CN103173373B - Pediococcus acidilactici with high bacteriostatic activity and application thereof - Google Patents
Pediococcus acidilactici with high bacteriostatic activity and application thereof Download PDFInfo
- Publication number
- CN103173373B CN103173373B CN201210240226.XA CN201210240226A CN103173373B CN 103173373 B CN103173373 B CN 103173373B CN 201210240226 A CN201210240226 A CN 201210240226A CN 103173373 B CN103173373 B CN 103173373B
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- Prior art keywords
- pediococcus acidilactici
- bacteriostatic activity
- bacteria
- gram
- vscc
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- 241000191998 Pediococcus acidilactici Species 0.000 title claims abstract description 38
- 230000003385 bacteriostatic effect Effects 0.000 title claims description 19
- 241000894006 Bacteria Species 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 abstract description 9
- 239000000843 powder Substances 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 238000001228 spectrum Methods 0.000 abstract description 5
- 238000002360 preparation method Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 241000186660 Lactobacillus Species 0.000 abstract description 2
- 229940039696 lactobacillus Drugs 0.000 abstract description 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 238000009777 vacuum freeze-drying Methods 0.000 abstract 1
- 239000006041 probiotic Substances 0.000 description 11
- 235000018291 probiotics Nutrition 0.000 description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 230000001580 bacterial effect Effects 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 238000004321 preservation Methods 0.000 description 5
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 244000144977 poultry Species 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000191938 Micrococcus luteus Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003640 drug residue Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000012533 medium component Substances 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 238000011218 seed culture Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229960002920 sorbitol Drugs 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- DHPRQBPJLMKORJ-XRNKAMNCSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O DHPRQBPJLMKORJ-XRNKAMNCSA-N 0.000 description 1
- 108020004465 16S ribosomal RNA Proteins 0.000 description 1
- 102000035101 Aspartic proteases Human genes 0.000 description 1
- 108091005502 Aspartic proteases Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010042566 Superinfection Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- RWVUEZAROXKXRT-VQLSFVLHSA-N maduramicin Chemical compound O1[C@@H](C)[C@H](OC)[C@@H](OC)C[C@H]1O[C@@H]1[C@H]([C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](O)C3)[C@@H](C)[C@H]3[C@@H]([C@@H](OC)[C@H](C)[C@@](O)(CC(O)=O)O3)OC)CC2)O[C@@H]([C@@H]2[C@H](C[C@@H](C)[C@@](C)(O)O2)C)C1 RWVUEZAROXKXRT-VQLSFVLHSA-N 0.000 description 1
- 229950006915 maduramicin Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
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Abstract
Description
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210240226.XA CN103173373B (en) | 2012-07-12 | 2012-07-12 | Pediococcus acidilactici with high bacteriostatic activity and application thereof |
Applications Claiming Priority (1)
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CN201210240226.XA CN103173373B (en) | 2012-07-12 | 2012-07-12 | Pediococcus acidilactici with high bacteriostatic activity and application thereof |
Publications (2)
Publication Number | Publication Date |
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CN103173373A CN103173373A (en) | 2013-06-26 |
CN103173373B true CN103173373B (en) | 2015-05-20 |
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CN201210240226.XA Active CN103173373B (en) | 2012-07-12 | 2012-07-12 | Pediococcus acidilactici with high bacteriostatic activity and application thereof |
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CN (1) | CN103173373B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103614325B (en) * | 2013-11-26 | 2015-07-08 | 江南大学 | Pediococcus pentosaceus and application thereof |
CN103627637A (en) * | 2013-11-29 | 2014-03-12 | 天津大学 | Preparation method for pediococcus acidilactici strain freeze-drying preparation |
LT6270B (en) * | 2014-09-24 | 2016-05-10 | Uab "Baltijos Biotechnologijos" | Probiotic fermented feed additives |
CN106721260A (en) * | 2016-11-30 | 2017-05-31 | 江西正邦科技股份有限公司 | A kind of preparation and its application of anti diar rhea type piglet specific complex probiotics |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101050437A (en) * | 2007-03-21 | 2007-10-10 | 华东理工大学 | Method for producing bacterial strain of Pediococcus acidilactici, and bacterin of Pediococcus acidilactici |
-
2012
- 2012-07-12 CN CN201210240226.XA patent/CN103173373B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101050437A (en) * | 2007-03-21 | 2007-10-10 | 华东理工大学 | Method for producing bacterial strain of Pediococcus acidilactici, and bacterin of Pediococcus acidilactici |
Non-Patent Citations (2)
Title |
---|
乳酸片球菌细菌素的活性及特性的研究;韩雪 等;《食品研究与开发》;20061231;第27卷(第4期);第20页第2节 * |
从酸白菜中分离出一株产细菌素的乳酸片球菌;周志江 等;《食品科学》;20061231;第27卷(第4期);89-92 * |
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CN103173373A (en) | 2013-06-26 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING VICA SHENGBANG BIOLOG TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: BEIJING VICA SHENGBANG BIOLOG TECHNOLOGY CO., LTD. BEIJING UNITE-WINER BIOTECHNOLOGY CO., LTD. Effective date: 20141225 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20141225 Address after: 100085 Beijing city Haidian District Third Street D-803 Wah Building Applicant after: Beijing Vicaren Biological Technology Co., Ltd. Applicant after: Beijing Vica Shengbang Biological Technology Co., Ltd. Address before: 100085 Beijing city Haidian District Third Street D-803 Wah Building Applicant before: Beijing Vicaren Biological Technology Co., Ltd. Applicant before: Beijing Vica Shengbang Biological Technology Co., Ltd. Applicant before: Beijing Lianhe Shengbang Bioscience Co., Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 100085 Beijing city Haidian District Third Street D-803 Wah Building Patentee after: Beijing WIK biotechnology Limited by Share Ltd Patentee after: Beijing Vica Shengbang Biological Technology Co., Ltd. Address before: 100085 Beijing city Haidian District Third Street D-803 Wah Building Patentee before: Beijing Vica Group Co., Ltd. Patentee before: Beijing Vica Shengbang Biological Technology Co., Ltd. |
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TR01 | Transfer of patent right | ||
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Effective date of registration: 20220510 Address after: 110027 No.5A 1-1, No.8 street, Shenyang Economic and Technological Development Zone, Shenyang City, Liaoning Province Patentee after: Shenyang Weijia Biotechnology Co.,Ltd. Address before: 100085 D-803, Jiahua building, Haidian District three street, Beijing. Patentee before: BEIJING VICA BIOTECHNOLOGY CO.,LTD. Patentee before: Beijing Weijia Shengbang Biotechnology Co., Ltd |