CN102935069A - 控释组合物的制备方法 - Google Patents
控释组合物的制备方法 Download PDFInfo
- Publication number
- CN102935069A CN102935069A CN2012104691508A CN201210469150A CN102935069A CN 102935069 A CN102935069 A CN 102935069A CN 2012104691508 A CN2012104691508 A CN 2012104691508A CN 201210469150 A CN201210469150 A CN 201210469150A CN 102935069 A CN102935069 A CN 102935069A
- Authority
- CN
- China
- Prior art keywords
- preparation
- bioactivator
- acid
- organic
- controlled release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (17)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48766303P | 2003-07-15 | 2003-07-15 | |
US60/487,663 | 2003-07-15 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200480026606.7A Division CN1852687B (zh) | 2003-07-15 | 2004-07-15 | 控释组合物的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102935069A true CN102935069A (zh) | 2013-02-20 |
Family
ID=34102710
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2012104691508A Pending CN102935069A (zh) | 2003-07-15 | 2004-07-15 | 控释组合物的制备方法 |
CN200480026606.7A Expired - Fee Related CN1852687B (zh) | 2003-07-15 | 2004-07-15 | 控释组合物的制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200480026606.7A Expired - Fee Related CN1852687B (zh) | 2003-07-15 | 2004-07-15 | 控释组合物的制备方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8871269B2 (zh) |
EP (2) | EP2462896A1 (zh) |
JP (2) | JP5165239B2 (zh) |
CN (2) | CN102935069A (zh) |
AU (1) | AU2004259208B2 (zh) |
BR (1) | BRPI0412059A (zh) |
CA (1) | CA2532302C (zh) |
ES (1) | ES2625343T3 (zh) |
WO (1) | WO2005009356A2 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102552948A (zh) * | 2010-12-10 | 2012-07-11 | 财团法人工业技术研究院 | 可控制释放的组合物及其制造方法 |
US8900636B2 (en) | 2003-07-23 | 2014-12-02 | Evonik Corporation | Controlled release compositions |
US8916196B2 (en) | 2003-04-10 | 2014-12-23 | Evonik Corporation | Method for the production of emulsion-based microparticles |
CN106999443A (zh) * | 2014-12-02 | 2017-08-01 | 安特里阿比奥有限公司 | 具有增加的疏水性的蛋白质及蛋白质偶联物 |
CN111643483A (zh) * | 2020-07-06 | 2020-09-11 | 济南大学 | 一种用于制备加兰他敏缓释微球的新方法 |
Families Citing this family (28)
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US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
WO2005009356A2 (en) | 2003-07-15 | 2005-02-03 | Pr Pharmaceuticals, Inc. | Method for the preparation of controlled release formulations |
JP2008518881A (ja) * | 2003-07-18 | 2008-06-05 | オークウッド ラボラトリーズ,エル.エル.シー. | 高分子組成物中の高分子の分子量低下、不純物形成およびゲル化の防止 |
EP1711159B1 (en) * | 2003-12-30 | 2013-03-20 | Durect Corporation | Solid implants containing a block copolymer for controlled release of a gnrh compound |
EP1679065A1 (en) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Controlled release compositions for interferon based on PEGT/PBT block copolymers |
US20100290982A1 (en) * | 2007-04-13 | 2010-11-18 | University Of North Texas Health Science Center At Fort Worth | Solid in oil/water emulsion-diffusion-evaporation formulation for preparing curcumin-loaded plga nanoparticles |
RU2473331C2 (ru) | 2007-04-13 | 2013-01-27 | Юниверсити Оф Норс Техас Хэлс Саенс Сентер Эт Форт Ворс | Состав активированных наночастиц plga, загруженных активным средством, для целенаправленной нанотерапии рака |
AU2008241699B2 (en) * | 2007-04-19 | 2011-02-03 | Dong-A Pharmaceutical. Co., Ltd | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
GB0709322D0 (en) * | 2007-05-15 | 2007-06-20 | Nordic Bioscience As | Exposure agent for detection of vitamin d |
WO2008145183A1 (en) * | 2007-05-30 | 2008-12-04 | Nestec S.A. | Oil-in-water emulsion and its use for the delayed release of active elements |
WO2009048929A1 (en) | 2007-10-08 | 2009-04-16 | Lux Biosciences, Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors |
ES2324009B1 (es) * | 2007-11-23 | 2010-05-21 | Gp Pharm S.A. | Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo. |
US8071914B2 (en) * | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
JP5222550B2 (ja) * | 2007-12-27 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
US9161943B2 (en) | 2007-12-31 | 2015-10-20 | Industrial Technology Research Institute | Sustained release composition and manufacturing method thereof |
US8586103B2 (en) * | 2008-02-08 | 2013-11-19 | Foresee Pharmaceuticals, Llc | Non-polymeric compositions for controlled drug delivery |
WO2010009291A1 (en) | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
CN102458370A (zh) | 2009-06-09 | 2012-05-16 | 卢克斯生物科技公司 | 用于眼科用途的表面药物递送*** |
RU2012107812A (ru) * | 2009-08-05 | 2013-09-10 | Аллерган, Инк. | Препараты мутеинов липокалинов с контролируемым высвобождением |
US20110151028A1 (en) * | 2009-12-19 | 2011-06-23 | Filiberto Zadini | Topical vaginal preparation |
ES2362604B1 (es) * | 2009-12-22 | 2012-06-28 | Bcn Peptides, S.A. | Formulación tópica oftálmica de péptidos. |
BR112012022873B1 (pt) * | 2010-03-11 | 2021-09-14 | Wyeth Llc | Composição farmacêutica para administração oral compreendendo brometo de metilnaltrexona e dodecil sulfato de sódio |
JP5222917B2 (ja) * | 2010-09-21 | 2013-06-26 | 財團法人工業技術研究院 | 徐放性組成物およびその製造方法 |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
US20190117573A1 (en) * | 2017-10-19 | 2019-04-25 | Hyalo Technologies, LLC | Composition and method of preparation of risperidone extended release preparation |
CA3165185A1 (en) * | 2020-01-24 | 2021-07-29 | W. L. Gore & Associates, Inc. | Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof |
AU2022226584A1 (en) | 2021-02-24 | 2023-08-17 | Oakwood Laboratories, Llc | Microsphere formulations comprising lurasidone and methods for making and using the same |
WO2023102018A1 (en) * | 2021-12-02 | 2023-06-08 | University Of Connecticut | Long-acting injectable in situ forming biodegradable implants comprising non-steroidal anti-inflammatory drugs |
Citations (1)
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CN1288387A (zh) * | 1998-01-16 | 2001-03-21 | 武田药品工业株式会社 | 缓释组合物、其制备方法及其应用 |
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-
2004
- 2004-07-15 WO PCT/US2004/022816 patent/WO2005009356A2/en active Application Filing
- 2004-07-15 AU AU2004259208A patent/AU2004259208B2/en not_active Ceased
- 2004-07-15 CN CN2012104691508A patent/CN102935069A/zh active Pending
- 2004-07-15 BR BRPI0412059-0A patent/BRPI0412059A/pt not_active IP Right Cessation
- 2004-07-15 EP EP11187402A patent/EP2462896A1/en not_active Withdrawn
- 2004-07-15 CN CN200480026606.7A patent/CN1852687B/zh not_active Expired - Fee Related
- 2004-07-15 ES ES04778360.0T patent/ES2625343T3/es not_active Expired - Lifetime
- 2004-07-15 CA CA2532302A patent/CA2532302C/en not_active Expired - Fee Related
- 2004-07-15 EP EP04778360.0A patent/EP1651136B1/en not_active Expired - Lifetime
- 2004-07-15 US US10/564,494 patent/US8871269B2/en active Active
- 2004-07-15 JP JP2006520347A patent/JP5165239B2/ja not_active Expired - Fee Related
-
2011
- 2011-04-27 JP JP2011100206A patent/JP2011144207A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1288387A (zh) * | 1998-01-16 | 2001-03-21 | 武田药品工业株式会社 | 缓释组合物、其制备方法及其应用 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8916196B2 (en) | 2003-04-10 | 2014-12-23 | Evonik Corporation | Method for the production of emulsion-based microparticles |
US10272044B2 (en) | 2003-04-10 | 2019-04-30 | Evonik Corporation | Method for the production of emulsion-based microparticles |
US8900636B2 (en) | 2003-07-23 | 2014-12-02 | Evonik Corporation | Controlled release compositions |
CN102552948A (zh) * | 2010-12-10 | 2012-07-11 | 财团法人工业技术研究院 | 可控制释放的组合物及其制造方法 |
CN102552948B (zh) * | 2010-12-10 | 2015-08-26 | 财团法人工业技术研究院 | 可控制释放的组合物及其制造方法 |
CN106999443A (zh) * | 2014-12-02 | 2017-08-01 | 安特里阿比奥有限公司 | 具有增加的疏水性的蛋白质及蛋白质偶联物 |
US10702611B2 (en) | 2014-12-02 | 2020-07-07 | Rezolute, Inc. | Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates |
CN111643483A (zh) * | 2020-07-06 | 2020-09-11 | 济南大学 | 一种用于制备加兰他敏缓释微球的新方法 |
Also Published As
Publication number | Publication date |
---|---|
US8871269B2 (en) | 2014-10-28 |
CN1852687B (zh) | 2014-01-22 |
JP2011144207A (ja) | 2011-07-28 |
EP1651136B1 (en) | 2017-03-08 |
CN1852687A (zh) | 2006-10-25 |
US20060228414A1 (en) | 2006-10-12 |
ES2625343T3 (es) | 2017-07-19 |
JP5165239B2 (ja) | 2013-03-21 |
WO2005009356A2 (en) | 2005-02-03 |
AU2004259208A1 (en) | 2005-02-03 |
CA2532302C (en) | 2016-12-20 |
EP1651136A2 (en) | 2006-05-03 |
EP1651136A4 (en) | 2009-07-08 |
CA2532302A1 (en) | 2005-02-03 |
AU2004259208B2 (en) | 2011-04-28 |
EP2462896A1 (en) | 2012-06-13 |
BRPI0412059A (pt) | 2006-09-05 |
WO2005009356A3 (en) | 2005-06-09 |
JP2007524645A (ja) | 2007-08-30 |
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