CN101147705A - Controllable released biological ceramic thrombus filter and manufacturing method thereof - Google Patents
Controllable released biological ceramic thrombus filter and manufacturing method thereof Download PDFInfo
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- CN101147705A CN101147705A CNA2006100626665A CN200610062666A CN101147705A CN 101147705 A CN101147705 A CN 101147705A CN A2006100626665 A CNA2006100626665 A CN A2006100626665A CN 200610062666 A CN200610062666 A CN 200610062666A CN 101147705 A CN101147705 A CN 101147705A
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Abstract
The present invention relates to a controllably-released bioceramic thrombus filter and its preparation method. Said thrombus filter is made up by using laser engraved metal tube, its end portion is equipped with a combination portion matched with a conveying portion, its centre is equipped with an elastic wire and its surface is convered with a layer of bioceramic membrance. It can be temporarily placed into blood vessel of human body, also can be permanently placed in the blood vessel of human body. Said invention also provides the concrete working principle of said thrombus filter.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, be specifically related to biological ceramic thrombus filter of a kind of controllable release that is used for pulmonary infarction (PE) treatment and preparation method thereof.
Background technology
Pulmonary thromboembolism, (pulmonary embolism PE) is a kind of cardiovascular diseases of serious harm people ' s health to be called for short pulmonary infarction.Currently used Therapeutic Method mainly is a thromboembolism treatment, anticoagulant therapy and surgical operation therapy, but there is the anticoagulant therapy contraindication, hemorrhage complication is arranged, is not suitable for the patient of surgical operation therapy for those, can adopt interventional therapy method, promptly in caval vein, place a machinery, to stop the up of thrombosis, prevention or minimizing pulmonary thromboembolism.This method has that wound is little, safety, good effect, easy and simple to handle, advantage such as the hospital stays is short, patients ' recovery is fast.
The type of existing caval vein thrombus filter is more, and filter commonly used has TitaniumGreenfield filter (TGF), Vena Tech-LGM filter (VTF) etc.The former is the conical device of being made by Nitinol, and its required catheter sheath bore is less, and external diameter is 12~14F, introduces easily and places; The latter is made by rustless steel, and its agnail structure can guarantee that this filter is fixed in the postcava wall.These filters commonly used can both be caught the thrombosis that comes off preferably, yet still exist not recyclable and the bigger drawback of impulsive force when discharging.
Existing thrombus filter is generally made by rustless steel or Nitinol, because Nitinol has good memory effect, thereby the Nitinol thrombus filter has obtained using widely clinically in recent years.But because the metal surface of filter directly contacts with blood, be subjected to the effect of multiple composite factors such as physics in the vital movement, chemistry, biology after implanting in the interior environment midium or long term of human body complexity, thereby tend to leak out a large amount of metal ions, cause symptoms such as inflammatory reaction or generation blood coagulation, blood compatibility is relatively poor.Therefore, provide a kind of and be recovered, the filter of good biocompatibility is significant.
Summary of the invention
Technical problem to be solved by this invention is, biological ceramic thrombus filter of a kind of controllable release and preparation method thereof is provided, this filter can be recovered, and can avoid discharging moment and impact forward and cause filter displacement, can also improve the biocompatibility with blood greatly.
For solving the problems of the technologies described above, the present invention has adopted following technical scheme: the biological ceramic thrombus filter that a kind of controllable release is provided, this filter is formed by the laser engraving metal tube, its end is provided with the joint portion of matching with carrier, the center is provided with an elastic yarn, and there is one deck bioceramic film on the Nitinol surface of filter or plates bioceramic film at alloy surface in advance.
The present invention can be female thread or external screw thread or the annulus circle that is connected with the external screw thread of carrier in described joint portion, is used for the sustained release thrombus filter; Described elastic yarn is spring wire or elastica, and its effect is to expand more effective seizure embolus as far as possible after making support discharge; The extension of described end is provided with the cover hook.Both ends are provided with the fixing point of front-end and back-end, are divided into leading portion, stage casing and back segment between two fixing points.The fixing point of rear and front end is coaxial, guarantees concentric locating, and the rod member with shape memory function constitutes forward and backward, stage casing. and described stage casing is that straight-bar constitutes, and at the circumferencial direction five equilibrium, forms concentric cylinder beam; Described forward and backward two sections is drainage screen.The shape of drainage screen can be netted by the conical surface of one group of " Y " shape bar formation, also can be netted by one group of " Λ " the shape bar and the common conical surface that constitutes of straight-bar.Because the back segment Conical Lattice mainly is used for catching embolus, thereby the mesh-density of back segment Conical Lattice is greater than the mesh-density of leading portion.A grasp is all arranged on the every straight-bar in described stage casing, be used for fixing filter, prevent filter displacement under the blood flow percussion.
Bioceramic of the present invention is to strengthen the Nitinol surface that vapour deposition process is plated in described thrombus filter through ion beam, and described bioceramic can be titanium nitride, titanium carbide or titanium oxide.
The invention provides a kind of manufacture method of biological ceramic thrombus filter of controllable release, comprise following two steps:
1) at first makes thrombus filter;
2) plate one deck bioceramic on the thrombus filter surface then.
Wherein, the bioceramic of step 2 is that using plasma strengthens the Nitinol surface that chemical gaseous phase depositing process (PECVD) is plated in thrombus filter.This bio-ceramic coating can be titanium nitride, titanium carbide and titanium oxide.
Owing to adopted technique scheme, the present invention compared with prior art has the following advantages:
1. the present invention adopts NiTi marmem pipe laser engraving to form incorporate design, connectionless point;
2. the present invention can be recovered, and both can forever place in vivo, also can place in vivo temporarily;
3. the present invention both can discharge thrombus filter owing to adopt screw thread between thrombus filter and the conveyer device or the connection of annulus cover during operation very stably, can regain filter again again and discharge;
4. the drainage screen at two ends of the present invention adopts the structural design of optimizing, and has both guaranteed filter effect, has reduced blood flow again and has impacted the negative effect that brings, and is therefore good to catching the thrombosis scouring effect, the long-term patency rates height, and occlusion rate is little;
5. the present invention adopts the grasp location, because grasp has certain directivity, so under blood flow impacted, thrombus filter can not produce displacement or drift phenomenon;
6. center of the present invention is provided with an elastic yarn, and filter is expanded after release as far as possible, thus more effective seizure embolus;
7. the present invention adopts bio-ceramic coating, not only can improve the biocompatibility of thrombus filter, can also reduce simultaneously blood to reactions such as the various physics of metal, chemistry and biologies, thereby reduce the leakage of metal ion, thereby can avoid inflammatory reaction or thrombosis;
8. the delivery sheath of the present invention's needs only is 6F, and the wound wound is little.
Description of drawings
Fig. 1 is the structural representation of inventive embodiments one;
Fig. 2 is the structural representation of inventive embodiments two;
Fig. 3 is the structural representation of inventive embodiments three;
Fig. 4 is the structural representation of inventive embodiments four;
Fig. 5 is the structural representation of inventive embodiments five;
Fig. 6 is the structural representation of invention implementation column six;
Fig. 7 is the structural representation of inventive embodiments seven;
Fig. 8 is the structural representation of inventive embodiments eight;
Fig. 9 is the structural representation of inventive embodiments nine;
Figure 10 is the structural representation of inventive embodiments ten.
The specific embodiment
Below in conjunction with drawings and the specific embodiments the present invention is described in further detail: as shown in Figure 1, the biological ceramic thrombus filter of the controllable release in the embodiment of the invention one, be to adopt NiTi compo pipe, plate bioceramic film again in the metal surface or plate bioceramic film in the metal surface in advance and form through laser engraving with shape memory function.It is the compactron pencil under compressive state, it is netted to be the conical surface under release conditions.Thrombus filter among the present invention comprises front end 6, rear end 1, leading portion 4, stage casing 3, back segment 2 and elastic yarn 10.Wherein stage casing 3 is made up of straight-bar, in the rotation of branches such as circumferencial direction, forms concentric cylinder beam.Described leading portion 4, back segment 2 are drainage screen, and the shape of drainage screen is that the conical surface that is made of one group of " Y " shape bar is netted, because the back segment Conical Lattice mainly is used for catching embolus, thereby the mesh-density of back segment Conical Lattice is greater than the mesh-density of leading portion.A grasp 5 is all arranged on the every straight-bar in described stage casing 3, be used for fixing filter, prevent filter displacement under the blood flow percussion.Described joint portion is the female thread 7 that is connected with carrier.
In the use, be used to send the female thread on the corresponding thrombus filter of conveying wirerope of thrombus filter, external screw thread be set, can rely between thrombus filter and the carrier to be threaded at a end near thrombus filter.In operation when needing to insert thrombus filter, at first thrombus filter is compressed in advance to be placed on and send in the sheath pipe, deliver to inferior caval appropriate location, hold the handle of induction system front end then, slowly rotation.Because the conveying wirerope of filter and induction system is extruded the epitheca pipe by being threaded so thrombus filter just is transferred the conveying wirerope of system gradually.In the process of extruding, thrombus filter is expanding gradually also.Straight-bar on the cylinder of stage casing is close on the blood vessel wall, and the conical surface of back segment 2 and leading portion 4 is released in the vein between two parties, and grasp 5 thrusts on the blood vessel wall gradually, stops thrombus filter to move.When thrombus filter breaks away from induction system fully, just finished the dispose procedure of thrombus filter.
If when taking out the thrombus filter inserted, need use the catching device system it is taken out.The puncture that at first undergos surgery advances the long sheath pipe of certain-length, by long sheath pipe propelling catching device.Under the supervision of developing apparatus, utilize the lasso of catching device to entangle the cover hook of thrombus filter, fixing lasso, preceding catching device conduit to the thrombus filter that pushes away overlaps hook, pushing away long sheath pipe forward, contacts with thrombus filter until long sheath pipe.Fixed length sheath pipe then, recession catching device conduit is all drawn in long sheath pipe until thrombus filter.Shift out long sheath pipe and catching device conduit integral body external at last.
A kind of manufacture method of the biological ceramic thrombus filter of the controllable release among the present invention is: at first choose the metal tube that is fit to size, adopt laser engraving to become the metal webmaster, form the joint-cutting of various kinds then on the surface of metal webmaster, pack into after the polishing in mould typing and send into vacuum heat treatment furnace and heat-treat, the method that adopts ion beam to strengthen vapour deposition plates one deck bioceramic film on its surface at last.
The another kind of manufacture method of the biological ceramic thrombus filter of the controllable release among the present invention is: the metal tube that will be fit to size in advance adopts the method for ion beam vapour deposition to plate one deck bioceramic on the surface, the laser engraving metal tube polishes and the heat-treating profiled biological ceramic thrombus filter that is made at last then.
As shown in Figure 2, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention two, itself and embodiment one difference are that the cover hook that has female thread is placed on rear end 1, so that thrombus filter is implanted from the downstream of human vein.
As shown in Figure 3, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention three, the difference of itself and example one is that all there is the cover hook at front end 6 and 1 place, rear end, can conveniently take out filter from the venous upstream and downstream.
As shown in Figure 4, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention four, itself and embodiment one difference are only to have comprised in its structure rear end 1, back segment 2 and stage casing 3, form pyramidal structure, and do not have grasp 5 on the straight-bar.
As shown in Figure 5, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention five, itself and embodiment one difference are the whole symmetrical structure that is, leading portion 4 is identical with the quantity of back segment 2 " Y " type bar, all there is the cover hook at front end 6 and 1 place, rear end, and wherein two cover hooks all have female thread.
As shown in Figure 6, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention six, itself and embodiment one difference are that this embodiment is for dividing body structure.In advance the end of leading portion bar is inserted in the circular hole 11 during use, compression is after induction system is delivered to desired location.This minute, the advantage of body structure was after the filter leading portion is blocked by big embolus, the back segment of filter can be fixed earlier with an instrument, utilized the system that arrests that the filter leading portion is taken out then.
As shown in Figure 7, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention seven, itself and embodiment one difference are that the junction surface is an external screw thread.
As shown in Figure 8, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention eight, itself and embodiment one difference are that the junction surface is an annulus circle.
As shown in Figure 9, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention nine, itself and embodiment one difference are that its Conical Lattice is by one group of " Λ " shape bar and the common formation of straight-bar.
As shown in figure 10, be the biological ceramic thrombus filter of the controllable release in the embodiment of the invention ten, itself and embodiment one difference are that filter front end place is provided with an elongated seal wire, and seal wire can extend external.When filter is implanted, seal wire can be penetrated in the tubule in advance, by this tubule emitting filter, return after discharging and remove sheath pipe and tubule, seal wire does not then break away from filter; When reclaiming filter, can insert a delivery sheath along seal wire, remove seal wire at external time then, filter is recycled in the sheath pipe and in body takes out.
Although feature of the present invention and advantage thereof have been described a lot; yet be understandable that; for the person of ordinary skill of the art; can make other various corresponding changes and distortion according to technical scheme of the present invention and technical conceive, and all these changes and distortion all should belong to the protection domain of claim of the present invention.
Claims (9)
1. the biological ceramic thrombus filter of a controllable release, form by metal tube integrated laser engraving with shape memory function, it is characterized in that described thrombus filter end is provided with the joint portion of matching with transmitter, the center is provided with an elastic yarn, and the surface is coated with one deck bioceramic film; Filter front end place is provided with one can extend external elongated seal wire.
2. the biological ceramic thrombus filter of controllable release according to claim 1 is characterized in that female thread or external screw thread or the annulus circle of described joint portion for being connected with the external screw thread of transmitter, and the extension of described end is provided with the cover hook, the embedded screw thread of cover hook; The front-end and back-end of described end are provided with fixing point, are divided into leading portion, stage casing and back segment between two fixing points.
3. the biological ceramic thrombus filter of controllable release according to claim 2, the fixing point that it is characterized in that described rear and front end is coaxial, guarantee concentric locating, rod member with super-elasticity function constitutes forward and backward, stage casing, under compressive state, be the compactron pencil, under release conditions, be Conical Lattice.
4. the biological ceramic thrombus filter of controllable release according to claim 3 is characterized in that described stage casing is that straight-bar constitutes, and at the circumferencial direction five equilibrium, forms concentric cylinder beam; Described leading portion and back segment are Conical Lattice, and Conical Lattice can be formed by one group of branches such as " Y " shape bar rotation; Each " Y " shape pole-footing portion is connected with the rear end fixing point, and the branch end is corresponding with middle straight-bar one end to link to each other.
5. the biological ceramic thrombus filter of controllable release according to claim 4, the quantity that it is characterized in that described leading portion " Y " shape bar only is half of straight-bar, the root of " Y " shape bar links to each other with the front end fixing point, and the branch end is corresponding continuous with an end of middle straight-bar; Described Conical Lattice can be made of jointly one group one group " Λ " shape bar and straight-bar; A grasp is all arranged on the described every straight-bar, and described grasp incline direction is consistent with cover hook direction.
6. the biological ceramic thrombus filter of controllable release according to claim 1 is characterized in that described bioceramic can be titanium nitride, titanium carbide or titanium oxide.
7. the manufacture method of the biological ceramic thrombus filter of a controllable release is characterized in that comprising the steps:
1) at first makes thrombus filter;
2) then at thrombus filter surface coating one deck bioceramic.
8. the manufacture method of the biological ceramic thrombus filter of the controllable release of controllable release according to claim 7 is characterized in that the bioceramic in the step 2 is that using plasma enhancing chemical vapour deposition (CVD) (PECVD) method is plated in the thrombus filter surface.
9. according to the manufacture method of the biological ceramic thrombus filter of claim 7 or 8 any described controllable release, the biological ceramic thrombus filter that it is characterized in that described controllable release is to make the metal webmaster by the engraving metal tube, through heat-treating profiled, plate bioceramic film at last and form.
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