CN101856120A - Health food for improving immunity of human body and preparation method thereof - Google Patents
Health food for improving immunity of human body and preparation method thereof Download PDFInfo
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Abstract
The invention discloses health food for improving the immunity of a human body and a preparation method thereof. The health food comprises the following components in percentage by weight: 5 to 25 percent of American ginseng extract, 5 to 15 percent of pseudo-ginseng extract, 45 to 75 percent of fermentation cordyceps, 10 to 15 percent of starch, and 0 to 1 percent of magnesium stearate. The preparation method for the health food comprises the followings steps of: screening the American ginseng extract, the pseudo-ginseng extract, the fermentation cordyceps, the starch and the magnesium stearate respectively; weighing in a proportion and mixing; and finally packaging the mixed powder into a capsule shell. By using the advantages of the Chinese medicaments, the health food has the effects of regulating qi and blood, harmonizing the Yin and Yang, regulating the vital organs of the human body, supporting healthy energy, and improving the immunity of the human body.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof, particularly relate to health food of a kind of human immunological competence of raising and preparation method thereof.
Background technology
Along with the quickening of social rhythm, the increase of life competitive pressure and the radiation interference of various electronic equipments, dysphoria, overwork, insomnia, irregular, the underfed state of daily life have appearred in many people.If body is in this state for a long time, can cause antibody in the body and growth factor secretory volume fluctuate widely and body in the instability of immunoglobulin content, immunity of organisms is descended, finally cause the sub-health state of body.According to the investigation of skill association of in July, 2002 China health dept. to 16 1,000,000 above population cities, Beijing, Shanghai, Guangdong three ground residents are in the ratio of inferior health all more than 70%.According to another observation, the people of China below 40 years old is in may accounting for more than 20% of sub-health state, and in rising trend.More seriously, during young and middle-aged people's health check-up by find blood viscosity, MCO unusual be not minority, illustrate that sub-health population has begun to transform to the disease crowd.Inferior health often can cause diseases such as coronary heart disease, gastric ulcer, duodenal ulcer, ulcerative colitis, diabetes, tumour, rheumatoid arthritis, also can make more infectivity of various infective virus, such as virus flu, hepatitis, SARS etc.Want fundamentally to prevent inferior health, optimal way is when strengthening physical training, and notes self health care, reasonable edible health food, thus make health reach best immune functional state.
Health food kind in the market is a lot, but mainly is the health food of regulating the painstaking effort tubing, can really play and regulate the human immune system, improves the human immunological competence, prevents health products or the phoenix feathers and unicorn horns of disease in possible trouble.
Summary of the invention
Goal of the invention: the present situation at the few DeGrain of present raising immunity health products provides a kind of new raising body immunity health products and preparation method thereof.
Summary of the invention: a kind of health products that improve body immunity comprise following components in weight percentage: American ginseng extract 5～25%, Notogineng Extract 5～15%, bat pretty young woman paecilomycerol powder 45～75%, starch 10～15%, dolomol 0～1%.
Wherein, described American ginseng extract is with 75% alcohol extract 2 times by medicinal material coarse powder, each 1.5h, the weight ratio of medicinal material coarse powder and ethanol is 1: 12, then with extract-0.06～-0.09Mpa, distillation concentrates under the 75-85 ℃ of condition, at last-0.08～-0.1Mpa, vacuum drying below 80 ℃ is until moisture content＜5%.
Wherein, described Notogineng Extract is with 70% alcohol extract 3 times by medicinal material coarse powder, each 1.5h, the weight ratio of medicinal material coarse powder and ethanol is 1: 10, then with extract-0.06～-0.09Mpa, distillation concentrates under the 75-85 ℃ of condition, at last-0.08～-0.1Mpa, vacuum drying below 80 ℃ is until moisture content＜5%.
Wherein, described bat pretty young woman paecilomycerol is selected from separating obtained Cordyceps Militaris-Paecilomyces hepiali chen in the fresh Cordyceps sinensis of Clavicipitaceae.
The method for preparing described health food may further comprise the steps:
(1) with American ginseng extract, Notogineng Extract, bat pretty young woman paecilomycerol powder, starch and dolomol are crossed 60 mesh sieves respectively, and the weighing side of going into is mixed in proportion;
(2) mixed powder is incapsulated in the shell every dress 0.4g with Autocapsulefillingmachine.
Wherein, the incorporation time of step (1) is best with 30min.
American ginseng extract derives from American Ginseng.American Ginseng is the dry root of Araliaceae American Ginseng Panaxquinquefolium L..American Ginseng is cool in nature, flavor is sweet, little hardship; The thoughts of returning home, lung, kidney channel; Have strengthening by means of tonics, the yin-nourishing of nourishing blood, the effect of strengthening the spleen and replenishing qi, and have BA widely, it often with other Chinese traditional medicine composition together, become one of component commonly used in the health food.Its main active ingredient is American ginseng saponin, can act on the panimmunity competent cell, promotes the secretion of some cell factor further to bring into play immunoregulation effect.Modern pharmacology shows that American Ginseng can strengthen the T cell and produce the lymphokine ability, can significantly strengthen the activity of NKC.Notogineng Extract derives from pseudo-ginseng.Pseudo-ginseng is the dry root of Araliaceae Panax notoginseng (Burk.) F.H.Chen.Sweet, the little hardship of pseudo-ginseng nature and flavor, temperature; Return liver, stomach warp; Have removing blood stasis and hemostasis, Repercusion analgesia, the strong effect of qi-restoratives.Pseudo-ginseng and invigorant genseng commonly used, American Ginseng are equal platymiscium, and the beginning is stated from Ming Dynasty's Compendium of Material Medica.Modern study shows that the chemical composition of pseudo-ginseng is mainly arasaponin, arasaponin is the main active ingredient of extracting from the pseudo-ginseng rhizome, pharmacological action is extensive, has antifatigue, improves hypoxia-bearing capability, hypoglycemic, promoting blood circulation and removing blood stasis and improve many-sided effect such as immunologic function.There is the bibliographical information arasaponin to have tangible humidification at aspects such as cellular immune function, humoral immune function and NK cells.The peacilomyce hepiahi bacterium powder that the present invention selects for use is to adopt the separating obtained Cordyceps Militaris-Paecilomyces hepiali chen of fresh Cordyceps sinensis, cultivates, processes through submerged fermentation.Cordyceps sinensis is a kind of rare traditional Chinese medicine of China, and this medicine is gone into lung, kidney two warps, and the flat flavor of property is sweet, has effect such as invigorate the lung and the kidney, and is used for that chronic cough void is breathed heavily, impotence and seminal emission, soreness of waist and knee joint etc.But its source is few, and price is extremely expensive, is difficult to satisfy the needs of domestic and international medical market, and for this reason, the scientific worker of China adopts the aweto fungus that obtains from natural cs, replaces Cordyceps sinensis with fermentation method productive manpower cordyceps mycelia.Main component natural and artificial Cordyceps sinensis has adenosine etc.Modern pharmacological research shows that Chinese caterpillar fungus and cordyceps mycelia all can obviously strengthen the phagocytic function of macrophage and improve the activity of serum hemolysin, and especially the low animal of pair cell or humoral immune function acts on more obvious.
Analyze from the raw material properties aspect, American ginseng extract, Notogineng Extract are bitter, and the peacilomyce hepiahi bacterium powder has peculiar smell, is not suitable for making the formulation of direct contact dispute, as electuary, pulvis and tablet etc.And capsule has the following advantages: the bad stink and the excitant that reduces medicine of covering medicine; Compare with tablet, pill etc., in gastro-intestinal Fluid, disperse soon good absorbing, bioavilability height; Can improve stability of drug etc.Therefore the present invention adopts capsule, without flavourings such as sugarings, has just solved the hard to bear drawback of bitter, for the eater provides optimum formulation.Capsule is easy to take in addition, and the production equipment of typing is arranged, and also is applicable to suitability for industrialized production.So formulation of the present invention is decided to be capsule, both met the characteristics of raw material, be convenient to edible object again and take, store and carry, and meet the industrialized production requirement.
Beneficial effect: the selected American ginseng extract of the present invention, Notogineng Extract, peacilomyce hepiahi bacterium powder, all medicines share, and play the effect that strengthens immunity altogether, utilization Chinese medicine advantage, regulation of qi and blood negative and positive, the conditioning vital organs of the human body are strengthened the body resistance to consolidate the constitution, and strengthen immunity of organisms.
The specific embodiment
Embodiment 1:
With 5% American ginseng extract, 14.5% Notogineng Extract, 70% bat pretty young woman paecilomycerol powder, (unit is a percetage by weight for 10% starch and 0.5% dolomol, cross 60 mesh sieves respectively down together), then above-mentioned raw materials is dropped in the Multidimensionblender, mix 30min and at last mixed powder is incapsulated in the shell with Autocapsulefillingmachine, every dress 0.4g.
Embodiment 2:
With 10% American ginseng extract, 12.5% Notogineng Extract, 65% bat pretty young woman paecilomycerol powder, 12% starch and 0.5% dolomol are crossed 60 mesh sieves respectively, then above-mentioned raw materials is dropped in the Multidimensionblender, mix 30min and at last mixed powder is incapsulated in the shell with Autocapsulefillingmachine, every dress 0.4g.
Embodiment 3:
With 15% American ginseng extract, 9.5% Notogineng Extract, 62.5% bat pretty young woman paecilomycerol powder, 12.5% starch and 0.5% dolomol are crossed 60 mesh sieves respectively, then above-mentioned raw materials is dropped in the Multidimensionblender, mix 30min and at last mixed powder is incapsulated in the shell with Autocapsulefillingmachine, every dress 0.4g.
Embodiment 4:
With 20% American ginseng extract, 9.5% Notogineng Extract, 55% bat pretty young woman paecilomycerol powder, 15% starch and 0.5% dolomol are crossed 60 mesh sieves respectively, then above-mentioned raw materials is dropped in the Multidimensionblender, mix 30min and at last mixed powder is incapsulated in the shell with Autocapsulefillingmachine, every dress 0.4g.
Embodiment 5:
With 25% American ginseng extract, 14% Notogineng Extract, 47.5% bat pretty young woman paecilomycerol powder, 13% starch and 0.5% dolomol are crossed 60 mesh sieves respectively, then above-mentioned raw materials is dropped in the Multidimensionblender, mix 30min and at last mixed powder is incapsulated in the shell with Autocapsulefillingmachine, every dress 0.4g.
Embodiment 6:
The present invention improves the immunity function experimental study
1. material
1.1 sample: provide by the Wuxi City health bio tech ltd of being bestowed by heaven.
1.2 reagent, experiment equipment and animal
1.2.1 reagent
SRBC (Mianyang red blood cell), Hank ' s liquid, DNFB (2,4 dinitrofluorobenzene), S
ABuffer solution, agarose, india ink, Na
2CO
3(sodium carbonate), RPMI1640 nutrient solution, chicken erythrocyte suspension, physiological saline, YAC-1 cell.Above reagent is provided by the disease prevention and control center, Sichuan Province.
1.2.2 experiment equipment
100 μ micro syringes, CO2gas incubator, electronic analytical balance, 723 spectrophotometers, centrifuge, operating theater instruments
1.2.3 animal used as test
160 of the Kunming mouses that Sichuan Academy of Medical Sciences institute of lab animals provides, female entirely, body weight 18-22g, production licence number are SCXK (river) 2004-16SPF level; The experimental animal room is the SPF level, and occupancy permit number is real moving pipe SYXK (river) 2008-043 in river.Temperature 20-25 ℃, relative humidity 40～70%.
2. experimental technique
2.1 dosage is selected
Tried thing and established 267mg/kg.BW, 533mg/kg.BW, three dosage groups of 800mg/kg.BW (be equivalent to respectively human body recommended intake 10 times, 20 times, 30 times), take by weighing 3.32g, 6.68g respectively, 10.00g is tried the thing adding distil water to the 250ml mixing, stored refrigerated, use up again and join, other establishes the distilled water negative control group, every group of 40 animals.Be divided into immune one group, two groups, three groups, four groups, wherein one group is used for Turnover of Mouse Peritoneal Macrophages and engulfs chicken red blood cell experiment; Two groups are used for NK cytoactive mensuration and lymphocyte transformation experiment; Three groups are used for antibody-producting cell experiment, serum hemolysin mensuration and delayed allergy; Four groups are used for mouse carbon and clean up experiment.Mouse is pressed per os of 20mg/kg.BW body weight and irritates stomach, gives 30 days continuously, claims body weight weekly one time, and it is long-pending to adjust the filling body of stomach.
2.2 experimental procedure
2.2.1 the clearance test of mouse carbon: the continuous irrigation stomach is after 30 days, in the india ink of mouse tail vein injection with 4 times of physiological saline dilutions, timing immediately after pressing 0.1ml/10g prepared Chinese ink and injecting is after injecting prepared Chinese ink the 2nd, 10min gets blood 20 μ l from the angular vein clump respectively, is added to 2mlNa
2CO
3In the solution, with Na
2CO
3Solution is made blank, measures OD value at the 600nm place with 723 spectrophotometers.Put to death mouse after getting blood, get liver, spleen is weighed, calculate phagocytic index.
2.2.2 Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell experiment (half intracorporal method): the continuous irrigation stomach is after 30 days, the chicken erythrocyte suspension 1ml of every mouse peritoneal injection 20%, after 30 minutes, the cervical vertebra dislocation is put to death, be fixed on the mouse plate, abdominal skin is cut off in the center, inject physiological saline 2ml through the abdominal cavity, rotated the mouse plate 1 minute, sucking-off abdominal cavity washing lotion 1ml, mean droplet is on 2 slides, put 37 ℃ in wet box 30 minutes, and took out in the physiological saline rinsing, dry, fixing, 4%GiemsaPBS dyeing 3 minutes, the distilled water rinsing is dried, microscopy.Calculate phagocytic percentage and phagocytic index.
2.2.3 delayed allergy (DTH) (the sufficient sole of the foot thickens method): irritate stomach after 30 days, inject 2% hematocrit SRBC (the every mouse of 0.2ml/) sensitization after 4 days to mouse peritoneal, measure left back sufficient sole of the foot thickness, and then measuring point hypodermic injection 20% (v/v) SRBC (the every mouse of 20 μ l/), 24h measures left back sufficient sole of the foot thickness in the injection back, same position is measured three times, averages, and represents the degree of DTH with sufficient sole of the foot thickness difference (swelling degree of the paw) before and after attacking.
2.2.4ConA the mouse lymphocyte conversion test (mtt assay) of inducing: at first carry out the preparation of splenocyte suspension.Cell concentration is adjusted into 3 * 10
6Individual/ml, then cell suspension is divided two holes to add in 24 well culture plates, every hole 1ml, a hole adds 75 μ lConA liquid, and another hole compares, and puts 5%CO
2Incubator is cultivated 72h for 37 ℃.Cultivate and finish preceding 4h, every hole is inhaled supernatant 0.7ml gently and is added the RPMI1640 nutrient solution that 0.7ml does not contain calf serum, add MTT (5mg/ml) 50 μ/hole simultaneously and continue to cultivate 4h, after cultivating end, every hole adds 1ml acid isopropyl alcohol, purple crystal is dissolved fully, then every hole liquid is moved in the cuvette, with 723 spectrophotometers in 570nm wavelength place's colorimetric estimation OD value.
2.2.5 antibody-producting cell detects (Jernr improves slide method): the continuous irrigation stomach is after 30 days, every mouse peritoneal is injected 2% hematocrit SRBC0.2ml, the mouse cervical vertebra dislocation of immunity after 5 days half put to death, take out spleen and be placed in the plate that fills Hank ' s liquid, make splenocyte suspension.Agarose is made into 1% aqueous solution, and 30min is boiled in water-bath, mix with the double Hank ' s of equivalent liquid, and the packing small test tube, every pipe 0.5ml adds 10% again and (uses S in pipe
AThe buffer solution preparation) hematocrit SRBC50 μ l, each 20 μ l of splenocyte suspension make two parallel samples, rapidly behind the mixing, be poured on the agarose thin layer slide, treat that agar solidifies after, the slide level buckled be placed on the horse, put into CO2gas incubator and hatch 1.5h, then complement is joined in the slide frame groove, continue incubation 1.5h, counting hemolysis plaque number.
2.2.6 serum hemolysin is measured (blood clotting method): at the continuous irrigation stomach after 30 days, every mouse peritoneal injection 2%SRBC0.2ml immunity, continue to irritate stomach after 5 days, extract eyeball and get blood in centrifuge tube, place 1h, peel off, the centrifugal 10min of 2000r/min collects serum, with physiological saline serum is made doubling dilution, every part of dilution 12 holes place blood-coagulation-board with the dilution serum of difference, every hole 100 μ l, add 0.5%SRBC suspension 100 μ l again, mixing is put observed result behind wet 37 ℃ of 3h of box, writes down the aggegation degree in every hole.The calculating antibody product.
2.2.7NK cytoactive is measured (lactate dehydrogenase L DH determination method): the continuous irrigation stomach is after 30 days, and animal is put to death in the cervical vertebra dislocation, takes out spleen, tears up, cross 200 eye mesh screens after, use Hank ' s liquid to wash 3 times, be made into 2 * 10 with complete RPMI1640 nutrient solution
7Individual/the ml cell suspension.The cell suspension of each mouse is got 300 μ l divide 3 holes to place 96 well culture plates, every hole 100 μ l, every hole adds target cell (YAC-1 cell, 4 * 10
5Individual/ml) 100 μ l, do target cell nature release aperture (target cell 100 μ l+ nutrient solutions 100 μ l) and each 8 hole of maximum release aperture (target cell 100 μ l+2.5%Triton100 μ l) simultaneously, 37 ℃ of 5%CO
2Cultivated 4 hours, and took out the centrifugal 5min of 1500r/min.Each hole supernatant 100 μ l is placed another culture plate, and every hole adds 100 μ l matrix liquid again, adds the HCL30 μ l cessation reaction of 1mol/L after 10 minutes, measures the OD value at the 490nm place, calculates NK cytoactive rate.
3. test data is added up
Test data adopts SPSS10.0 for Windows software kit to handle.The data of control group and dosage group are through the variance test of homogeneity, and variance is neat, carry out variance analysis,, then compare in twos with the Dunnett method less than 0.05 as the P value; If heterogeneity of variance then carries out data transaction, and is still uneven, use rank test instead, less than 0.05, then use Dunnett ' sT3 method to compare (P＞0.05 is non-significant difference, and P＜0.05 is a significant difference) in twos as the P value.
4. result
4.1 the present invention sees Table 1-4 to the influence of mouse body weight.
Table 1 is respectively organized the initial body weight (X ± S) of mouse
Table 2 is respectively organized body weight in the mid-term (X ± S) of mouse
Table 3 is respectively organized the end body weight (X ± S) of mouse
Table 4 the present invention is to the influence of mouse weight gain (X ± S)
By table 1-4 as seen, the initial body weight of one group, immune two groups of the present invention immunity, immune three groups and immune four groups of mouse is compared with negative control group, through the variance test of homogeneity, variance neat (P＞0.05), and The results of analysis of variance (P＞0.05) illustrates that the initial body weight of respectively organizing between mouse and the negative control group is balanced.Three dosage group mouse test mid-terms, the body weight in latter stage and the growths of duration of test mouse body weight are compared with negative control group, and learn by statistics and handle, there was no significant difference (P＞0.05), i.e. the present invention does not have influence to the body weight gain of mouse.
4.2 the present invention is to the influence of mouse monokaryon-macrophage phagocytic function
Table 5 the present invention cleans up the influence (X ± S) of function to mouse monokaryon-macrophage carbon
By table 5 as seen, the continuous irrigation stomach is after 30 days, and the carbon of three dosage group mouse is cleaned up ability and compared with negative control group, learns by statistics and handles, and middle and high dosage group has significant difference (P＜0.05).
Table 6 the present invention engulfs the influence (X ± S) of chicken red blood cell ability to mouse macrophage
By table 6 as seen, the continuous irrigation stomach is after 30 days, and the phagocytic rate of three dosage treated animals is compared with negative control group with phagocytic index, learns by statistics and handles, and the high dose group phagocytic index has significant difference (P＜0.05).
By table 5, table 6 as seen, the present invention is to mouse monokaryon-macrophage phagocytic function test positive as a result.
4.3 the present invention is to the influence of mouse cell immunity
Table 7 the present invention is to the influence of mouse delayed allergy (DTH) (X ± S)
By table 7 as seen, the continuous irrigation stomach is after 30 days, and the swelling degree of the paw of three dosage group mouse is compared with negative control group, learns by statistics and handles there was no significant difference (P＞0.05)
The influence of the mouse lymphocyte conversion test that table 8 the present invention induces ConA (X ± S)
By table 8 as seen, continuous irrigation stomach mouse is after 30 days, and the lymphopoiesis ability of three dosage group mouse is compared with negative control, learns by statistics and handles there was no significant difference (P＞0.05).
Visible the present invention is negative to mouse cell immunity test result by table 7, table 8.
4.4 the present invention is to the influence of mouse humoral immune
Table 9 the present invention is to the influence of mouse antibodies cellulation (X ± S)
By table 9 as seen, the continuous irrigation stomach is after 30 days, and the hemolysis plaque number of three dosage group mouse is compared with negative control, learns by statistics and handles, and low, high dose group has significant difference (P＜0.05).
Table 10 the present invention is to the influence of mice serum hemolysin (X ± S)
By table 10 as seen, the continuous irrigation stomach is after 30 days, and the antibody product of three dosage group mouse is compared with negative control group, learns by statistics and handles there was no significant difference (P＞0.05)
By table 9, table 10 as seen, the present invention is positive to the mouse humoral immune result of the test.
4.5 the present invention is to the influence of NK cells in mice activity
Table 11 the present invention is to the influence of NK cells in mice activity (X ± S)
By table 11 as seen, the continuous irrigation stomach is after 30 days, and three dosage group NK cells in mice activity are compared with negative control, learns by statistics and handles there was no significant difference (P＞0.05).The present invention shows negative to the NK cytoactive result of the test of mouse.
5. sum up
Continuous irrigation stomach mouse of the present invention did not have obvious influence to the mouse body weight after 30 days; To the test for celluar immunity of mouse feminine gender as a result; To the NK test cell line of mouse feminine gender as a result; To monokaryon-macrophage phagocytic function test of mouse, the carbon of three dosage group mouse cleans up ability and negative control group compares, and middle and high dosage group difference has conspicuousness (P＜0.05), the result of the test positive; To the test for humoral immunity of mouse, the hemolysis plaque number of three dosage groups and negative control group compare, and low, high dose group difference all has conspicuousness (P＜0.05), the result of the test positive.
Can judge that according to " health food check and assessment technique standard " version in 2003 the present invention has the function that improves immunity to animal.
Claims (7)
1. health food that improves body immunity, it is characterized in that it comprises following components in weight percentage: American ginseng extract 5～25%, Notogineng Extract 5～15%, bat pretty young woman paecilomycerol powder 45～75%, starch 10～15%, dolomol 0～1%.
2. the health food of raising body immunity according to claim 1, it is characterized in that described American ginseng extract is with 75% alcohol extract 2 times by medicinal material coarse powder, each 1.5h, the weight ratio of medicinal material coarse powder and ethanol is 1: 12, then with extract-0.06～-0.09Mpa, distillation concentrates under the 75-85 ℃ of condition, at last-0.08～-0.1Mpa, vacuum drying below 80 ℃, until moisture content＜5%.
3. a kind of health food that improves body immunity according to claim 1, it is characterized in that described Notogineng Extract is with 70% alcohol extract 3 times by medicinal material coarse powder, each 1.5h, the weight ratio of medicinal material coarse powder and ethanol is 1: 10, then with extract-0.06～-0.09Mpa, distillation concentrates under the 75-85 ℃ of condition, at last-0.08～-0.1Mpa, vacuum drying below 80 ℃ is until moisture content＜5%.
4. a kind of health food that improves body immunity according to claim 1 is characterized in that described bat pretty young woman paecilomycerol is selected from separating obtained Cordyceps Militaris-Paecilomyces hepiali chen in the fresh Cordyceps sinensis of Clavicipitaceae.
5. prepare the described a kind of method that improves the health food of body immunity of claim 1, it is characterized in that it may further comprise the steps:
(1) with American ginseng extract, Notogineng Extract, bat pretty young woman paecilomycerol powder, starch and dolomol sieve respectively, and the weighing side of going into is mixed in proportion;
(2) mixed powder is incapsulated shell.
6. a kind of method that improves the health food of body immunity of preparation according to claim 5 is characterized in that selecting 60 mesh sieves for use in the step (1).
7. a kind of method that improves the health food of body immunity of preparation according to claim 5 is characterized in that stating in the step (1), and incorporation time is 30min.
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| CN102960715A (en) * | 2012-09-07 | 2013-03-13 | 无锡市天赐康生物科技有限公司 | Immunity-enhancing and hypoxia tolerant health food and preparation method thereof |
| CN103211220A (en) * | 2013-04-25 | 2013-07-24 | 福建永生活力生物工程有限公司 | Health food with function of enhancing immunity and preparation method thereof |
| CN104146238A (en) * | 2014-07-11 | 2014-11-19 | 吉林大学 | Health food with function of enhancing immunity of human body |
| CN104146238B (en) * | 2014-07-11 | 2015-08-05 | 吉林大学 | A kind of have the health food strengthening body immunity function |
| CN104382972A (en) * | 2014-11-21 | 2015-03-04 | 江苏鹏鹞药业有限公司 | Composition of paecilomyces hepialid, ginseng and pseudo-ginseng and preparation method of composition |
| CN104783182A (en) * | 2015-04-13 | 2015-07-22 | 广州赛莱拉干细胞科技股份有限公司 | Compound for improving immunity and preparation method thereof |
| CN105327025A (en) * | 2015-12-08 | 2016-02-17 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of composition capable of relieving physical fatigue |
| CN106690121A (en) * | 2016-11-14 | 2017-05-24 | 威海力元海洋生物科技有限公司 | Trepang, hippophae rhamnoides fruit, cordyceps militaris and selenium preparation and preparation technology thereof |
| CN106820145A (en) * | 2017-01-13 | 2017-06-13 | 北京君合康医药科技有限公司 | A kind of health-care food composition of strengthen immunity and preparation method thereof |
| CN109077317A (en) * | 2018-07-19 | 2018-12-25 | 深圳市博奥生物科技有限公司 | A kind of lycopene capsules and preparation method thereof |
| CN109833340A (en) * | 2019-04-08 | 2019-06-04 | 内蒙古亿利制药有限公司 | Protect member pellet and its production technology |
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