AR059964A1 - Metodos para reducir la aglomeracion de proteina - Google Patents
Metodos para reducir la aglomeracion de proteinaInfo
- Publication number
- AR059964A1 AR059964A1 ARP070101104A ARP070101104A AR059964A1 AR 059964 A1 AR059964 A1 AR 059964A1 AR P070101104 A ARP070101104 A AR P070101104A AR P070101104 A ARP070101104 A AR P070101104A AR 059964 A1 AR059964 A1 AR 059964A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- protein
- aglomeration
- reduce protein
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere a métodos para reducir la aglomeracion de una proteína o proteínas en una formulacion y formulaciones de proteínas que tienen propiedades de aglomeracion reducidas. Los métodos y formulaciones descritas en este documento, mantienen la actividad biologica de una proteína e incrementan la vida de anaquel de las formulaciones de proteína.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78413006P | 2006-03-20 | 2006-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059964A1 true AR059964A1 (es) | 2008-05-14 |
Family
ID=38523027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101104A AR059964A1 (es) | 2006-03-20 | 2007-03-19 | Metodos para reducir la aglomeracion de proteina |
Country Status (18)
Country | Link |
---|---|
US (1) | US20080064856A1 (es) |
EP (1) | EP1996221A2 (es) |
JP (1) | JP2009530380A (es) |
KR (1) | KR20080108554A (es) |
CN (1) | CN101420972A (es) |
AR (1) | AR059964A1 (es) |
AU (1) | AU2007227408A1 (es) |
BR (1) | BRPI0709059A2 (es) |
CA (1) | CA2646934C (es) |
CR (1) | CR10290A (es) |
EC (1) | ECSP088758A (es) |
IL (1) | IL194123A0 (es) |
MX (1) | MX2008011888A (es) |
NO (1) | NO20083940L (es) |
PE (1) | PE20080121A1 (es) |
RU (1) | RU2008137634A (es) |
TW (1) | TW200806317A (es) |
WO (1) | WO2007109221A2 (es) |
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US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
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WO2009079837A1 (fr) * | 2007-12-18 | 2009-07-02 | Hangzhou Jiuyuan Gene Engineering Co., Ltd. | Formulation pharmaceutique contenant une protéine de fusion sérum albumine humaine recombinante-interféron alpha |
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EP2310412B1 (en) * | 2008-06-20 | 2018-02-21 | Novartis AG | Immunoglobulins with reduced aggregation |
BRPI0915414A2 (pt) | 2008-06-20 | 2021-09-08 | Novartis Ag | Métodos para identificar uma região propensa à agregação e uma região de ligação de macromolécula em uma proteína, bem como métodos para produzir uma variante de proteína e uma composição farmacêutica. |
JP5364310B2 (ja) * | 2008-07-14 | 2013-12-11 | アルフレッサファーマ株式会社 | 反応性物質が結合した微小粒子の安定化方法および該微小粒子含有試薬 |
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ES2531385T3 (es) * | 2008-09-19 | 2015-03-13 | Hoffmann La Roche | Formulación que comprende un anticuerpo contra la selectina P |
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KR20180056805A (ko) | 2009-06-04 | 2018-05-29 | 노파르티스 아게 | IgG 콘쥬게이션을 위한 자리의 확인 방법 |
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AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
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JP2000247903A (ja) * | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
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EP1309312A2 (en) * | 2000-08-07 | 2003-05-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
WO2002055101A2 (en) * | 2000-12-21 | 2002-07-18 | Inhale Therapeutic Syst | Storage stable powder compositions of interleukin-4 receptor |
US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
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CA2512681A1 (en) * | 2003-01-08 | 2004-07-29 | Chiron Corporation | Stabilized aqueous compositions comprising tissue factor pathway inhibitor (tfpi) or tissue factor pathway inhibitor variant |
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CN1993139B (zh) * | 2004-06-01 | 2011-02-16 | 阿雷斯贸易股份有限公司 | 稳定的干扰素液体制剂 |
TW200638943A (en) * | 2005-01-28 | 2006-11-16 | Wyeth Corp | Stabilized liquid polypeptide formulations |
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2007
- 2007-03-08 TW TW096108014A patent/TW200806317A/zh unknown
- 2007-03-16 PE PE2007000286A patent/PE20080121A1/es not_active Application Discontinuation
- 2007-03-19 BR BRPI0709059-5A patent/BRPI0709059A2/pt not_active IP Right Cessation
- 2007-03-19 EP EP07753416A patent/EP1996221A2/en not_active Ceased
- 2007-03-19 US US11/725,534 patent/US20080064856A1/en not_active Abandoned
- 2007-03-19 RU RU2008137634/15A patent/RU2008137634A/ru not_active Application Discontinuation
- 2007-03-19 AU AU2007227408A patent/AU2007227408A1/en not_active Abandoned
- 2007-03-19 KR KR1020087025501A patent/KR20080108554A/ko not_active Application Discontinuation
- 2007-03-19 AR ARP070101104A patent/AR059964A1/es unknown
- 2007-03-19 CN CNA2007800132437A patent/CN101420972A/zh active Pending
- 2007-03-19 WO PCT/US2007/006787 patent/WO2007109221A2/en active Application Filing
- 2007-03-19 JP JP2009501487A patent/JP2009530380A/ja active Pending
- 2007-03-19 CA CA2646934A patent/CA2646934C/en not_active Expired - Fee Related
- 2007-03-19 MX MX2008011888A patent/MX2008011888A/es not_active Application Discontinuation
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- 2008-09-16 IL IL194123A patent/IL194123A0/en unknown
- 2008-09-16 NO NO20083940A patent/NO20083940L/no unknown
- 2008-09-22 EC EC2008008758A patent/ECSP088758A/es unknown
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CA2646934A1 (en) | 2007-09-27 |
BRPI0709059A2 (pt) | 2011-06-21 |
CR10290A (es) | 2008-11-26 |
US20080064856A1 (en) | 2008-03-13 |
NO20083940L (no) | 2008-10-16 |
PE20080121A1 (es) | 2008-03-05 |
KR20080108554A (ko) | 2008-12-15 |
AU2007227408A1 (en) | 2007-09-27 |
EP1996221A2 (en) | 2008-12-03 |
JP2009530380A (ja) | 2009-08-27 |
WO2007109221A2 (en) | 2007-09-27 |
WO2007109221A3 (en) | 2008-02-21 |
CA2646934C (en) | 2014-09-23 |
MX2008011888A (es) | 2008-09-29 |
RU2008137634A (ru) | 2010-04-27 |
CN101420972A (zh) | 2009-04-29 |
WO2007109221A9 (en) | 2007-12-06 |
IL194123A0 (en) | 2011-08-01 |
TW200806317A (en) | 2008-02-01 |
ECSP088758A (es) | 2008-10-31 |
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