CN100998787B - Traditional Chinese medicine effervescent tablets for treating gastrointestinal disease and its preparing method - Google Patents

Traditional Chinese medicine effervescent tablets for treating gastrointestinal disease and its preparing method Download PDF

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CN100998787B
CN100998787B CN200610011183A CN200610011183A CN100998787B CN 100998787 B CN100998787 B CN 100998787B CN 200610011183 A CN200610011183 A CN 200610011183A CN 200610011183 A CN200610011183 A CN 200610011183A CN 100998787 B CN100998787 B CN 100998787B
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CN100998787A (en
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李祖泽
施少斌
郑荣波
沈军
黄晓丹
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WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
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WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
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Abstract

A Chinese medicine in the form of effervescent tablet for treating gastrointestinal disease is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.

Description

A kind of treatment gastrointestinal disease Chinese medicine effervescent tablet and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is a kind of treatment gastrointestinal disease Chinese medicine effervescent tablet of processing of raw material and preparation method thereof.
Background technology
Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, these symptoms can be caused by multiple reason.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment that affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache are vomited and diarrhoea clinically, mainly be with stomachache, diarrhoea; The food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia; The dizzy wave of journey; Pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is a kind of traditional Chinese medicines, is the novel formulation that on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, develops, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials, general ball, coating "; Its productive labor intensity is big, with low content of technology, prescription Chinese medicine effective ingredient is not extracted; Thereby cause Health pill to exist the medicine active ingredient in gastrointestinal dissolution rate and absorbance reduction; Soak time prolongs, and onset is slow, and because Health pill bad smell when taking can make the patient produce resentment.
Chinese invention patent number 200410027334.4 titles are processed and are protected the Ji sheet; In its technology that adopts because the Ramulus Uncariae Cum Uncis decocte with water; Be not easy to extract fat-soluble effective ingredient in the Ramulus Uncariae Cum Uncis, and multiple medical material as: Six-element medicines such as the Radix Aucklandiae, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Pogostemonis adopt CO respectively 2The process more complicated of extraction, the cycle of accomplishing production is long, and cost is higher.
Effervescent tablet begins to be used for oral drug preparation in recent years.Because the effervescent effect of effervescent can be accelerated dispersion and the dissolution velocity of medicine in water, and have easy to carry, steady quality, high, the fast characteristics of drug effect of bioavailability.
Summary of the invention
The purpose of this invention is to provide a kind of treatment gastrointestinal disease Chinese medicine effervescent.
Another object of the present invention provides a kind of active constituents of medicine of treating gastrointestinal disease.
Another object of the present invention provides a kind of method for preparing of treating gastrointestinal disease Chinese medicine effervescent.
Medicine of the present invention is to be processed by Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis.Through test, a kind of effervescent tablet of treating headache of in many adjuvants, selecting definite effervescent adjuvant to process.It is little, soluble in water that the effervescent adjuvant that the present invention selected for use has a molecular weight, and disintegration rate is fast; The pure natural degree is high, and toxic and side effects is lower, owing to itself promptly be the food correctives; So can reduce the medicine irritation abnormal smells from the patient, take that mouthfeel is good, the acceptant characteristics of patient.
The selection of the consumption of drug component of the present invention and disintegrating agent adjuvant thereof also gropes to sum up to draw through the inventor in a large number; This medicine is formed and is comprised following raw materials in weight portion: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss, 105～12000 parts of effervescent adjuvants, and wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following one or more adjuvant: citric acid, tartaric acid, fumaric acid, adipic acid, malic acid, water-soluble amino acid, boric acid, citric acid;
Carbon dioxide source is selected from following one or more adjuvant: calcium bicarbonate, sodium carbonate, sodium bicarbonate, sodium bitartrate, potassium carbonate, potassium bicarbonate;
The fillibility adjuvant is selected from following one or more adjuvant: Polyethylene Glycol, erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, isomalt, lactose, maltose and they contain the water of crystallization chemical compound;
Disintegrating agent is selected from following one or more adjuvant: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Said starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, said cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
The amounts of components and the effervescent adjuvant of preferred medicine of the present invention comprise following materials of weight proportions medicine: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss, 105～6700 parts of effervescent adjuvants, and wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following one or more adjuvant: citric acid, fumaric acid, malic acid, boric acid, citric acid;
Carbon dioxide source is selected from following one or more adjuvant: calcium bicarbonate, sodium carbonate, sodium bicarbonate, sodium bitartrate;
The fillibility adjuvant is selected from following one or more adjuvant: Polyethylene Glycol, xylitol, lactose and they contain the water of crystallization chemical compound;
Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, cyclodextrin, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
The amounts of components and the effervescent adjuvant of further preferred medicine of the present invention comprise following materials of weight proportions medicine: 34.10 parts of Ramulus Uncariae Cum Uncis; 136.40 parts of Cortex Magnoliae Officinalis; 102.30 parts of Radix Trichosanthis; 272.80 parts in Poria; 136.40 parts of the Radixs Angelicae Dahuricae; 136.40 parts of Guangdong Massa Medicata Fermentata; 34.10 parts of Fructus Tribulis; 136.40 parts of Rhizoma Atractylodis; 136.40 parts of Radix Puerariaes; 68.20 parts of Exocarpium Citri Grandises; 102.30 parts of Fructus Oryzae Germinatus; 68.20 parts of Flos Chrysanthemis; 136.40 parts of the Radix Aucklandiae; 136.40 parts of Herba Pogostemonis; 68.20 parts of Herba Menthaes; 170.50 parts of Semen Coiciss; 380～4560 parts of effervescent adjuvants; Wherein the effervescent adjuvant comprises carbon dioxide source, acid source, disintegrating agent and filler:
Acid source wherein is selected from following one or more adjuvant: citric acid, boric acid, citric acid; Carbon dioxide source is selected from following one or more adjuvant: sodium carbonate, sodium bicarbonate; The fillibility adjuvant is selected from following one or more adjuvant: Polyethylene Glycol, xylitol, lactose; Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, cyclodextrin, methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
Preferred medicine effervescent adjuvant of the present invention, wherein, acid source is selected from following one or more adjuvant: citric acid, citric acid; Carbon dioxide source is selected from following one or more adjuvant: sodium carbonate, sodium bicarbonate; The fillibility adjuvant is selected from following one or more adjuvant: xylitol, lactose; Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, modified starch, microcrystalline Cellulose, hydroxypropyl emthylcellulose, hydroxyethylmethyl-cellulose, cyclodextrin, hydroxyethyl-cellulose, hydroxypropyl cellulose.
Best medicine effervescent adjuvant of the present invention, wherein, acid source is: citric acid; Carbon dioxide source is: sodium bicarbonate; The fillibility adjuvant is selected from following one or more adjuvant: xylitol, lactose; Disintegrating agent is selected from following one or more adjuvant: pregelatinized Starch, cyclodextrin.
The effervescent adjuvant is 1: 0.1～1 with the ratio of the gross weight of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract among the present invention.
Preferred effervescent adjuvant of the present invention is 1: 0.1～1: 0.6 with the ratio of the gross weight of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract.
Best effervescent adjuvant of the present invention is 1: 0.2～1: 0.4 with the ratio of Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis extract gross weight.
Disintegrating agent in the effervescent adjuvant among the present invention: acid source: the ratio of the weight of carbon dioxide source is 0.1～1.5: 0.1～1: 0.1～1: 0.1～1.
Disintegrating agent in the effervescent adjuvant among preferred the present invention: acid source: the ratio of the weight of carbon dioxide source is 0.3～1: 0.3～0.8: 0.25～0.7: 0.3～0.7.
Disintegrating agent in the effervescent adjuvant among best the present invention: acid source: the ratio of the weight of carbon dioxide source is 0.5～0.8: 0.4～0.6: 0.3～0.6: 0.4～0.6.
Among the present invention, disintegrating agent in the effervescent adjuvant: acid source: the ratio of the weight of carbon dioxide source is 0.1～1.5: 0.1～1: 0.1～1: 0.1～1.
Among preferred the present invention, disintegrating agent in the effervescent adjuvant: acid source: the ratio of the weight of carbon dioxide source is 0.3～1: 0.3～0.8: 0.25～0.7: 0.3～0.7.
Among best the present invention, disintegrating agent in the effervescent adjuvant: acid source: the ratio of the weight of carbon dioxide source is 0.5～0.8: 0.4～0.6: 0.3～0.6: 0.4～0.6.
The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.Medicine of the present invention can adopt the conventional method for preparing preparation of at present common effervescent.The present invention can adopt wet granulation: acid and/or alkali are granulated respectively, before tabletting, mix, tabletting is processed effervescent tablet; The present invention can adopt non-water to granulate: the extract dry ingredient is granulated with on-aqueous liquid (like ethanol) in will writing out a prescription, and tabletting is processed effervescent tablet; The present invention can adopt direct compression process: with suitable component mix homogeneously, direct compression is processed effervescent tablet; The present invention can adopt the dry granulation method: with component with hydraulic pressure or double compression corning.
The present invention adopts following technology to extract, and employing is prepared as follows method and prepares effervescent tablet, is intended to further specify the present invention, but the present invention is not constituted restriction.
Process for preparing medicine one of the present invention:
Process for preparing medicine of the present invention comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 80.40～215.50 parts of Cortex Magnoliae Officinalis; 55.50～205.80 parts of Radix Trichosanthis; 155.60～423.20 parts in Poria; 80.40～215.50 parts of the Radixs Angelicae Dahuricae; 80.40～215.50 parts of Guangdong Massa Medicata Fermentata; 15.50～55.80 parts of Fructus Tribulis; 80.40～215.50 parts of Rhizoma Atractylodis; 80.40～215.50 parts of Radix Puerariaes; 36.70～125.40 parts of Exocarpium Citri Grandises; 55.50～205.80 parts of Fructus Oryzae Germinatus; 36.70～125.40 parts of Flos Chrysanthemis; 80.40～215.50 parts of the Radix Aucklandiae; 80.40～215.50 parts of Herba Pogostemonis; 36.70～125.40 parts of Herba Menthaes; 95.20～324.80 parts of Semen Coiciss are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 1～10 times of extract amount, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 25～90 ℃ of temperature are extracted each 0.2～3 hour 1～3 time; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 4～12 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. with dry extract fine powder, dextrin embedding thing, Fructus Oryzae Germinatus superfine powder and effervescent adjuvant mixing granulation, tabletting.
Preferred process for preparing medicine of the present invention comprises the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 109.12～163.68 parts of Cortex Magnoliae Officinalis; 81.80～123.17 parts of Radix Trichosanthis; 217.94～327.85 parts in Poria; 109.12～165.56 parts of the Radixs Angelicae Dahuricae; 109.12～165.56 parts of Guangdong Massa Medicata Fermentata; 27.17～41.20 parts of Fructus Tribulis; 109.12～163.68 parts of Rhizoma Atractylodis; 109.12～163.68 parts of Radix Puerariaes; 54.48～81.73 parts of Exocarpium Citri Grandises; 81.80～123.17 parts of Fructus Oryzae Germinatus; 54.48～81.73 parts of Flos Chrysanthemis; 109.12～163.68 parts of the Radix Aucklandiae; 109.12～163.6 parts of Herba Pogostemonis; 54.48～81.73 parts of Herba Menthaes; 136.77～206.10 parts of Semen Coiciss are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2～7 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 35～80 ℃ of temperature are extracted each 0.5～2 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6～10 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. with dry extract fine powder, dextrin embedding thing, Fructus Oryzae Germinatus superfine powder and effervescent adjuvant mixing granulation, tabletting.
The method for preparing of best medicine of the present invention comprises the steps:
A. it is subsequent use to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 35～80 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. with dry extract fine powder, dextrin embedding thing, Fructus Oryzae Germinatus superfine powder and effervescent adjuvant mixing granulation, tabletting.
Effervescent method for preparing two of the present invention:
Effervescent method for preparing of the present invention comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 80.40～215.50 parts of Cortex Magnoliae Officinalis; 55.50～205.80 parts of Radix Trichosanthis; 155.60～423.20 parts in Poria; 80.40～215.50 parts of the Radixs Angelicae Dahuricae; 80.40～215.50 parts of Guangdong Massa Medicata Fermentata; 15.50～55.80 parts of Fructus Tribulis; 80.40～215.50 parts of Rhizoma Atractylodis; 80.40～215.50 parts of Radix Puerariaes; 36.70～125.40 parts of Exocarpium Citri Grandises; 55.50～205.80 parts of Fructus Oryzae Germinatus; 36.70～125.40 parts of Flos Chrysanthemis; 80.40～215.50 parts of the Radix Aucklandiae; 80.40～215.50 parts of Herba Pogostemonis; 36.70～125.40 parts of Herba Menthaes; 95.20～324.80 parts of Semen Coiciss are subsequent use;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 1～10 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃;
C. qinghuo reagent I, clear paste II, dextrin embedding thing are with effervescent adjuvant mixing granulation, tabletting.
Preferred effervescent method for preparing of the present invention comprises the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 109.12～163.68 parts of Cortex Magnoliae Officinalis; 81.80～123.17 parts of Radix Trichosanthis; 217.94～327.85 parts in Poria; 109.12～165.56 parts of the Radixs Angelicae Dahuricae; 109.12～165.56 parts of Guangdong Massa Medicata Fermentata; 27.17～41.20 parts of Fructus Tribulis; 109.12～163.68 parts of Rhizoma Atractylodis; 109.12～163.68 parts of Radix Puerariaes; 54.48～81.73 parts of Exocarpium Citri Grandises; 81.80～123.17 parts of Fructus Oryzae Germinatus; 54.48～81.73 parts of Flos Chrysanthemis; 109.12～163.68 parts of the Radix Aucklandiae; 109.12～163.6 parts of Herba Pogostemonis; 54.48～81.73 parts of Herba Menthaes; 136.77～206.10 parts of Semen Coiciss are subsequent use;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50～70 ℃;
C. qinghuo reagent I, clear paste II, dextrin embedding thing are with effervescent adjuvant mixing granulation, tabletting.
Best effervescent method for preparing of the present invention comprises the steps:
A. it is subsequent use to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃;
C. qinghuo reagent I, clear paste II, dextrin embedding thing are with effervescent adjuvant mixing granulation, tabletting.
Process for preparing medicine three of the present invention:
Effervescent method for preparing of the present invention comprises the steps:
A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 80.40～215.50 parts of Cortex Magnoliae Officinalis; 55.50～205.80 parts of Radix Trichosanthis; 155.60～423.20 parts in Poria; 80.40～215.50 parts of the Radixs Angelicae Dahuricae; 80.40～215.50 parts of Guangdong Massa Medicata Fermentata; 15.50～55.80 parts of Fructus Tribulis; 80.40～215.50 parts of Rhizoma Atractylodis; 80.40～215.50 parts of Radix Puerariaes; 36.70～125.40 parts of Exocarpium Citri Grandises; 55.50～205.80 parts of Fructus Oryzae Germinatus; 36.70～125.40 parts of Flos Chrysanthemis; 80.40～215.50 parts of the Radix Aucklandiae; 80.40～215.50 parts of Herba Pogostemonis; 36.70～125.40 parts of Herba Menthaes; 95.20～324.80 parts of Semen Coiciss are subsequent use;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1～10 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃;
Add ethanol to clear paste I and make and contain alcohol amount and reach 50～80%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.01～1.15, and is centrifugal with 5000～20000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well; Earlier with the water elution of 1～5 times of column volume 1～3 time, 20%～80% ethanol elution of 2～8 times of column volumes of reuse 1～3 time, merging ethanol elution; Being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrates; Drying is pulverized, and it is subsequent use to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 2～10 times distilled water eluting of column volume 1～3 time, water liquid discards; Reuse 50～80% ethanol elutions 1～3 time; Eluting uses ethanol 2～10 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II is with dextrin embedding thing, effervescent adjuvant mixing granulation, tabletting.
Preferred effervescent method for preparing of the present invention comprises the steps:
A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis; 109.12～163.68 parts of Cortex Magnoliae Officinalis; 81.80～123.17 parts of Radix Trichosanthis; 217.94～327.85 parts in Poria; 109.12～165.56 parts of the Radixs Angelicae Dahuricae; 109.12～165.56 parts of Guangdong Massa Medicata Fermentata; 27.17～41.20 parts of Fructus Tribulis; 109.12～163.68 parts of Rhizoma Atractylodis; 109.12～163.68 parts of Radix Puerariaes; 54.48～81.73 parts of Exocarpium Citri Grandises; 81.80～123.17 parts of Fructus Oryzae Germinatus; 54.48～81.73 parts of Flos Chrysanthemis; 109.12～163.68 parts of the Radix Aucklandiae; 109.12～163.6 parts of Herba Pogostemonis; 54.48～81.73 parts of Herba Menthaes; 136.77～206.10 parts of Semen Coiciss are subsequent use;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50～70 ℃;
Add ethanol to clear paste I and make and contain alcohol amount and reach 60～70%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 10000～15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well; Earlier with the water elution of 2～4 times of column volumes 2～3 times, 40～70% ethanol elution of 3～6 times of column volumes of reuse 2～3 times, merging ethanol elution; Being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrates; Drying is pulverized, and it is subsequent use to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.02～1.10, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 2～8 times distilled water eluting of column volume 2～3 times, water liquid discards; Reuse 60～70% ethanol elutions 2～3 times; Eluting uses ethanol 2～8 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II is with dextrin embedding thing, effervescent adjuvant mixing granulation, tabletting.
Best effervescent method for preparing of the present invention comprises the steps:
A. it is subsequent use to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;
B. active component preparation:
Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃;
Add ethanol to clear paste I and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 60% ethanol elution of 4 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and it is subsequent use to get dry extract I;
Add water to clear paste II that to be diluted to density be 1.02～1.08, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 4 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II is with dextrin embedding thing, effervescent adjuvant mixing granulation, tabletting.
In the preparation process of the active component of medicine three of the present invention, can part clear paste I further be purified, dry extract I; Can part clear paste II further be purified, dry extract II, will remain then clear paste I, further purify obtain dry extract I, residue clear paste II, further the acquisition dry extract II that purifies carries out combination in any.
In the above process for preparing medicine, acid source, carbon dioxide source can wrap up with Polyethylene Glycol separately, or with other adjuvants parcels, react in governance process to reduce.
Can add an amount of correctives such as Oleum menthae, menthol, artificial Rhizoma et radix valerianae, Cortex Cinnamomi and other fruity etc. in the medicine of the present invention.
Can add an amount of sweeting agent in the medicine of the present invention like sugar, saccharin sodium, Calcium o-benzolsulfimide, cyclohexane sulfamic acid (sodium), GLYCYRRHIN, alcohol sugar, radix asparagi sweet extract etc.
Can also add moderate lubrication agent such as Stepanol MG, Polyethylene Glycol, magnesium stearate (calcium), hydrogenated vegetable wet goods in the medicine of the present invention.
More than form when producing and to increase or to reduce according to corresponding ratio; Like large-scale production can be unit with kilogram or with the ton; Small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
To those skilled in the art, technology contents disclosed according to the present invention, those skilled in the art will very clear other embodiment of the present invention, and the embodiment of the invention is only as an example.Under the situation of not violating purport of the present invention and scope, can carry out various changes and improvement to the present invention.For example; Use different drug effective ingredient or active constituents of medicine and effervescent adjuvant provided by the invention to adopt identical or obstructed method for preparing to process effervescent; But as long as use effervescent adjuvant of the present invention, all within protection domain of the present invention.
The specific embodiment
In order to understand the present invention better, logical below Test Example is further set forth the beneficial effect of medicine of the present invention.These Test Example comprise the pharmacodynamics test of medicine of the present invention.Below institute's medicament prepares according to embodiment 15 methods in the test.
One, medicine of the present invention is to the mice gastric emptying, the influence of intestinal propulsion
Medicine of the present invention according to the preparation of embodiment 15 methods, grinds, and adds water and becomes pasty state.
Control drug: Health pill, commercially available, adopt identical pastel.
1. adopt the semi-solid gastric emptying experimental technique of mice, observe medicine of the present invention normal mouse and dopamine hydrochloride are caused the influence of mice delayed gastric emptying, the result shows: (1) medicine of the present invention, Health pill are not obvious to the normal mouse gastric emptying.(2) the simple dopamine hydrochloride group of nutrition paste residual quantity significantly reduces (P＜0.01 or P＜0.05) in two dosage of medicine of the present invention (1.85g/kg, 3.70g/kg), Health pill (1.85g/kg), fourth woods (5mg/kg) stomach, and medicine of the present invention, the Health pill of prompting doses all have antagonism to the mice delayed gastric emptying that dopamine hydrochloride causes.
2. adopt mouse small intestine charcoal end propulsion trial, observe medicine of the present invention and contrast medicine Health pill, and at neostigmine, epinephrine, atropine cause that mouse small intestine advances antagonism hyperfunction or that suppress the propulsive influence of small intestine movement of mice.The result shows that (1) medicine low dose of the present invention has the propulsive effect of the small intestine movement of mice of quickening, and two dosage effects of middle and high dosage and Health pill are not obvious.(2) small intestinal that causes at neostigmine of two dosage of middle and high dosage of medicine of the present invention and Health pill is hyperfunction has an inhibitory action.(3) medicine high dose of the present invention causes that to atropine intestinal propulsion suppresses antagonism is arranged, and two dosage effects of little, middle dosage and Health pill are not obvious.(4) three dosage of medicine of the present invention cause that at epinephrine intestinal propulsion suppresses antagonism is arranged, and the Health pill effect is not obvious.
Above result shows, medicine doses of the present invention causes that at neostigmine mouse small intestine advances the hyperfunction inhibitory action that has, and the mouse small intestine that epinephrine or atropine are caused advances and suppresses also to have certain antagonism.Results suggest, medicine of the present invention has regulating action to mice gastric emptying, intestinal motility disorder.One of symptom that medicine of the present invention cures mainly is a gastrointestinal upset, dyspepsia, and both all can show the gastrointestinal motility dysfunction, this effect should be that its treatment gastrointestinal is not transported, one of dyspeptic pharmacological action.
The result shows, drug effect of the present invention and Health pill effect acquaintance, and medicine of the present invention also causes that to epinephrine intestinal propulsion suppresses antagonism is arranged, and Health pill except that epinephrine is caused mouse small intestine advance the effect that suppresses not obvious.
Two, medicine antidiarrheal of the present invention, analgesia and spasmolysis test.
1. the test of mouse anti diarrhoea shows: three dosage of medicine of the present invention and two dosage of Health pill cause the diarrhea of mouse model with Folium Sennae has obvious diarrhea effect.Show as 6 hours accumulative total of administration group and rush down following just number of times than the obvious minimizing of matched group (P＜0.05 or P＜0.01); In the medicine wherein of the present invention, low dose of (3.70g/kg, 1.85g/kg), and Health pill low dose of (1.85g/kg) after giving the agent of Folium Sennae diarrhea inducing second 2 hours and the 3rd were rushed down down just in 2 hours, and number of times also obviously reduces (P＜0.05 or P＜0.01) than matched group.
2. (1) hot-plate analgesic test shows: after low dose of (1.85g/kg) administration of medicine of the present invention 120 minutes, 90 minutes, 120 minutes pain thresholds were than the obvious rising of matched group (P＜0.05 or P＜0.01) after middle high dose (3.70g/kg, the 5.55g/) administration; Dosage in the Health pill (3.70g/kg), high dose administration 60 minutes, pain threshold was than the obvious rising of matched group (P＜0.05 or P＜0.01) in 90 minutes.
(2) test of acetic acid twisting method shows; Each dose groups of medicine of the present invention and Health pill and matched group are relatively; The equal no significant difference incubation period of writhing response (P＞0.05); Medicine high dose group of the present invention (5.55g/kg) is turned round the body number of times and is obviously reduced (P＜0.05) than matched group, and two dose groups of Health pill also have certain minimizing, but difference not significantly (P＞0.05).
The result shows that medicine of the present invention and Health pill have certain analgesic activity, but onset is slow and effect a little less than.
3. the test of isolated rabbit small intestinal and stripped small intestine of guinea pig spasmolysis shows that medicine doses of the present invention causes that to acecoline the spastic contraction of isolated rabbit ileum has certain antagonism.The spastic contraction of GPI that histamine phosphate is caused has tangible antagonism, and the tonicity of dosing metagaster obviously descends.
Results suggest, medicine of the present invention has certain spasmolysis, and the Health pill spasmolysis of same dose is not obvious.
Three, medicine Chinese People's Anti-Japanese Military and Political College's Mus acute gastric mucosal lesion of the present invention and to the influence of rat tolerance secretion
1. adopt the sticking damage model of touching of acidic alcohol rat acute stomach; Observe the sticking effect of touching damage of anti-acute stomach of medicine of the present invention and Health pill; The result shows that three dosage of medicine of the present invention (0.925g/kg, 1.85g/kg, 33.70) and Health pill (1.85g/kg) can reduce obviously that the stomach of rat model is sticking touches damage index, and the stomach of point out two kinds of preparations that some foreign substance is caused glues to be touched acute injury protective effect is arranged.
2. adopt rat pylorus ligature law stomachial secretion test to show, in the medicine of the present invention in, low dosage (1.85,0.925g/kg) do not have tangible influence to the pylorus ligation rat tolerance secretion; High dose (3.70g/kg) shows as gastric secretion, total acid output obviously reduces than matched group, points out this dosage that gastric acid secretion is had inhibitory action.Health pill (1.85g/kg) does not have tangible influence to stomachial secretion.
In order to understand the present invention better, below with medicine of the present invention test disintegration explanation advantage of the present invention.
Test Example 1: effervescent tablet of the present invention experiment disintegration
In vitro tests
Through measuring medicine of the present invention disintegration, whether ripe, whether be fit to suitability for industrialized production if investigating its releasing effect and preparation technology thereof.
1. test medication: medicine effervescent tablet of the present invention (according to the preparation of embodiment 15 methods).
2. method and result:
Disintegration: according to nineteen ninety-five the version official method detect disintegration.
Get 1 of effervescent tablet and put in the 250ml beaker that fills 200ml water, water temperature 15-25 ℃, see that bubble emits.When gas stopped to overflow, tablet was answered disintegrate and dissolving, no aggregated particle residue.The record disintegration time.Repeat to survey 6, must exceed equal disintegration of value.
Result of the test is seen table one.
6 batches in table one medicine effervescent tablet of the present invention disintegration
Figure G2006111183220060116D000131
Insoluble matter has (+) not have (-)
Visible by table one, medicine dissolution property of the present invention and disintegration are more satisfactory, and all disintegrates within 5min disintegration of 6 batches the medicine effervescent tablet of the present invention of getting meet the requirement of Chinese Pharmacopoeia nineteen ninety-five version.
Test Example 2: medicine effervescent tablet reserved sample observing of the present invention relatively
1. test medication: medicine effervescent tablet of the present invention (according to the preparation of embodiment 15 methods).
2. method and result: three batches of the things of getting it filled are loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, again exsiccator is put into 40 ℃ of drying baker of constant temperature, and timing sampling is observed the effervescent tablet surface condition, and the result sees table two.
6 batches of medicine effervescent tablet reserved sample observings of the present invention of table two
Result of the test shows that it is little that each batch of medicine effervescent tablet of the present invention sees that adhesion phenomenon changes, but the effervescent tablet suitability for industrialized production that adopts this prescription and effervescent adjuvant to process is described.
Below further set forth the method for preparing of medicine of the present invention through embodiment.
Embodiment 1:
A. get prescription one: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 6.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 65～70 ℃ of temperature are extracted each 2.5 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 9 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 700 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 10g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 1g, it is subsequent use to add xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g; With the above-mentioned raw materials mix homogeneously, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 2:
A. get prescription two: Ramulus Uncariae Cum Uncis 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 50～60 ℃ of temperature are extracted each 3 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 7 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. get above-mentioned dry extract 9g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 0.5g, xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g are subsequent use; With dry extract, cyclodextrin inclusion compound, xylitol, xanthan gum, sodium bicarbonate, starch; Fully mix, drying is sieved; Granulate, obtain spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 3:
A. get prescription three: Ramulus Uncariae Cum Uncis 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 85～90 ℃ of temperature are extracted each 2 hours 3 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 3 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 900 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. with dry extract fine powder 30g and dextrin embedding thing 1g, Fructus Oryzae Germinatus superfine powder 1g, mix homogeneously adds xylitol 40g, pregelatinized Starch 15g, sodium bicarbonate 35g, starch 9g, citric acid 40g, fully mixes, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 4:
A. get prescription four: Ramulus Uncariae Cum Uncis 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 25 ℃ of temperature are extracted 2 times, extract 1 hour; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 5 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 800 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 0.5g, Fructus Oryzae Germinatus superfine powder 0.8g, xylitol 8g, arabic gum 5g, microcrystalline Cellulose 10g, citric acid 12g, sodium carbonate 14g fully mix above-mentioned raw materials, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 5:
A. get prescription five: Ramulus Uncariae Cum Uncis 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, to change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 45～55 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 5 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 650 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 16g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 0.8g adds lactose 25g, Lac 10g, hydroxyethyl-cellulose 20g, pregelatinized Starch 40g, calcium bicarbonate 30g, tartaric acid 26g; Fully mix, drying is sieved; Granulate, obtain spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 6
A. get prescription six: Ramulus Uncariae Cum Uncis 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 35～45 ℃ of temperature are extracted each 2.5 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 4.5 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 400～500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 9g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 1g, Polyethylene Glycol 8g, hydroxypropyl emthylcellulose 5g, gelatin 4g, sodium bicarbonate 8g, fumaric acid 6g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 7:
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 63 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 7.5 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. get above-mentioned dry extract 5g, cyclodextrin inclusion compound 5g, Fructus Oryzae Germinatus superfine powder 5g, crospolyvinylpyrrolidone 10g, hydroxypropyl emthylcellulose 5g, lactose 4g, sodium bitartrate 16g, tartaric acid 15g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 8:
A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 48 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 7 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 22g, cyclodextrin inclusion compound 3g, Fructus Oryzae Germinatus superfine powder 3g, xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 24g, citric acid 10g, sodium bicarbonate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 9:
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 8 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 75 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 1000 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 7g, cyclodextrin inclusion compound 3g, Fructus Oryzae Germinatus superfine powder 1g, xylitol 8g, arabic gum 4g, hydroxypropyl cellulose 5g, citric acid 12g, boric acid 11g,, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 10:
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 90 ℃ of temperature are extracted each 0.5 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 3 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 5g, cyclodextrin inclusion compound 5g, Fructus Oryzae Germinatus superfine powder 5g, xylitol 80g, cyclodextrin 20g, citric acid 30g, sodium bicarbonate 40g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 11:
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 80 ℃ of temperature are extracted 2 times, extract 2 hours for the first time, extract 0.5 hour for the second time; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. with dry extract fine powder 11g, dextrin embedding thing 5g, Fructus Oryzae Germinatus superfine powder 2g, mix homogeneously, lactose 12g, pregelatinized Starch 6g, citric acid 12g, sodium bicarbonate 12g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 12
A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 35 ℃ of temperature are extracted each 1.5 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 25g, cyclodextrin inclusion compound 5g, Fructus Oryzae Germinatus superfine powder 1g, citric acid 60g, sodium bicarbonate 70g fully mix, and drying is sieved, and granulate, and obtain spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 13
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 60 ℃ of temperature are extracted each 1.5 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 4g, cyclodextrin inclusion compound 2g, Fructus Oryzae Germinatus superfine powder 20g, tartaric acid 30g, sodium bicarbonate 34g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 14
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 50 ℃ of temperature are extracted 2 times, extract 2.5 hours for the first time, extract 1.5 hours for the second time; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 3.5 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 800 orders, subsequent use;
C. get above-mentioned dry extract, cyclodextrin inclusion compound 15g, Fructus Oryzae Germinatus superfine powder 1g altogether, fumaric acid 10g, sodium bitartrate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 15
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 10 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 60 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. get above-mentioned dry extract 14g, cyclodextrin inclusion compound 6g, Fructus Oryzae Germinatus superfine powder 4g, fumaric acid 20g, sodium bitartrate 25g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 16
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 8 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 40 ℃ of temperature are extracted 2 times, extract 1 hour for the first time, extract 0.5 hour for the second time; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 12 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 700 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 10g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 3g, adipic acid 22g, calcium bicarbonate 20g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 17
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 1 times of extract amount, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 85 ℃ of temperature are extracted 2 times, extract 3 hours for the first time, extract 2 hours for the second time; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 10 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. get above-mentioned dry extract 35g, cyclodextrin inclusion compound 5g, Fructus Oryzae Germinatus superfine powder 6g, malic acid 50g, potassium bicarbonate 60g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 18
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 10 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 90 ℃ of temperature are extracted each 1.5 hours 3 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 12 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C.. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 12g, Fructus Oryzae Germinatus superfine powder 4g, boric acid 35g, potassium carbonate 34g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 19
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 4 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 35～40 ℃ of temperature are extracted 2 times, and 2 hours for the first time, 1 hour for the second time; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 10g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 8g, add xylitol 22g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g mix homogeneously, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 20
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 9 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 90 ℃ of temperature are extracted each 3 hours 3 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 12 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 800 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C.. get above-mentioned dry extract 18g, cyclodextrin inclusion compound 2g, Fructus Oryzae Germinatus superfine powder 3g, boric acid 50g, potassium carbonate 50g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 21
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 1.5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 25 ℃ of temperature are extracted 1 time, extract 3 hours; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 4 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 33g, cyclodextrin inclusion compound 4g, Fructus Oryzae Germinatus superfine powder 25g, malic acid 60g, potassium bicarbonate 70g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 22
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 7 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 75～80 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 10 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 600 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 12g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 1g, adipic acid 26g, calcium bicarbonate 20g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 23
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 2 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 35～40 ℃ of temperature are extracted each 0.5 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 700 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 6g, cyclodextrin inclusion compound 8g, Fructus Oryzae Germinatus superfine powder 1g, fumaric acid 20g, sodium bitartrate 25g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 24
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 50～60 ℃ of temperature are extracted each 1～1.5 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 8 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 9g, cyclodextrin inclusion compound 4g, Fructus Oryzae Germinatus superfine powder 4g, fumaric acid 10g, sodium bitartrate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 25
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
A. Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, the Semen Coicis of getting embodiment 7 prescriptions are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 4 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 40～50 ℃ of temperature are extracted each 2 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 6 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 800 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 6g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 9g, tartaric acid 10g, sodium bicarbonate 11g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 26
A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 3 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 45～55 ℃ of temperature are extracted each 1 hour 2 times; Filter, get supersound extraction liquid, subsequent use; Medical materials such as hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata add 5 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, 400～500 order Fructus Oryzae Germinatus superfine powder, subsequent use;
C. get above-mentioned dry extract 2g, cyclodextrin inclusion compound 5g, Fructus Oryzae Germinatus superfine powder 2g, citric acid 6g, sodium bicarbonate 7g fully mix, and drying is sieved, and granulate, and obtain spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 27
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 4 times, each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 4 times respectively of Massa Medicata Fermentata, Poria, each 3 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 65%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 4 times, each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 4 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 4 times with 85% alcohol heating reflux respectively, and each 3.5 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 4 times with 85% alcohol heating reflux, and each 3.5 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 14% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 95 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;
C. with dry extract fine powder 11g and dextrin embedding thing 5g mix homogeneously, lactose 12g, pregelatinized Starch 6g, citric acid 12g, sodium bicarbonate 12g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 28
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decocte with water 1 time was extracted 0.2 hour, filtered, and merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 1 time respectively of Massa Medicata Fermentata, Poria was extracted 0.2 hour, filters, and merging filtrate, filtrating is concentrated into an amount of, and add ethanol and make and contain the alcohol amount and reach 30%, hold over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 1 time, inferior 0.2 hour of every extraction filters, and merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 1 time, extract 0.2 hour, filter, and merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1 time with 50% alcohol heating reflux respectively, extract 0.5 hour, filter, and merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 1 time with 50% alcohol heating reflux, and each 0.5 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 6% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 50 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;
C. get above-mentioned dry extract 5g, cyclodextrin inclusion compound 5g, xylitol 20g, cyclodextrin 6g, citric acid 22g, sodium bicarbonate 21g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 29
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved medicinal residues decocte with water 3 times; 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter; Merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, the decocte with water of Poria difference 3 times 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter; Merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 30～65%, hold over night; Filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, 3 hours per first time, and 2 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 75% alcohol heating reflux respectively, and 3.5 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 75% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time; Filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs; Filter, filtrating is concentrated into the thick paste shape with 14% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 75 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;
C. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 3g, xylitol 18g, arabic gum 14g, hydroxypropyl cellulose 5g, citric acid 12g, boric acid 11g,, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 30
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water 3 times, each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The decocte with water 3 times respectively of Massa Medicata Fermentata, Poria, each 2 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 55%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water 3 times, each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi are distinguished decocte with water 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 80% alcohol heating reflux respectively, and each 3 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts 3 times with 80% alcohol heating reflux, and each 3 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 90 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;
C. get above-mentioned dry extract 42g, cyclodextrin inclusion compound 3g, xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 4g, citric acid 40g, sodium bicarbonate 41g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 31
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, medicinal residues decocte with water secondary, 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Massa Medicata Fermentata, Poria be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrating is concentrated into an amount of, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and filtrate recycling ethanol is concentrated into the thick paste shape, and is subsequent use; Fructus Oryzae Germinatus decocte with water secondary, each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi be the decocte with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is subsequent use; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is subsequent use; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrating is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is subsequent use; Semen Coicis is ground into fine powder 80 ℃ of oven dry, adds above-mentioned thick paste and an amount of starch, and fully mixing adds the volatile oil with an amount of dissolve with ethanol, and drying gets dry extract;
C. get above-mentioned dry extract 15g, cyclodextrin inclusion compound 5g, crospolyvinylpyrrolidone 10g, hydroxypropyl emthylcellulose 5g, lactose 14g, sodium bitartrate 16g, tartaric acid 15g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 32
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 50%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction; Filter, filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40%; Hold over night filters, and reclaims ethanol and is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 40%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 2 times, 2 hours for the first time, 1 hour for the second time, collecting decoction; Filter, filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 60%, hold over night; Filter, reclaim ethanol, be concentrated into an amount of, subsequent use;
C. get above-mentioned dry extract 29g, cyclodextrin inclusion compound 1g, Polyethylene Glycol 28g, hydroxypropyl emthylcellulose 25g, gelatin 24g, sodium bicarbonate 28g, fumaric acid 26g fully mix, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 33
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. above ten Six-elements are got the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis and use vapor distillation, and collection volatile oil is subsequent use; Medicinal residues decocte with water 2 times, each 1 hour, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and reclaims ethanol, is concentrated into certain volume, and is subsequent use; Ramulus Uncariae Cum Uncis, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, medicated leaven decocte with water 2 times, each 2.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45%, and hold over night filters, and reclaims ethanol and also is concentrated into certain volume, and is subsequent use; Get Semen Coicis, Fructus Oryzae Germinatus decocte with water 2 times, each 1.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, put coldly, added ethanol and made and contain the alcohol amount and reach 40%, and hold over night reclaims ethanol, is concentrated into certain volume, and is subsequent use; Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, Radix Puerariae, decocte with water 2 times, each 2.5 hours, collecting decoction filtered, and filtrating is concentrated into an amount of, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 60%, and hold over night filters, and reclaims ethanol, is concentrated into an amount of, subsequent use;
C. said extracted liquid is mixed, drying adds volatile oil, gets dry extract; Get above-mentioned dry extract, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 34
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 10 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 100 ℃ with 12 times of water gagings, and each 5 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 12 times of amount ethanol of 80%, and each 5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 80 ℃;
C. clear paste I 10g, clear paste II 30g are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is got malic acid 50g, potassium bicarbonate 60g is subsequent use; Said mixture is fully mixed with potassium bicarbonate, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 35
A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 35 ℃ with 2 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 35 ℃; Medicinal residues after the extraction extract 2 times at 100 ℃ with 2 times of amount ethanol of 30%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying, with the cyclodextrin clathrate mix homogeneously, it is subsequent use to get an amount of sweetener, adipic acid 22g, calcium bicarbonate 20g; Said mixture is fully mixed with calcium bicarbonate, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 36
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 6 times of water gagings, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 8 times of amount ethanol of 50%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 70 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying with the cyclodextrin clathrate mix homogeneously, is got said mixture and 15g, fumaric acid 10g, sodium bitartrate 11g is subsequent use; Medicine, sodium bitartrate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 37
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 90 ℃ with 8 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 70 ℃; Medicinal residues after the extraction extract 2～3 times at 80 ℃ with 8 times of amount ethanol of 70%, and each 3 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 70 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying is with the cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 6g, tartaric acid 10g, sodium bicarbonate 11g; Medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 38
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 50 ℃ with 3 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 3 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying is with the cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 5g, citric acid 6g, sodium bicarbonate 7g; Medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 39
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 60 ℃ with 7 times of water gagings, and 2.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 4 times of amount ethanol of 60%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 60 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying is with the cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 5g, citric acid 6g, sodium bicarbonate 7g; Medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 40
A. get prescription, it is subsequent use with embodiment 7 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 2～8 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 65 ℃ with 3 times of water gagings, and 1.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 65 ℃; Medicinal residues after the extraction extract 2 times at 59 ℃ with 4 times of amount ethanol of 65%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 65 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying, with the cyclodextrin clathrate mix homogeneously, it is subsequent use to get said mixture 16g, lactose 12g, pregelatinized Starch 6g, citric acid 12g, sodium bicarbonate 12g; Medicated powder, lactose, pregelatinized Starch, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 41
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃;
C. clear paste I, clear paste II are merged, concentrate, drying is with the cyclodextrin clathrate mix homogeneously; Get said mixture and 8g, xylitol 10g, cyclodextrin 6g, citric acid 12g, sodium bicarbonate 11g is subsequent use; Medicated powder, xylitol, cyclodextrin, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 42
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 9 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 100 ℃ with 10 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 5 times of amount ethanol of 80%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃;
Add ethanol to clear paste I and make and contain alcohol amount and reach 80%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.01～1.15, and is centrifugal with 20000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 5 times of column volumes 3 times; 80% ethanol elution of 8 times of column volumes of reuse 3 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and it is subsequent use to get dry extract I; Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 10 times distilled water eluting of column volume 3 times, water liquid discards; Reuse 80% ethanol elution 3 times; Eluting uses ethanol 10 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II.
C. with dry extract I 5g, dry extract II 5g and cyclodextrin clathrate mix homogeneously; It is subsequent use to get xylitol 8g, arabic gum 4g, hydroxypropyl cellulose 5g, citric acid 12g, boric acid 11g; With medicated powder, xylitol, arabic gum, sodium bicarbonate, hydroxypropyl emthylcellulose, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 43
A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 1 times of extract amount of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 1 time at 35 ℃ with 2 times of water gagings, extract 5 hours, and merge extractive liquid, filters, and the relative density when being concentrated into 35 ℃ of filtrating is that 1.05～1.30 clear paste I is subsequent use; Medicinal residues after the extraction extract 1 time at 100 ℃ with 2 times of amount ethanol of 30%, extract 5 hours, and merge extractive liquid, filters, extracting solution recovery ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 50%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.01～1.15, and is centrifugal with 5000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 2 times; 20% ethanol elution of 3 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I;
C. 10g dry extract I, 15g clear paste II are merged, concentrate drying; It is subsequent use to get xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 4g, citric acid 10g, sodium bicarbonate 11g; With medicated powder, xylitol, arabic gum, sodium bicarbonate, hydroxypropyl emthylcellulose, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 44
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 6 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 55 ℃ with 5.5 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 55 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 5.5 times of amount ethanol of 55%, and each 2.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 35～80 ℃; Clear paste II adds water to and is diluted to density is 1.01～1.15, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5.5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 2 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. clear paste I, dry extract II are merged, concentrate drying; It is subsequent use to get said mixture 10g, crospolyvinylpyrrolidone 10g, hydroxypropyl emthylcellulose 5g, lactose 4g, sodium bitartrate 6g, tartaric acid 5g; With medicated powder, crospolyvinylpyrrolidone, hydroxypropyl emthylcellulose, lactose, sodium bitartrate, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 45
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Dextrin enclose with 3 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 85 ℃ with 3 times of water gagings, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is subsequent use when filtrating was concentrated into 75 ℃; Medicinal residues after the extraction extract 2 times at 75 ℃ with 7 times of amount ethanol of 75%, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is subsequent use when being concentrated into 75 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 60%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 10000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2 times of column volumes 3 times; 70% ethanol elution of 6 times of column volumes of reuse 3 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 8 times distilled water eluting of column volume 3 times, water liquid discards; Reuse 70% ethanol elution 3 times; Eluting uses ethanol 8 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 10g, Polyethylene Glycol 8g, hydroxypropyl emthylcellulose 5g, gelatin 4g, sodium bicarbonate 8g, fumaric acid 6g; With medicated powder, Polyethylene Glycol, hydroxypropyl emthylcellulose, gelatin, sodium bicarbonate, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 46
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 7 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 7 times of water gagings, and each 2.5 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 70 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 4 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 50 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 70%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 40～70% ethanol elution of 5 times of column volumes of reuse 3 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 2 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 60% ethanol elution 2 times; Eluting uses ethanol 2 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 6g, lactose 15g, Lac 10g, hydroxyethyl-cellulose 20g, pregelatinized Starch 10g, calcium bicarbonate 30g, tartaric acid 26g; With medicated powder, lactose, hydroxyethyl-cellulose, Lac, pregelatinized Starch, calcium bicarbonate, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 47
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 4.5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 80 ℃ with 4.5 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is subsequent use when filtrating was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 7.5 times of amount ethanol of 45%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is subsequent use when being concentrated into 65 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 75%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.10, and is centrifugal with 12000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 1 time; 60% ethanol elution of 6 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 7 times distilled water eluting of column volume 3 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 2 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 15g, xylitol 8g, arabic gum 5g, microcrystalline Cellulose 10g, citric acid 12g, sodium carbonate 14g; With medicated powder, xylitol, arabic gum, sodium carbonate, starch, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 48
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃;
Clear paste I adds ethanol to be made and contains alcohol amount and reach 65%, leaves standstill, and filters, and filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 60% ethanol elution of 4 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.08, leaves standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 4 times as column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;
C. with dry extract I, dry extract II and cyclodextrin clathrate mix homogeneously; It is subsequent use to get said mixture 5g, xylitol 20g, pregelatinized Starch 5g, sodium bicarbonate 25g, starch 9g, citric acid 30g; With medicated powder, xylitol, pregelatinized Starch, sour hydrogen sodium, starch, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 49 active component method for preparinies of the present invention
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Cyclodextrin inclusion compound with 5 times of extract amounts of volatile oil adding gets cyclodextrin clathrate, and is subsequent use; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is subsequent use when filtrating was concentrated into 60 ℃; Get part clear paste I and add ethanol and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrating is concentrated into does not have the alcohol flavor; Thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times; 60% ethanol elution of 4 times of column volumes of reuse 2 times merges ethanol elution, and being recycled to does not have the alcohol flavor, merges with water elution liquid; Concentrate, drying is pulverized, and it is subsequent use to get dry extract I;
Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is subsequent use when being concentrated into 60 ℃; Get part clear paste II and add water to that to be diluted to density be 1.02～1.08, leave standstill, centrifugal; Centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, and earlier with 5 times distilled water eluting of column volume 2 times, water liquid discards; Reuse 65% ethanol elution 2 times; Eluting uses ethanol 4 times as column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is subsequent use to get dry extract II;
C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II with the cyclodextrin clathrate mix homogeneously, is processed active component of the present invention.
Embodiment 50
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the clear paste I, dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 1g, dry extract I 1g, clear paste II 1g, dry extract II 1g and cyclodextrin clathrate mix homogeneously; It is subsequent use to get xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g; With medicated powder, xylitol, xanthan gum, sodium bicarbonate, starch, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 51
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the clear paste I, dry extract I, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 15g, dry extract I 0.5g, dry extract II 0.5g and cyclodextrin clathrate mix homogeneously, it is subsequent use to get xylitol 10g, arabic gum 3g, citric acid 10g, sodium bicarbonate 11g; With medicated powder, xylitol, arabic gum, sodium bicarbonate, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 52
A. get prescription, it is subsequent use with embodiment 3 to write out a prescription;
B. the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with dry extract I 20g, clear paste II 2g, dry extract II 3g and cyclodextrin clathrate mix homogeneously; It is subsequent use to get xylitol 10g, cyclodextrin 6g, citric acid 12g, sodium bicarbonate 11g; Medicated powder, xylitol, cyclodextrin, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 53
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
B. the clear paste I, dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 3g, dry extract I 1g, clear paste II 8g, dry extract II 1g and cyclodextrin clathrate mix homogeneously; Get tartaric acid 10g, sodium bicarbonate 11g is subsequent use; Medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 54
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the clear paste I, the clear paste II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously; Get citric acid 160g, sodium bicarbonate 170g is subsequent use; Medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 55
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the dry extract I, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with dry extract I 15g, dry extract II 7g and cyclodextrin clathrate mix homogeneously, add an amount of lactose; Get adipic acid 22g, calcium bicarbonate 20g is subsequent use; Medicated powder, calcium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add adipic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 54
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the clear paste I, the clear paste II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 50g, clear paste II 30g and cyclodextrin clathrate mix homogeneously; Get malic acid 50g, potassium bicarbonate 60g is subsequent use; Medicated powder, potassium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add malic acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 55
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the dry extract I, the clear paste II that get the acquisition of embodiment 49 methods are subsequent use;
C. with dry extract I 15g, clear paste II 7g and cyclodextrin clathrate mix homogeneously; Get boric acid 15g, potassium carbonate 14g is subsequent use; Medicated powder, potassium carbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add boric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 56
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the clear paste I that gets the acquisition of embodiment 49 methods is subsequent use;
C. with clear paste I 100g and cyclodextrin clathrate mix homogeneously; Get citric acid 6g, sodium bicarbonate 7g is subsequent use; Medicated powder, sodium bicarbonate are fully mixed, and drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 57
A. get prescription, it is subsequent use with embodiment 2 to write out a prescription;
B. the dry extract I that gets the acquisition of embodiment 49 methods is subsequent use;
C. with dry extract I 15g and cyclodextrin clathrate mix homogeneously; It is subsequent use to get xylitol 10g, arabic gum 3g, hydroxypropyl emthylcellulose 4g, citric acid 10g, sodium bicarbonate 11g; With medicated powder, xylitol, arabic gum, sodium bicarbonate, hydroxypropyl emthylcellulose, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 58
A. get prescription, it is subsequent use with embodiment 6 to write out a prescription;
B. the dry extract II that gets the acquisition of embodiment 49 methods is subsequent use;
C. with dry extract II 4g and cyclodextrin clathrate mix homogeneously; Taking polyethylene glycol 8g, hydroxypropyl emthylcellulose 5g, gelatin 4g, sodium bicarbonate 8g, fumaric acid 6g are subsequent use; With medicated powder, Polyethylene Glycol, hydroxypropyl emthylcellulose, gelatin, sodium bicarbonate, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add fumaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 59
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. the clear paste II that gets the acquisition of embodiment 49 methods is subsequent use;
C. with clear paste II 13g and cyclodextrin clathrate mix homogeneously; It is subsequent use to get xylitol 8g, arabic gum 5g, microcrystalline Cellulose 10g, citric acid 12g, sodium carbonate 14g; With medicated powder, xylitol, arabic gum, sodium carbonate, starch, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 60
A. get prescription, it is subsequent use with embodiment 4 to write out a prescription;
B. the clear paste I, the dry extract I that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 15g, dry extract I 2g and cyclodextrin clathrate mix homogeneously, add the 30g dextrin, mixing is granulated drying, granulate; Add magnesium stearate, mix homogeneously, tabletting promptly gets tablet.
Embodiment 61
A. get prescription, it is subsequent use with embodiment 5 to write out a prescription;
B. the clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste II 3g, dry extract II 25g and cyclodextrin clathrate mix homogeneously; Xylitol 100g, xanthan gum 10g, sodium bicarbonate 200g, starch 18g fully mix, and drying is sieved, and granulate, and obtain spares; In spares, add citric acid 150g, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
Embodiment 62
A. get prescription, it is subsequent use with embodiment 1 to write out a prescription;
B. the clear paste I, dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 49 methods are subsequent use;
C. with clear paste I 14g, dry extract I 3g, clear paste II 5g, dry extract II 29g and cyclodextrin clathrate mix homogeneously; It is subsequent use to get lactose 15g, Lac 10g, hydroxyethyl-cellulose 20g, pregelatinized Starch 10g, calcium bicarbonate 30g, tartaric acid 26g; With medicated powder, lactose, hydroxyethyl-cellulose, Lac, pregelatinized Starch, calcium bicarbonate, fully to mix, drying is sieved, and granulates, and obtains spares; In spares, add tartaric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.

Claims (1)

1. a method for preparing of treating gastrointestinal disease Chinese medicine effervescent is characterized in that, comprises the steps:
A. hook taking rattan 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are subsequent use;
B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, place the extractor of supercritical CO 2 device to extract respectively, get extract; Extract is mixed, add the cyclodextrin inclusion compound of 5 times of extract amounts, get cyclodextrin clathrate, subsequent use; Medicinal residues combine, supersound extraction, and 50～60 ℃ of temperature are extracted each 3 hours 2 times; Filter, get supersound extraction liquid, subsequent use; Hook taking rattan, Exocarpium Citri Grandis, Radix Puerariae, Poria, Flos Chrysanthemi, Fructus Tribuli, Radix Trichosanthis, Semen Coicis, Guangdong Massa Medicata Fermentata medical material add 7 times of water gagings and soak, and heating decocts three times, filters; Filtrating merges with supersound extraction liquid, concentrates, and high speed centrifugation concentrates; Spray drying gets dry extract, and is subsequent use; Get the Fructus Oryzae Germinatus of crude drug proportioning, be ground into coarse powder after, put continuous pulverizing in the micron ultra shifter, the above Fructus Oryzae Germinatus superfine powder of 400 orders, subsequent use;
C. get above-mentioned dry extract 9g, cyclodextrin inclusion compound 1g, Fructus Oryzae Germinatus superfine powder 0.5g, xylitol 12g, xanthan gum 3g, sodium bicarbonate 30g, starch 10g, citric acid 20g are subsequent use; With dry extract, cyclodextrin inclusion compound, Fructus Oryzae Germinatus superfine powder 0.5g, xylitol, xanthan gum, sodium bicarbonate, starch fully mix; Dry; Sieve, granulate, obtain spares; In spares, add citric acid, mixing, tabletting is processed the effervescent tablet of every 1g, promptly gets.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1583086A (en) * 2004-05-27 2005-02-23 广州王老吉药业股份有限公司 Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production

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