The object of the invention provides a kind of invigorating the spleen benefit liver, reduces internal heat and quenches the thirst, Dealcoholic sobering-up, orectic sobering-up health-care tea.
The composition of raw materials that nourishes iced tea of relieving the effect of alcohol of the present invention is as follows: followingly calculate by per hundred kg of water dosing (raw material) kg
Coloured malt 1kg-2kg dried peppermint leaf 0.5kg-1.5kg
Mung bean sprouts 1kg-2kg fruit of Chinese wolfberry 0.5kg-1.5kg
Root of kudzu vine 1kg-2kg chrysanthemum 1kg-2kg
Dried orange peel 0.5kg-1.5kg radix bupleuri 0.5kg-1.5kg
Rhizoma zingiberis 1kg-2kg Poria cocos 0.5kg-1.5kg
Radix Glycyrrhizae 1kg-kg lophatherum gracile 1kg-2kg
Hawthorn 1kg-3kg rock sugar 1kg-2kg
The preferred mass proportioning of above-mentioned each component is as follows:
Coloured malt 1.5kg dried peppermint leaf 1kg
Mung bean sprouts 1.5kg fruit of Chinese wolfberry 1kg
Root of kudzu vine 1.5kg chrysanthemum 1.5kg
Dried orange peel 1kg radix bupleuri 1kg
Rhizoma zingiberis 1.5kg Poria cocos 1kg
Radix Glycyrrhizae 1.5kg lophatherum gracile 1.5kg
Hawthorn 2kg rock sugar 1.5kg
With above-mentioned prescription is Chinese medicinal ingredients, existing that micro-medicine composition prescription of the present invention is as follows:
Health protection tea drink of the present invention includes the trace element that various needed by human body are wanted, its elementary composition sees content how much, formulating the consumption standard by country adds, or the content interpolation of pressing per kilogram water with reference to the consumption of " national drug use grand ceremony ", (it is fixed that the content percentage of its former medicine owing to can not come to a conclusion, used medicine all have manufacturer to come).The used trace element of the present invention is the preliminary experiment consumption.Sincerely for reference:
(former powder or stoste)
1 grape glycogen powder, 3% 7 steviosides 1%
2 xylitols, 2.5% 8 Sodium Benzoates 0.1%
3 white granulated sugars, 2% 9 vitamin Cs 0.3%
4 calcium lactates, 1.5% 10 vitamin B1s 0.25%
5 citric acids, 0.5% 11 vitamin B2s 0.2%
6 salt compounded of iodine 0.25%
Component with above-mentioned prescription is a raw material, can adopt conventional extraction process to extract its effective ingredient, is prepared into beverage, and as health protection tea, oral liquid also can be encapsulated with pulverizing behind the above-mentioned component convection drying.
Medicine of the present invention is formed preparation rationally, effect balancing, wherein:
Fructus Hordei Germinatus is monarch drug in a prescription, and nature and flavor are sweet flat, return spleen, stomach, Liver Channel.Have help digestion and in, therapeutic method to keep the adverse qi flowing downward delaactation, soothing liver and strengthening spleen effect; Mung bean sprouts is worked as ministerial drug, and stomach is returned in the sweet cold of nature and flavor, the heart channel of Hang-Shaoyin, detoxifcation, dampness removing, Compendium of Material Medica day: " relieving alcoholism, heat poison, sharp three warmers "; The root of kudzu vine is a ministerial drug: sweet, flat, go into spleen, and the stomach warp, promoting eruption is given birth to dregs and is quenched the thirst relieving alcoholism.Rhizoma zingiberis is an adjutant: suffering, and heat is gone into the heart, the liver lung, spleen, the stomach warp, warming spleen and stomach for dispelling cold, four sun are promoted blood circulation, dry temperature dissolving phlegm.Hawthorn is an adjutant: the sweet tepor of nature and flavor acid, go into spleen, stomach, Liver Channel.Help digestion and amass, stagnation resolvation antidiarrheal.Radix bupleuri is for making medicine, hardship, suffering is slightly cold, and goes into liver, gallbladder channel and induce sweat in, soothing the liver liter sun.Poria cocos is for making medicine: sweet, light, flat, go into the heart, spleen, lung channel.Ooze Wen Lishui, beneficial spleen and stomach, antitoxic heart-soothing and sedative.
Fructus Hordei Germinatus and mung bean sprouts or the root of kudzu vine, a monarch two ministers, have help digestion and in, pleasant, relieving muscles to expel heat, promoting eruption, promote the production of body fluid to quench thirst relieving alcoholism, heat poison, sharp three warmers are regulated the effect of human body state balance, and coloured malt and hawthorn are the good merchantable brand of digestion-promoting spleen-invigorating altogether, be total to promotion human consumption absorption, the hawthorn regulating qi to disperse stagnation is good for the stomach and promotes the production of body fluid, the root of kudzu vine has the Dealcoholic sobering-up effect from ancient times, adds the relieving alcoholism effect of mung bean sprouts again, neutralizes with Radix Glycyrrhizae in addition, to the reaction of relieving the effect of alcohol, more obvious, so: to the crowd who does not drink: as children, the women, heat-clearing is also arranged, detoxifcation, relieving muscles to expel heat, give birth to dregs's effect of quenching the thirst, be more suitable for most of crowds, the dried orange peel therapeutic method to keep the adverse qi flowing downward that is good for the stomach, open chest, peppermint and chrysanthemum wind-dispelling heat-dissipating are warded off dirty detoxifcation, removing heat to brighten vision, matrimony vine and Radix Glycyrrhizae, nourishing liver and kidney, the moistening lung that makes eye bright is invigorated the spleen and benefited qi, and is clearing heat and detoxicating, moisten the lung and relieve the cough, relieving restlessness is reduced internal heat, clearing lung-heat heat, diuresis is promoted the production of body fluid, and sobers up.The number medicine cooperates, and monarch is clear and definite, and effect is outstanding, plays strengthening spleen, tonifying kidney altogether, and Dealcoholic sobering-up moistens life, delays senility.
The present invention is in pharmacological action, added the indispensable trace element of human body again in right amount: as vitamin C, or vitamin B1 B2: the glucose of liver is protected in diuresis, the effect that is Dealcoholic sobering-up is more obvious, strengthens the calcium lactate of human body, the allusion quotation salt that quenches the thirst fast, give and more lack vitamin C, comprehensively replenishing of vitamin B1 B2 and calcium, thus solved, sober up, limbs fatigue, remember unclearly, eyesight descends, or expelling pathogenic factors from muscles for clearing heat, the effect of preventing phlegm from forming and stopping coughing, bring more fully energy supplement for more crowd, play nourishing life, delaying senility function.
The method for making of health beverages medicinal tea of the present invention is as follows:
Preceding ten four traditional Chinese medicine thing compositions are put into pot, add purify waste water boiled, cold 5-10 minute, add carbohydrate and trace element again, after filtration the sterilization, can bottle.
Easy to carry for more crowds, medicine preferred dosage form of the present invention " capsule " and method for making as follows:
With coloured malt, mung bean sprouts, the root of kudzu vine, dried orange peel, rhizoma zingiberis, Radix Glycyrrhizae, hawthorn, dried peppermint leaf, the fruit of Chinese wolfberry, chrysanthemum, radix bupleuri, Poria cocos, lophatherum gracile, rock sugar is in proportion, mixing adds 75% alcohol immersion and crosses powder, refluxing extraction three times, each 1.5-2.0 hour, extract merged, decompression concentrate medicinal extract (25 ℃ of proportion 1.30-1.40).The medicinal extract vacuum drying.
With carbohydrate and microelement powder or liquid mixing, after vacuum drying, pulverize the back and mix with preceding 14 flavor dry drugs, cross sieve No. 4.During medicinal powder incapsulated promptly.
The present invention keeps healthy and nourishes drink or medicine, reasonable recipe not only, the effect equilibrium, and have the function of good stomach strengthening and digestion promoting Dealcoholic sobering-up, can also play the effect of regulating immunologic mechanism, be a kind of health drink tea or capsule pharmaceutical that most of people drink or take that be suitable for.
Experimental example 1
The evaluation of effect of medicine of the present invention (the commodity antialcoholism capsule that nourishes by name in this experiment, down together) functions of strengthening stomach and promoting digestion.
1, the influence that mouse small intestine is wriggled
Materials and methods
Animal used as test: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 25.34 ± 2.23.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (07) 01-3001 of doctor.
Be subjected to the reagent thing: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.0.45g/ grain.
Test method: get mouse and be divided into four groups at random, 10 every group.Give the medicine that contains the 0.5g/ml active carbon of various dose respectively.30 fens execution mouse after 1 administration.Separate small intestine, divide survey the small intestine total length and and charcoal not the forward position to the length of small intestine terminal.Calculate charcoal off-duty length and charcoal off-duty length percentage [=charcoal off-duty length/small intestine total length %].The administration volume, 0.2ml/10g.
The test grouping:
Positive control drug: digestion-promoting stomachic.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 09060033. function with cure mainly: stomach strengthening and digestion promoting.Be used for weakness of the spleen and the stomach, indigestion.
The result
The influence of table 1 nourishing antialcoholism capsule energy mouse small intestine motion (x ± s)
Compare * P<0.05 with the 1st group.n=10。
Conclusion
Nourish antialcoholism capsule to the obviously effect of mouse small intestine motion nothing.
2, to the influence of mouse food-intake
Materials and methods
Animal used as test: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 16.9 ± 2.93.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (07) 01-3001 of doctor.
Be subjected to the reagent thing: nourish antialcoholism capsule.This institute new drug research center provides.Lot number 090928.0.45g/ grain.
Experimental technique: get mouse and be divided into four groups at random.Every group 20 (every group is divided four boxes to raise again.5/box).Give the medicine of various dose respectively.Be administered once every day.Successive administration 10 days.Respectively at the 1st, 3,5,7 before the administration and after the administration, 24 hours food-intakes of 10 days mensuration mouse.
Experiment grouping: the same.
Positive control drug: digestion-promoting stomachic.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 09060033.Function with cure mainly: stomach strengthening and digestion promoting.Be used for weakness of the spleen and the stomach, indigestion.
The result
Table 2 nourishes antialcoholism capsule to the influence of mouse food-intake (x ± s)
Compare * P<0.05 with the 1st group.n=20。
Conclusion
Nourish antialcoholism capsule and have the effect that certain promotion mouse is taken food.Positive control drug does not have obvious effect.
3, to the influence of small intestine absorption
Materials and methods
Experimental animal: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 16.9 ± 2.93.Available from Institute of Zoology, Academia Sinica.Card number: moving word (07) 01-3001 of doctor.
Be subjected to the reagent thing: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.0.45g/ grain.
Test method: the KM mouse is divided into 5 groups at random.Every group 10 (the 5th group 4).Give the medicine of various dose respectively.Be administered once every day.Successive administration 10 days.The mouse fasting is 12 hours after administration in the 10th day.Tested in second day.Every mouse stomach includes the GC liquid (giving equal-volume distilled water for the 5th group) of 10% glucose and 5% cholesterol during test.0.2ml/10g。Irritate behind the stomach and to pluck eyeball in 20 minutes and get blood, separation of serum is surveyed blood sugar and cholesterol level.Used kit all available from living biochemical reagents company.Lot number: 090407,090405.Tester is the ZS-1A semi-automatic biochemical analyzer.
The test grouping:
Positive control drug: digestion-promoting stomachic.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 09060033.Function with cure mainly: stomach strengthening and digestion promoting.Be used for weakness of the spleen and the stomach, indigestion.
The result
The influence that table 3 nourishing antialcoholism capsule absorbs mouse small intestine (x ± s)
Compare △ △ △ P<0.05, P<0.01 with the 3rd group.
Compare * * * P<0.05, P<0.01 with the 5th group.n=10。
Conclusion
The nourishing antialcoholism capsule has the effect of certain little intestinal absorption of promotion.But dose-effect relationship is not obvious.
Experimental example 2 medicines of the present invention are to the regulating action evaluation of immunologic function
1, to the effect of mouse carbon particle clearance
Materials and methods
Experimental animal: KM mouse, male and female half and half.Non-inbred strais closed colony.Body weight: 21.12 ± 1.89.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (07) 01-3001 of doctor.
Be subjected to the reagent thing: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.0.45g/ grain.Test method: get mouse and be divided into 4 groups at random.Every group 10.Give the medicine of various dose respectively.Be administered once every day.Successive administration 10 days.After administration in the 10th day 1 hour, the india ink of mouse tail vein injection dilution (with 4 times of physiological saline dilutions).0.1ml/10g。Get blood 20ul respectively at 2,10 minutes mouse angular vein clumps behind the injection india ink, and it be dissolved in the 2ml0.1%Na2CO3 liquid, with 752 spectrophotometers at 600nm place photometry density value.And make blank with Na2CO3.
After mouse execution, get liver, spleen is weighed, and calculates phagocytic index (a) fully.
Index is expressed: the K value=(logOD1-logOD2)/(t2-t1)
A=body weight/(liver weight+spleen is heavy) 3 K
The test grouping:
Positive control drug: digestion-promoting stomachic.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 090928.Function with cure mainly: stomach strengthening and digestion promoting.Be used for weakness of the spleen and the stomach, indigestion.
The result
Table 4 nourishes the influence (x ± s) of antialcoholism capsule and spleen weight wide to the mouse carbon granules
Compare * P<0.05 with the 1st group.n=10。
Conclusion
The nourishing antialcoholism capsule has the effect of certain promotion mouse monokaryon macrophage phagocytic.Low dose promptly has tangible effect.
2, to the influence of mouse spleen lymphocyte transformation
Materials and methods
Experimental animal: KM mouse, part of speech.Non-inbred strais closed colony.Body weight: 20.83 ± 1.02g.Available from zooscopy institute of the Chinese Academy of Medical Sciences.Card number: moving word (07) 01-3001 of doctor.
Be subjected to the reagent thing: nourish antialcoholism capsule.This institute new drug research center provides.Lot number: 090928.1.45g/ grain.
Reagent: RPMI1640 nutrient solution (Sigma).Acid isopropyl alcohol liquid (adding 4mllmol/LHCl in the 96ml isopropyl alcohol liquid).MTT(sigma)。ConA(Sigma)。
Test method: get mouse and be divided into 4 groups at random.Every group 3.Give the medicine of various dose respectively.Be administered once every day.Successive administration 7 days.Put to death mouse in 1 hour after administration in the 7th day, the aseptic spleen of getting extracts the T cell.Adjusting cell concentration is 2 * 10
6Cell/ml.Divide 2 holes to add in 24 well culture plates 1ml/ hole in cell liquid.And do not add ConA liquid control wells.Add CoaA concentration 100ug/ml 50ul.Place 5%CO2, cultivated 72 hours for 37 ℃.Cultivate and finish preceding 4 hours, every hole adds 5mg/ml MTT50ul/ hole.Continue to cultivate 4 hours.After cultivating end, do not have the hole to add 1ml acid isopropyl alcohol, the piping and druming mixing dissolves purple crystal fully.Divide then and be filled in 96 orifice plates every hole packing 3 holes.Detect wavelength 570nm with the 318MC ELIASA.Calculate T ability of cell proliferation (=OD adds conA-OD and do not add conA).T cell proliferation percentage [=(OD adds conA-OD and does not add conA/OD and do not add conA].
The test grouping:
Positive control drug: digestion-promoting stomachic.Pharmaceutical factory produces in the river.0.8g/ sheet.Lot number: 090928.Function with cure mainly: stomach strengthening and digestion promoting.Be used for weakness of the spleen and the stomach, indigestion.
The result
Table 5 nourishes antialcoholism capsule to the influence of mouse spleen T cell proliferation function (x ± s)
Compare * * * P<0.05, P<0.01 with the 1st group.n=3。
Conclusion
Nourish antialcoholism capsule and have the ability that promotes that spleen lymphocyte transforms, this product has invigorating the spleen benefit liver, relieves the effect of alcohol and the advantage such as fast of sobering up.Obvious with heavy dose of effect.