CN101269116B - 柴黄软胶囊的检测方法 - Google Patents
柴黄软胶囊的检测方法 Download PDFInfo
- Publication number
- CN101269116B CN101269116B CN2007102003042A CN200710200304A CN101269116B CN 101269116 B CN101269116 B CN 101269116B CN 2007102003042 A CN2007102003042 A CN 2007102003042A CN 200710200304 A CN200710200304 A CN 200710200304A CN 101269116 B CN101269116 B CN 101269116B
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- CN
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- Prior art keywords
- soft capsule
- baicalin
- methyl alcohol
- extractive
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 42
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 31
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
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- 241000050051 Chelone glabra Species 0.000 claims description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 13
- 239000013558 reference substance Substances 0.000 claims description 12
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- 238000002156 mixing Methods 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
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- 239000000843 powder Substances 0.000 claims description 3
- FZRCKLPSHGTOAU-UHFFFAOYSA-N 6-amino-1,4-dimethylcyclohexa-2,4-diene-1-carbaldehyde Chemical compound CC1=CC(N)C(C)(C=O)C=C1 FZRCKLPSHGTOAU-UHFFFAOYSA-N 0.000 claims description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
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- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 239000003518 caustics Substances 0.000 claims description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000011003 system suitability test Methods 0.000 claims description 2
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 11
- 239000002775 capsule Substances 0.000 abstract description 9
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- 230000000694 effects Effects 0.000 abstract description 6
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- 239000000203 mixture Substances 0.000 abstract description 6
- 239000003085 diluting agent Substances 0.000 abstract description 3
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 abstract 7
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 abstract 7
- 229960003321 baicalin Drugs 0.000 abstract 7
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 abstract 7
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 abstract 6
- 244000236521 Bupleurum rotundifolium Species 0.000 abstract 6
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 abstract 1
- 239000013049 sediment Substances 0.000 abstract 1
- 239000012749 thinning agent Substances 0.000 description 8
- 230000036760 body temperature Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 238000003825 pressing Methods 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
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- 239000002612 dispersion medium Substances 0.000 description 1
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 238000005728 strengthening Methods 0.000 description 1
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Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2007102003042A CN101269116B (zh) | 2007-03-20 | 2007-03-20 | 柴黄软胶囊的检测方法 |
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CN2007102003042A CN101269116B (zh) | 2007-03-20 | 2007-03-20 | 柴黄软胶囊的检测方法 |
Publications (2)
Publication Number | Publication Date |
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CN101269116A CN101269116A (zh) | 2008-09-24 |
CN101269116B true CN101269116B (zh) | 2012-08-15 |
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CN2007102003042A Expired - Fee Related CN101269116B (zh) | 2007-03-20 | 2007-03-20 | 柴黄软胶囊的检测方法 |
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CN (1) | CN101269116B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104257927A (zh) * | 2014-10-16 | 2015-01-07 | 徐艳 | 一种治疗小柴胡软胶囊及制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1846730A (zh) * | 2005-04-11 | 2006-10-18 | 安徽科创中药天然药物研究所有限责任公司 | 柴黄软胶囊的制备方法和质量控制技术 |
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2007
- 2007-03-20 CN CN2007102003042A patent/CN101269116B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1846730A (zh) * | 2005-04-11 | 2006-10-18 | 安徽科创中药天然药物研究所有限责任公司 | 柴黄软胶囊的制备方法和质量控制技术 |
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CN101269116A (zh) | 2008-09-24 |
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Owner name: BAISHAN POWER SUPPLY COMPANY, STATE GRID JILIN ELE Effective date: 20131224 Owner name: STATE ELECTRIC NET CROP. Free format text: FORMER OWNER: TONGHUA SHENGHE PHARMACEUTICAL CO., LTD. Effective date: 20131224 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 134001 TONGHUA, JILIN PROVINCE TO: 100033 XICHENG, BEIJING |
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TR01 | Transfer of patent right |
Effective date of registration: 20131224 Address after: 100033 West Chang'an Avenue, Beijing, No. 86, No. Patentee after: State Grid Corporation of China Patentee after: STATE GRID JILIN ELECTRIC POWER COMPANY LIMITED BAISHAN POWER SUPPLY COMPANY Address before: 134001 Tonghua city of Jilin Province Dongchang District Binjiang Road No. 3 Patentee before: Tonghua Shenghe Yao Ye Co., Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120815 Termination date: 20180320 |