚糖含量测定方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5389618A (en) * | 1990-06-26 | 1995-02-14 | Rhone-Poulenc Rorer S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
CN1450076A (zh) * | 2003-04-18 | 2003-10-22 | 山东大学 | 一种多硫酸寡糖及其制备方法 |
CN1531555A (zh) * | 2000-12-18 | 2004-09-22 | 由k5多糖衍生具有高抗血栓形成活性的糖胺聚糖及其制备方法 | |
CN102329397A (zh) * | 2011-10-19 | 2012-01-25 | 中国科学院昆明植物研究所 | 一种岩藻糖化糖胺聚糖衍生物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4351938A (en) | 1980-05-19 | 1982-09-28 | Riker Laboratories, Inc. | Anticoagulant substance |
US5519010A (en) * | 1989-02-06 | 1996-05-21 | Taiho Pharmaceutical Co., Ltd. | Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component |
CN1997657A (zh) * | 2004-04-19 | 2007-07-11 | 海普密姆生物科学控股公司 | 治疗性肝素及其与白细胞介素4和5以及pecam-1的结合 |
CN101735336B (zh) | 2009-11-06 | 2012-07-18 | 深圳海王药业有限公司 | 低聚岩藻糖化糖胺聚糖及其制备方法 |
CN101724086B (zh) * | 2009-11-25 | 2012-09-26 | 深圳海王药业有限公司 | 低聚凤梨参糖胺聚糖及其制备方法 |
CN103214591B (zh) * | 2013-04-12 | 2015-11-04 | 中国科学院昆明植物研究所 | 一种含末端2,5-脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
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2013
- 2013-04-12 CN CN201310127447.0A patent/CN103214591B/zh active Active
- 2013-12-20 EP EP13881924.8A patent/EP2985298B1/en active Active
- 2013-12-20 JP JP2016506758A patent/JP6248179B2/ja active Active
- 2013-12-20 WO PCT/CN2013/090124 patent/WO2014166282A1/zh active Application Filing
- 2013-12-20 CA CA2908959A patent/CA2908959C/en active Active
- 2013-12-20 US US14/779,934 patent/US10494452B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5389618A (en) * | 1990-06-26 | 1995-02-14 | Rhone-Poulenc Rorer S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
CN1531555A (zh) * | 2000-12-18 | 2004-09-22 | 由k5多糖衍生具有高抗血栓形成活性的糖胺聚糖及其制备方法 | |
CN1450076A (zh) * | 2003-04-18 | 2003-10-22 | 山东大学 | 一种多硫酸寡糖及其制备方法 |
CN102329397A (zh) * | 2011-10-19 | 2012-01-25 | 中国科学院昆明植物研究所 | 一种岩藻糖化糖胺聚糖衍生物及其制备方法 |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014166282A1 (zh) * | 2013-04-12 | 2014-10-16 | 中国科学院昆明植物研究所 | 一种含末端2,5−脱水塔罗糖或其衍生物的低分子量糖胺聚糖衍生物 |
US10494452B2 (en) | 2013-04-12 | 2019-12-03 | Jiuzhitang Co., Ltd. | Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof |
CN103788222A (zh) * | 2014-01-08 | 2014-05-14 | 中国科学院昆明植物研究所 | Fuc3S4S取代的低聚糖胺聚糖及其制备方法 |
WO2015103921A1 (zh) | 2014-01-08 | 2015-07-16 | 中国科学院昆明植物研究所 | Fuc3S4S取代的低聚糖胺聚糖及其制备方法 |
CN103788222B (zh) * | 2014-01-08 | 2016-08-31 | 中国科学院昆明植物研究所 | Fuc3S4S取代的低聚糖胺聚糖及其制备方法 |
JP2017502154A (ja) * | 2014-01-08 | 2017-01-19 | 九芝堂股▲ふん▼有限公司Jiuzhitang Co., Ltd. | Fuc3S4S置換の低分子グリコサミノグリカン及びその製造方法 |
CN108285498A (zh) * | 2017-01-10 | 2018-07-17 | 九芝堂股份有限公司 | 一种抑制内源性凝血因子x酶复合物的寡糖化合物及其制备方法与用途 |
WO2018129647A1 (zh) | 2017-01-10 | 2018-07-19 | 九芝堂股份有限公司 | 一种抑制内源性凝血因子x酶复合物的寡糖化合物及其制备方法与用途 |
WO2020010534A1 (zh) * | 2018-07-11 | 2020-01-16 | 浙江大学 | 一种海参硫酸软骨素寡糖及其快速制备方法 |
US11202797B2 (en) | 2018-07-11 | 2021-12-21 | Zhejiang University | Mixture of fucosylated chondroitin sulfate oligosaccharides and method for rapidly producing the same |
CN114252546A (zh) * | 2020-09-23 | 2022-03-29 | 牡丹江友搏药业有限责任公司 | 一种低分子量岩藻糖化糖胺聚糖含量测定方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2985298A1 (en) | 2016-02-17 |
CA2908959C (en) | 2020-10-06 |
CA2908959A1 (en) | 2014-10-16 |
WO2014166282A1 (zh) | 2014-10-16 |
US20160060364A1 (en) | 2016-03-03 |
CN103214591B (zh) | 2015-11-04 |
JP2016519188A (ja) | 2016-06-30 |
JP6248179B2 (ja) | 2017-12-13 |
EP2985298B1 (en) | 2019-09-25 |
EP2985298A4 (en) | 2017-03-01 |
US10494452B2 (en) | 2019-12-03 |
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C06 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160913 Address after: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Patentee after: Jiuzhitang Co., Ltd. Address before: 650201 Yunnan Province, Kunming City Blue Black Road No. 132 Patentee before: Kunming Institute of Botany, Chinese Academy of Sciences |
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TR01 | Transfer of patent right |
Effective date of registration: 20170727 Address after: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Co-patentee after: Friends of Mudanjiang Bo Pharmaceutical Co., Ltd. Patentee after: Jiuzhitang Co., Ltd. Co-patentee after: Hainan Jiuzhitang Pharmacy Co., Ltd. Address before: 410205 Changsha high tech Zone, Tongzi, west slope road, No. 339, No. Patentee before: Jiuzhitang Co., Ltd. |
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TR01 | Transfer of patent right | ||
CI03 | Correction of invention patent |
Correction item: Patentee|Address|Patentee Correct: Jiuzhitang Co., Ltd.|410205 No. 339 west slope, Tongzi hi tech Development Zone, Hunan, Changsha|Mudanjiang Youbo Pharmaceutical Co.,Ltd.|Hainan Jiuzhitang Pharmacy Co., Ltd. False: Jiuzhitang Co., Ltd.|410205 No. 339 west slope, Tongzi hi tech Development Zone, Hunan, Changsha|Friends of Mudanjiang Bo Pharmaceutical Co., Ltd.|Hainan Jiuzhitang Pharmacy Co., Ltd. Number: 33-01 Volume: 33 |
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CI03 | Correction of invention patent |