CN101337041A - Preparation method of strong loquat dew - Google Patents
Preparation method of strong loquat dew Download PDFInfo
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- CN101337041A CN101337041A CNA2008101474885A CN200810147488A CN101337041A CN 101337041 A CN101337041 A CN 101337041A CN A2008101474885 A CNA2008101474885 A CN A2008101474885A CN 200810147488 A CN200810147488 A CN 200810147488A CN 101337041 A CN101337041 A CN 101337041A
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- pericarpium papaveris
- ethanol
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- pericarpium
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Abstract
The invention relates to a method for preparing powerful eriobotryae syrup. The powerful eriobotryae syrup is prepared from seven materials, such as eriobotryae. The preparation method comprises the following steps: extracting pericarpium papaveris by ethanol, filtering and concentrating the filtered liquid; decocting the filter residue and other five materials except menthol by water for twice, mixing the filtered liquids, filtering, concentrating, adding sodium benzoate, stirring for dissolving, adding simple syrup, continuing heating, cooling, adding the extracted ethanol solution of pericarpium papaveris, citric acid, and essence and menthol dissolved in the ethanol, stirring to dissolve, adding water in a specified amount and stirring uniformly to obtain the powerful eriobotryae syrup.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine.
Background technology
Intensified loquet distillate is to add Pericarpium Papaveris and make on the basis of traditional cough-relieving Distillate Folium Eriobotryae.Have yin nourishing and astringe the lung, the relieving cough and expelling phlegm function.Be used for chronic cough due to asthenia of viscera, bronchitis etc.Because of the Distillate Folium Eriobotryae that its cough-relieving function ratio is general is strengthened greatly, so be called intensified loquet distillate.Existing intensified loquet distillate preparation method: Six-element water except that Mentholum is decocted, filter, concentrate, adding preservative agent, sucrose again, heat sterilization adds citric acid and Mentholum and essence etc. again, filters, standardize solution, stirring and evenly mixing, promptly.Present method exists the interior Main Ingredients and Appearance morphine of Pericarpium Papaveris and extracts not exclusively, thereby affects the treatment, and has the problem of waste Chinese crude drug.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of effective extraction ratio of morphine in the Pericarpium Papaveris that can improve in the intensified loquet distillate, thereby improve the effect of intensified loquet distillate, reduce the waste of Chinese crude drug.Preparation technology of the present invention is convenient and practical, and is easy to control product quality.The present invention realizes by following structure.
Intensified loquet distillate of the present invention, its mass ratio composition is:
Folium Eriobotryae 68～72 Pericarpium Papaveriss 20～55 Radixs Stemonae 14～16 Rhizoma Cynanchi Stauntoniis 8～10
Cortex Mori 5～7 Radix Platycodoniss 5～7 Mentholums 0.1～0.2
Preparation method of the present invention is:
(1) with Pericarpium Papaveris with 50～95% alcohol refluxs 0.5～2 hour or slow percolation 8～20 hours, filter, reclaim ethanol, Pericarpium Papaveris slag and concentrated solution are standby.
(2) the Pericarpium Papaveris slag decocts with water twice with Folium Eriobotryae, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, each 2 hours.Merge decocting liquid twice, filter, heating is concentrated into relative density about 1.07.
(3) add an amount of sodium benzoate in decocting liquid, stir and to make dissolving, continuously add an amount of simple syrup post-heating and boil, filter, put cold.
(4) the continuous Pericarpium Papaveris ethanol extraction concentrated solution that adds, an amount of citric acid with the essence and the Mentholum of dissolve with ethanol, stirs, and makes its dissolving, adds water to recipe quantity, and mixing is promptly.
Preparation method of the present invention, preparation method with respect to existing intensified loquet distillate, increased first step with the ethanol extraction Pericarpium Papaveris, this improvement, produced beyond thought effect:, find that content with morphine in the prepared intensified loquet distillate of the present invention is 2 times of morphine content in the intensified loquet distillate that makes of prior art with the content of morphine in the high performance liquid chromatogram method testing product.Just the extraction ratio of morphine is 2 times of existing technology of preparing in the Pericarpium Papaveris.
The specific embodiment
Embodiment one:
Prescription: Folium Eriobotryae 69g Pericarpium Papaveris 50g Radix Stemonae 15g Rhizoma Cynanchi Stauntonii 9g
Cortex Mori 6g Radix Platycodonis 6g Mentholum 0.15g
Method for making:
(1) get Pericarpium Papaveris 50g, refluxed 1 hour with 80% ethanol 800ml, filter, filtrate recycling ethanol is not to there being the ethanol flavor, and Pericarpium Papaveris slag and concentrated solution are standby.
(2) the Pericarpium Papaveris slag decocts with water twice with Folium Eriobotryae, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, each 2 hours.Merge decocting liquid twice, filter, heating is concentrated into relative density 1.07.
(3) add the 2.5g sodium benzoate in decocting liquid, stir and to make dissolving, continuously add 710ml simple syrup post-heating and boil, filter, put cold.
(4) continuously add Pericarpium Papaveris ethanol extraction concentrated solution, the 0.5g citric acid with the essence and the Mentholum of dissolve with ethanol, stirs, and makes its dissolving, adds water to recipe quantity, and mixing promptly.
Embodiment two:
Prescription: Folium Eriobotryae 69g Pericarpium Papaveris 25g Radix Stemonae 15g Rhizoma Cynanchi Stauntonii 9g
Cortex Mori 6g Radix Platycodonis 6g Mentholum 0.15g
Method for making:
(1) get Pericarpium Papaveris 50g, refluxed 1 hour with 50% ethanol 800ml, filter, filtrate recycling ethanol is not to there being the ethanol flavor, and Pericarpium Papaveris slag and concentrated solution are standby.
(2) the Pericarpium Papaveris slag decocts with water twice with Folium Eriobotryae, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, each 2 hours.Merge decocting liquid twice, filter, heating is concentrated into about 750ml.
(3) add the 2.5g sodium benzoate in decocting liquid, stir and to make dissolving, continuously add 710ml simple syrup post-heating and boil, filter, put cold.
(4) continuously add Pericarpium Papaveris ethanol extraction concentrated solution, the 0.5g citric acid with the essence and the Mentholum of dissolve with ethanol, stirs, and makes its dissolving, adds water to recipe quantity, and mixing promptly.
Embodiment three:
Prescription: Folium Eriobotryae 69g Pericarpium Papaveris 50g Radix Stemonae 15g Rhizoma Cynanchi Stauntonii 9g
Cortex Mori 6g Radix Platycodonis 6g Mentholum 0.15g
Method for making:
(1) get Pericarpium Papaveris 50g, with the slow percolation of 95% ethanol 12 hours, filter, filtrate recycling ethanol is to there being the ethanol flavor, and Pericarpium Papaveris slag and concentrated solution are standby.
(2) the Pericarpium Papaveris slag decocts with water twice with Folium Eriobotryae, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, each 2 hours.Merge decocting liquid twice, filter, heating is concentrated into relative density 1.07.
(3) add the 2.5g sodium benzoate in decocting liquid, stir and to make dissolving, continuously add 710ml simple syrup post-heating and boil, filter, put cold.
(4) continuously add Pericarpium Papaveris ethanol extraction concentrated solution, the 0.5g citric acid with the essence and the Mentholum of dissolve with ethanol, stirs, and makes its dissolving, adds water to recipe quantity, and mixing promptly.
Embodiment four:
Prescription: Folium Eriobotryae 69g Pericarpium Papaveris 50g Radix Stemonae 15g Rhizoma Cynanchi Stauntonii 9g
Cortex Mori 6g Radix Platycodonis 6g Mentholum 0.15g
Method for making:
(1) get Pericarpium Papaveris 50g, with the slow percolation of 80% ethanol 20 hours, filter, filtrate recycling ethanol is to there being the ethanol flavor, and Pericarpium Papaveris slag and concentrated solution are standby.
(2) the Pericarpium Papaveris slag decocts with water twice with Folium Eriobotryae, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, each 2 hours.Merge decocting liquid twice, filter, heating is concentrated into relative density 1.07.
(3) add the 2.5g sodium benzoate in decocting liquid, stir and to make dissolving, continuously add 710ml simple syrup post-heating and boil, filter, put cold.
(4) continuously add Pericarpium Papaveris ethanol extraction concentrated solution, the 0.5g citric acid with the essence and the Mentholum of dissolve with ethanol, stirs, and makes its dissolving, adds water to recipe quantity, and mixing promptly.
Claims (2)
1, a kind of preparation technology of intensified loquet distillate is characterized in that its main component Pericarpium Papaveris adopts two-phase to extract.
2, the preparation method of a kind of intensified loquet distillate according to claim 1 is characterized in that:
Each composition quality ratio of intensified loquet distillate is:
Folium Eriobotryae 68～72 Pericarpium Papaveriss 20～55 Radixs Stemonae 14～16 Rhizoma Cynanchi Stauntoniis 8～10
Cortex Mori 5～7 Radix Platycodoniss 5～7 Mentholums 0.1～0.2
Preparation as follows:
(1) with Pericarpium Papaveris with 50～95% alcohol refluxs 0.5～2 hour or slow percolation 8～20 hours, preferred 80% alcohol reflux 1 hour.Filter, reclaim ethanol, Pericarpium Papaveris slag and concentrated solution are standby.
(2) the Pericarpium Papaveris slag decocts with water twice with Folium Eriobotryae, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, each 2 hours.Merge decocting liquid twice, filter, it is 1.02～1.10 that heating is concentrated into relative density, is preferably 1.07.
(3) add sodium benzoate in decocting liquid, stir and to make dissolving, continuously add the simple syrup post-heating and boil, filter, put cold.
(4) continuous essence and the Mentholum that adds Pericarpium Papaveris ethanol extraction concentrated solution, citric acid, uses dissolve with ethanol stirs, and makes its dissolving, adds water to recipe quantity, and mixing promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101474885A CN101337041A (en) | 2008-08-21 | 2008-08-21 | Preparation method of strong loquat dew |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101474885A CN101337041A (en) | 2008-08-21 | 2008-08-21 | Preparation method of strong loquat dew |
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| Publication Number | Publication Date |
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| CN101337041A true CN101337041A (en) | 2009-01-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101474885A Pending CN101337041A (en) | 2008-08-21 | 2008-08-21 | Preparation method of strong loquat dew |
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| CN (1) | CN101337041A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110869A (en) * | 2013-02-04 | 2013-05-22 | 合肥今越制药有限公司 | Extraction method of strong loquat syrup |
| CN109045231A (en) * | 2018-09-11 | 2018-12-21 | 华润三九（雅安）药业有限公司 | A kind of loquat dew and preparation method thereof |
-
2008
- 2008-08-21 CN CNA2008101474885A patent/CN101337041A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110869A (en) * | 2013-02-04 | 2013-05-22 | 合肥今越制药有限公司 | Extraction method of strong loquat syrup |
| CN109045231A (en) * | 2018-09-11 | 2018-12-21 | 华润三九（雅安）药业有限公司 | A kind of loquat dew and preparation method thereof |
| CN109045231B (en) * | 2018-09-11 | 2021-10-08 | 华润三九（雅安）药业有限公司 | Loquat syrup and preparation method thereof |
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Addressee: Zhu Xiaohua Document name: Notification of Publication of the Application for Invention |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20090107 |