AR110068A2 - 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas - Google Patents

2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas

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Publication number
AR110068A2
AR110068A2 ARP170103158A ARP170103158A AR110068A2 AR 110068 A2 AR110068 A2 AR 110068A2 AR P170103158 A ARP170103158 A AR P170103158A AR P170103158 A ARP170103158 A AR P170103158A AR 110068 A2 AR110068 A2 AR 110068A2
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
amino
phenyl
group
Prior art date
Application number
ARP170103158A
Other languages
English (en)
Inventor
Zhenhai Gao
Kristin Brinner
John Tulinsky
Dan Gu
Baoqing Gong
Yasheen Zhou
Maureen Mkenna
John Dolan
Barry H Levine
Brandon M Doughan
William Antonios-Mcrea
Christopher Mbride
Cynthia M Shafer
Timothy D Machajewski
Kris Mendenhall
X Michael Wang
Yi Xia
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR110068A2 publication Critical patent/AR110068A2/es

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto con la fórmula [1], o un esteroisómero, tautómero, sal farmacéuticamente aceptable, o promedicamento del mismo, en donde: Rᵃ se selecciona de un grupo compuesto de (1) hidrógeno, (2) halógeno, (3) hidroxilo, (4) C₁₋₆ alcoxi, (5) tiol, (6) C₁₋₆ alquiltiol, (7) C₁₋₆ alquilo sustituido o no sustituido, (8) amino o amino sustituido, (9) arilo sustituido o no sustituido, (10) heteroarilo sustituido o no sustituido, y (11) heterociclilo sustituido o no sustituido; R se selecciona de un grupo compuesto de: (1) hidrógeno, (2) C₁₋₆ alquilo sustituido o no sustituido, (3) C₂₋₆ alquenilo sustituido o no sustituido, (4) C₂₋₆ alquinilo sustituido o no sustituido, (5) C₂₋₆ cicloalquilo sustituido o no sustituido, (6) C₅₋₇ cicloalquenilo sustituido o no sustituido, (7) arilo sustituido o no sustituido, (8) heteroarilo sustituido o no sustituido, y (9) heterociclilo sustituido o no sustituido; Rᵇ se selecciona de un grupo compuesto de (1) cicloalquilo C₃₋₇ sustituido o no sustituido, (2) cicloalquenilo C₅₋₇ sustituido o no sustituido, (3) arilo sustituido o no sustituido, (4) heteroarilo sustituido o no sustituido, y (5) heterociclilo sustituido o no sustituido; y con la condición de que cuando Rᵃ es amino, entonces Rᵇ no es fenilo, 4-alquilo-fenilo, 4-alcoxi-fenilo, o 4-halo-fenilo.
ARP170103158A 2005-09-30 2017-11-13 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas AR110068A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30

Publications (1)

Publication Number Publication Date
AR110068A2 true AR110068A2 (es) 2019-02-20

Family

ID=40059303

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170103158A AR110068A2 (es) 2005-09-30 2017-11-13 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidina-5-onas

Country Status (6)

Country Link
CN (1) CN101287734B (es)
AR (1) AR110068A2 (es)
SI (1) SI1928875T1 (es)
SV (1) SV2008002856A (es)
UA (1) UA93522C2 (es)
ZA (1) ZA200803658B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010034670A2 (en) * 2008-09-26 2010-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Host cell kinases as targets for antiviral therapies against hcv infection
KR20170113683A (ko) * 2008-11-28 2017-10-12 노파르티스 아게 피리도〔4,3-ｄ〕피리미딘 유래의 ｈｓｐ90-억제제 및 ｈｅｒ2 억제제를 포함하는 제약 조합물
RU2519673C2 (ru) * 2008-11-28 2014-06-20 Новартис Аг Комбинации ингибитора hsp90
EP3292120B1 (en) * 2015-05-04 2019-06-19 H. Hoffnabb-La Roche Ag Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections
CN113056475A (zh) * 2018-11-30 2021-06-29 中外制药株式会社 用于肽化合物或酰胺化合物的脱保护方法和在固相反应中的树脂脱除方法以及用于生产肽化合物的方法
CN109846886A (zh) * 2019-03-26 2019-06-07 中国医学科学院基础医学研究所 Nvp-hsp990在制备治疗癫痫的药物中的用途
CN114681463B (zh) * 2022-04-29 2024-03-15 暨南大学 Hsp990在制备预防和/或治疗腺病毒感染的药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165873A (ja) * 1984-09-07 1986-04-04 Mitsui Petrochem Ind Ltd ２−ピペラジノピリミジン誘導体
US4734418A (en) * 1984-12-14 1988-03-29 Mitsui Petrochemical Industries, Ltd. Quinazoline compounds and antihypertensives
IL85347A0 (en) * 1987-02-11 1988-07-31 May & Baker Ltd Cyclic diones

Also Published As

Publication number Publication date
UA93522C2 (en) 2011-02-25
SI1928875T1 (sl) 2011-10-28
SV2008002856A (es) 2008-06-30
ZA200803658B (en) 2009-09-30
CN101287734A (zh) 2008-10-15
CN101287734B (zh) 2011-07-20

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