AR023101A1 - Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina - Google Patents
Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitinaInfo
- Publication number
- AR023101A1 AR023101A1 ARP000101222A ARP000101222A AR023101A1 AR 023101 A1 AR023101 A1 AR 023101A1 AR P000101222 A ARP000101222 A AR P000101222A AR P000101222 A ARP000101222 A AR P000101222A AR 023101 A1 AR023101 A1 AR 023101A1
- Authority
- AR
- Argentina
- Prior art keywords
- carnitine
- preparation
- improved process
- hygroscopic salts
- hygroscopic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un proceso mejorado para la preparacion de sales no higroscopicas de L(-)-carnitina, en el cual el paso de caracterizacion comprende el calentamiento deuna mezcla que comprende una sal interna de L(-)-carnitina y de un ácido salificante.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000551A IT1312018B1 (it) | 1999-03-19 | 1999-03-19 | Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023101A1 true AR023101A1 (es) | 2002-09-04 |
Family
ID=11382333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000101222A AR023101A1 (es) | 1999-03-19 | 2000-03-17 | Un proceso mejorado para la preparacion de sales no higroscopicas de l(-)-carnitina |
Country Status (22)
Country | Link |
---|---|
US (1) | US6372940B1 (es) |
EP (1) | EP1163207B1 (es) |
JP (1) | JP2002540094A (es) |
KR (1) | KR100664560B1 (es) |
CN (1) | CN1147462C (es) |
AR (1) | AR023101A1 (es) |
AT (1) | ATE247627T1 (es) |
AU (1) | AU4105800A (es) |
CA (1) | CA2359106A1 (es) |
CZ (1) | CZ299312B6 (es) |
DE (1) | DE60004649T2 (es) |
DK (1) | DK1163207T3 (es) |
ES (1) | ES2204555T3 (es) |
HK (1) | HK1042468A1 (es) |
HU (1) | HUP0200402A3 (es) |
IT (1) | IT1312018B1 (es) |
NZ (1) | NZ512640A (es) |
PL (1) | PL199614B1 (es) |
PT (1) | PT1163207E (es) |
SI (1) | SI1163207T1 (es) |
SK (1) | SK13312001A3 (es) |
WO (1) | WO2000056701A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2631569B1 (fr) * | 1988-05-20 | 1990-07-27 | Renault Automation | Detecteur de proximite magnetique destine notamment a la decoupe laser |
ITRM20010030A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr |
PT1757606E (pt) * | 2001-02-24 | 2009-05-26 | Boehringer Ingelheim Pharma | Utilização de derivados de xantina como produto farmacêutico, bem como seu processo de preparação |
US7407955B2 (en) * | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PE20110235A1 (es) * | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
CA2873524C (en) | 2006-05-04 | 2018-02-20 | Boehringer Ingelheim International Gmbh | A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine |
CN101209975B (zh) * | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
ES2733348T3 (es) * | 2007-08-17 | 2019-11-28 | Boehringer Ingelheim Int | Derivados de purina para uso en el tratamiento de enfermedades relacionadas con FAP |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
US20110190322A1 (en) * | 2008-08-14 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
BRPI0923121A2 (pt) | 2008-12-23 | 2015-08-11 | Boehringer Ingelheim Int | Formas salinas de compostos orgânico |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
CN102753161A (zh) | 2009-11-27 | 2012-10-24 | 贝林格尔.英格海姆国际有限公司 | 基因型糖尿病患者利用dpp-iv抑制剂例如利拉利汀的治疗 |
WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
EP3124041A1 (en) | 2010-06-24 | 2017-02-01 | Boehringer Ingelheim International GmbH | Diabetes therapy |
EP2425834A1 (en) * | 2010-09-06 | 2012-03-07 | Lonza Ltd. | Process for the production of l-carnitine tartrate |
JP2012092036A (ja) * | 2010-10-26 | 2012-05-17 | Mitsubishi Rayon Co Ltd | カルニチンの塩の製造方法 |
AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
ES2713566T3 (es) | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
WO2013171167A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
US20140316156A1 (en) * | 2013-04-18 | 2014-10-23 | Deborah Warner | Method of producing therapeutic agent |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
JP2019517542A (ja) | 2016-06-10 | 2019-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | リナグリプチンおよびメトホルミンの組合せ |
CN106748845B (zh) * | 2016-12-23 | 2018-11-20 | 东北制药集团股份有限公司 | 一种左旋肉碱盐微粉的制备方法 |
KR20190017310A (ko) | 2017-08-10 | 2019-02-20 | 주식회사 셀트리온화학연구소 | 약제학적 성질이 개선된 l-카르니틴 화합물의 염, 이의 제조방법, 이를 함유하는 약학 조성물 |
JP6964876B2 (ja) * | 2017-11-27 | 2021-11-10 | 株式会社古川リサーチオフィス | オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法 |
CN108383741A (zh) * | 2018-03-16 | 2018-08-10 | 开原亨泰化工有限公司 | 一种制备左旋肉碱成盐的新方法 |
CN109096129B (zh) * | 2018-09-30 | 2021-04-27 | 东北制药集团股份有限公司 | 一种左旋肉碱酒石酸盐的制备方法 |
CN109535022B (zh) * | 2018-11-12 | 2022-03-01 | 天津大学 | 一种提高左旋肉碱富马酸盐流动性的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3463261D1 (en) * | 1983-12-28 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
IT1289974B1 (it) * | 1997-02-25 | 1998-10-19 | Aldo Fassi | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
EP0914315B1 (en) * | 1996-05-31 | 2001-04-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts |
-
1999
- 1999-03-19 IT IT1999MI000551A patent/IT1312018B1/it active
-
2000
- 2000-03-16 CN CNB008034001A patent/CN1147462C/zh not_active Expired - Fee Related
- 2000-03-16 SK SK1331-2001A patent/SK13312001A3/sk unknown
- 2000-03-16 PT PT00920506T patent/PT1163207E/pt unknown
- 2000-03-16 ES ES00920506T patent/ES2204555T3/es not_active Expired - Lifetime
- 2000-03-16 NZ NZ512640A patent/NZ512640A/xx unknown
- 2000-03-16 DK DK00920506T patent/DK1163207T3/da active
- 2000-03-16 AU AU41058/00A patent/AU4105800A/en not_active Abandoned
- 2000-03-16 CZ CZ20013376A patent/CZ299312B6/cs not_active IP Right Cessation
- 2000-03-16 HU HU0200402A patent/HUP0200402A3/hu unknown
- 2000-03-16 AT AT00920506T patent/ATE247627T1/de not_active IP Right Cessation
- 2000-03-16 WO PCT/EP2000/002344 patent/WO2000056701A1/en active IP Right Grant
- 2000-03-16 PL PL349894A patent/PL199614B1/pl not_active IP Right Cessation
- 2000-03-16 JP JP2000606564A patent/JP2002540094A/ja not_active Ceased
- 2000-03-16 EP EP00920506A patent/EP1163207B1/en not_active Expired - Lifetime
- 2000-03-16 DE DE60004649T patent/DE60004649T2/de not_active Expired - Lifetime
- 2000-03-16 SI SI200030176T patent/SI1163207T1/xx unknown
- 2000-03-16 US US09/868,980 patent/US6372940B1/en not_active Expired - Fee Related
- 2000-03-16 CA CA002359106A patent/CA2359106A1/en not_active Abandoned
- 2000-03-16 KR KR1020017010602A patent/KR100664560B1/ko not_active IP Right Cessation
- 2000-03-17 AR ARP000101222A patent/AR023101A1/es unknown
-
2002
- 2002-05-31 HK HK02104080.1A patent/HK1042468A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
PL349894A1 (en) | 2002-09-23 |
NZ512640A (en) | 2003-03-28 |
ATE247627T1 (de) | 2003-09-15 |
CZ299312B6 (cs) | 2008-06-18 |
JP2002540094A (ja) | 2002-11-26 |
CN1339023A (zh) | 2002-03-06 |
KR20010102288A (ko) | 2001-11-15 |
HUP0200402A3 (en) | 2002-11-28 |
DE60004649T2 (de) | 2004-03-18 |
DK1163207T3 (da) | 2003-12-01 |
AU4105800A (en) | 2000-10-09 |
DE60004649D1 (de) | 2003-09-25 |
CA2359106A1 (en) | 2000-09-28 |
IT1312018B1 (it) | 2002-04-04 |
PT1163207E (pt) | 2003-12-31 |
CZ20013376A3 (cs) | 2002-02-13 |
US6372940B1 (en) | 2002-04-16 |
SK13312001A3 (sk) | 2002-05-09 |
PL199614B1 (pl) | 2008-10-31 |
HUP0200402A2 (hu) | 2002-05-29 |
WO2000056701A1 (en) | 2000-09-28 |
ES2204555T3 (es) | 2004-05-01 |
EP1163207A1 (en) | 2001-12-19 |
ITMI990551A1 (it) | 2000-09-19 |
SI1163207T1 (en) | 2003-12-31 |
HK1042468A1 (zh) | 2002-08-16 |
CN1147462C (zh) | 2004-04-28 |
EP1163207B1 (en) | 2003-08-20 |
KR100664560B1 (ko) | 2007-01-03 |
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