BR9809658A - Processo para a preparação de um composto contendo um anel benzeno 2, 4, 6- triiodado - Google Patents

Processo para a preparação de um composto contendo um anel benzeno 2, 4, 6- triiodado

Info

Publication number
BR9809658A
BR9809658A BR9809658-3A BR9809658A BR9809658A BR 9809658 A BR9809658 A BR 9809658A BR 9809658 A BR9809658 A BR 9809658A BR 9809658 A BR9809658 A BR 9809658A
Authority
BR
Brazil
Prior art keywords
agent
added
temperature
preparation
benzene ring
Prior art date
Application number
BR9809658-3A
Other languages
English (en)
Inventor
Dick Malthe-S Renssen
Ole Magne Homestad
Britt Sterud
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of BR9809658A publication Critical patent/BR9809658A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO CONTENDO UM ANEL BENZENO 2,4,6- TRIIODADO". A invenção proporciona um processo melhorado para a preparação de um composto contendo um anel benzeno 2,4,6- triiodado, compreendendo esse mencionado processo reagir um ácido 5-aminobenzóico 2,4,6-não substituído ou um derivado do mesmo com um agente de iodação de halogeneto de iodo, em um meio aquoso de reação, caracterizado pelo fato de que o agente de iodação é adicionado a um meio aquoso contendo o ácido 5-amino benzóico, ou um seu derivado, em duas diferentes faixas de temperatura: (A) uma ou mais primeiras porções do agente são adicionadas a uma temperatura na faixa de 40 a 70° C e em seguida uma ou mais segundas porções do agente são adicionadas a uma temperatura na faixa de 75 a 95° C ou, (B) uma ou mais primeiras porções do agente são adicionadas a uma temperatura na faixa de 75 a 95° C e em seguida uma ou mais segundas porções do agente são adicionadas a uma temperatura de 60 a 70° C.
BR9809658-3A 1997-05-23 1998-05-22 Processo para a preparação de um composto contendo um anel benzeno 2, 4, 6- triiodado BR9809658A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710725.4A GB9710725D0 (en) 1997-05-23 1997-05-23 Process
PCT/GB1998/001488 WO1998052908A1 (en) 1997-05-23 1998-05-22 Preparation of tri-iodo benzene compounds

Publications (1)

Publication Number Publication Date
BR9809658A true BR9809658A (pt) 2000-07-11

Family

ID=10812987

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809658-3A BR9809658A (pt) 1997-05-23 1998-05-22 Processo para a preparação de um composto contendo um anel benzeno 2, 4, 6- triiodado

Country Status (17)

Country Link
US (1) US6274762B1 (pt)
EP (1) EP0984922B1 (pt)
JP (1) JP4039700B2 (pt)
KR (1) KR100544932B1 (pt)
CN (1) CN1152854C (pt)
AT (1) ATE221872T1 (pt)
AU (1) AU7540498A (pt)
BR (1) BR9809658A (pt)
CA (1) CA2290529A1 (pt)
CZ (1) CZ296389B6 (pt)
DE (1) DE69807073T2 (pt)
ES (1) ES2183366T3 (pt)
GB (1) GB9710725D0 (pt)
IL (1) IL133099A0 (pt)
NO (1) NO327489B1 (pt)
PT (1) PT984922E (pt)
WO (1) WO1998052908A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100355710C (zh) * 2005-12-15 2007-12-19 上海交通大学 芳烃碘代物的制备方法
EP2243767A1 (en) * 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
US20110020238A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Stabilizing aqueous solution of iodine chloride by adding sodium chloride
US20110021834A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous process of preparing intermediate for non-ionic x-ray contrast agents
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US7863484B1 (en) 2009-07-21 2011-01-04 Ge Healthcare As Method for reducing aminoisophthalic acid bisamide related impurities in preparation of non-ionic X-ray contrast agents
EP2277846A1 (en) 2009-07-21 2011-01-26 GE Healthcare AS Obtaining free iodine in preparation of aqueous iodine chloride by adding potassium iodide
JP5754842B2 (ja) * 2011-03-02 2015-07-29 株式会社 東邦アーステック ｐ−ヨードフェノールの製造方法
EP2773610B1 (en) * 2011-10-31 2017-09-06 iMAX Diagnostic Imaging Holding Limited Iodination process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines compounds
CN103086915A (zh) * 2011-10-31 2013-05-08 上海海神化学生物科技有限公司 制备3,5-二取代-2,4,6-三碘代芳香胺类化合物的碘化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145197A (en) * 1961-06-26 1964-08-18 Mallinckrodt Chemical Works 5-acetamido-nu-alkyl-2, 4, 6-trhodoiso-phthalamic acid compounds
SE348727B (pt) * 1969-07-08 1972-09-11 Pharmacia Ab
GB1466852A (en) * 1973-05-18 1977-03-09 Nyegaard & Co As Iodination process
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4125599A (en) * 1976-08-19 1978-11-14 Mallinckrodt, Inc. X-ray contrast agents
FR2614299B1 (fr) * 1987-04-23 1989-08-18 Guerbet Sa Composes diamino benzeniques iodes, leur procede de preparation et produits de contraste les contenant.
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
DE68922850T2 (de) * 1988-04-06 1995-12-21 Mallinckrodt Inc Verfahren zur herstellung von 2,4,6-triiodo-5-amino-n-alkyl-isophthalsäure.

Also Published As

Publication number Publication date
CN1257476A (zh) 2000-06-21
US6274762B1 (en) 2001-08-14
KR20010012824A (ko) 2001-02-26
PT984922E (pt) 2002-12-31
GB9710725D0 (en) 1997-07-16
JP4039700B2 (ja) 2008-01-30
NO327489B1 (no) 2009-07-13
EP0984922A1 (en) 2000-03-15
WO1998052908A1 (en) 1998-11-26
CA2290529A1 (en) 1998-11-26
IL133099A0 (en) 2001-03-19
CZ296389B6 (cs) 2006-03-15
AU7540498A (en) 1998-12-11
ATE221872T1 (de) 2002-08-15
KR100544932B1 (ko) 2006-01-24
NO995675D0 (no) 1999-11-19
DE69807073D1 (de) 2002-09-12
ES2183366T3 (es) 2003-03-16
CZ417299A3 (cs) 2000-05-17
DE69807073T2 (de) 2003-10-09
CN1152854C (zh) 2004-06-09
EP0984922B1 (en) 2002-08-07
NO995675L (no) 1999-11-19
JP2001526677A (ja) 2001-12-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A,7A,8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.